• Tuberculosis and Respiratory Diseases
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• 제78권2호
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• pp.47-55
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• 2015

Extrapulmonary tuberculosis (EPTB) constitutes about 20% of all cases of tuberculosis (TB) in Korea. Diagnosing EPTB remains challenging because clinical samples obtained from relatively inaccessible sites may be paucibacillary, thus decreasing the sensitivity of diagnostic tests. Whenever practical, every effort should be made to obtain appropriate specimens for both mycobacteriologic and histopathologic examinations. The measurement of biochemical markers in TB-affected serosal fluids (adenosine deaminase or gamma interferon) and molecular biology techniques such as polymerase chain reaction may be useful adjuncts in the diagnosis of EPTB. Although the disease usually responds to standard anti-TB drug therapy, the ideal regimen and duration of treatment have not yet been established. A paradoxical response frequently occurs during anti-TB therapy. It should be distinguished from other causes of clinical deterioration. Surgery is required mainly to obtain valid diagnostic specimens and to manage complications. Because smear microscopy or culture is not available to monitor patients with EPTB, clinical monitoring is the usual way to assess the response to treatment.

• 대한핵의학회지
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• 제13권1_2호
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• pp.37-43
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• 1979

This is an analysis of 39 patients studied at the Yonsei Medical Center from January, 1976 to March 1979. Of these35 patient were suspected of having hypothalamic insufficiency and subjected to the L-Dopa stimulation test to observe growth hormone sceretory function while four acromegaly patient received the glucose loading test and L-Dopa stimulation test. The results are as follows: 1. The basal level of GH in the various disease was as follows: a. The basal level was lower than the control level but was not statistically significant b. In diabetes the mean value tended to be higher than the control level but was not significant statistically c. In all four acromegaly patients the GH level was significantly higher than the control level 2. Of 13 patients with diabetes, nine had diabetic retinopathy, and of those nine, sir showed increased L-Dopa response. However, of the four non retinopathic DM patients, only one showed increased response to L-Dopa. 3. Two patients out of ten with Sheehan's syndrome responded to L-Dopa stimulation. 4. One Patient of eight with pituitary chromophobe adenoma responded to L-Dopa stimulation. 5. Four acromegaly patients revealed 3 acidophilic adenoma and one chromophobe adenoma histologically. Of patients receiving the L-Dopa stimulation test. Two showed a paradoxical response. Two patients who received the glucose loading test showed supressed response. 6. Of two craniopharyngioma patients, one showed increased GH response after L-Dopa stimulation. Increased response of GH after L-Dopa stimulation was seen in one of two craniopharyngioma patients and also in one of two patients with

• 수완나부미
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• 제10권2호
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• pp.157-180
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• 2018

Area studies, including Asian and Southeast Asian studies, in the post-Cold War era have been facing an epochal challenge that is rooted in two conditions: on the one hand, the end of the Cold War and the fading geopolitical rationale, and on the other, the emergence of the technology-driven transformation of the global economy and society. The consequences thus far are paradoxical: 1) While the technology-led transformation needs a workforce with critical and innovative abilities, higher education becomes more hyper-utilitarian; 2) While the transformation instigates increasing diversity of identities in global cultures, many countries thrive for STEM education at the expense of learning languages and cultures, including area studies which are essential for diversity. Southeast Asian studies programs need to change in response to these new conditions. These changing conditions and paradoxes, nevertheless, take different forms and degrees in the American, European and Asian academies, thanks to their different histories of higher education. The prospects for Southeast Asian Studies in these various academies are likely to be different too.

• The Korean Journal of Physiology
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• 제3권2호
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• pp.25-31
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• 1969

Effects of graded increase of positive lung inflation upon heart rates and arterial blood pressure were observed in the anesthetized dogs to analyze the mechanical and neural regulatory factor in response to the positive inflation of the lung. The results obtained were summarized as followings: 1) When the low grade of positive lung inflation was employed under the mild to moderate anesthesia, central venous pressure was linearly increased while heart rate was decreased. After bilateral vagotomy, central venous pressure was obviously increased while heart rate was constant. 2) When the high degree of positive lung inflation was employed, changes of central venous pressure and heart rate were not significant. 3) The low grade of intrapulmonary pressure increase caused reflex tachycardia in phase 2 and overshooting in phase 4 in response to the systemic arterial blood pressure change. 4) On the other hand, the high degree of intrapulmonary pressure increase caused paradoxical bradycardia in phase 2 and lack of overshooting in phase 4 in response to the systemic arterial blood pressure change. 5) It may be noted that the experimental model employed in the present study is a useful tool to evaluate and analyze the neural and mechanical regulatory factor in response to the graded increase of the positive lung inflation.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.231-236
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• 2001

