• Journal of Biomedical Engineering Research
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• v.23 no.6
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• pp.485-489
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• 2002

In this study. respiratory efforts were monitored by the change of pulse transit time (PTT) which is related with the arterial pressure PTT is the time interval between the peak of R wave in ECG and the maximal slope point of photoplethysmogram(PPG). Biosignals, ECG and finger photoplethysmogram(PPG), were converted to digital data, and PTT was evaluated in personal computer with every heart beat. Results were presented as a graph using spline interpolation. The software was implemented in C$\^$++/ as a window-based application program. PTT was periodically changed according to airflow in resting respiration. In the resting respiration, PTT was changed according to the respiratory cycle. The amplitude of PTT fluctuation was increased by deep respiration, and increased by partial airway obstruction. These results suggest that PTT is responsible to respiratory effort which could be evaluated by the pattern of PTT change. And it is expected that PTT could be applied in the monitoring of respiratory effort by noninvasive methods, and is very useful method for the evaluation of respiratory distress.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.8
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• pp.1514-1520
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• 2007

Currently, the signal of the human body is measured with various methods, and a noninvasive investigation of various methods is useful diagnosis method. PTT(Pulse Transit Time) which is noninvasive investigation make use of to estimate the physiological phenomena. PTT has a latent information of cardiovascular system. So we have the experiments for analysis of the relations between PTT and physiological parameters. We examine to correlate to the physiological parameters, an age and degree of paralysis on the ultrasound therapy. The 40 patients who has a such paralysis join our experiment, and we obtain the PTT data that normal condition and states after ultrasound therapy. We study that PTT after the ultrasound therapy for patients who have a paralysis was related to an age and degree of paralysis.

• Proceedings of the IEEK Conference
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• 2009.05a
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• pp.138-140
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• 2009

Hemorrhage shock occupies high rate in trauma patient's mortality and blood pressure is the variance that judges early diagnosis and the effect of remedy. Systolic blood pressure is related to pulse transit time(PTT). PTT means the time that is required to flow from the heart to peripheral artery. PTT is influenced from the length, cross section and stiffness of the blood vessels. It is hard to evaluate the correlation between systolic blood pressure and PTT because they are variable in human body. In this paper, we evaluated the correlation between the systolic blood pressure and PTT in normal and hemorrhage states using standardized rat. PTT is defined as the time differences between the R peak and the peak of pulse wave. The analyzed time differences of ECG and blood pressure are analyzed every 5minutes for 30 seconds when there is before and after bleeding. Before bleeding, systolic blood pressure and PTT are steadily preserved but when the bleeding comes started, systolic blood pressure is declined. However PTT was increased and decreased. Under the circumstance that the standardized rat is controlled by age, the length of the blood vessels, and any disease, it shows that PTT measurement using systolic blood pressure of bleeding is impossible.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2345-2350
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• 2008

Recently, ultrasound is becoming a universal way of treatment when it comes to clinic. The thermal effect of therapeutic ultrasound can raise the temperature of tissue without damage and thus increases the flow rate, and this leads to the oxygen transportation velocity of peripheral tissue and ultimately facilitates the metabolism. The purpose of this research is analyzing relations between PTT and transmission time of therapeutic ultrasound, and in this study the PTT variation due to respective transmission time of ultrasound upon 17 normal persons was measured and as a result, it was observed that PTT increases as transmission time of therapeutic ultrasound

• Journal of Sensor Science and Technology
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• v.13 no.5
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• pp.383-391
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• 2004

In this study, we implemented the pulse transit time (PTT) system to examine usefulness of the monitoring method of distensibility and elasticity using photoplethysmography sensor in vivo. PTT is defined as the time interval between the peak of QRS complex in ECG signal and the maximum slope point of photoplethysmography. these two signals were converted to digital data by means of AID converter, then PTT was evaluated by heartbeat using PC. Results of analysis were displayed as a graph using spline interpolation method. The variance of PTT was measured repetitiously to verify efficiency of PTT system in resting state and hyperemic state. Repeated measurement of PTT was not same value but showed that coefficients of correlation were related with each other as 0.8302 (P<0.01) in resting state. And also repeated measurement of PTT showed significant correlation as 0.868 (P<0.01) in the hyperemic state. These result showed that PTT is reflect on transient pressure variance in the artery and is very useful method for the evaluation of prognosis of the hypertension and arteriosclerosis.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.54 no.8
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• pp.504-509
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• 2005

