• Journal of Applied Biological Chemistry
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• v.50 no.4
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• pp.215-220
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• 2007

One of the important functions of skin is protection from harmful environments. Many studies have explored how to prevent skin from wrinkling and the occurrence of pigmentation changes. Skin wrinkling and pigmentation changes could be caused by unusual disruption of connective tissue, the formation of free radicals and ultraviolet radiation. In this study, extracts obtained from 254 different kinds of Jeju medicinal plants were screened for inhibitory effects on tyrosinase and elastase, and for free radical scavenging effects. Four herbs, Phormium tenax, Morus bombycis, Morus alba, and Cudrania tricuspidata, were potent inhibitors of tyrosinase ($IC_{50}$ values 4.62, 5.46, 8.17, and 64.17 ${\mu}g$/mL, respectively). Aleurites fordii [$IC_{50}$: 5.29 ${\mu}g$/mL, 1,1-diphenyl-2-picrylhydrazyl (DPPH)], Distylium racemosum ($IC_{50}$: 6.14 ${\mu}g$/mL), Acer palmatum ($IC_{50}$: 5.44 ${\mu}g$/mL), and Spiraea salicifolia ($IC_{50}$: 5.25 ${\mu}g$/mL) showed good antioxidative effects. Furthermore, Distylium racemosum ($IC_{50}$: 7.51 ${\mu}g$/mL), Diospyros kaki ($IC_{50}$: 15.1 ${\mu}g$/mL), Cornus macrophylla ($IC_{50}:$ 16.59 ${\mu}g$/mL), and Psidium guajava ($IC_{50}$: 40.25 ${\mu}g$/mL) exhibited potent inhibitory effects on elastase. These results suggest that medicinal plants possessing several biological activities may be potent inhibitors of the processes involved in pigmentation increases and aging. Further investigations will focus on in vivo assays and on the chemical identification of the major active components responsible for whitening and anti-aging activity in the screened efficacious extracts.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.1
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• pp.1-22
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• 2005

Background and purpose: Gin Ga Chu Yo(該家樞要) was written in the year 1359 by Hwal Su(滑壽) who was a famous oriental doctor between Won(元) and Myeong(明) dynasty. As specialized in sphygmology(脈學), this book was brought together most things about sphygmology(脈學) before Won(元) dynasty by the author. Moreover he added the self-realized things to this book. Methods: In this book, there are all 20 chapters; Chu Yo Hyeon Eon(樞要玄言), Jwa U Su Bae Jang Bu Bu Wi (左右手配臟腑部立), O Jang(五臟), Sa Si peong Maek(四時平脈), Nae Gyeong Sam Bu Maek Beop(內經三部脈法), Ho Heup Chim Bu Jeong O Jang Beop(呼吸沈浮定五臟法), In Ji Ha Gyeong Jung I Jeong O Jang Beop(因指下輕重以定五臟法), Sam Bu So Ju(三部所主), Ji Maek Su Beop(持脈手法), Maek Gwi Yu Sin(脈實有神), Maek Eum Yang Yu Seong(脈陰陽類成 ), Gyeom Hyeon Maek Ryu(兼見脈類), Je Maek Ui Gi Ryu(諸脈宜忌類), Heom Je Sa Jeung Ryu(驗諸死症類) , Sa Jeol Maek Ryu(死絶脈類), O Jang Dong Ji Maek(五藏動止脈), Bu In Maek Beop(婦人脈法), So A Maek Beop(小兒脈法), Maek Sang Tong Hoe(脈象統會), Maek Sang Ga(脈象歌) and an epilogue in the end. This treatise is made up of principal, notes, study and conclusion, we tried to make a translation faithful to the original. Results and Conclusion: Looking into this book, we can know that it is very detail in analyzing item by item, bright and simple in explaining and it is very useful in studying pulse evaluation(脈診). In his preface, Hwal Su(滑壽) expresses his opinion with firm confidence that 'Do(道) of the World scattered in several scholarships and books of method and technique(方術). Nothing of method and technique(方術 ) is more important than medicine. Nothing of medicine goes before pulse evaluation(脈診).' With such good reasons, as a student of sphygmology(脈學), I think this book is very valuable in studying pulse evaluation. So I add Hangul suffixes(吐) to a part of this book and translate it into Korean.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.10 no.1
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• pp.1-35
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• 2006

