• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.9
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• pp.1-21
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• 2004

Die sogenannten verba pura bilden eine Teilmenge der germanischen starken Verben der VII. KLasse. Sie sind auf einsilbige langvokalisch auslautende Wurzeln des Vorurgermanischen $zur\"{u}ckzufuhren$: z. B. ${\ast}kn\bar{e}an$ 'erkennen', ${\ast}m\bar{e}an$ '$m\"{a}hen$', ${\ast}bl\bar{o}an$ $'bl\"{u}hen'$, ${\ast}m\bar{o}an$ $'qu\"{a}hlen'$. Um den Begriff der verba pura genau zu $erkl\"{a}ren$, stellt man diesen Verben die sogenannten verba impura $gegen\"{u}ber$, bei denen auf die lang Wurzelvokale urgerm. ${\ast}-\bar{e}-$ und ${\ast}-\ber{o}-$ ein Konsonant folgl: z.. B. urgerm. ${\ast}l\bar{e}tan$ (got. \etan) 'lassen', ${\ast}hw\bar{o}pan$ (got. hvopan) 'sich $r\"{u}hmen$'. Die germanischen starken Verben der VII. Klasse hat die $st\"{a}rksten$ Umgestaltungen mitgemacht, und zwar die verba pura noch mehr. In diesem Aufsatz untersuchte ich die $Gr\"{u}nde$ ihrer Umgestaltungen im germanischen Verbalsystem. Danach wird der Vorgang erschlossen, wie die verba pura in Ahd. zu den schwachen Verben I $\"{u}bertraten$. Dabei werden die folgenden Punkte besonders behandelt: Hatten die $fr\"{u}hzeitigen${\;}Pr\"{a}sensformen$ der verba pura -i-, das aus -jan herausgeht? Wenn nein, wie haben die verba pura zur schwachen Flexion $\"{u}bertraten$? Warum konnten die verba pura wie die anderen redupliziernden Verben in Ahd. nicht zu ablautenden Verben $\"{u}bergehen$?

• Journal of Ginseng Research
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• v.47 no.5
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• pp.662-671
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• 2023

Background: 20(S)-protopanaxadiol (PPD), a ginsenoside metabolite, has prominent benefits for the central nervous system, especially in improving learning and memory. However, its transcriptional targets in brain tissue remain unknown. Methods: In this study, we first used mass spectrometry-based drug affinity responsive target stability (DARTS) to identify the potential proteins of ginsenosides and intersected them with the transcription factor library. Second, the transcription factor PURA was confirmed as a target of PPD by biolayer interferometry (BLI) and molecular docking. Next, the effect of PPD on the transcriptional levels of target genes of PURA in brain tissues was determined by qRT-PCR. Finally, bioinformatics analysis was used to analyze the potential biological features of these target proteins. Results: The results showed three overlapping transcription factors between the proteomics of DARTS and transcription factor library. BLI analysis further showed that PPD had a higher direct interaction with PURA than parent ginsenosides. Subsequently, BLI kinetic analysis, molecular docking, and mutations in key amino acids of PURA indicated that PPD specifically bound to PURA. The results of qRT-PCR showed that PPD could increase the transcription levels of PURA target genes in brain. Finally, bioinformatics analysis showed that these target proteins were involved in learning and memory function. Conclusion: The above-mentioned findings indicate that PURA is a transcription target of PPD in brain, and PPD upregulate the transcription levels of target genes related to cognitive dysfunction by binding PURA, which could provide a chemical and biological basis for the study of treating cognitive impairment by targeting PURA.

• Advances in nano research
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• v.12 no.5
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• pp.501-514
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• 2022

This study aimed to investigate the effects and potential mechanisms of Chikusetsusaponin V (CsV) on endothelial nitric oxide synthase (eNOS) and vascular endothelial cell functions. Different concentrations of CsV were added to animal models, bovine aorta endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs) cultured in vitro. qPCR, Western blotting (WB), and B ultrasound were performed to explore the effects of CsV on mouse endothelial cell functions, vascular stiffness and cellular eNOS mRNA, protein expression and NO release. Bioinformatics analysis, network pharmacology, molecular docking and protein mass spectrometry analysis were conducted to jointly predict the upstream transcription factors of eNOS. Furthermore, pulldown and ChIP and dual luciferase assays were employed for subsequent verification. At the presence or absence of CsV stimulation, either overexpression or knockdown of purine rich element binding protein A (PURA) was conducted, and PCR assay was employed to detect PURA and eNOS mRNA expressions, Western blot was used to detect PURA and eNOS protein expressions, cell NO release and serum NO levels. Tube formation experiment was conducted to detect the tube forming capability of HUVECs cells. The animal vasodilation function test detected the vasodilation functions. Ultrasonic detection was performed to determine the mouse aortic arch pulse wave velocity to identify aortic stiffness. CsV stimulus on bovine aortic cells revealed that CsV could upregulate eNOS protein levels in vascular endothelial cells in a concentration and time dependent manner. The expression levels of eNOS mRNA and phosphorylation sites Ser1177, Ser633 and Thr495 increased significantly after CsV stimulation. Meanwhile, CsV could also enhance the tube forming capability of HUVECs cells. Following the mice were gavaged using CsV, the eNOS protein level of mouse aortic endothelial cells was upregulated in a concentration- and time-dependent manner, and serum NO release and vasodilation ability were simultaneously elevated whereas arterial stiffness was alleviated. The pulldown, ChIP and dual luciferase assays demonstrated that PURA could bind to the eNOS promoter and facilitate the transcription of eNOS. Under the conditions of presence or absence of CsV stimulation, overexpression or knockdown of PURA indicated that the effect of CsV on vascular endothelial function and eNOS was weakened following PURA gene silence, whereas overexpression of PURA gene could enhance the effect of CsV upregulating eNOS expression. CsV could promote NO release from endothelial cells by upregulating the expression of PURA/eNOS pathway, improve endothelial cell functions, enhance vasodilation capability, and alleviate vessel stiffness. The present study plays a role in offering a theoretical basis for the development and application of CsV in vascular function improvement, and it also provides a more comprehensive understanding of the pharmacodynamics of CsV.