This paper presents a new method for obtaining the noninvasive and unrestrained blood pressure readings noninvasively and unrestrainedly using based on reflected wave arrival time(RAT) in the volume of pulse. Since this new method employs only volume pulse, is more rapider and simpler than the method using pulse transit time(PTT) because it only employs the volume of pulse. Blood pressure, PTT and RAT were acquired from 15 healthy subjects. Each subjects were performed forty trials of each measurement. As a result of those trials, the mean error between oscillometric and RAT measurements for systolic blood pressure was $4.55\pm5.64mmHg$. This result showed quite equal with the mean error between oscillometric and PPT measurf:ments, $4.22\pm5.30mmHg$, However, it was not obtained a satisfactory result in the relativity of oscillometric to both RAT and PPT measurements for diastolic blood pressure because of personal difference. To conclude, the method of systolic blood pressure estimation noninvasively and unrestrainedly using by RAT may be used as the method by PTT. Nevertheless, additional studies would be necessary for the RAT/PTT estimation of diastolic blood Pressure measurement.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.7
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• pp.1020-1026
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• 2013

Multirate filtering process on the biological signals like Electrocardiogram (ECG) and Photoplethysmogram (PPG) can be defined as the digital signal processing algorithm in which the sampling rate varies to omit or interpolate the intermediate values between the sampled data. With this aim, we suggest a new multirate filtering algorithm by deleting the extraneous data to eliminate the unwanted degradations such as granular noise due to the usage of high sampling frequency and simultaneously to detect the fiducial features of ECG and PPG with reducing the complexity of resolving fiducial points such as R-peak, Pulse peak and Pulse Transit Time (PTT). After the experimental simulations performed, we can conclude the fact that we can detect the fiducial features of ECG and PPG signal in terms of R-peak, Pulse peak and PTT without the loss of accuracy even if we do not maintain the original sampling frequency.

• Journal of the Korean Society for Nondestructive Testing
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• v.25 no.4
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• pp.262-267
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• 2005

Epidural block under general anesthesia has been widely used to control postoperative pain. In this anesthetic state many hemodynamic parameters are changed. Moreover pulse transit time is influenced by this memodynamic change. m change in the finger and the toe due to relaxation of arterial wall muscle after general anesthesia and epidural block under general anesthesia. This study, in the both general anesthesia and epidural block under general anesthesia, ${\Delta}PTT$ of the toe and of the finger are measured. In addition, ${\Delta}PTT$(toe-finger) of the epidural block under general anesthesia and of the general anesthesia were compared.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.21 no.8
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• pp.770-775
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• 2008

Autonomic nervous system of the anesthetized patients can be influenced by the many kinds of stimulations such as intubation, surgical incision and so on. The changes of the heart rates and blood pressures are surrogates of responses of the autonomic system to the external stimulations. Recently, the power spectral analysis of the heart rate variability (HRV) made it easy to know the fractions and changes of sympathetic and parasympathetic autonomic systems. In this study, the changes of pulse transit time, one of the response of vessels to stimulations, was investigated in relation to the HRV. Ten patients were examined and average age is 22.5 $\pm$ 11.04, average weight is 63 $\pm$ 14.4 kg. The patients were anesthetized only by sevoflurane inhalation. Pulse transit time is determined by calculating the difference of the time between the R peak of ECG and the characteristic point of the plethysmography. Power spectral density (PSD) of the HRV was achieved in the frequency of 0.04-0.15 (LF) and 0.15-0.4 (HF). Compared to preanesthetic period the values of LF and LF/HF ratio of HRV were decreased (p<0.05). HF and PTT was increased in anesthetic state with sevoflurane. Otherwise, after intubation, the HF was decreased and LF, LF/HF ratio and PTT were increased. PSD of the HRV is well-known for the index of the autonomic nervous activity. Not only HRV but PTT analysis also is a useful index reflecting the autonomic responses to various stimulations. And this analysis is useful in bed side monitoring because the calculating method is simple and it takes shorter processing time compared to the HRV analysis.

• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.370-375
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• 2006

The purpose of this work is to predict the systolic blood pressure (BP) during exercise from pulse transit time (PTT) for warning of possible danger. PTT was calculated as the time between R-peak of ECG and the peak of differential photoplethysmograph (PPG). For the PTT-BP model, we used regress equations from previous studies and 3 kinds of new models combining linear and nonlinear regress equation. The model parameters were estimated with the data measured under low to middle intensity exercise, and then was tested with the data measured under high intensity exercise. Predicted BP values after high intensity exercise were compared with those measured by cuff-type sphygmomanometer. The results showed that the error between measured and predicted values were acceptable for the monitoring BP. We tested PTT-BP models 1 month after the identification without further calibration. Models could predict the BP and the errors between measured and predicted BP were about 5mmHg. The suggested system is expected to be helpful in recognizing any danger during exercise.