Background and purpose: Giu Ga Chu Yo(診家樞要) was written in the year 1359 by Hwal Su(滑壽) who was a famous oriental doctor between Won(元) and Myeong(明) dynasty. As specialized in sphygmology (脈學), this book was brought together most things about sphygmology(脈擧) before Won(元) dynasty by e author. Moreover he added the self-realized things to this book. Methods: In this book, besides a author's preface, there are all 20 chapters which are Chu Yo Hyeon Eon(權要玄言), Jwa U Su Bae Jang Bu Bu Wi(左右手配臟腑部位), O Jang(五臟), Sa Si Peong Maek(四時平脈), Nae Gyeong Sam Bu Maek Beop(內經三部脈法), Ho Heup Chim Bu Jeong O Jang Beop(呼吸沈浮定五臟法), In Ji Ha Gyeong Jung I Jeing O Jang Beop(因指下重以定五腑法), Sam Bu So Ju(三部所主), Ji Maek Su Beop(持脈手法), Maek Gwi Yu Sin(脈貴有神), Maek Eum Yang Yu Seong(脈陰陽類成), Gyeom Hyeon Maek Ryu(兼見脈類), Je Maek Ui Gi Ryu(諾脈宜忌類), Heom Je Sa Jeung Ryu(驗諸死症類), Sa Jeol Maek Ryu(死絶脈類), O Jang Dong Ji Maek(五藏動止脈), Bu In Maek Beop(婦人脈法), So A Mrek Beop(小兒脈法), Maek Sang Tong Hoe(脈象統會), Maek Sang Ga(脈象歌) and an epilogue in the end. Result and Conclusion: Looking into this book, we can know that it is very detail in analyzing item by item, bright and simple in explaining and it is very useful in studying pulse evaluation(脈診). In his preface, Hwal Su(辨壽) expresses his opinion with firm confidence that 'Do(道) of the World scattered in several scholarships and books of method and technique(術). Nothing of method and technique(力術) is more important than medicine. Nothing of medicine goes before pulse evaluation(脈診).' With such good reasons, as a student of sphygmology(脈學), I think this book is very valuable in studying pulse evaluation.' So I add Hangul suffixes(吐) to a part of this book and translate it into Korean.

• Korean Journal of Acupuncture
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• v.20 no.1
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• pp.45-55
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• 2003

Backgrounds : It has been investigated about ageing theory. However, ageing mechanism still remains to be unknown. Since Harman proposes that ageing and ageing related diseases might be due to oxidative damage and these are modifiable by genetic and environmental factors. For designing an optimal nutritional countermeasure against ageing and ageing related disease, it is necessary to understand the ageing mechanism and other reactive species. Objectives : Schizandra Chinesis has been clinically used to treat brain disease, respiratory or inflammatory disease etc. in Oriental medicine. The purpose of this study is to investigate the scavenging effect of Schizandrae Fructus herbal-acupuncture solution(SFHA) on NO, DPPH and IL-4. Results : The results are summarized as follows; (1) There is a significant scavenging effect of SFHA on NO in 0.1, 1, 10mg/ml group after 24hrs. (2) There is a significant scavenging effect of SFHA on DPPH in 1, $10{\mu}g/ml$ group. (3) There is a significant inhibitory effect of SFHA on IL-4 in 1, 10, $100{\mu}g/ml$ group. Conclusions : These findings indicate that SFHA can be used as antioxidant or antiimflammatory drug. But further study is needed about the effect of SFHA.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.6
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• pp.519-526
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• 2009

