• 지역사회간호학회지
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• 제22권2호
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• pp.192-203
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• 2011

Purpose: This study was conducted to develop and assess the feasibility of an upper extremity exercise program based on Patterned Sensory Enhancement (PSE) for home-bound stroke patients by measuring the level of upper extremity function, depression, and interpersonal relationship. Methods: The experiments were performed on stroke patients at three different rehabilitation centers in Incheon City. Twenty patients participated in the experimental group or in the control group. The program was executed three times a week for 6 weeks. Data were collected from August to October, 2006. Manual Function Test was used to quantify and evaluate upper extremity function. The depression level and the effectiveness of interpersonal relationship were quantified and measured using CES-D and Relationship Change Scale, respectively. Results: The effectiveness of upper extremity function of stroke patients who participated in the PSE upper extremity exercise program was higher than that of non-participating patients. The depression level decreased and interpersonal relationship improved in the stroke patients who participated in this program compared to those who did not. Conclusion: These findings prove that the PSE upper extremity exercise program for home-bound stroke patients was an effective strategy for enhancing upper extremity function, decreasing the depression level, and improving interpersonal relationships.

• Molecules and Cells
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• 제26권3호
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• pp.291-298
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• 2008

Human karyopherin ${\beta}3$, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway. Previously, we showed that karyopherin ${\beta}3$ complemented the PSE1 and KAP123 double mutant. Our research suggested that karyopherin beta has an evolutionary function similar to that of yeast PSE1 and/or KAP 123. In this study, we performed yeast two-hybrid screening to find a protein which would interact with karyopherin ${\beta}3$ and identified apolipoprotein A-I (apo A-I), a secretion protein with a primary function in cholesterol transport. By using in vitro binding assay, co-immunoprecipitation, and colocalization studies, we defined an interaction between karyopherin ${\beta}3$ and apo A-I. In addition, overexpression of karyopherin ${\beta}3$ significantly increased apo A-I secretion. These results suggest that karyopherin ${\beta}3$ plays a crucial role in apo A-I secretion. These findings may be relevant to the study of a novel function of karyopherin ${\beta}3$ and coronary artery diseases associated with apo A-I.

• 대한한의학방제학회지
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• 제28권4호
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• pp.451-458
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• 2020

뇌졸중 후 발생한 뇌전증 환자에서 항경련제와 함께 진간식풍탕가감방(鎭肝熄風湯加減方), 우황청심원(牛黃淸心元)을 위주로 하는 한의 치료를 병행하여 발작 억제 효과를 확인하였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제7권1호
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• pp.92-97
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• 2004

저자들은 간 이식 후 지속적 비기능 항진에 발생된 내과적 치료에 반응하지 않는 림프세포증식성질환의 6세된 남아에서 부분적 비동맥 색전술을 치료의 한 방법으로 선택하였다. 비기능항진의 억제 효과로 면역력 증강을 통해 혈액학적 호전을 유도하고자 하였으며 치료 후 PTLD의 호전을 보인 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1119-1122
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• 2016

Background: Punica granatum (PG) has been demonstrated to possess antitumor effects on various types of cancer cells. In this study, we determined antiproliferative properties of a seed extract of PG (PSE) from Iran in different human cancer cells. Materials and Methods: A methanolic extract of pomegranate seeds was prepared. Total phenolic content (TPC) and total flavonoid content (TFC) were assessed by colorimetric assays. Antioxidant activity was determined with reference to DPPH radical scavenging activity. The cytotoxicity of different doses of PSE (0, 5, 20, 100, 250, 500, $1000{\mu}g/ml$) was evaluated by MTT assays with A549 (lung non small cell carcinoma), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer cells), and PC-3 (prostate adenocarcinoma) cells. Results: Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison to negative controls at all tested doses ($5-1000{\mu}g/ml$). In all studied cancer cells, PSE reduced the cell viability to values below 23%, even at the lowest doses. In all cases, IC50 was determined at doses below $5{\mu}g/ml$. In this regard, SKOV3 ovarian cancer cells were the most responsive to antiproliferative effects of PSE with a maximum mean growth inhibition of 86.8% vs. 82.8%, 81.4% and 80.0% in MCF-7, PC-3 and A549 cells, respectively. Conclusions: Low doses of PSE exert potent antiproliferative effects on different human cancer cells SKOV3 ovarian cancer cells as most and A549 cells ar least responsive regarding cytotoxic effects. However, the mechanisms of action need to be addressed.

