• Title/Summary/Keyword: Papillary carcinoma

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XPC-PAT Polymorphism in Korean Thyroid Papillary Carcinoma (한국인 갑상선 유두상암종 환자에서 XPC-PAT 유전자 다형)

  • Tae, Kyung;Lee, Keun-Young;Kim, Hee-Ok;Lee, Yong-Seop;Lee, Hyung-Seok;Ahn, You-Hern
    • Korean Journal of Head & Neck Oncology
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    • v.22 no.2
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    • pp.117-122
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    • 2006
  • Background and Objectives : Thyroid carcinoma is the sixth commonest cancer in Korea and the papillary carcinoma is the most common type(88%) of the malignant thyroid tumors. Bulky DNA adducts formed by the carcinogens are repaired by DNA repair process, but failure to repair this DNA damage can cause mutations in oncogenes and tumor suppressor genes resulting in tumor formation. The xeroderma pigmentosum group C(XPC) gene is essential for this repair procedure and the XPC-PolyAT(PAT) polymorphisms may alter DNA repair capacity(DRC) and genetic susceptibility to cancer. Subjects and Methods : In a case-control study of 113 Korean patients with pathologically diagnosed thyroid papillary carcinoma and 65 control subjects, we investigated the association between the three XPC-PAT gene polymorphisms and thyroid papillary cancer susceptibility. Results : The frequency of the variant XPC-PAT allele was lower in the cases(0.349) than in the controls (0.423), but the difference was not significant(p=0.140). Using logistic regression adjusting for age and sex, risk for thyroid papillary cancer was not increased in the XPC-PAT-/+ and XPC-PAT+/+ compared to XPCPAT-/-(adjusted overall odds ratio[95% confidence intervals;95%CI]=0.52[0.26-1.03] and 0.62 [0.22-1.75], respectively; trend test, p=0.167). Conclusion : There are no relationship between the XPC-PAT polymorphism and the risk of thyroid papillary carcinoma in Korean population. Based on our results, XPC-PAT polymorphism do not modulate genetic susceptibility to thyroid papillary cancer.

Cytologic Feature of Papillary Carcinoma of the Thyroid (세침흡인 검사로 진단된 갑상선 유두상 암종의 세포학적 소견)

  • Park, Jeong-Hee;Chang, Hee-Jin;Kang, Kyung-Ha;Sohn, Jin-Hee;Suh, Jung-Il
    • The Korean Journal of Cytopathology
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    • v.2 no.2
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    • pp.111-118
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    • 1991
  • Fine needle aspiration biopsy cytology (FNA) is an important diagnostic tool in the management of thyroid nodule. Especially, papillary carcinoma of the thyroid has distinct morphologic features that allow a definite cytologic diagnosis with high degree of accuracy. We examined the characteristic cytologic features of 57 cases of papillary carcinoma of the thyroid, and their frequency and diagnostic significance were evaluated. The results obtained are summerized as follows; 1. In pattern of cellular arrangement, papillary structure with or without stroma is predominant feature (96%). 2. In individual cell morphology, grooved nuclei (95%), intranuclear cytoplasmic invagination (89%) and nuclear lobulation (74%) are most frequent and important cytologic findings. 3. Chromatin pattern is usually fine. Coarse chromatin is infrequent finding (37%). Nucleoli are inconspicuous. Cytoplasm us plump and distinctly eosinophilic. 4. Psammoma bodies are identified only in 4 cases (7%), but they are considered as helpful diagnostic features. 5. There are other associated findings including multinucleated giant cells (51%), macrophages (37%) and cystic degeneration (16%).

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Flow Cytometric DNA Analysis of Thyroid Papillary Carcinoma (갑상선 유두상암의 핵산분석)

  • Chu Hyung-Ro;Jung Do-Kwang;Woo Jeong-Su;Choi Jong-Ouck;Kim In-Sun
    • Korean Journal of Head & Neck Oncology
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    • v.10 no.2
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    • pp.102-105
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    • 1994
  • The indolent course of most thyroid papillary carcinomas, even the presence of regional lymph node metastasis, make them unique among human malignant head and neck cancers. Age, sex, extracapsular invasion and anaplastic change are known to be correlated with prognosis. The purpose of this study is to clarify the significance of DNA content analysis as a prognostic factor. Twenty five thyroid papillary carcinomas were possible to be examined by flow cytometric analysis using fresh surgical specimens and three nodular hyperplasias and seven follicular adenomas were included as control group. The results were as follows: l) All of twenty five thyroid papillary carcinomas showed diploidy. 2) S-phase fraction was $1.94{\pm}2.77%$ in normal control group and $2.60{\pm}2.66%$ in papillary carcinoma group. The proliferation index was $8.44{\pm}3.89%$ in normal control and $7.70{\pm}3.63%$ in papillary carcinoma group with even low value. 3) Age, sex, extracapsular spread and lymph node metastasis showed no significant difference. In conclusion, low proliferative activity of thyroid papillary carcinomas are thought to be related with good prognosis.