This paper describes a research result of a external shape optimization study to maximize the range of the guided missile with canards and tailfins in atmospheric flight. For this purpose, the external shape optimization program which can enhance the range of a missile was developed, incorporated with the trajectory analysis and the optimization technique. In the trajectory analysis part, Missile DATCOM which utilizes the semi-empirical method was directly connected to the trajectory code to supply the aerodynamic coefficients efficiently at every time step. In the gliding flight trajectory after apogee, a maximum $C_L/C_D$ trim condition calculation module was attached under the assumption of the missile continuously flying at maximum $C_L/C_D$ condition. In the optimization part, a Response Surface Method(RSM) was adopted to reduce the computing time.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.2
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• pp.25-56
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• 2005

Background and purpose: Gin Ga Chu Yo(診家樞要) was written in the year 1359 by Hwal Su(滑壽) who was a famous oriental doctor between Won(元) and Myeong(明) dynasty. As specialized in sphygmology(脈學), this book was brought together most things about sphygmology(脈學) before Won(元) dynasty by the author. Moreover he added the self-realized things to this book. Methods: In this book, besides a author's preface, there are all 20 chapters which are Chu Yo Hyeon Eon(樞要玄言), Jwa U Su Bae Jang Bu Bu Wi(左右手配臟腑部位), O Jang(五臟), Sa Si peong Maek(四時平脈), Nae Gyeong Sam Bu Maek Beop(內經三部脈法), Ho Heup Chim Bu Jeong O Jang Beop(呼吸沈浮定五臟法), In Ji Ha Gyeong Jung I Jeong 0 Jang Beop(因指下輕重以定五臟法), Sam Bu So Ju(三部所主), Ji Maek Su Beop(持脈手法), Maek Gwi Yu Sin(脈貴有神), Maek Eum Yang Yu Seong(脈陰陽類成), Gyeom Hyeon Maek Ryu(兼見脈類), Je Maek Ui Gi Ryu(諸脈宜忌類), Heom Je Sa Jeung Ryu(驗諸死症類), Sa Jeol Maek Ryu(死絶脈類), O Jang Dong Ji Maek(五藏動止脈), Bu In Maek Beop(婦人脈法), So A Maek Beop(小兒脈法), Maek Sang Tong Hoe(脈象統會), Maek Sang Ga(脈象歌) and an epilogue in the end. Result and Conclusion: Looking into this book, we can know that it is very detail in analyzing item by item, bright and simple in explaining and it is very useful in studying pulse evaluation(脈診). In his preface, Hwal Su(滑壽) expresses his opinion with firm confidence that ‘Do(道) of the World scattered in several scholarships and books of method and technique(方術). Nothing of method and technique(方術) is more important than medicine. Nothing of medicine goes before pulse evaluation(脈診).’ With such good reasons, as a student of sphygmology(脈學), I think this book is very valuable in studying pulse evaluation. So I add Hangul suffixes(吐) to a part of this book and translate it into Korean.

• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.1-9
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• 2002

I think that the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$ of ${\ulcorner}$DongMuYooGo${\lrcorner}$ is basic material explaining the character of sasang-herb and prescription. Through the study on the ${\ulcorner}$DongMuSunSaSaSangYakSungSangHumGoGa${\lrcorner}$'s origin and meaning, I can take the result as follows. The first, that is composed of total 237 herbs of 90 spleen-herb (Soeumin-herb), 61 kidney-herb (Soyangin-herb), 67 lung-herb (Taeeumin-herb) and 19 liver-herb (Taeyangin-herb). The second, the origin of that is ${\ulcorner}$JeJungSinPyun${\lrcorner}$, ${\ulcorner}$BangYakHapPyun${\lrcorner}$ and ${\ulcorner}$EuiHakIpMum${\lrcorner}$. And DongMu classified traditional YakSungGa as spleen-herb, kidney-herb, lung-herb and liver-herb which is suitable to Sasangin, not created that. So we can know that the first understanding for DongMu' s herb is focused on the traditional YakSungGa. The third, DongMu's unique terminology of spleen-herb, kidney-herb, lung-herb and liver herb show his sight of symptom, disease and pharmacology, that is focused on small JangBu. The forth, through herb-nature gathered from traditional YakSungGa, that purposed to classfying each constitutional herb. So we can know his idea that the choice of herb is not in general efficacy but in personal constitution. As mentioned abovet, that can refer to an herbal argument of DongMu and ${\ulcorner}$DongMuYooGoYakSungGa${\lrcorner}$ that make known to be common can refer to an prescriptional argument of DongMu.

