• KIISE Transactions on Computing Practices
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• v.22 no.10
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• pp.497-503
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• 2016

Emerging next-generation storage technologies such as non-volatile memory will help eliminate almost all of the storage latency that has plagued previous storage devices. In conventional storage systems, the latency of slow storage devices dominates access latency; hence, software efficiency is not critical. With low-latency storage, software costs can quickly dominate memory latency. Hence, researchers have proposed the memory mapped file I/O to avoid the software overhead. Mapping a file into the user memory space enables users to access the file directly. Therefore, it is possible to avoid the complicated I/O stack. This minimizes the number of user/kernel mode switchings. In addition, there is no data copy between kernel and user areas. Despite of the benefits in the memory mapped file I/O, its overhead still needs to be addressed, as the existing mechanism for the memory mapped file I/O is designed for slow block devices. In this paper, we identify the overheads of the memory mapped file I/O via experiments.

• YAKHAK HOEJI
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• v.45 no.2
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• pp.227-236
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• 2001

The complexity and variability of both the biologicals and the bioassays used to test them led to the use of the reference standard- a sample of the product of defined purity and potency, against which all preparations of that product must be calibrated. In order to prepare and establish KFDA reference standard for recombinant human growth hormone (somatropin), somatropin substance was filled in ampoules in National Institute for Biological Standards and Control (NIBSC). The candidate KFDA reference standard for somatropin (designated as 98/674) was evaluated to determine the suitability of serving as a KFDA reference standard for somatropin by the collaborative study, in which 10 laboratories participated. Physicochemical analysis and in vivo bioassay were performed by direct comparison with the international somatropin standard 88/624. 98/674 was identified as somatropin by SDS-PAGE, IEF, peptide mapping, and HPLC. Determination of somatropin content by SE-HPLC yielded a mean estimate of 2.01 mg somatropin per ampoule. Data from the study also yielded mean values of 0.39 $\pm$ 0.26% for high molecular weight impurities by SE-HPLC and mean values of 2.13 $\pm$ 1.29% for somatropin related proteins by RP-HPLC. Estimates of relative potency by weight gain bioassay in the hypophysectomised rats showed that relative potency of KS 98/674 was 1.07 aganist IS 88/624. Based on the results of the collaborative study, the candidate reference standard for somatropin is suitable to serve as a KFDA reference standard for somatropin.

• Journal of the Ergonomics Society of Korea
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• v.31 no.4
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• pp.515-523
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• 2012

Objective: The aim of this study is to investigate users' intuitive stereotypes on non-touch gestures and establish the gesture dictionary that can be applied to gesture-based interaction designs. Background: Recently, the interaction based on non-touch gestures is emerging as an alternative for natural interactions between human and systems. However, in order for non-touch gestures to become a universe interaction method, the studies on what kinds of gestures are intuitive and effective should be prerequisite. Method: In this study, as applicable domains of non-touch gestures, four devices(i.e. TV, Audio, Computer, Car Navigation) and sixteen basic operations(i.e. power on/off, previous/next page, volume up/down, list up/down, zoom in/out, play, cancel, delete, search, mute, save) were drawn from both focus group interview and survey. Then, a user participatory design was performed. The participants were requested to design three gestures suitable to each operation in the devices, and they evaluated intuitiveness, memorability, convenience, and satisfaction of their derived gestures. Through the participatory design, agreement scores, frequencies and planning times of each distinguished gesture were measured. Results: The derived gestures were not different in terms of four devices. However, diverse but common gestures were derived in terms of kinds of operations. In special, manipulative gestures were suitable for all kinds of operations. On the contrary, semantic or descriptive gestures were proper to one-shot operations like power on/off, play, cancel or search. Conclusion: The touchless gesture dictionary was established by mapping intuitive and valuable gestures onto each operation. Application: The dictionary can be applied to interaction designs based on non-touch gestures. Moreover, it will be used as a basic reference for standardizing non-touch gestures.

• Journal of the Korean Chemical Society
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• v.57 no.3
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• pp.398-404
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• 2013

In this study, the analogies in the chemistry domain of middle school science textbooks developed under the 2007 revised National Curriculum were analyzed. A total of 235 analogies were found in 27 middle school science textbooks analysed, which means that one analogy per 10 pages was used on average. The number of analogies found in each textbook considerably varied depending on both publishing company and chemistry domain. Functional analogies, verbal and pictorial analogies, analogies with abstract target and concrete analog, enriched analogies, everyday contexts analogies, student-centered analogies, and analogies with low systematicity were frequently used. On presenting the analogies in the textbooks, the term analogy and description about the limitations of the analogies were rarely mentioned. In comparison with the analogies in the science textbooks developed under the 7th National Curriculum, the frequency of analogies per page was increased. There were positive changes in the aspects of representation, extent of mapping and artificiality. No differences, however, were found in the patterns of the other aspects.