• 한국축산식품학회지
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• 제18권3호
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• pp.248-254
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• 1998

The two hundreds and twenty two pork carcasses from commercial breed were tested to compare technical quality characteristics and relationships with meat quality parameters between PSE and normal pork classified buy 24hr postmortem conductivity($C_u$). In characteristics of PSE and normal pork by $C_u$ value, highly significant differences were found in NPPC color scale and CIE L*(p＜0.001), moderately significant differences in $C_3$ and cooking loss(p＜0.01), and significant differences were in $C_6$, CIE b*, WHC and juiciness(p＜0.05). In correlation coefficients between $C_u$ and other meat quality determining factors, $C_u$ was poorly related with $pH_1$($R^2$=0.28, p<0.001), CIE a*($R^2$=0.14, p＜0.05), b*($R^2$=0.28, p＜0.01) and cooking loss($R^2$=0.26, p＜0.01). Also, relatively low correlation coefficients were observed in $pH_u$($R^2$=0.32, p＜0.001), WHC($R^2$=0.39, p＜0.001) and juiciness($R^2$=0.41, p＜0.001). Moderately high coefficients were found in NPPC color scale($R^2$=0.59, p＜0.001) and CIE L*($R^2$=0.58, p＜0.001).

• 한국철도학회논문집
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• 제19권5호
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• pp.609-616
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• 2016

승객서비스 장치는 역정보 등 다양한 열차운행 정보를 제공하기 위해 설치된 승객 접점장치로 고장이나 오류 시 열차운행에 영향은 적지만 승객들은 큰 불편을 느끼게 된다. 이에 본 논문에서는 신뢰성기반 유지보수(RCM)를 운영자 입장에서 적용했던 기존 시각에서 벗어나, 승객 입장에서 중요장치인 승객서비스 장치를 분석대상으로 선정하였다. 서울도시철도공사의 데이터를 기초로 승객서비스 장치에 대한 고장분석 및 FMEA/FMECA수행, 심각-발생도 매트릭스 및 위험우선순위평가 결과를 기반으로 통합 설정기를 분석대상으로 선정하였으며, 와이블분포를 통해 고장패턴, 고장률 등 고장해석을 수행하였다. 이를 바탕으로 승객서비스 장치의 고장 최소화 방안을 제시하였다.

• Journal of Animal Science and Technology
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• 제60권1호
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• pp.30.1-30.10
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• 2018

Background: The poultry industry suffers losses from problems as pale, soft and exudative (PSE), and dark, firm and dry (DFD) meat can develop in meat as a result of short- and long-term stress, respectively. These abnormalities are impacted by pre-slaughter animal welfare. Methods: This work evaluated the effects of open vehicle container microclimate, throughout the $38{\pm}10km$ journey from the farm to the slaughterhouse, on commercially turkey transported during the Brazilian winter season. The journey was initiated immediately after water bath in truck fitted with portable Kestrel anemometers to measure air ventilation, relative humidity, temperature and ventilation. Results: The inferior compartments of the middle and rear truck regions showed highest temperature and relative humidity, and lower air ventilation. In addition, the superior compartments of the front truck regions presented lower temperature and wind chill, and highest air ventilation. The breast meat samples from animals located at the inferior compartments of the middle and rear truck regions and subjected to with water bath (WiB) treatment presented highest DFD-like and had lowest PSE-like meat incidence than those from animals located at other compartments within the container. Lower incidence of PSE-like meat was observed in birds without water bath (WoB). Conclusions: Assessment on turkeys transported under Brazilian southern winter conditions revealed that breast meat quality can be affected by relative humidity, air ventilation, temperature, and transport under subtropical conditions promoting color abnormalities and the formation of simultaneously PSE-like and DFD-like meat.