• Journal of Sasang Constitutional Medicine
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• v.13 no.2
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• pp.28-48
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• 2001

1. Background and Purpose Since ${\ulcorner}$Dongri Sasang Shinpyun${\lrcorner}$ was published in 1929, it had great effects on the publications related to Sasang Constitutional Medicine. However there had been no practical research or its applications about ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ at all in spite of its importance. So through the study on the ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ we highly intend to utilize the book. 2. Methods In this dissertation, you'll find our research of ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ regarding the author, the people who were involved in the publishing, the formations and the contents, our another research of ${\ulcorner}$Dongyi Sasang Shinpyun Chebang${\lrcorner}$(東醫四象新編劑方) to make its medical characteristics and meaning clear. 3. Results and Conclusion 1) Won Chi Sang was Chang Bong Young's granduncle's son-in-law. Nam Dae-hee is suspected of Nam Tae-hee who lived in YeoJu Bam Gol at that time though, it's not certain. 2) ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ is consisted of two pans. ${\ulcorner}$The Internal part${\lrcorner}$ is the basic explanation and ${\ulcorner}$The External part${\lrcorner}$, is the prescriptions depending on the symptoms. ${\ulcorner}$Sasang Byunron${\lrcorner}$,(四象辯論) is mostly that's for the explanations about analysis of Sasang Constitution. ${\ulcorner}$Sasang Kyunghum${\lrcorner}$(四象經驗) is mainly it's for the prescriptions depends on Sasangin's symptoms. ${\ulcorner}$Sasang Kukyul${\lrcorner}$(四象口訣), ${\ulcorner}$Tong Sasang Changbu Sochaedo${\lrcorner}$(通四象臟腑所在圖), ${\ulcorner}$Tong Sasang Chunche Sosokdo${\lrcorner}$(通四象全體所屬圖) are about the analysis of Sasangin's characteristics from metaphysical concepts to Changbustic concepts. In ${\ulcorner}$Sasangin oyak${\lrcorner}$(四象人要藥), among them, 10 types of medicines were categorized separately by constitutional difference in ${\ulcorner}$Dongui Sasang Shinpyun${\lrcorner}$ and ${\ulcorner}$Dongmu Youg${\lrcorner}$(東武遺槁). The unique style of ${\ulcorner}$Dongyi Sasang Yongyak Huebun${\lrcorner}$(東醫四象用藥索分) is originated from ${\ulcorner}$Bangyak Happyun${\lrcorner}$ ${\ulcorner}$Euibang Whaltu${\lrcorner}$(${\ulcorner}$方藥合編${\lrcorner}$${\ulcorner}$醫方活套${\lrcorner}$), ${\ulcorner}$Whaltu Chimsun${\lrcorner}$,(${\ulcorner}$方藥合編${\lrcorner}$ ${\ulcorner}$活套鎭線${\lrcorner}$). 3) There are 293 prescriptions in ${\ulcorner}$Dongyi Sasang Shinpyun Chebang${\lrcorner}$. 36 out of 44 prescriptions in ${\ulcorner}$Gapont${\lrcorner}$(甲午本) are quoted in ${\ulcorner}$kyunghumbang${\lrcorner}$. Therefore it could be very possible that those unknown prescriptions in ${\ulcorner}$Kyunghumbang${\lrcorner}$ can be from lee Je Ma. 4) We are assumed that ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ was made by some other doctors not from one single person, based on Lee Je Ma's prescriptions, after Lee Je Ma died. ${\ulcorner}$Dongyi Sasang Shinpyun${\lrcorner}$ is very different from ${\ulcorner}$Dongeyi Suse Bowon${\lrcorner}$, ${\ulcorner}$Dongmu Yougo${\lrcorner}$(東武遺稿). ${\ulcorner}$Chobonkwun${\lrcorner}$(草本卷) by lee Je Ma since it was published for utilizing Sasang Constitutional Medicine and medical practice not for the basic principles of Sasang Constitution by Lee Je Ma. Therefore it could be highly possible to look over the spirit of Sasang Constitution by lee Je-ma.