How much do we know about the biology of aging from cell culture studies Most normal somatic cells have a finite potential to divide due to a process termed cellular or replicative senescence. A growing body evidence suggests that senescence evolved to protect higher eu-karyotes, particularly mammals, from developing cancer, We now know that telomere shortening due to the biochemistry of DNA replication, induces replicative senescence in human cells. How-ever in rodent cells, replicative senescence occurs despite very long telomeres. Recent findings suggest that replicative senescence is just the tip of the iceberg of a more general process termed cellular senescence. It appears that cellular senescence is a response to potentially oncogenic in-sults, including oxidative damage. In young orgainsms, growth arrest by cell senescence sup-presses tumor development, but later in life, due to the accumulation of senescent cells which se-cret factors that can disrupt tissues during aging, cellular senescence promotes tumorigenesis. Therefore, antagonistic pleiotropy may explain, if not in whole the apparently paradoxical effects of cellular senescence, though this still remains an open question.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2007년도 한국지능정보시스템학회
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• pp.101-110
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• 2007

본 연구는 웹의 플랫폼화에 대응하기 위한 서비스 유통 및 소프트웨어 개발방식의 핵심이슈로 '규모의 경제'와 '서비스화'이라는 모순적인 요구를 동시적으로 해결하는 것임을 제시했다. 소프트웨어 관점에서 본 이른바 웹 2.0 시대의 주요한 특징은 웹의 플랫폼화와 롱테일 서비스 시장의 등장이다. 웹이 독립적인 유통채널로 기능하게 되는데, 본 연구는 개발자 및 사용자 커뮤니티를 구축하기 위한 플랫폼전략을 규모의 경제와 상호소통(Interaction)의 관점에서 분석했다. 플랫폼 전략에서 제기된 이슈를 해결하기 위해서는 소프트웨어 개발전략도 오픈소스 커뮤니티를 활용한 레고형 개발이 필요하다. 비용절감과 사용자 채널을 확보하기 위해서는 오픈소스 커뮤니티를 이용한 조직화방식이 필요하고, 고객화된 서 비스의 가격경쟁 력을 확보 하기 위한 레고형 개발 방법이 필요하다.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.132-135
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• 2016

We report the case of a 43-year-old male with both giant left atrial appendage (LAA) aneurysm and drug-refractory atrial fibrillation (AF). The patient was treated with percutaneous electrical isolation of cardiac arrhythmogenic substrate, and has been free of AF symptom over one year. Although the surgical resection of giant LAA aneurysm is mostly used to prevent systemic thromboembolism, we have performed follow-up of the giant LAA aneurysm using cardiac magnetic resonance (CMR) imaging and transesophageal echocardiography (TEE) after the successful catheter ablation of refractory AF. At one-year follow-up CMR, the giant LAA aneurysm showed remarkable enlargement as well as decreased contractility. Additionally, one-year follow-up TEE showed spontaneous echo contrast as an indicator of blood stasis in the giant LAA aneurysm. Those findings of giant LAA aneurysm suggest that the risk of thromboembolism may be high despite termination of AF.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6233-6239
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• 2013

Diabetes represents a serious health problem. In the diabetic state, alterations in metabolism, increased susceptibility to infections and immunological changes occur. The suppression of the immune response has been identified as a relevant factor that contributes to the increase in the rate of infections in these patients. At the same time, breast cancer is the most frequent malignant tumor in women. The molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Breastfeeding has been hypothesized to reduce the risk of breast cancer. However, early systematic reviews have not yielded consistent findings for this association. The demand for human milk is increasing due to the promotion and consumer acceptance of the health benefits of consuming a natural product rich in bioactive components. However, due to changes in glucose metabolism, the components of the milk from diabetic women are modified depending on the time of evaluation. In this literature review, we summarize important new findings revealing the paradoxical role of breastfeeding in preventing the onset of breast cancer in diabetic mothers. We hypothesized that the milk component production in diabetic mothers is affected by changes in glucose metabolism. Therefore, adequate maternal glycemic control and an adequate duration of breastfeeding for diabetic mothers are crucial to ensure that the immunity components are able to confer protection against breast cancer.

• 문화기술의 융합
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• 제10권3호
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• pp.643-650
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• 2024

