• 산업경영시스템학회지
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• 제32권4호
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• pp.215-222
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• 2009

Human voice reacts very sensitively to human's minute physical condition. For instance, human voice disorders affect patients profoundly especially in the case of Parkinson's disease. Acoustic tools such as MDVP, can function as an equipment that measures various voice in different objects. Many different approaches have been applied for analyzing the voice disorders for diagnosis of Parkinson's disease. According to the voice data of suspected Parkinson's patients from UCI Machine Learning Repository, it is reported to have 23 people with Parkinson's disease and 8 healthy people. Applying Mahalanobis Taguchi System (MTS) for diagnosis of Parkinson's disease, the correct diagnosis performance is compared to previous research results.

• 사상체질의학회지
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• 제28권2호
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• pp.184-192
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• 2016

Objectives The purpose of this case study is to report significant improvement of headache, constipation and a slight improvement of tremor after treatment with Hyeongbangjihwhang-tang in a Soyangin patient with Parkinson's disease.Methods This Soyangin patient is treated by Hyeongbangjihwhang-tang and acupuncture therapy. The progress was evaluated using the Unified Parkinson Disease Rating Scale before and after treatment. Secondary results assessments include Global Assessment Scale, change of patient's omniloquilism, Xerostomia and Cold hands & Feet Syndrome.Results and Conclusions The patient's symptoms of headache, constipation and tremor were improved after using Hyeongbangjihwhang-tang. and UDPRS score decreased in Part Ⅰ, Part Ⅱ, and Part Ⅲ. In conclusion, this study shows that Hyeongbangjihwhang-tang can be effective treatment for Soyangin patient with early-stage Parkinson''s disease. Overall, Sasang medicine can be a solution of the symptoms caused by Parkinson's disease. Through Sasang medicine we can contribute Parkinson's disease Patient's quality of life get better.

• 턱관절균형의학회지
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• 제11권1호
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• pp.12-19
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• 2021

There are many studies that show the association between Parkinson's disease and temporomandibular joint disorder. However, no clinical studies have yet been reported that TMJ Banlancing Therapy (TBT) can treat Parkinson's disease. In this study, the applicability of TBT for the treatment of Parkinson's disease was investigated by reviewing several studies on the factors related to Parkinson's disease and temporomandibular joint disorder and clinical studies of patients with Parkinson's disease using conventional oral appliances and exercises. In summary, it is considered that TBT has a high potential for use in the treatment of Parkinson's disease, but it is thought that prospective clinical research is needed in the future to establish objective evidence related to this.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.135-145
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• 2006

Background: Parkinson's disease is movement disorder due to dopaminergic deficiency. It has been noted that cognitive dysfunction also presented on Parkinson's disease patients. But, it is not clear whether such a cognitive dysfunction was a dopaminergic dysfunction or cholinergic dysfunction. Using linear and non-linear analyses, we analysed the effect of cognitive and motor symptom on EEG change. Methods: EEGs were recorded from patients with Parkinson's disease and essential tremor, and normal controls during rest. We calculated the power spectrum, correlation dimension and Lyapunov exponent by using 'Complexity'program. The power spectrum, correlation dimension, and Lyapunov exponent were compared between Parkinson's disease patients and essential tremor patients. Results: Theta power was increased in Parkinson's disease patient group. Correlation dimension was increased in Parkinson's disease patients. Positive correlation was noted between MMSE and correlation dimension, and negative correlation was noted between MMSE and Lyapunov exponent. Lyapunov exponent was decreased in Parkinson's disease patient. Conclusions: We conclude that the state of Parkinson's disease patient is characterized by increased correlation dimension and decreased Lyapunov exponent.

• 말소리와 음성과학
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• 제4권1호
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• pp.119-124
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• 2012

The purpose of this study is to compare the voice differences of persons with Idiopathic Parkinson's disease and a normal group according to five vowels. Eight persons with Idiopathic Parkinson's disease and a healthy control group of 22 were selected and every voice analyzed by MDVP. The first result showed that jitter measurements between the two group showed a significant statistical difference according to all vowels. Second, the two groups' shimmer measurements showed a significant statistical difference according to nearly all vowels. Third, jitter measurements between the five vowels were more relatively closely correlated persons with Idiopathic Parkinson's disease than the normal group. Fourth, shimmer figures between the five vowels more relatively closely correlated persons with Idiopathic Parkinson's disease than the normal group.

