• BMB Reports
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• 제48권10호
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• pp.539-540
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• 2015

It has been proposed that the selective elimination of cancer stem cells (CSCs) using targeted therapy could greatly reduce tumor growth, recurrence, and metastasis. To develop effective therapeutic targets for CSC elimination, we aimed to define the properties of CSC mitochondria, and identify CSC-mitochondria-specific targets in colon cancer. We found that colon CSCs utilize mitochondrial oxidative phosphorylation (OXPHOS) to produce ATP. We also found that forkhead box protein 1 (FOXM1)-induced peroxiredoxin 3 (PRDX3) maintains the mitochondrial function, and the FOXM1/PRDX3 mitochondrial pathway maintains survival of colon CSCs. Furthermore, FOXM1 induces CD133 (PROM1/prominin 1) expression, which maintains the stemness of colon CSCs. Together, our findings indicate that FOXM1, PRDX3, and CD133 are potential therapeutic targets for the elimination of CSCs in colon cancer.

• 대한족부족관절학회지
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• 제21권1호
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• pp.33-38
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• 2017

Purpose: The patient-reported outcome measure (PROM) is used to quantify the subjective state of patients before and after the treatment. The electronic method was recently developed and used for the completion of PROM, in addition to the conventional paper and pencil method. This study identified whether the results of Foot Function Index (FFI) and Foot and Ankle Outcome Score (FAOS) using the paper and pencil method was different from those using the electronic method. Materials and Methods: Between May 2016 and August 2016, 42 patients who were admitted to the Seoul Foot and Ankle Center two days before surgery were included for evaluation. The mean age was 46 years (range, 21~72 years). There were 29 males and 13 females. To use the electronic method, the PADAS software (PADAS, Seoul, Korea) was implemented using a touch pad. The primary trial of FFI and FAOS was performed using either the paper-and-pencil method or the electronic method. At 24 hours after the primary test, a secondary trial of FFI and FAOS was performed using the other method. Then, we identified the reliability of FFI and FAOS between the two methods by calculating the intraclass coefficient. Results: Twenty-two patients underwent the first trial using the paper-and-pencil method, and 20 patients underwent the first trial using the electronic method. Of the 42 patients, 8 patients were excluded from this study and only 34 patients were included in this study. The reliability of FFI was excellent with an intraclass coefficient of 0.957, and the reliability of FAOS was also excellent with an intraclass coefficient of 0.840. Conclusion: The paper-and-pencil method and the electronic method have the same result for the completion of FFI and FAOS in this study. Therefore, it is commonly considered that the completion of FFI and FAOS using the electronic method can be applied in practice.

• Clinical and Experimental Pediatrics
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• 제45권7호
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• pp.855-861
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• 2002

