• Economic Analysis
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• v.17 no.1
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• pp.103-130
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• 2011

This paper intends to provide applied economists which study the effects of research and development with valuable information on econometric model selection. It includes extensive discussion on econometric models which have been applied for the study on the relationship between research and development and productivity. In particular, it compares various stochastic production frontier models which have been developed recently. The discussion decomposes them into models with scaling property and the ones with nonscaling property as well as models with monotonic and nonmonotonic relationships between research and development and productivity. Finally, this paper applies the models to two different panel data sets (firm level data and country level data) and compare estimation results from competing econometric models.

• Korean Journal of Computational Design and Engineering
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• v.12 no.1
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• pp.39-49
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• 2007

Recently three-dimensional (3-D) die design and production process has been widely introduced into the tooling shops of automotive manufacturers to reduce time-to-production of brand-new automobiles. 3-D solid models created in CAD systems are used not only for various simulations for design verification, but also for NC tool path generation to machine dies and their Styrofoam patterns. However, a lot of time and cost will be required to build solid models for dies if designers use only the generalized modeling capabilities of commercial 3-D CAD systems. To solve this problem, it is necessary to customize 3-D CAD system for the specific die design and manufacturing process. This paper describes a dedicated 3-D CAD system based on Unigraphics for die design for automotive body panels. The system provides not only 3-D design capabilities, but also standard part libraries, to enhance design productivity. The design process modeling technology has been introduced to facilitate redesign of the die for the modified panel. By introducing this system, dies can be designed more rapidly in the 3-D space, and their solid data can be directly transferred to CAM tools for NC tool path generation and simulation tools for virtual manufacturing.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.4853-4856
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• 2016

Objective: Gimatecan is a new camptothecin (CPT) analogue that inhibits tumor growth by targeting DNA topoisomerase I (TOP I) and introducing strong and persistent DNA cleavage. Anti-tumor activity has been demonstrated with a wide range of solid tumors in previous preclinical and clinical studies. Here, we investigated for the first time the effects of gimatecan on the proliferation of hepatocellular carcinoma (HCC) cells both in vitro and in vivo. Methods: Anticancer efficacy of gimatecan were evaluated in a panel of HCC cell lines and corresponding mouse xenograft models. Inhibition of cell proliferation was measured by CellTiter-Glo cell viability assay. In vivo, gimatecan and control preparations were orally administered every four days, for a total of four times. Tumor volume and body weights of the mice were measured twice weekly. Results: In vitro cytotoxicity evaluation showed that gimatecan inhibited the proliferation of a large panel of HCC cell lines in a dose dependent manner, with IC50 values ranging between 12.1~1085.0 nM. In vivo evaluation in mouse xenograft models showed significant antitumor effects of gimatecan at 0.8mg/kg and 0.4mg/kg as compared to the control group. Conclusion: This study suggested that gimatecan may have the potential to be used as a chemotherapeutic agent for the treatment of HCC.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.133-143
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• 2020

The paper investigates the factors affecting the profitability of commercial banks in Asian developing countries, including Vietnam, Malaysia and Thailand. We use panel data of four entities; ten banks in Vietnam, eight banks in Malaysia, nine banks in Thailand and all 27 commercial banks from the period 2012 to 2016. Particularly, Return on Asset, Return on Equity and TOBINQ are defined as profitability indicators, which are impacted by three main types of independent variables, namely bank-specifics, which include CAR, NPL, Cost to income, Liquidity ratio and Bank size, industry-specific variable-concentration HHI and macroeconomic-specific variables, which consist of GDP growth and Inflation. Using panel data regressions, the paper identifies several similarities and differences among empirical results on the models of four entities, each of three countries and the overall sample. The most outstanding similarity is that all entities record the significantly negative relationship between operational risk and banking profitability. Likewise, the significantly negative influence of bank size to profitability is found on models of Vietnam and Thailand and no significant effect on the model of Malaysia. Meanwhile, the most controversial result comes up with the negative relationship between CAR and profitability indicators as well as the positive association between credit risk and banking profitability.

• Steel and Composite Structures
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• v.20 no.3
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• pp.487-500
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• 2016

In order to investigate the flexural bearing capacity of panel zone of diaphragm-through joint between concrete filled square steel tubular column and steel beam, four specimens were tested under static tension loads to study the mechanical properties and bearing capacity of diaphragm-through joints with a failure mode of panel zone. Finite element models of these specimens were developed to simulate the test and compare the predicted failure modes, load-displacement curves and bearing capacities with the experimentally observed. It was found that the tensile load from the steel beam flange is mainly shared by the square steel tube and the diaphragm. The diaphragm plastic zone appears along the cross-section lines enclosed by the square steel tube and the influence of steel beam web on the plastic zone of the steel tube is significant and cannot be neglected. Computational models of yield lines on square steel tube and diaphragm are established based on the distribution pattern of the plastic zone, and an analytical method for the evaluation of the bearing capacity of the joint is proposed. The theoretical results and the experimental data are compared and found in good agreement.