• Journal of the Korean Mathematical Society
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• v.56 no.5
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• pp.1387-1401
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• 2019

Consider a finite measure space (${\Omega}$, ${\Sigma}$, ${\mu}$) and a Banach space $X({\mu})$ consisting of (equivalence classes of) real measurable functions defined on ${\Omega}$ such that $f{\chi}_A{\in}X({\mu})$ and ${\parallel}f{\chi}_A{\parallel}{\leq}{\parallel}f{\parallel}$, ${\forall}f{\in}({\mu})$, $A{\in}{\Sigma}$. We prove that if it satisfies the subsequence property, then it is an ideal of measurable functions and has an equivalent norm under which it is a Banach function space. As an application we characterize norms that are equivalent to a Banach function space norm.

• Journal of Information Science Theory and Practice
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• v.6 no.4
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• pp.6-16
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• 2018

This article shows an approach to the study of two fundamental aspects of the prepublication of scientific manuscripts in specialized repositories (arXiv). The first refers to the size of the interaction of "standard papers" in journals appearing in the Web of Science (WoS)-now Clarivate Analytics-and "non-standard papers" (manuscripts appearing in arXiv). Specifically, we analyze the citations found in the WoS to articles in arXiv. The second aspect is how publication in arXiv affects the citation count of authors. The question is whether or not prepublishing in arXiv benefits authors from the point of view of increasing their citations, or rather produces a dispersion, which would diminish the relevance of their publications in evaluation processes. Data have been collected from arXiv, the websites of the journals, Google Scholar, and WoS following a specific ad hoc procedure. The number of citations in journal articles published in WoS to preprints in arXiv is not large. We show that citation counts from regular papers and preprints using different sources (arXiv, the journal's website, WoS) give completely different results. This suggests a rather scattered picture of citations that could distort the citation count of a given article against the author's interest. However, the number of WoS references to arXiv preprints is small, minimizing this potential negative effect.

• Journal of the Korean Mathematical Society
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• v.41 no.3
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• pp.407-421
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• 2004

By using a recursive algorithm, we construct edge-coloured graphs representing products of spheres and consequently we give upper bounds for the regular genus of ${\mathbb{S}}^{m}\;\times\;{\mathbb{S}}^{n}$, for each m, n > 0.

• The Korean Journal of Mycology
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• v.6 no.1
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• pp.43-47
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• 1978

Some 50 fungi were collected and identified at Youngu and Mt. Sobaek from April to October in 1977. The results have shown that, following ten species are new to Korean list. Collybia dryophila (BULL. ex FR.), QUEL., Mycena polygramma (BULL. ex FR.) S.F. GRAY., M. pura (PERS. ex FR.) QUEL., Crepidotus nephrodes (BERK. et CURT.) SACC., lnocybe montana KOBAY., I. squamulosa KOBAY., Rhodophllus ater HONGO, R. violaceus (MURR.) SING., Leccinum aurantiacum (BULL.) S.F. GRAY., and Suillus aeruginascens (SECR.) SNELL. The authors wish to express our thanks to Asan Foundation for the financial support for a part of this research project.

• The Korean Journal of Mycology
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• v.22 no.3
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• pp.216-221
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• 1994

As a part of studies on the fungal flora of Korea, authors have collected over 60 higher fungi specimens during summer season in 1993 in Mt. Hungjung which was located in eastern part of Korea. Among them two genera are new to Korea: Neobulgaria Petrak and Melastiza Boudier. Following five species are recorded for the first time in Korea: Psilocybe xeroderma Huijsm, Galerina vittaeformis (Fr.) Singer var. vittaeformis f. vittaeformis (Fr.) Singer, Gyromitra infula (Schaeffer ex Fries) Quelet, Neobulgaria pura (Fries) Petrak and Melastiza chateri (W. G. Smith) Boudier, for which Korean common names are designated in this present paper. All color names and terms within quotation marks are taken from Kornerup and Wanscher 1983, Methuen handbook of colour. The specimens are all deposited in the RDAGB's herbarium.

• Journal of the Korean Mathematical Society
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• v.45 no.2
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• pp.455-466
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• 2008

Current studies on products of analytic functionals have been based on applying convolution products in D' and the Fourier exchange formula. There are very few results directly computed from the ultradistribution space Z'. The goal of this paper is to introduce a definition for the product of analytic functionals and construct a new multiplier space $F(N_m)$ for $\delta^{(m)}(s)$ in a one or multiple dimension space, where Nm may contain functions without compact support. Several examples of the products are presented using the Cauchy integral formula and the multiplier space, including the fractional derivative of the delta function $\delta^{(\alpha)}(s)$ for $\alpha>0$.

• Communications of the Korean Mathematical Society
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• v.18 no.2
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• pp.263-280
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• 2003

We prove weighted L$^{p}$ estimates with respect to the non-isotropic norm for the (equation omitted)-equation on real ellipsoids, where weights are powers of the distance to the boundary. The non-isotropic norm is smaller than the usual norm, by a factor which is equal to the distance to the boundary in the complex tangential component and which is equal to the m-th root of the distance to the boundary in the complex normal component. Here n is the maximal order of contact of the boundary of the real ellipsoid with complex analytic curves.