• Journal of Animal Science and Technology
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• 제45권5호
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• pp.835-840
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• 2003

NPPC 육색기준에 의한 PSE육과 정상육의 pH$_1$ 및 pH$_{u}$ 특성은 기준 전구간에서 유의한 차이가(p〈0.05)가 있었으며 중증 PSE, 경증 PSE, 정상육 및 경증 DFD 순으로 낮게 나타났으나, pH$_3$와 pH$_6$는 중증 PSE에서 정상육의 구간에서는 유의한 차이가 없었고 경중 DFD에서만 유의차(p〈0.05)가 있었다. 따라서 NPPC 육색기준에 의한 pH특성은 pH 측정시간에 따라 달라지는 것으로 사료되었다. CIE L$^{*}$은 중증 PSE에서 경증 DFD로 변화함에 따라 낮아지는 경향을 나타내었으며 측정부위에 관계없이 NPPC기준 전구간에서 유의차(p〈0.05)가 있었다. CIE a$^{*}$값은 제4~5늑골 직상부의 LD 근육절단면에서는 중증, 경증 PSE, 정상육과 경증 DFD간에는 유의한 차이(p<0.05)가 있으나 마지막 요추부위 절단면에서는 전구간에서 차이가 없었다. CIE b$^{*}$값은 제4~5늑골 직상부에서는 중증, 경증 PSE, 정상육과 경증 DFD 간에 유의한(p〈0.05) 결과를 나타내었다. 마지막 요추에서는 중증 PSE와 정상육 및 경증 DFD에서 유의차(p〈0.05)가 있어 측정위치에 따라 색차값의 특징이 달랐다. 보수성 및 가열감량은 NPPC 기준 전 구간에서 유의차(p〈0.05)가 있었다. 관능특성 중 다즙성은 중.경증 PSE와 정상육, 경증 DFD에서 유의한(p〈0.05) 차이가 있었고 연도와 향미에서는 차이가 없었다. NPPC 육색기준과 CIE L$^{*}$, 보수성, Cu 및 pH$^{u}$와의 단순회귀 상관계수(R$^2$)는 각각 0.77, 0.66, 0.59 및 0.54였다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (B)
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• pp.547-552
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• 2008

여러 분야를 고려해야 하는 항공기나 자동차와 같은 대형기기의 설계에서 순차적 설계는 효과에 비하여 시간과 비용이 비효율적이며, 이러한 비효율성을 해결하기 위해 다분야 최적설계(MDO) 기법이 필요 하게 되었다. 비행체 설계는 시간이 지날수록 그 중요성이 커지고 있고, 설계 시 설계 전 분야를 통합하며 분석 할 수 있는 통합 환경이 요구되고 있다. MDO 기법을 이용한 비행체 설계는 이기종 분산 컴퓨팅 능력을 제공해야하고 각 분야의 데이터 공유를 통한 효율적 관리 및, 설계 최적화 도출을 제공하며 이기종의 환경을 고려해야 하므로, 분산 컴퓨팅 기술을 요구한다. 그리드 환경은 그리드 미들웨어를 중심으로 많은 분산 컴퓨팅 자원을 효율적으로 활용하고 다양한 분야의 문제들을 풀기 위한 고성능 환경을 제공하는 기술이다. 본 논문에서는 각 설계자원을 통합하기 위해 Globus toolkit ver.4(GT4)를 그리드 미들웨어로 사용하였고, 이들을 쉽고 효율적으로 이용하기 위한 PSE포탈을 제시한다.