• Genomics & Informatics
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• v.8 no.3
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• pp.122-130
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• 2010

Abnormal hematological values are associated with various disorders including cancer and cardiovascular, metabolic, infectious, and immune diseases. We report the copy number variations (CNVs) in clinically relevant hematological parameters, including hemoglobin level, red and white blood cell counts, platelet counts, and red blood cell (RBC) volume. We describe CNVs in several loci associated with these hematological parameters in 8,842 samples from Korean population-based studies. The data that we evaluated included four RBC parameters, one platelet parameter, and one associated with total white blood cell (WBC) count, exceeding the genome-wide significance. We show that CNVs in hematological parameters are associated with some loci, different from previously associated loci reported in single nucleotide polymorphism (SNP) association studies.

• Tribology and Lubricants
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• v.31 no.6
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• pp.239-244
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• 2015

Chemical mechanical polishing (CMP) is one of the most important processes for enabling sub-14 nm semiconductor manufacturing. Moreover, post-CMP defect control is a key process parameter for the purpose of yield enhancement and device reliability. Due to the complexity of device with sub-14 nm node structure, CMP-induced defects need to be fixed in the CMP in-situ cleaning module instead of during post ex-situ wet cleaning. Therefore, post-CMP in-situ cleaning optimization and cleaning efficiency improvement play a pivotal role in post-CMP defect control. CMP in-situ cleaning module normally consists of megasonic and brush scrubber processes. And there has been an increasing effort for the optimization of cleaning chemistry and brush scrubber cleaning in the CMP cleaning module. Although there have been many studies conducted on improving particle removal efficiency by brush cleaning, these studies do not consider the effects of brush contamination. Depending on the process condition and brush condition, brush cross contamination effects significantly influence post-CMP cleaning defects. This study investigates brush cross contamination effects in the CMP in-situ cleaning module by conducting experiments using 300mm tetraethyl orthosilicate (TEOS) blanket wafers. This study also explores brush pre-treatment in the CMP tool and proposes recipe effects, and critical process parameters for optimized CMP in-situ cleaning process through experimental results.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.26 no.10
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• pp.1989-1996
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• 2002

Extended Kalman Filter(EKF) is used to estimate friction and spring characteristics on the swash plate of a variable displacement pump. In earlier studies, the feasibility of the approach was established using simulation studies to establish limits of accuracy for the EKF approach when it was applied to an ideal situation. In this study, the EKF is applied to an experimental system and the issue of re liability in estimation of certain pump parameters is addressed. In addition, an approach to assign values to accommodate convergence of the EKF is considered. A special experimental system was set up to facilitate the measurement of certain states to enhance the EKF approach. Estimated parameters show ed some scatter about a specified operating point but in general, were reasonably repeatable. The study also showed that changes in the system parameters could be accurately tracked.

• Nuclear Engineering and Technology
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• v.53 no.6
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• pp.1756-1768
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• 2021

The containment filtered venting system (CFVS) filters the atmosphere of the containment building and discharges a part of it to the outside environment to prevent containment overpressure during severe accidents. The Korean CFVS has a tank that filters fission products from the containment atmosphere by pool scrubbing, which is the primary decontamination process; however, prediction of its performance has been done based on researches conducted under mild conditions than those of severe accidents. Bubble behavior in a pool is a key parameter of pool scrubbing. Therefore, the bubble behavior in the pool was analyzed under various injection flow rates observed at the venturi nozzles used in the Korean CFVS using a wire-mesh sensor. Based on the experimental results, void fraction model was modified using the existing correlation, and a new bubble size prediction model was developed. The modified void fraction model agreed well with the obtained experimental data. However, the newly developed bubble size prediction model showed different results to those established in previous studies because the venturi nozzle diameter considered in this study was larger than those in previous studies. Therefore, this is the first model that reflects actual design of a venturi scrubbing nozzle.

• Bulletin of the Korean Chemical Society
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• v.20 no.3
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• pp.285-290
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• 1999

In the present paper, we report a molecular dynamics (MD) simulation study for the structure and dynamics of H+ ions in non-rigid dehydrated H12-A zeolite framework at 298.15 K, using the same method we used in our previous studies of rigid and non-rigid zeolite-A frameworks. It is found that two different structures appear, depending on the choice of the Lennard-Jones parameter (σ) for the H+ ion, as is also observed in the study of rigid dehydrated H12-A zeolite framework, but the ranges of σ are different for the two structures. It is also found that some of the H+ ions exchanged their sites without changing the number of H+ ions at each site. The agreement between experimental and calculated structural parameters for non-rigid dehydrated H12-A zeolite is generally quite good. The calculated IR spectrum by Fourier transform of the total dipole moment auto-correlation function shows two major peaks, one around 2700 cm-1 and the other around 7000 cm-1. The former appears in the calculated IR spectra of non-rigid zeolite-A framework only system and the latter remains unexplained except, perhaps, as an indication of a new formation of a vibrational mode of the framework due to the adsorption of the H+ ions.