• Journal of Intelligence and Information Systems
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• v.11 no.2
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• pp.31-45
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• 2005

In this paper, convert in RDF triple and a RDF document through RDF document converters and design metadata schema about a digital camcorder after use Wrapper technology, and acquiring commodity information of a HTML page about the digital camcorder which these papers are defined so as to be different by electronic commerce stores, and is expressed. Save in digital camcorder domain ontology storage that implemented to relational database to DCC knowledge base ontology as convert to OWL Web ontology based on designed metadata schema. Through compare with rdf and DCCKBO, mapping, and inference process, provide to buyers by DCC information of the store that had the commodity purchasing information which is the best, and proposed a dynamic Web ontology guessed to contents of the best commodity purchasing information, and to define domain ontology saved in DCCKBO.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.6
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• pp.880-884
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• 2001

Rumen microbiology research has undergone several evolutionary steps: the isolation and nutritional characterization of readily cultivated microbes; followed by the cloning and sequence analysis of individual genes relevant to key digestive processes; through to the use of small subunit ribosomal RNA (SSU rRNA) sequences for a cultivation-independent examination of microbial diversity. Our knowledge of rumen microbiology has expanded as a result, but the translation of this information into productive alterations of ruminal function has been rather limited. For instance, the cloning and characterization of cellulase genes in Escherichia coli has yielded some valuable information about this complex enzyme system in ruminal bacteria. SSU rRNA analyses have also confirmed that a considerable amount of the microbial diversity in the rumen is not represented in existing culture collections. However, we still have little idea of whether the key, and potentially rate-limiting, gene products and (or) microbial interactions have been identified. Technologies allowing high throughput nucleotide and protein sequence analysis have led to the emergence of two new fields of investigation, genomics and proteomics. Both disciplines can be further subdivided into functional and comparative lines of investigation. The massive accumulation of microbial DNA and protein sequence data, including complete genome sequences, is revolutionizing the way we examine microbial physiology and diversity. We describe here some examples of our use of genomics- and proteomics-based methods, to analyze the cellulase system of Ruminococcus flavefaciens FD-1 and explore the genome of Ruminococcus albus 8. At Illinois, we are using bacterial artificial chromosome (BAC) vectors to create libraries containing large (>75 kbases), contiguous segments of DNA from R. flavefaciens FD-1. Considering that every bacterium is not a candidate for whole genome sequencing, BAC libraries offer an attractive, alternative method to perform physical and functional analyses of a bacterium's genome. Our first plan is to use these BAC clones to determine whether or not cellulases and accessory genes in R. flavefaciens exist in clusters of orthologous genes (COGs). Proteomics is also being used to complement the BAC library/DNA sequencing approach. Proteins differentially expressed in response to carbon source are being identified by 2-D SDS-PAGE, followed by in-gel-digests and peptide mass mapping by MALDI-TOF Mass Spectrometry, as well as peptide sequencing by Edman degradation. At Ohio State, we have used a combination of functional proteomics, mutational analysis and differential display RT-PCR to obtain evidence suggesting that in addition to a cellulosome-like mechanism, R. albus 8 possesses other mechanisms for adhesion to plant surfaces. Genome walking on either side of these differentially expressed transcripts has also resulted in two interesting observations: i) a relatively large number of genes with no matches in the current databases and; ii) the identification of genes with a high level of sequence identity to those identified, until now, in the archaebacteria. Genomics and proteomics will also accelerate our understanding of microbial interactions, and allow a greater degree of in situ analyses in the future. The challenge is to utilize genomics and proteomics to improve our fundamental understanding of microbial physiology, diversity and ecology, and overcome constraints to ruminal function.

