• Journal of Korean Neurosurgical Society
• /
• 제60권5호
• /
• pp.534-539
• /
• 2017

Objective : Patients with hematological malignancies frequently encounter spine-related symptoms, which are caused by disease itself or process of treatment. However, there is still lack of knowledge on their epidemiology and clinical courses. The purpose of this article is to review clinical presentations and surgical results for spinal involvement of hematologic malignancies. Methods : From January 2011 to September 2014, 195 patients (98 males and 97 females) suffering from hematological malignancies combined with spinal problems were retrospectively analyzed for clinical and radiological characteristics and their clinical results. Results : The most common diagnosis of hematological malignancy was multiple myeloma (96 patients, 49.7%), followed by chronic myeloid leukemia (30, 15.2%), acute myeloid leukemia (22, 11.2%), and lymphoma (15, 7.56%). The major presenting symptoms were mechanical axial pain (132, 67.7%) resulting from pathologic fractures, and followed by radiating pain (49, 25.1%). Progressive neurologic deficits were noted in 15 patients (7.7%), which revealed as cord compression by epidural mass or compressive myelopathy combined with pathologic fractures. Reconstructive surgery for neurologic compromise was done in 16 patients. Even though surgical intervention was useful for early paralysis (Frankel grade D or E), neurologic recovery was not satisfactory for the progressed paralysis (Frankel grade A or B). Conclusion : Hematological malignancies may cause various spinal problems related to disease progression or consequences of treatments. Conservative and palliative treatments are mainstay for these lesions. However, timely surgical interventions should be considered for the cases of pathologic fractures with progressive neurologic compromise.

• Journal of Yeungnam Medical Science
• /
• 제31권2호
• /
• pp.139-143
• /
• 2014

Spontaneous intramuscular hematoma of the abdominal wall is a rare condition characterized by acute abdominal pain. It is often misdiagnosed as a surgical condition. It used to be associated with risk factors such as coughing, pregnancy, and anticoagulant therapy. Most cases of abdominal wall hematomas were rectus sheath hematomas caused by the rupture of either the superior or inferior epigastric artery, but spontaneous internal oblique hematoma was extremely rare. In this report, we present a case of spontaneous internal oblique hematoma in a 69-year-old man with non-dialysis chronic kidney disease who was taking cilostazol. The patient complained of abrupt abdominal pain with a painful palpable lateral abdominal mass while sleeping. The abdominal computed tomography showed an 8 cm-sized mass in the patient's left internal oblique muscle. The administration of cilostazol was immediately stopped, and the intramuscular hematoma of the lateral oblique muscle disappeared with conservative management.

• 대한한방부인과학회지
• /
• 제20권3호
• /
• pp.45-64
• /
• 2007

Purpose: This study was performed to evaluate anti-thrombotic and anti-inflammatory effects of NeungaSoJeokTang water extract (NSJT). Methods: In the study of anti-inflammatory effects, NSJT was investigated using cultured cells and murine models. As for the parameters of inflammation, levels of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were determined in mouse lung fibroblast cells(mLFC) and RAW 264.7 cells. Results: Prior to the experiment, we evaluated sGOT, sGPT, BUN and creatine after the treatment. As a result, NSJT was innoxious on liver and kidney. In experiment of anti-thrombotic effect, NSJT inhibited the platelet aggregation induced by ADP and epinephrine, and inhibited pulmonary embolism induced by collagen and epinephrine. NSJT did not affect significantly the blood flow rate both in vitro and in vivo. NSJT increased platelet number and fibrinogen amount, and NSJT shortened PT and APTT in thrombus model induced by dextran. In experiment of anti-inflammatory effect, NSJT inhibited $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, COX-2 and NOS-II mRNA expression in a concentration-dependent manner in RAW 264.7 cell line, and inhibited significantly NO production at 50, 100 ${\mu}g/ml$, and also inhibited ROS production in a concentration-dependent manner. NSJT inhibited $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production significantly in serum of acute inflammation-induced Balb/c mice, and decreased $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production in spleen tissue, but increased $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ production in liver tissue. NSJT increased survival rate at the 3th day in ICR mice with lethal endotoxemia induced by LPS. Conclusion: These results suggest that NSJT can be used for treating diverse female diseases caused by thrombosis and inflammation such as pelvic pain, pelvic inflammatory disease as well as vulvar pain due to vulvitis, vulvar vestibulitis and so on.