• The Journal of Korean Physical Therapy
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• 제12권2호
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• pp.203-217
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• 2000

This review describes the overall knowledges of parkinson's disease. There are involved the causes. chemical characteristics, clinical features including tremor. bradykinesia, and rigidity. evaluation of movement disorders. and physical therapy of parkinson's disease. People who are diagnosed with parkinson's disease experience movement disorders that, if not managed, can lead to considerable disability. Before treated with parkinson's disease, it is important to recognise the pathogenesis of that. Then we need to develop physiotherapeutic programs based on the pathophysiology of parkinson's disease.

• 근관절건강학회지
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• 제26권2호
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• pp.102-110
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• 2019

Purpose: The purpose of this study was to investigate the factors affecting the quality of life of family caregivers of patients with Parkinson disease in Korea. Methods: A total of 162 family caregivers of patients with Parkinson disease who were visiting the D hospital in B city completed questionnaires, including general and disease-specific characteristics, family burden, patient-caregiver relationship satisfaction, family support and quality of life. Data were analyzed with t-test, ANOVA with $Scheff{\acute{e}}$ test, Pearson's correlation coefficient, and multiple regression analysis using SPSS 23.0. Results: The average score of the quality of life was $85.54{\pm}17.74$ (range: 26~130) among family caregivers of patients with Parkinson disease. Stepwise multiple regression analysis revealed that fifty percent of the quality of life was explained by family support, family burden, and patient-caregiver relationship satisfaction. Conclusion: Family support, family burden, and patient-caregiver relationship satisfaction were identified as factors affecting the quality of life of family caregivers of patients with Parkinson disease. Therefore, it is necessary to develop a program to enhance family support and reduce family burden to improve the quality of life of family members caring for patients with Parkinson disease.

• The Journal of Korean Physical Therapy
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• 제28권4호
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• pp.227-231
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• 2016

Purpose: This study was conducted to explore the effects of aerobic exercise on the severity of disease and walking ability in patients with Parkinson's disease. Methods: Twelve patients with Parkinson's disease participated in the study. Participants were randomly assigned to either an aerobic exercise group (n=6) or a self-exercise group (n=6). All participants underwent treadmill training for 30 minutes. In addition, the experimental group (aerobic exercise group) and control group (self-exercise group) participated in a 30 minutes exercise program. In both groups, exercise was performed five times a week for four weeks. Outcome including disease severity (Unified Parkinson's Disease Rating Scale) and walking ability (10 m walking speed test, 6 minutes walking test, timed up-and-go test) were measured at baseline and after 4-weeks. Results: Significant differences in disease severity and walking ability were observed between the pre- and post-exercise groups (p<0.05). The improvement of disease severity and walking endurance was significantly higher in the experimental group than in the control group (p<0.05). Conclusion: These findings demonstrate that aerobic exercise is effective at improving disease severity and walking endurance in patients with Parkinson's disease.

• 동의생리병리학회지
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• 제30권5호
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• pp.327-337
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• 2016

The objective of this study was to review the current clinical studies about the effect of herbal medicine for Parkinson's disease in China over the last 5 years and then to suggest the foundation for treatment and further studies. We had searched for studies in China National Knowledge Infrastructure(CNKI, http://www.cnki.net) and PubMed from January 2010 to December 2014. Key words were the various combinations of '帕金森', '湯', '丸', '散', '中醫藥', 'Parkinson's disease', and 'herbal medicine'. Total 53 clinical studies were selected and analyzed. The most frequently used diagnostic criteria of Parkinson's disease was the Unified Parkinson's Disease Rating Scale(UPDRS). The most frequently used medical herb was Paeoniae Radix alba(白芍藥) more 30 times and the highest amount was Astragali radix(黃芪) 100g per day. The most frequent syndrome differentiation was liver kidney yin deficiency(肝腎陰 虛). We found out there are many clinical studies of herbal medicine for Parkinson's disease in China. These studies would be able to provide the basis of clinical research on Parkinson's disease, and also applied to the treatment of Parkinson's disease in Korea.

• BMB Reports
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• 제47권8호
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• pp.424-432
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• 2014

The defining feature of Parkinson's disease is a progressive and selective demise of dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates that poly (ADP-ribose) (PAR) dependent cell death, also named parthanatos, is accountable for selective dopaminergic neuronal loss. Parthanatos is a programmed necrotic cell death, characterized by PARP1 activation, apoptosis inducing factor (AIF) nuclear translocation, and large scale DNA fragmentation. Besides cell death regulation via interaction with AIF, PAR molecule mediates diverse cellular processes including genomic stability, cell division, transcription, epigenetic regulation, and stress granule formation. In this review, we will discuss the roles of PARP1 activation and PAR molecules in the pathological processes of Parkinson's disease. Potential interaction between PAR molecule and Parkinson's disease protein interactome are briefly introduced. Finally, we suggest promising points of therapeutic intervention in the pathological PAR signaling cascade to halt progression in Parkinson's disease.