• 한국정보통신설비학회:학술대회논문집
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• 2009.08a
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• pp.275-280
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• 2009

Femtocells are viewed as a promising option for mobile operators to improve coverage and provide high-data-rate services in a cost-effective manner Femtocells can be used to serve indoor users, resulting in a powerful solution for ubiquitous indoor and outdoor coverage. TThe frequency accuracy and phase alignment is necessary for ensuring the quality of service (QoS) forapplications such as voice, real-time video, wireless hand-off, and data over a converged access medium at the femtocell. But, the GPS has some problem to be used at the femtocell, because it is difficult to set-up, depends on the satellite condition, and very expensive. The IEEE 1588 specification provides a low-cost means for clock synchronisation over a broadband Internet connection. The Time of Packet (ToP) specified in IEEE 1588 is able to synchronize distributed clocks with an accuracy of less than one microsecond in packet networks. However, the timing synchronization over packet switched networks is a difficult task because packet networks introduce large and highly variable packet delays. This paper proposes an enhanced filter algorithm to reduce ths packet delay variation effects and maintain ToP slave clock synchronization performance. The results are presented to demonstrate in the intra-networks and show the improved performance case when the efficient ToP filter algorithm is applied.

• BMB Reports
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• v.46 no.11
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• pp.539-543
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• 2013

There is a correlation between obesity and the amount of brown adipose tissue; however, the molecular mechanism of brown adipogenic differentiation has not been as extensively studied. In this study, we performed a protein tyrosine phosphatase (PTP) profiling analysis during the brown adipogenic differentiation of mouse primary brown preadipocytes. Several PTPs, including PTPRF, PTPRZ, and DUSP12 showing differential expression patterns were identified. In the case of DUSP12, the expression level is dramatically downregulated during brown adipogenesis. The ectopic expression of DUSP12 using a retroviral expression system induces the suppression of adipogenic differentiation, whereas a catalytic inactive DUSP12 mutant showed no effect on differentiation. These results suggest that DUSP12 is involved in brown adipogenic differentiation and may be used as a target protein for the treatment or prevention of obesity by the regulation of brown adipogenic differentiation.

• BMB Reports
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• v.45 no.5
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• pp.317-322
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• 2012

2-deoxy-D-glucose(2DG)-caused endoplasmic reticulum (ER) stress inhibits protein phosphorylation at tyrosine residues. However, the accurate regulatory mechanisms, which determine the inflammatory response of chondrocytes to ER stress via protein tyrosine phosphorylation, have not been systematically evaluated. Thus, in this study, we examined whether protein phosphorylation at tyrosine residues can modulate the expression and glycosylation of COX-2, which is reduced by 2DG-induced ER stress. We observed that protein tyrosine phosphatase (PTP) inhibitors, sodium orthovanadate (SOV), and phenylarsine oxide (PAO) significantly decreased expression of ER stress inducible proteins, glucose-regulated protein 94 (GRP94), and CCAAT/ enhancer-binding-protein- related gene (GADD153), which was induced by 2DG. In addition, we demonstrated that SOV and PAO noticeably restored the expression and glycosylation of COX-2 after treatment with 2DG. These results suggest that protein phosphorylation of tyrosine residues plays an important role in the regulation of expression and glycosylation during 2DG-induced ER stress in rabbit articular chondrocytes.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.742-746
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• 2008

With the trend of factory automation, nowadays, much industrial machinery tends to be put into 24-hours operation a day. However, these trends in industrial equipments also increase the possibility of various mechanical problems and bring about innumerable maintenance cost. There is a strong need of the condition monitoring and diagnosis for industrial equipment, especially rotating machinery, since they are connected not only to the reduction in the maintenance costs but also connected to the enhancement of production efficiency. Generally, to evaluate the operating conditions in the machinery in the industrial field, various physical properties are monitored. Among them, vibration and Noise signals are the mist important indicator and it is effectively used in many diagnosis systems for machinery. Much previous research is based in the FFT (Fast Fourier Transform) method. The spectral analysis is assumed that the signal is stationary. However, almost random signals are non-stationary. The wavelet transform has been recognized an efficient Method. Most interesting sounds have time-varying features. Signal processing techniques for the analysis of transient sound have been not clearly given yet.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.29 no.1
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• pp.24-29
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• 2018

Background and Objectives : The purpose of this study was to evaluate the impact of surgical extent on voice using acoustic and aerodynamic measurements in a serially followed thyroidectomy patients. Materials and Method : From October 2015 to January 2017, 108 patients who had undergone thyroid surgery and voice test for preoperative, 2, 3, and 6 months postoperatively were classified into five operative types. The radiological stage preoperatively and histopathological stage postoperatively were classified according to the invasion of thyroid capsule and surrounding tissue. For each classification, the results of the voice analysis according to the period were compared and analyzed. Results : The difference of voice according to surgical extent, radiological stage, and histopathologic stage showed significant difference only with Maximal phonation time (MPT) over time. However, in the analysis of interaction between each classification and period, Phonation threshold pressure (PTP) only showed significant results. Conclusion : Differences in imaging and histopathologic stages have no significant effect on recovery of voice symptoms after thyroid surgery. As the extent of operation increases, the pressure to start vocalization is relatively higher, which also varies with time after surgery.