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Correlation Analysis of Apoptosis and Cell Proliferating Marker (Ki-67) in Thyroid Tumors (갑상선 종양에서 아포프토시스(Apoptosis)와 세포증식 표지자(Ki-67)의 상관관계 분석)

  • Han, Kyung-Hee;Yang, Woo-Ick;Kim, Sun-Jung;Kim, Tai-Jeon
    • Korean Journal of Clinical Laboratory Science
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    • v.39 no.3
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    • pp.241-248
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    • 2007
  • To clarify the growth mechanisms of thyroid tumors, we investigated apoptotic cells in 88 thyroid tumors, consisting of 24 adenomas, 58 papillary thyroid carcinomas, and 6 undifferentiated carcinoma, using terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate digoxigenin-nick end labeling (TUNEL). The cell proliferating marker was also evaluated immunohistochemically using the monoclonal antibody to Ki-67 antigen (MIB-1) in the same tumors. The apoptosis was expressed as a percentage of the TUNEL-positive cells in the tumor cells, and a proliferating marker, being the percentage of Ki-67 positive cells, was counted up each tumor. The statistical analysis were used analysis of variance (ANOVA) and student's t-test that were analyze the differences in the rate of each histological types of the thyroid tumors. The overall level of apoptosis was extremely low in all histological types of the thyroid tumors analyzed, the mean apoptosis being $0.31{\pm}0.40$ in adenoma, $0.55{\pm}0.48 $in papillary thyroid carcinoma, and $4.60{\pm}3.27$ in undifferentiated carcinoma. The Ki-67 protein in the thyroid tumor subtypes was significantly lower in adenoma and papillary carcinoma, at $2.45{\pm}2.99$ and $6.27{\pm}4.42$, respectively, than that in undifferentiated carcinoma at $26.47{\pm}23.88$ (p<0.0001). There was no correlation between clinicopathological factors and apoptosis or Ki-67 in papillary thyroid carcinoma. In conclusion, our findings suggest that apoptosis occurs infrequently in thyroid tumor, and that cell proliferating maker Ki-67 markedly differs according to the thyroid tumor subtypes. Moreover, the ratio between proliferating cells and apoptotic cells may reflect thyroid tumor progression.

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A Case of Skin Metastasis from Papillary Thyroid Carcinoma (유두상 갑상선암의 피부전이 1예)

  • Lim Chi-Young;Lee Jan-Dee;Nam Kee-Hyun;Kwhan Ji-Eun;Chang Hang-Seok;Chung Woong-Yoon;Park Cheong-Soo
    • Korean Journal of Head & Neck Oncology
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    • v.21 no.2
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    • pp.174-177
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    • 2005
  • Skin metastasis from papillary thyroid carcinoma is extremely rare. Due to similar histopathologic features, it is difficult to differentiate skin metastatic papillary thyroid carcinoma and some primary skin neoplasms without a clinical history. However, most of metastatic skin lesions showed a strong reactivity to the antithyroglobulin antibodies unlike primary skin neoplasms. Metastatic skin lesions must be completely removed and radiotherapy can be added. Investigators reported that prognosis of skin metastases from thyroid carcinoma is dismal and the average survival after it's diagnosis was only 19 months because distant metastases were often discovered at diagnosis of skin metastasis or during follow-up period. We report a case of skin metastasis from tall cell variant of papillary thyroid carcinoma. In our case, the anti thyroglobulin antibodies measured from cystic fluid from a skin lesion was more than 2000 IU/ml. Skin metastasis was diagnosed at 20 months after primary surgery for thyroid cancer and brain metastasis at 12 months after diagnosis of skin metastasis. Although skin metastasis is an ominous prognostic indicator in patients with thyroid carcinoma, a radical treatment for skin lesions and early diagnosis of distant metastasis could provide a chance to the patients to improve their survival.

A CASE REPORT OF PAPILLARY THYROID CARCINOMA METASTASIZED TO MANDIBULAR CONDYLE (하악골과두부에 전이된 유두상 갑상선암의 치험례)

  • Kim, J.K.;Lee, B.I.;Kim, H.J.;Suh, C.H.;Cha, I.H.;Lee, E.W.
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.17 no.4
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    • pp.442-446
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    • 1995
  • Thyroid carcinomas are usually classified as papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma and anaplastic thyroid carcinoma. Among the thyroid carcinomas, the incidence of medullary and anaplastic thyroid carcinoma is low, but the rate of lymph node & distant metastasis from them are more common compared to other types. Follicular thyroid carcinoma has a low rate of lymph node metastasis as 10% and has a high occurrence of hematogenous metastasis to lung, bone, brain and liver. Papillary thyroid carcinoma accounts for $60{\sim}70%$ of whole thyroid carcinomas and the cervical lymph node metastasis is $21{\sim}81%$ including micrometastasis, but the distant metastasis is rare. In the case of bone metastasis, follicular type reveals most frequent, and the rate is about 5%, and more likely to be found on vertebra, pelvis, ribs, femur, and skull. The clinical symptoms of bone metastasis are pain, swelling, pathological fracture and radiologically osteolytic lesions can be observed. But distant metastasis of papillary thyroid carcinoma is very rare and especially, bone metastasis has hardly been reported. The treatment modalities of metastatic thyroid carcinoma to mandible are known as follows : thyroidectomy to treat primary site, resection of the affected site of mandible, external beam radiotherapy and radioiodine therapy etc.

