• 건축역사연구
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• 제28권2호
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• pp.53-64
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• 2019

This study examines the restoration project of Sokkuram, and introduces its preliminary plans by the architect Pai Ki Hyung. The restoration project started in 1958 with an inquiry committee of the restoration project, and was completed in 1964. Despite having undergone extensive repair work under Japanese supervision from 1913 and 1923, the repair work caused water leakages inside Sokkuram, and regular cleaning work that began in 1933 caused a lot of damage to the sculpture. In result of the surveys, the top priority of this project was to protect the sculptures inside Sokkuram by improving the environment of the cave. At that time, the architect Mr. Pai participated as a head of the fourth field surveyors to plan the restoration project and to design the preliminary plans. He proposed the installation of a double dome structure to prevent further water leakages on the concrete addition that was built up around the grotto by the Japanese. However, in 1961, the Cultural Heritage Committee of Korea examined the plans of Mr. Pai and immediately rejected them. The factors of the rejection were the omitting of entrance design, system of new double dome structure that presses the existing structure, and these changes that had to be made outside of the drainage plans. The repair work of Sokkuram began in 1961, and the main construction was building double dome structure and entrance installation. In this we realize that Mr. Pai's double dome structure plans were very important key concept of this project. This study attempts to demonstrate the double dome installations that Mr. Pai initially proposed, which ultimately remains as emblematic factors of Sokkuram's legacy.

• 건축역사연구
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• 제30권4호
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• pp.41-52
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• 2021

This study examines the Gyeongju Seokguram Grotto restoration project (1961-1962) by architect Kim Chung Up (1922-1988) and introduces the documents he wrote at the time of planning. The study highlights Kim's Plan attempt to adopt Buckminster Fuller's idea of the Geodesic Dome, while inheriting the architect Pai Ki Hyung's previous design plan which was nullified. As Seokguram Grotto's water leak and deterioration issues have been brought up, the four-times survey was carried out by experts team between 1958 and 1960, under Ministry of Education's direction. Pai designed an initial restoration plan based on the survey's result, which was a double-dome structure with a concrete film on the outer periphery as a way to protect Seokguram Grotto in January 1961. However, as drawbacks, such as the heavy load of the concrete dome, and non-installation of entrance hall, have been indicated in the review process, the Cultural Properties Committee rejected the plan. Subsequently, Kim was appointed as the supervisor of the second restoration project. Kim drew up a process management schedule to be implemented from August 1961 to December 1963 and designed the conception plans for the second restoration design. This study analyzes Kim's Plan by examining sketches, site plans, floor plans, and sections. Kim planned to maintain the idea of the double-dome structure proposed by Pai while applying Buckminster Fuller's idea of the Geodesic Dome. Kim planned to lighten the dome structure by applying a steel-frame Geodesic Dome so that the dome structure could be supported by its own. The study is expected to reclaim the omitted parts from Seokguram Grotto's historical description and Kim's careers.

• 건축역사연구
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• 제31권2호
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• pp.35-50
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• 2022

This study examines the design intent and the construction background of the UNESCO House in Korea planned in the 1950s, with a focus on the initial plans of the House by Kuzosa Architects & Engineers in 1959. To this day, the House has been evaluated as a representative example of an office building in the 1960s, and an early case of introducing curtain walls in Korea. However, only its technical characteristics have been explored with less emphasis on further research data. This study attempts to demonstrate the social and cultural expectations and the demands of the construction of the House by examining the documents produced at the time and the initial plan. This study also highlights the fact that the House was the first project of the architect Pai Ki Hyung to realize high-rise reinforced concrete construction in Seoul's dense center. In the 1950s, the House was planned as a modern building with a complex of various cultural facilities and offices due to the character of activities of the Commission, and the lack of public cultural facilities in Korea. The plan of the Kuzosa Architects & Engineers was selected through a design competition held in 1959. The House was completed in 1967, which took about eight years from planning to completion with design modification in the 1960s. The initial plan submitted before the design modification shows that Pai used the vocabulary and logic of modern architecture and planned the House not as a simple office building but as a complex cultural facility.