• Wind and Structures
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• v.35 no.5
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• pp.337-351
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• 2022

As central-slotted box decks usually have excellent flutter performance, studies on this type of deck mostly focus on the vortex-induced vibration (VIV) control. Yet with the increasing span lengths, cable-supported bridges may have critical wind speeds of wind-induced static instability lower than that of the flutter. This is especially likely for bridges with a central-slotted box deck. As a result, the overall aerodynamic performance of such a bridge will depend on its wind-induced static stability. Taking a 1400 m-main-span cable-stayed bridge as an example, this study investigates the influence of a series of deck shape parameters on both static and flutter instabilities. Some crucial shape parameters, like the height ratio of wind fairing and the angle of the inner-lower web, show opposite influences on the two kinds of instabilities. The aerodynamic shape optimization conducted for both static and flutter instabilities on the deck based on parameter-sensitivity studies raises the static critical wind speed by about 10%, and the overall critical wind speed by about 8%. Effective VIV countermeasures for this type of bridge deck have also been proposed.

• Computers and Concrete
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• v.28 no.5
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• pp.507-519
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• 2021

In this study, a new procedure was proposed in order to predict the crack pattern and failure mode of steel fiber reinforced concrete (SFRC) corbels. Moreover, an experimental study was carried out in order to investigate the effect of several parameters, such as compressive strength, tensile strength, steel fiber ratio, shear span on the mechanical behavior of SFRC corbels in detail. Totally, 24 RC and SFRC corbels were prepared for the experimental study. Experimental results indicate that each investigated parameter has noticeable effect on the load capacity and failure mode of SFRC corbels. Moreover, finite element (FE) model of the tested corbels were prepared and efficiency of FE model was investigated for further studies. Comparison of FE and experimental results show that there is an acceptable fit between them regarding load capacity and crack patterns. Thereafter, parametric study was carried out via FE analyses in order to obtain a methodology for crack pattern and failure mode prediction of SFRC corbels. As a result of parametric studies, a new procedure was proposed as flowcharts in order to predict the failure mode of SFRC corbels for normal and high strength concrete class separately.

• Advances in nano research
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• v.14 no.2
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• pp.127-139
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• 2023

This paper studies the free vibration behavior of bi-dimensional functionally graded (BFG) nanobeams subjected to arbitrary boundary conditions. According to Eringen's nonlocal theory and Hamilton's principle, the underlying equations of motion have been obtained for BFG nanobeams. Moreover, the variable substitution method is utilized to establish the structure's state-space differential equations, followed by forming the dynamic stiffness matrix based on state-space differential equations. In order to compute the natural frequencies, the current study utilizes the Wittrick-Williams algorithm as a solution technique. Moreover, the nonlinear vibration frequencies calculated by employing the proposed method are compared to the frequencies obtained in previous studies to evaluate the proposed method's performance. Some illustrative numerical examples are also given in order to study the impacts of the nonlocal parameters, material property gradient indices, nanobeam length, and boundary conditions on the BFG nanobeam's frequency. It is found that reducing the nonlocal parameter will usually result in increased vibration frequencies.

• Computers and Concrete
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• v.33 no.1
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• pp.91-102
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• 2024

Beam-shaped components commonly rotate along a fixed axis when massive mechanical structures like rotors, jet engine blades, motor turbines, and rotating railway crossings perform their functions. For these structures to be useful in real life, their mechanical behavior is essential. Therefore, this is the first article to use the modified shear deformation theory type hyperbolic sine functions theory and the FEM to study the static bending response of rotating functionally graded GPL-reinforced composite (FG-GPLRC) beams with initial geometrical deficiencies in thermal media. Graphene platelets (GPLs) in three different configurations are woven into the beam's composition to increase its strength. By comparing the numerical results with those of previously published studies, we can assess the robustness of the theory and mechanical model employed in this study. Parameter studies are performed to determine the effect of various geometric and physical variables, such as rotation speed and temperature, on the bending reactions of structures.

• Advances in concrete construction
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• v.16 no.5
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• pp.243-254
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• 2023

Microtubules in the cell are influenced by internal and external stimulation and play an important part in conveying protein substances and in carrying out medications to the intended targets. Waves are produced during these functions and in order to control the biological cell functions, it is important to know the wave velocities of microtubules. Owing to cylindrical shell shaped and mechanically elastic and orthotropic, cylindrical shell model based on gradient elasticity theory has been used. Wave velocities of the protein microtubule are carried out by considering Love's thin shell theory and Navier solution. Also the effect of size parameter and other variables on the results are investigated.