• The Korean Journal of Physiology and Pharmacology
• /
• 제25권3호
• /
• pp.207-216
• /
• 2021

Several studies have previously reported that exposure to stress provokes behavioral changes, including antinociception, in rodents. In the present study, we studied the effect of acute cold-water (4℃) swimming stress (CWSS) on nociception and the possible changes in several signal molecules in male ICR mice. Here, we show that 3 min of CWSS was sufficient to produce antinociception in tail-flick, hot-plate, von-Frey, writhing, and formalin-induced pain models. Significantly, CWSS strongly reduced nociceptive behavior in the first phase, but not in the second phase, of the formalin-induced pain model. We further examined some signal molecules' expressions in the dorsal root ganglia (DRG) and spinal cord to delineate the possible molecular mechanism involved in the antinociceptive effect under CWSS. CWSS reduced p-ERK, p-AMPKα1, p-AMPKα2, p-Tyk2, and p-STAT3 expression both in the spinal cord and DRG. However, the phosphorylation of mTOR was activated after CWSS in the spinal cord and DRG. Moreover, p-JNK and p-CREB activation were significantly increased by CWSS in the spinal cord, whereas CWSS alleviated JNK and CREB phosphorylation levels in DRG. Our results suggest that the antinociception induced by CWSS may be mediated by several molecules, such as ERK, JNK, CREB, AMPKα1, AMPKα2, mTOR, Tyk2, and STAT3 located in the spinal cord and DRG.

• 대한한의학회지
• /
• 제42권2호
• /
• pp.107-119
• /
• 2021

Objectives: This study was aimed to report changes in clinical symptoms and signs after treatment with Korean medicine in patients who suffered from calf edema due to deep vein thrombosis (DVT). Methods: A 46-year-old male patient, who discharged home after receiving standardized treatment for acute DVT in the right leg, suffered pain and heat sense due to edema of the affected calf. Oral administration of herbal medicine (Gyejibongnyeong-hwan 4 g, twice daily) and acupuncture therapy were given to him for 6 weeks. The change in chief complaints, Villalta score, the right and left side difference of the circumference and the skin surface temperature of both calves, and blood level of D-dimer were observed before and after treatment. Results: The patient's chief complaints began to significantly improve from 2 weeks after treatment, and disappeared completely within 4 weeks. At the end of the treatment, a substantial decrease in the difference between the right and left calves in the circumference and skin surface temperature was observed. This effect was maintained even at the time of follow-up 3 months after the end of treatment, and the patient completely recovered indoor and outdoor life to the level before onset. Conclusions: This case suggests that Korean medicine treatment, including Gyejibongnyeong-hwan administration and acupuncture therapy, can be a viable option to improve edema and related clinical problems in the affected limbs due to DVT.

• PNF and Movement
• /
• 제20권2호
• /
• pp.167-177
• /
• 2022

Purpose: Pes planus is a common foot deformity that involves the loss of the medial longitudinal arch. The medial longitudinal arch deformity is usually asymptomatic; however, it can lead to an increased risk of pain and injury. Low-Dye taping is designed to treat plantar heel pain and pes planus. However, low-Dye taping is relatively complex, and a considerable amount of time is required to apply the tape correctly. The purpose of this study was to compare the acute effect of two different types of taping (low-Dye taping and modified Mulligan taping) on arch reformation, plantar pressure, and gait characteristics in participants with asymptomatic flexible pes planus. Methods: Twenty subjects (9 males and 11 females; mean age = 21.95 years) with asymptomatic flexible pes planus voluntarily participated in this study. Arch reformation was evaluated using navicular height measurements. Changes in plantar pressure distribution were measured using BioRecue equipment. Gait parameters were measured using spatiotemporal data collected during consecutive gait cycles using a G-WALK device. One-way analysis of variance was used to compare the three different conditions (i.e., bare foot, low-Dye taping, and modified Mulligan taping) for each variable. Results: Navicular height was significantly increased in subjects who underwent the two types of taping compared to those who experienced the bare foot condition. The plantar pressure was significantly shifted to the posterolateral area after modified Mulligan taping compared with the bare foot condition. There were no significant differences in the gait parameters. Conclusion: The findings of this study indicate that modified Mulligan taping has a similar effect to low-Dye taping, and modified Mulligan taping is a simpler method than low-Dye taping.

• 대한약침학회지
• /
• 제25권4호
• /
• pp.396-403
• /
• 2022

Objectives: Gout is an inflammatory arthritis of the joints and soft tissues occurring due to deposition of monosodium urate (MSU) crystals, which are caused by persistent hyperuricemia. Soyeom pharmacopuncture is one treatment method that has been traditionally used for pain management in Oriental medicine. However, studies on its effect in reducing gout pain have been insufficient. Therefore, we selected Soyeom pharmacopuncture among natural products used in Korea as the new target of our study. Methods: The effects of Soyeom pharmacopuncture were examined in mouse models of acute gout induced by injection of MSU crystals into footpads. IL-1β, IL-6, and TNF-α production were examined by immunoblotting and enzyme-linked immunosorbent assay as hallmarks of NLRP3 inflammasome and cytokine activation. Results: Soyeom pharmacopuncture reduced foot edema in gout-induced mice, as well as IL-1β, nitrite, IL-6, and TNF-α production. Moreover, Soyeom pharmacopuncture also reduced MSU-induced gout inflammatory gene expressions, specifically those in the NF-kB pathway. Conclusion: Pharmacopuncture may serve as a new solution for other inflammatory diseases as well. Through active follow-up studies, we could thoroughly understand the clinical value of Soyeom pharmacopuncture.