현재 한국은 구인난과 구직난이 공존하는 모순된 상황을 겪고 있다. 이러한 환경 속에서 퇴직자들은 상사/동료와의 갈등과 조직문화 불만족을 가장 큰 퇴사원인으로 삼고 있으며, 이는 특히 MZ세대에게 더 큰 영향을 미치고 있다. 이에 학자들은 MZ세대의 조직문화와 다른 변수간 영향관계를 파악하는 선행연구들을 진행하여왔다. 하지만 대부분의 연구들은 MZ세대를 하나의 그룹으로 보는 MZ세대론을 바탕으로 진행되어 두 세대를 구분하여야 한다는 실무자들의 요구를 충족하지 못하고 있는 실정이다. 이에 본 연구에서는 호텔기업 종사원을 M세대와 Z세대로 구분하여 두 집단간 변수간 영향관계 차이를 파악하고자 한다. 이를 위해 M세대 170명, Z세대 110명을 대상으로 설문조사를 실시하고 이를 AMOS 구조방정식을 통해 분석하였다. 이를 통해 모든 세대에게 위계지향문화와 세대갈등이 유의한정의 관계에 있으며, 세대갈등은 조직몰입에 부정적인 영향을 미치는 것을 확인할 수 있었다. 또한, M세대는 관계지향문화가 세대갈등에 부정적 영향을 미치는 반면, Z세대에서는 영향관계가 없는 것과 같은 차이가 있음을 검증하였다. 본 연구를 통해 M세대와 Z세대간 영향관계 차이를 파악할 수 있었다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1984년도 학술대회지
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• pp.83-88
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• 1984

고려홍삼에서 추출한 성분(RGF-3)이 살서제 Vacor로 유발된 당뇨병에 어떤 영향을 미치는가를 흰쥐에서 관찰하였다. 홍삼 RGF-3 분획의 복강내투여 (20mg/kg)는 allo-xan-유발고혈당을 저하시키고 소량(10mg/kg)의 Vacor로 유발된 당불내성을 개선시켰다. 소량의 Vacor로 중독된 흰쥐는 정상대조군에 비하여 높은 혈중 insulin치를 나타내는 경향이었으며, Vacor투여 3시간 전에 복강내 투여한 RGF-3은 정상대조군에 있어서보다 더 높은 혈중 insulin치의 증가를 가져 왔다. 흰쥐의 부고환지방세포의 glucose대사[(1-$^{14}C$-glucose 의 $^{14}CO_{2}$에로의 전환]와 glucose로부터의 지방합성 [(1-$^{14}C$) glucose로부터의 $^{14}C$-lipid에로의 전환]은 Vacor중독에 의하여 저하되었으나, RGF-3 투여에 의하여 정상수준까지 회복되었으나, 그러나 정상지방세포에 대해서는 RGF-3은 별다른 영향을 주지 아니하였다. 한편 이상과 같은 말초지방세포의 glucose 대사는 insulin의 in vitro 첨가에 의하여 촉진되었으나, Vacor 중독에 의하여 감약되었고, RGF-3은 Vacor 중독에 의한 감약된 반응을 어느정도 회복시켰다. 홍삼의 수침추출물 (30mg/kg)과 RGF-3분획 (20mg/kg)의 $10{\~}20$일간 격일 투여는 그 후 대량(25mg/kg)의 Vacor 중독으로 유발되는 고혈당 발생에는 별 영향을 주지 아니하였다. 이와 간은 실험결과에 비추어 홍삼의 RGF-3분획은 Vacor 중독으로 저하된 말초조직의 당대사를 개선시켜 소량의 Vacor 중독시의 당불내성을 정상으로 회복시키는 것이라 사료되었다.\alpha}$-tocopherol의 항 산화작용을 더욱 효과적으로 촉진 시킬 것으로 생각된다.-L(독성 호르몬-L)의 작용을 억제함으로서 암환자의 체중 감소를 방지하고, 식욕감퇴를 개선할것으로 생각된다.해되었으며, $Rb_{1}$은 장내의 효소와 tetracycline-resistantant bacteria에 의해 Rd와 2 종류의 미확인 물질로 분해되었다.xA_{2}$ synthetase 억제제인 imidazole의 효과와 유사하였다. 4. G-Re는 $1{\times}10^{-5}g/ml$ 이하의 농도에서는 효과가 없으나 $1{\times}10^{-4}g/ml$ 이상의 농도에서 농도의존적으로 유의성 있는 $PGE_{2},\;PGF_{2}{\alpha},\;TXB_{2}$의 생성억제와 함께 6-keto-$PGF_{1}{\alpha}$ 증가를 보였다. 이는 prostacyclin synthetase를 자극하는 serotonin의 효과와 같은 작용으로서 prostacyclin synthetase 억제제인 tranylcypromine에 대하여 길항효과를 보였다. 5. $TxB_{2}$생성억제 작용을 나타내는 ginsenoside들의 효과를 뒷받침하기 위하여 인삼 saponin 성분을 전처치한 patelet rich plasma에서 혈소판 응집시험 결과, ADP로 유도된 혈소판 응집반응에는 모든 인삼 saponin 성분들이 효과가 없었으나 arachidonic acid로 유도된 혈소판 응집반응에는 $G-Rb_{2}$, G-Rc, G-Re의 순으로 농도 의존적인 억제현상을 보였다. 이상의 결과와 같이 인삼 saponin 성분들은 arachidonic acid로부터 cy