• Journal of Sasang Constitutional Medicine
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• v.10 no.1
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• pp.311-341
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• 1998

The objective of this article is to induce that the conception of 'Qi-jul(氣質) and Qi-pum(氣稟)' was introduced to the Sasang(四象) Constitutional Medicine from bibliographic study on the theory of 'Qi-pum(氣稟)'. The conclusions summerized as followings. 1. In the oriental medicine, qualitative difference of 'zheng-qi(正氣)' among the individuals, the opposing power against a disease, is regarded as constitution. Having been used as 'nature(素)', 'quality(質)' and 'character(氣質)' in the oriental medical book, the word of 'Che-Jil(體質)' was used in good earnest at the end of 'Qing(情)' dynasty. 2. The nature(性) is divided into two, original nature(本然之性) and charicteristic nature(氣質之性) in the 'New confucianism(新儒學)' and the former means a principle(理), is a pure and good thing and used as a conception of universality, the latter is a principle of character and a imperfect imitation of principle(理). 3. It was repeatedly confirmed that 'Qi-jil and Qi-pum' meant the difference among the individuals by the dispute of 'Li-Qi(理氣)' caused by Lee Hwang(李滉) and Lee Yi(李耳) and by that of 'Ho-Rak(湖洛)' in the Ch'o-son(朝鮮) dynasty. 4. Han Sok-Ji, based on Meng-Zi(孟子)'s doctrine that man's inborn nature is good, criticized the theory of 'Qi-pum' which was 'Zhu-Zi(朱子)'s opinion and his opinion about the life(命) was thought to clue to the classification of the 'Sasang(四象)' invented by Lee Je-Ma as Park Se-Dang's theory that everyone has common nature but has different life(命). 5. By introducing the theory of 'Qi-pum' and the conception of life(命) which was understood as a special character by Han Sok-Ji and Park Se-Dang to Sa-sang constitutional medicine, Lee Je-Ma explained the reason why each man who was classified four constitutions, 'Taiyang'(太陽), 'Taiyin'(太陰), 'Shaoyang'(少陽), 'Shaoyin'(少陰), had the different formation of the visceral department(臟局).

• The Korea Journal of Herbology
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• v.23 no.3
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• pp.127-134
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• 2008

Objectives : The present study was designed to investigate whether Ostericum koreanum (OK) could regulate lipopolysaccharide (LPS)-induced inflammatory response in vitro and in vivo. Methods : To evaluate of anti-inflammatory effect of OK, we examined Nitric oxide (NO), proinflammatory cytokines production in LPS-stimulated RAW264.7 cells. Furthermore, we checked molecular mechanism especially in the phosphorylation of mitogen-activated protein kinases (MAPKs) and the degradation of inhibitory kappa B a ($Ik-B{\alpha}$) using western blot and also investigated survival of mice in LPS-mediated endotoxin shock. Results : 1. Extract from OK itself have weak cytotoxic effect on RAW264.7 cells. Extract from OK inhibited LPS-induced NO, tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), interleukin $(IL)-1{\beta}$, IL-6 and IL-10 production in RAW264.7 cells. 2. OK inhibited the phosphorylation of MAPKs, such as p38, extracelluar signal-regulated kinase (ERK1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of $I{\kappa}-B{\alpha}$ in the LPS-stimulated RAW264.7 cells 3. OK did not inhibit LPS-induced endotoxin shock. Conclusions : OK down-regulated LPS-induced NO and cytokines production through suppressing activation of MAPKs and degradation of $I{\kappa}-B{\alpha}$. Our results suggested that OK may be a beneficial drug against inflammatory diseases.