• Corrosion Science and Technology
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• v.11 no.5
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• pp.173-178
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• 2012

To manage the wall thinning of carbon steel piping in nuclear power plants, the utility of Korea has performed thickness inspection for some quantity of pipe components during refueling outages and determined whether repair or replacement after evaluating UT (Ultrasonic Test) data. When the existing UT data evaluation methods, such as Band, Blanket, PTP (Point to Point) Methods, are applied to a certain pipe component, unnecessary re-inspecting situations may be generated even though the component does not thinned. In those cases, economical loss caused by repeated inspection and problems of maintaining the pipe integrity followed by decreasing of newly inspected components may be generated. EPRI (Electric Power Research Institute) in USA has suggested several statistical methods, TPM (Total Point Method), LSS (Least Square Slope) Method, etc. to distinguish whether multiple inspecting components have thinned or not. This paper presents the analysis results for multiple inspecting components over three times based on both NAM (Near Area of Minimum) Method developed by KEPCO-E&C and the other methods suggested by EPRI.

• Current Industrial and Technological Trends in Aerospace
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• v.6 no.1
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• pp.116-123
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• 2008

In the launch mission, mission control systems and tracking systems need time synchronization for data monitoring and data analysis. There are several standards for time synchronization and an adequate standard is selected according to the requirement of time accuracy and cost among time synchronization standards. Oscillators are used to maintain time accuracy. There are some kinds of oscillators with diverse characteristics and an adequate oscillator can be adopted according to time accuracy. In this paper, we will specify characteristics of several oscillators and standards generally used for time synchronization. And we will also introduce TSDN(time synchronization and display network) for time synchronization in Naro Space Center.

• Journal of Yeungnam Medical Science
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• v.30 no.1
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• pp.4-9
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• 2013

Leptin, a 16-kDa cytokine, is secreted by adipose tissue in response to the surplus of fat store. Thereby, the brain is informed about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations (e.g., POMC and NPY neurons) and activates several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway, which eventually translates into decreased food intake and increased energy expenditure. Leptin signal is inhibited by a feedback inhibitory pathway mediated by SOCS3. PTP1B involves another inhibitory pathway of leptin. Leptin potently promotes fat mass loss and body weight reduction in lean subjects. However, it is not widely used in the clinical field because of leptin resistance, which is a common feature of obesity characterized by hyperleptinemia and the failure of exogenous leptin administration to provide therapeutic benefit in rodents and humans. The potential mechanisms of leptin resistance include the following: 1) increases in circulating leptin-binding proteins, 2) reduced transport of leptin across the blood-brain barrier, 3) decreased leptin receptor-B (LRB), and/or 4) the provocation of processes that diminish cellular leptin signaling (inflammation, endoplasmic reticulum stress, feedback inhibition, etc.). Thus, interference of the cellular mechanisms that attenuate leptin signaling improves leptin action in cells and animal models, suggesting the potential utility of these processes as points of therapeutic intervention. Various experimental trials and compounds that improve leptin resistance are introduced in this paper.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.18 no.2
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• pp.154-161
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• 2009

In order to implement continuous-path motion on a robot, it is necessary to blend one joint motion to another joint motion near a via point in a trapezoidal form of joint velocity. First, the velocity superposition using parametric interpolation is proposed. Hybrid motion blending is defined as the blending of different two type's motions such as blending of joint motion with linear motion, in the neighborhood of a via point. Second, hybrid motion blending algorithm is proposed based on velocity superposition using parametric interpolation. By using a 3-axis SCARA (Selective Compliance Assembly Robot Arm) robot with $LabVIEW^{(R)}$ $controller^{(1)}$, the velocity superposition algorithm using parametric interpolation is shown to result in less vibration, compared with PTP(Point- To-Point) motion and Kim's algorithm. Moreover, the hybrid motion $algorithm^{(2)}$ is implemented on the robot using $LabVIEW^{(R)(1)}$ programming, which is confirmed by showing the end-effector path of joint-linear hybrid motion.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1994.10a
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• pp.266-272
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• 1994

An essential ingredient in precision machining is a positioning system that responds quickly and precisely to very small input signal. In this paper, two different positioning systems were presented fot the precision positioning control. The one is a friction drive system, the other is a ballscrew system. The friction drive system was composed of an air sliding guide and a friction drive. The ballscrew system was made of a ballscrew and a linear guide. Nonlinear behaviors of the given systems tend to make the system inaccurate. The paper looked at the phenomena that has caused the positioning error. These apparently nonlinear phenomena can be attributed mainly to the presence of the nonlinear friction and slip effect plus the dynamic change from the microdynamic to the macrodynamic and form the macrodynamic to the microdynamic. For the control of the positioning system, the control algorithm based on a neural network is suggested. The FEL(Feedback Error Learning) controller can learn the inverse dynamics of a nonlinear system by using the neural network controller, and stabilize the system by a linear controller. In the experiment, PTP control is implemented withen the maximum error of 0.05 .mu.m ~0.1 .mu. m when i .mu.m step reference input is applied and that of maximum 1 .mu. m when 100 .mu.m step reference input is given. Sinusoidal inputs with the amplitude of 1 .mu.m and 100 .mu. m are used for the tracking control of the positioning system. Experimental results of the proposed algorithm are shown to be superior to those of conventional PD controls.