• Biomolecules & Therapeutics
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• 제20권5호
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• pp.492-498
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• 2012

Phytochemicals have been known to exhibit potent antioxidant activity. This study examined cytoprotective effects of phytochemicals including quercetin, catechin, caffeic acid, and phytic acid against oxidative damage in SK-Hep-1 cells induced by the oxidative and non-oxidative metabolism of ethanol. Exposure of the cells to excess ethanol resulted in a significant increase in cytotoxicity, reactive oxygen species (ROS) production, lipid hydroperoxide (LPO), and antioxidant enzyme activity. Excess ethanol also caused a reduction in mitochondrial membrane potential (MMP) and the quantity of reduced glutathione (GSH). Co-treatment of cells with ethanol and quercetin, catechin, caffeic acid and phytic acid significantly inhibited oxidative ethanol metabolism-induced cytotoxicity by blocking ROS production. When the cells were treated with ethanol after pretreatment of 4-methylpyrazole (4-MP), increased cytotoxicity, ROS production, antioxidant enzyme activity, and loss of MMP were observed. The addition of quercetin, catechin, caffeic acid and phytic acid to these cells showed suppression of non-oxidative ethanol metabolism-induced cytotoxicity, similar to oxidative ethanol metabolism. These results suggest that quercetin, catechin, caffeic acid and phytic acid have protective effects against ethanol metabolism-induced oxidative insult in SK-Hep-1 cells by blocking ROS production and elevating antioxidant potentials.

• Childhood Kidney Diseases
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• 제6권2호
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• pp.259-265
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• 2002

저자들은 본원 소아과에 입원한 9년 3개월된 남아에서 만성병색소견, 심한 근무력증, 왜소증, 저칼륨성 대사성 알칼리혈증 및 신석회증과 좌측 요관의 확장을 보이는 영아기 이후 발병한 Bartter 증후군 1례를 경험하였기에 치료반응 및 임상경과를 문헌 고찰과 함께 보고하는 바이다.

• Childhood Kidney Diseases
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• 제9권1호
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• pp.21-30
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• 2005

목 적 : 소아 신질환 환자들의 골상태 평가 및 골다공증의 유병률을 산출하고 스테로이드 치료 기간 및 용량과의 연관성을 알아본 후 예방과 치료를 위한 진료에 지침을 마련하고자 시행하였다. 방 법 1994년 이후 아주대병원 소아과에서 신장질환을 진단 받은 환자들을 대상으로 초음파 골량측정법으로 골밀도를 측정한 후 한국 소아표준골밀도치를 참조하여 골상태를 평가하였고 환자의 임상소견 및 생화학적 지표들의 평균값간에 차이가 있는 지를 알아보았다. 결 과 : 골밀도를 측정 받은 환자는 총44명이었다. 진단시 나이는 6.7$\pm$4.2세였고, 골밀도 측정시 역연령은 9.3$\pm$4.2세, 골연령은 8.2$\pm$4.6세로 골연령이 저하되어 있었다. 질환별로는 특발성 신증후군 24명(54.5%), Henoch Shonlein 신염 7명(15.9%), IgA 신병증 5명(13.6%), 역류성 신병증 2명(4.5%), 기타 5명(11.4%)이었다. 환아 13명(29%)의 골밀도가 감소되어 있었고 이중 5명(11%)은 골다공증 범주에 속하였다 질환별로는 특발성 신증후군 1명(4%), Henoch Shonlein 신염 2명(29%), 역류성 신병증 1명(50%), 기타 1명(23%)이었다. 정상, 골감소증, 골다공증 세 군으로 나누었을 때 골밀도 측정시점까지 스테로이드 투여기간은 각각 26.5$\pm$27.3개월, 32.1$\pm$39.6개월, 8.9$\pm$12.9개월이었고, 투여한 축적 용량은 221.7 $\pm$248.6 mg/kg, 177.1 $\pm$302.9 mg/kg, 49.9$\pm$45.5 mg/kg이었으며 세 군간에 유의한 차이는 없었다. 스테로이드의 투여기간을 장기간(6개월이상)과 단기간(6개월 미만)으로 나누어 비교했을 때 골밀도 측정값 및 골관련 생화학적 수치들은 차이가 없었다.결 론 : 초음파 골량측정법이 보편화되지 않았지만 정상 참고치와 비교가 가능하였으며 측정결과 골감소증은 29%, 골다공증은 11%로 상당수에서 골상태가 비정상임을 알 수 있었다. 본 연구에서는 스테로이드 사용기간 및 축적용량이 골상내의 변화에 특별한 영향을 미치지 않는 것으로 나타났다. 동일 환자들의 골상태의 변화관찰과 신질환 관련 골감소의 요인을 밝혀내기 위한 추가적인 연구가 필요할 것으로 사료된다.