• The Journal of Economics, Marketing and Management
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• v.9 no.4
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• pp.1-8
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• 2021

Purpose: This study empirically investigates what factors contribute to corporate value in the Korea New Exchange (KONEX) market and determines whether financial constraints contribute any effect on it. Research design, data and methodology: A fixed-effect panel regression model was utilized to analyze financial constraints on firm value for KONEX listed firms through the fiscal period from 2013 to 2020. Results: we find that firms' research and development, volatility, size, and sales growth give significant impacts to firm value, but the significance and direction are different. In addition, no significant relationship exists between the largest shareholder's equity ratio and firm value in all models. The debt-to-equity ratio did not show a significant relationship with corporate value. A significant negative relationship was found between R&D and corporate value in the entire sample. Volitility exhibited a positive relationship with corporate value in the entire sample and financially unconstrained companies. Firm size presented a significant negative relationship with company value in all models. Sales growth showed a significant negative relationship with corporate value in financially constrained companies. Conclusions: No difference is found between financially constrained and unconstrained companies in the KONEX market. We can infer that KONEX companies have a large difference with KOSPI or KOSDAQ. Further analysis is needed on the differences among these markets.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.35 no.9
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• pp.151-158
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• 2019

A concrete core is used widely as lateral stability systems in high-rise modular buildings. As an alternative to traditional cast in-situ core, the precast concrete(PC) method can accelerate the construction of reinforced concrete cores. A core composed of precast elements differs from a in-situ core in having connections between the precast elements. The typical vertical connection between PC panels is consisted of shear keys, loop bars, lacer bars and grout. In this study, the effect of vertical connection components on shear strength is investigated experimentally. The test results show that the contribution to the shear strength is greater in order of grout strength, shear keys, lacer bars and loop bars. In addition, the numerical models to estimate the shear strength according to two crack patterns in the vertical joint of the PC panels are derived. The feasibility of the numerical models is evaluated by comparing the estimated shear strength and the test results.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.12
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• pp.1201-1206
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• 2008

This study is focused on the investigation of the modal characteristics of the preliminary models of science technology satellite-3 (STSAT-3). Prior to the final decision of the composite structure model, several candidate structure models have been developed so as to find the most qualified structures with respect to the satellite structure systems' requirements and then utilize the information achieved to a real design. The main structure is composed of fiber reinforced composite faced honeycomb sandwich panel whose modal characteristics are found and compared to each other by means of finite element numerical analyses. Results from the current study demonstrate that a rectangular box shape having supporting inner panel shows relatively higher fundamental mode frequencies than octagonal box shape and etc., and regardless of the structure model shape tested herein, the fundamental mode turns out lateral bending mode.

• Earthquakes and Structures
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• v.23 no.6
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• pp.549-580
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• 2022

This paper assesses the influences of modeling assumptions and uncertainties on the performance of the non-linear finite element (FE) model updating procedure and model clustering method. The results of a shaking table test on a four-story steel moment-resisting frame are employed for both calibrations and clustering of the FE models. In the first part, simple to detailed non-linear FE models of the test frame is calibrated to minimize the difference between the various data features of the models and the structure. To investigate the effect of the specified data feature, four of which include the acceleration, displacement, hysteretic energy, and instantaneous features of responses, have been considered. In the last part of the work, a model-based clustering approach to group models of a four-story frame with similar behavior is introduced to detect abnormal ones. The approach is a composition of property derivation, outlier removal based on k-Nearest neighbors, and a K-means clustering approach using specified data features. The clustering results showed correlations among similar models. Moreover, it also helped to detect the best strategy for modeling different structural components.

• Steel and Composite Structures
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• v.27 no.6
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• pp.717-725
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• 2018

One of the most important design criteria in military tunnels and armoured doors is to resist the blast loads with minimum structural weight. This can be achieved by using steel sandwich panels. In this paper, the nonlinear behaviour of steel sandwich panels, with different core materials: (1) Hollow (no core material); (2) Rigid Polyurethane Foam (RPF); and (3) Vulcanized Rubber (VR) under free air blast loads, was investigated using detailed 3D nonlinear finite element models in Ansys Autodyn. The accuracy of the finite element model proposed was verified using available experimental test data of a similar steel sandwich panel tested. The results show the developed finite element model can be reliably used to simulate the nonlinear behaviour of the steel sandwich panels under free air blast loads. The verified finite element model was used to examine the different parameters of the steel sandwich panel with different core materials. The result shows that the sandwich panel with RPF core material is more efficient than the VR sandwich panel followed by the Hollow sandwich panels. The average maximum displacement of RPF sandwich panel under different ranges of TNT charge (1 kg to 10 kg at a standoff distance of 1 m) is 49% and 53% less than the VR and Hollow sandwich panels, respectively. Detailed empirical design equations were provided to quantify the maximum deformation of the steel sandwich panels with different core materials and core thickness under a different range of blast loads. The developed equations can be used as a guide for engineer to design steel sandwich panels with RPF and VR core material under a different range of free air blast loads.