• Journal of Ginseng Research
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• v.33 no.3
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• pp.199-205
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• 2009

Ginseng (Panax ginseng C.A. Meyer) is one of the most important medicinal plants in East Asia. Microsatellite or simple sequence repeat (SSR) markers are used in obtaining genetic analysis and authentication in many plants. The present study examined five microsatellites in conjunction with P. ginseng in Korea. The total observed allelic number was 17 (mean = 3.4), and gene diversities varied from 0.078 to 0.543 with an average of 0.314. Through a combined analysis of five loci in 100 ginseng samples, 44 different combined genotypes were observed. Expected and observed heterozygosites ranged from 0.077 to 0.541 (mean = 0.313) and 0.040 to 0.130 (0.083), respectively. All examined loci exhibited deficiency of heterozygosity and deviation from the Hardy-Weinberg equilibrium. Such results may be explained by the non-random mating and inbreeding that has occurred for several hundred years. These microsatellite markers could be used for the study of molecular genetics and the establishment of DNA marker database, as well as authentication of ginseng species and chromosomal mapping of QTL loci in P. ginseng.

• Journal of KIISE:Computer Systems and Theory
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• v.35 no.6
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• pp.293-303
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• 2008

As the computing environment moves to the wireless and handheld system, the power efficiency is getting more important. That is the case especially in the embedded hand-held system and the power consumed by the memory system takes the second largest portion in overall. To save energy consumed in the memory system we can utilize low power mode of SDRAM. In the case of RDRAM, nap mode consumes less than 5% of the power consumed in active or standby mode. However hardware controller itself can't use this facility efficiently unless the operating system cooperates. In this paper we focus on how to minimize the number of active units of SDRAM. The operating system allocates its physical pages so that only a few units of SDRAM need to be activated and the unnecessary SDRAM can be put into nap mode. This work can be considered as a generalized and system-wide version of PAVM(Power-Aware Virtual Memory) research. We take all the physical memory into account, especially buffer cache, which takes an half of total memory usage on average. Because of the portion of buffer cache and its importance, PAVM approach cannot be robust without taking the buffer cache into account. In this paper, we analyze the RAM usage and propose power-aware page allocation policy. Especially the pages mapped into the process' address space and the buffer cache pages are considered. The relationship and interactions of these two kinds of pages are analyzed and exploited for energy saving.

• Applied Biological Chemistry
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• v.41 no.2
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• pp.125-129
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• 1998

Xanthomonas sp. isolated from soil exhibited cell wall lytic activity of Candida albicans and secreted chitinase in chitin media. Especially, the chitinase activity was induced by chitin and reached a maximum level at 3 days culture in chitin media. We constructed genomic library of Xanthomonas sp. using cosmid vector in E. coli. Oligonucleotide probe was synthesized from the consensus sequence corresponding to chitinase active site, which was derived from the comparison of amino acid sequences of bacterial chitinase genes. Using this oligonucleotide probe, we screened the genomic library. By restriction enzyme mapping of the positive clones, we identified 4 independent clones which may contain the chitinase gene. One of the clones, named pXCH1 (1.2 kb insert), was further analyzed. Northern blot analysis indicated that is transcripts, 1 kb and 0.8 kb, were induced by chitin. When the cloned gene was induced by IPTG in E.coli cell, chitinase activity which was secreted onto culture media was not observed. However, when the cell was disrupted by using sonicator and then centrifuged, the supernatant exhibited chitinase activity. SDS-PAGE of the supernatant indicated that about 35 kDa protein was induced by IPTG. From these results, it was concluded that the cloned DNA was one of the chitinase genes of Xanthomonas sp.

• Journal of Korean Society for Geospatial Information Science
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• v.1 no.2 s.2
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• pp.223-235
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• 1993

This study associates with socio-economic status in a slice section area of Chicago metropolitan to get spatial patterns of urban windows. GSIS(Geo-spatial Information System) has been monitored with several statistic methods, and geo-spatial map presentations. From the grouping analysis, the result displays that most suburban town have high income values, such as Elmhurst, Melrose Park, North Lake(Income ranges between $25,000${\sim}$30,000 : 1980 Sensus data). The factors produced form both analyses of SAS and BMDP are socio-ethnic, economic, hispanic, black, life expectancy, and multiple car ownership. In the study area the socio-ethnic factor is striking, and is composed of nine out of the fourteen varialbles. Geo-spatial 3-D mapping represents a socio-economic configuration of the study area. The high income value areas are Elmhurst and North Lack, and a spot between Belmont Ave. and the Lake Shore. Economic configuration is a vital importance of socio-economic activities in the urban areas. In the study area a minimum average income level is about $4,364 and maximun is $30,311.