• 대한중풍순환신경학회지
• /
• 제14권1호
• /
• pp.107-114
• /
• 2013

■ Objectives The purpose is to review the application of the Kampo medicine(traditional Japanese medicine) in the neurosurgical field, through the analysis of the studies are presented at the Annual Meeting of Kampo Medicine Association of the Japan Neurosurgical Society. ■ Methods We have reviewed the studies that were reported at the 21th annual meeting of the Kampo medicine association of the Japan neurosurgical society was held on November 3 2012 in Tokyo, Japan. Seventeen included clinical reports were analyzed among all 25 studies at the meeting. Five studies were related with headache and eight were focused on the cerebrovascular disease including chronic subdural hemorrhage(CSDH) treated with Orungsan(Goreisan: 五苓散) or Siryungtang(Saireto: 柴苓湯), and other four were for pain managements. In the matters of headache, a unique feature was that Osuyutang(Gosyuyuto: 吳茱萸湯) or Oryungsan was considered as the first choice of the treatment for the headache, unlike Korea. It seems to consider to application the treatment of CSDH using Oryungsan in neurosurgery field of Korea. In addition, herbal prescription using Jackyakgamchotang(Syakuya kukanzoto: 芍藥甘草湯), Ukgansan(Yokkansan: 抑肝散), Chitabakilbang(Jidabokuippo: 治打撲一方) for acute/chronic pain is as well one of the peculiar points of Kampo medicine in Japan. ■ Conclusion It is expected that the recent studies performed in Japan neurosurgery fields to inspire domestic research and clinical applications, and needed to additional research and utilize in practice in Korea.

• Journal of Digestive Cancer Research
• /
• 제5권1호
• /
• pp.58-61
• /
• 2017

5-FU로 인한 심장독성은 드물지만 협심증, 심근경색, 심지어 심장 돌연사까지 유발할 수 있다. 그러므로 약물치료를 계획하기 전 환자의 기저 심질환 여부를 정확히 평가해야 하며, 지연반응으로 인해 약물 투여와 증상 발생의 시간적 간격이 늘어날 수도 있으므로 증상과 EKG에서의 변화가 명확하다면 5-FU로 인한 관상동맥의 일시적인 연축으로 볼 수 있다. 심장효소의 상승과 관상동맥 조영술에서 심혈관의 협착 소견이 없더라도 약물을 중단하고 칼슘통로차단제 등의 혈관확장제를 사용하여야 한다. 그리고 재발의 위험성이 매우 높기 때문에 재투여는 피해야 한다.

• Nuclear Medicine and Molecular Imaging
• /
• 제42권1호
• /
• pp.44-51
• /
• 2008

목적: 외상 후 복합부위통증증후군으로 진단된 환자에서 시행한 삼상 뼈 스캔의 판독 신뢰도를 평가하기 위하여 판독 일치도를 조사하였다. 대상 및 방법: 1994년 국제통증연구학회(IASP) 기준에 따라 외상 후 복합부위통증증후군으로 진단된 34명을 대상으로 하였다. 두 명의 핵의학 전문의가 삼상 뼈 스캔의 세부영상에서 섭취의 양상, 정도와 범위를 평가하여 관찰자내 와 관찰자간 일치도(kappa value)를 구하였다. 환측 사지 전체의 관류와 섭취가 증가되었을 때(기준 1), 지연영상에서 전체적으로 증가되었을 때(기준2), 국소이상의 섭취가 증가되었을 때(기준3)를 양성으로 판정하는 기준에 따라 재분류하여 판독자 임의로 분류하였을 때와 최종판독 일치도를 비교하였다. 결과: 세 영상에서 섭취 양상, 정도, 범위에 대한 관찰자내 일치도는 우수하였다. 세부 영상에 대한 관찰자간 일치도(0.64-0.90)에 비하여 혈액풀의 섭취 범위에 대한 일치도는 낮았다(0.55). 관찰자간 일치도는 임의의 기준으로 최종 판정하였을 때(0.63)에 비하여 공통의 양성 판정 기준에 따라 다시 분류하였을 때 약간 향상되었다(0.77-0.88). 임상시기별 임의 기준으로 분류한 관찰자간 일치도는(급성: 0.29, 만성: 0.37) 양성 판정 기준을 적용시에 크게 향상되었다(급성: 0.47-0.82, 만성: 1.0). 임상시기별 예민도는 급성에 비해 만성에서 대체적으로 낮았다. 결론: 본 연구에서 외상 후 복합부위통증증후군 환자에서 시행한 삼상 뼈 스캔의 판독 시 관찰자간 변동성이 있는 것이 검증되었다. 그 변동성은 양성 평가의 기준이 관찰자마다 다른데서 기인하였다. 외상 후 복합통증증후군 환자에서 삼상 뼈 스캔의 판독 신뢰도를 높이기 위해서는 세부 영상 및 임상시기에 따른 구체적인 양성 판정 기준을 정할 필요가 있다.