목 적: 흉선의 크기는 여러 가지 요인과 관련되어 있으며, 이를 통해 주산기 환아의 상태를 짐작할 수 있다. 이에 저자들은 흉부 방사선 사진의 심흉선/흉곽 비율을 통해 흉선의 크기를 간접적으로 측정하고, 이를 통한 흉선의 크기와 호흡곤란증후군과 자궁내 발육지연과 같은 주산기 사건(perinatal event)과의 관계를 알아보고자 하였다. 방 법 : 2000년 6월부터 2001년 10월까지 1년 5개월간 대구가톨릭대학교병원 신생아 집중치료실에 입원한 호흡곤란증후군 환아 51명, 감염 등 다른 질환이 동반되지 않았던 자궁내 발육지연 환아 27명 및 대조군으로 패혈증 소견이 없었던 조기양막파수 환아 48명을 대상으로 하였다. 흉선의 크기는 생후 6시간 이내 촬영한 흉부 방사선 사진에서 심흉선/흉곽 비율로 측정하였으며, 호흡곤란증후군 환아는 생후 2-3일째, 생후 5-7일째에도 심흉선/흉곽 비율을 측정하였다. 결 과 : 1) 호흡곤란증후군군, 자궁내 발육지연군, 조기양막 파수군의 심흉선/흉곽 비율이 각각 $0.46{\pm}0.07$, $0.32{\pm}0.04$. $0.36{\pm}0.06$으로 세군 간의 심흉선/흉곽 비율 차이는 통계적으로 유의성이 있었다(P<0.01). 2) 호흡곤란증후군군에서 생후 6시간 이내, 생후 2-3일째, 생후 5-7일째의 심흉선/흉곽 비율이 각각 $0.43{\pm}0.07$, $0.34{\pm}0.06$, $0.25{\pm}0.04$으로 호흡곤란 소견이 호전됨에 따라 심흉선/흉곽 비율의 감소가 통계적으로 유의성이 있었다(P<0.01). 3) 출생시 재태연령에 따른 세 군 간의 회귀분석 상에서 심흉선/흉곽 비율의 차이는 통계적으로 유의성이 없었다(P>0.05). 4) 출생시 전체 환아의 재태연령과 심흉선/흉곽 비율간의 상관분석은 통계적으로 유의성이 있었다(P<0.01). 5) 출생시 정상질식분만과 제왕절개분만 방법에 따른 호흡곤란증후군군, 자궁내 발육지연군, 조기양막파수군 및 전체에서의 심흉선/흉곽 비율의 차이는 통계적으로 유의성이 없었다(P>0.05). 6) 출생 전 dexamethasone을 사용한 군(n=33)과 사용하지 않은 군(n=17) 간의 심흉선/흉곽비율의 차이는 통계적으로 유의성이 없었다(P>0.05). 결 론: 흉부 방사선 사진에서 흉선의 크기를 평가하여 주산기 질환 중 신생아 호흡곤란증군, 자궁내 발육지연과 같은 주산기 질환들의 진행 여부 및 변화를 예측하고 조기 진단에 이용 가능하리라 생각된다.

• Journal of Yeungnam Medical Science
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• 제4권2호
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• pp.97-103
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• 1987

1983년 5월부터 1987년 2월까지 만 3년 8개월 간 본원에서 출생한 신생아 3,803명중 저출생체중아 186명에 대한 관찰 결과 다음과 같은 결론을 얻었다. (1) 출생빈도는 4.9%였고 성별출생빈도는 남녀비 1.02:1이었다. (2) 산모의 연령이 19세이하, 30~39세에서 25~29세에 비해 발생율이 높았다. (3) 초산모와 경산모에서는 113:73으로 차이는 없었다. (4) 산과적 합병증은 multiple pregnancy가 가장 많았고 그 다음 임신중독증, PROM순으로 많았다. (5) 출생후 볼 수 있었던 문제점으로는 Jaundice, RDS, asphyxia 및 metabolic derangement가 많았다.

• 사상체질의학회지
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• 제35권4호
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• pp.23-41
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• 2023

Objectives This study is aimed to develop criteria for assessing the health level of cancer survivors through patient reported outcome based on sasang constitutional symtomology. Methods As a result of the researchers' meetings and the first round of expert group consultation, the constitutional health level assessment items that would be common to all Sasang constitutions were extracted, and constitutional health level assessment items for cancer survivors were selected. A second round of expert group consultation was conducted to determine the importance and weighting of these items for each constitution. Results & Conclusions For soeumin, the importance ranking and calculated weight were as follows: 'I had sweats even when I was not hot or exercising.(1st, 4.09)', 'I had night sweats while sleeping(2nd, 3.94)', 'I lost weight.(3rd, 3. 75)', etc. For soyangin, as follows: 'I had night sweats while sleeping.(1st, 3.08)', 'I had vomiting.(2nd, 3.02)', 'I felt hot flashes in the afternoon or at night. (3rd, 2.73)', etc. For taeumin, as follows: 'I was out of breath.(1st, 3.48)', 'My heart was pounding for no reason.(2nd, 3.45)', 'My body was swollen.(3rd, 3.22)', etc. For taeyangins, as follows: 'I couldn't urinate well.(1st, 4.49)', 'I vomited(2nd, 4.44).', 'My upper abdomen were hard.(3rd, 3. 14)', etc. Based on the results, we developed a draft of a questionnaire to assess the Sasang constitutional health level of cancer survivors, weighted for each item.