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Cytologic Features of Endometrial Papillary Serous Carcinoma (자궁 내막의 유두상 장액성 암종의 세포학적 소견)

  • Kong, Gu;Hong, Eun-Kyung;Lee, Jung-Dal
    • The Korean Journal of Cytopathology
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    • v.1 no.2
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    • pp.121-128
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    • 1990
  • Endometrial papillary serous carcinoma (EPSC) is a distinct variant of endometrial adenocarcinoma that histologically resembles ovarian serous papillary adenocarcinoma and has an aggressive clinical course. Usually, the tumor is diagnosed at the advanced stage. The tumor has well confused with metastatic ovarian tumor of identical histology. Dignosis of EPSC should be considered when the cervico-vaginal smear reveals nomerous papillary clusters of tumor cells with macronucleoli and psammoma bodies. Recently, we have experienced two cases of EPSC diagnosed on cervico-vaginal smears, which revealed characteristic cytologic features including numerous papillary clusters of tumor cells with macronucleoli. The cytologic diagnoses were confirmed on histologic sections.

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A Case of Recurrent Papillary Thyroid Carcinoma with Adrenal Metastasis (재발 유두 갑상선암의 부신전이 1예)

  • Kim, Chang-Woo;Yun, Ji-Sup;Lee, Yong-Sang;Nam, Kee-Hyun;Chung, Woong-Youn;Hong, Soon-Won;Park, Cheong-Soo
    • Korean Journal of Head & Neck Oncology
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    • v.23 no.1
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    • pp.50-53
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    • 2007
  • Adrenal metastasis from papillary thyroid carcinoma is extremely rare. We present herein a patient with adrenal metastases from recurrent papillary carcinoma of the thyroid. A 54 year-old woman had received a total thyroidectomy and postoperative radioactive iodine therapy for locally advanced papillary thyroid carcinoma. One year after initial surgery, distant metastases to multiple organs including right cervical lymph nodes, left upper lung, left 2nd and 3rd ribs, 2nd thoracic vertebra and left adrenal gland were found by 18-FDG-PET-CT whole body scan. She underwent right modified neck dissection, partial resection of left 2nd and 3rd ribs, posterior arch of 2nd thoracic vertebra, left upper lobectomy of lung, and left adrenalectomy. On histologic examination, metastases to the left adrenal gland and cervical lymph nodes were papillary thyroid carcinomas, while other metastatic sites turned out to be anaplastic thyroid carcinomas. Despite aggressive surgery and postoperative adjuvant therapy, her general clinical conditions were getting worse day by day due to regrowing of the anaplastic thyroid carcinomas. To our knowledge, this is the first case reported in Korea.

A Case of Papillary Thyroid Carcinoma Arising in Thyroglossal Duct Cyst (갑상설관 낭종에서 발생한 유두상 선암 1예)

  • Lee Kyoung-Keun;Ahn Hae-Sun;Lee Kwang-Man
    • Korean Journal of Head & Neck Oncology
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    • v.16 no.1
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    • pp.83-86
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    • 2000
  • Thyroglossal duct cyst is common midline mass, which is related to hyoid bone and may show signs of inflammation. Carcinoma arising in the thyroglossal duct cyst is rare, occuring in less than 1% of thyroglossal duct cyst. Papillary adenocarcinoma is the most common histologic type(75-85%). The initial treatement of choice is wide excision of the tumor bearing tissue(Sistrunk procedure), resection of associated lymph node alone is enough when they are small and isolated, but a modified neck dissection must be done if regional involvement is more extensive. Its prognosis is excellent(the incidence of regional lymph node metastasis is 7% compare to 89% for papillary cancer of thyroid gland proper).

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A Case of Papillary Carcinoma arising in a Thyroglossal duct cyst (갑상설관낭종에서 기원한 유두상 암종 1례)

  • 정필섭;정필상;현민환
    • Korean Journal of Bronchoesophagology
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    • v.3 no.2
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    • pp.338-342
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    • 1997
  • Thyroglossal duct cysts are the most common anomaly in thyroid development. Generally, duct cysts are benign, but 1 per cent of cases may be malignant. Tumors of the thyroglossal duct are very rare and are usually papillary thyroid carcinomas. In most cases the diagnosis is only established after excison of a clinically benign thyroglossal duct cysts. The etiology of such tumors is unclear, but do novo origin and spread from a primary thyroid gland tumor has been suggested. We reported a case of papillary carcinoma arising in a thyroglossal duct cyst treated successfully with surgical excision in 37-year-old-female.

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