• 대한의생명과학회지
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• 제23권3호
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• pp.238-250
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• 2017

Patient's primary tumor-derived tumor cell lines likely represent ideal tools for human tumor biology in vitro and in vivo. Here, we describe eight human gastric carcinoma cell lines derived from established tumors in vivo upon subcutaneous transplantation of primary gastric carcinoma specimens in BALB/c nude mice. These xenografted gastric tumor cell lines (GTX) displayed close similarity with primary gastric tumor tissues in their in vivo growth pattern and genomic alterations. GTX-085 cells were resistant to cisplatin, while GTX-087 was the most sensitive cell line. GTX-085 was the only cell line showing a metastatic potential. Epithelial cell adhesion molecule (EPCAM) expression was especially strong in all tissue samples, as well as in cell cultures. GTX-139, the largest tumor graft obtained after injection, displayed distinct expression of CD44v6, fibroblast growth factor receptor 2 (FGFR2), and prominin 1 (PROM1, also known as CD133). In summary, we established eight xenograft gastric cancer cell lines from gastric cancer patient tissues, with their histological and molecular features consistent with those of the primary tumors. The established GTX cell lines will enable future studies of their responses to various treatments for gastric cancer.

• Parasites, Hosts and Diseases
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• 제32권2호
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• pp.117-120
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• 1994

광절열두조충(DiphvIobothrium latum)의 parvum형 [syn. DiphvLlobothrium pnnlum (Stephens, 1908)]에 의한 희귀한 인체 감염 2례를 발견하여 보고하고자 한다. 첫 환자는 46세 된 가정주부로서 대변검사에서 의엽조충류의 충란이 발견되어 프라지콴텔과 하제를 투 여하여 치료한 결과 두절이 있는 길이 120 cm인 열두조충의 완전한 충체 1마리를 회수하였 다. 환자는 충주호 부근의 횟집에서 송어회를 먹은 적이 있다고 하였다. 또 한 명의 환자는 평소 각종 생선회를 즐겨 먹는 22세 남자 의과대학생으로, 대변에서 길이 15 cm 정도의 조 충류 편절이 자연 배출되어 동정을 의뢰해 왔다 자세한 형태학적 검토 결과 충체들은 D. parvum으로 과거 문헌에 기록된 충체와 동일하였으나 D. parvum의 분류학적 위치가 정립되어 있지 않으며, 충체. 충란 및 각 기관의 크기가 광절열두조충보다 작다는 점 이외에 별다른 차이점을 인정할 수 없었다. 따라서 본 충체들을 광절열두조충의 소형(parvum형)으로 동정하였고. 이 유형에 의한 국내 최초의 감염 증례들로 보고하는 바이다.

• 혜화의학회지
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• 제29권2호
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• pp.38-44
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• 2020

Objective : The aim of this study was to report the effectiveness of Korean medicine on a Intracerebral hemorrhage patient with shoulder subluxation induced shoulder pain. Method : The patient was treated with acupuncture, electroacupunture, soyeom pharmacopuncture, electrical stimulation therapy, and rehabilitation exercise. The treatment effect was evaluated through the Numeral Rating Scale(NRS), Passive Range Of Motion(PROM) and Fingerbreadth Palpation Method(FPM). Results : After 31days of Korean Medicine including acupuncture, electroacupunture, soyeom pharmacopuncture, electrical stimulation therapy, and rehabilitation exercise treatment, the pain parameters and range of motions improved. Conclusion : This study suggested that Korean medicine might be effective for shoulder pain and range of motions in patients with intracerebral hemorrhage.

• 항공우주기술
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• 제7권1호
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• pp.83-90
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• 2008

차세대 저궤도 위성의 탑재소프트웨어 저장메모리는 부트 코드와 모니터 소프트웨어를 내장한 부트 롬과 비행소프트웨어 이미지를 저장한 듀얼 NVMEM 형태로 개발되고 있다. 부트 롬에 내재된 부트 로더는 프로세서 초기화 이후 GPIO의 입력에 따라 비행소프트웨어 모드 혹은 모니터 모드로 천이하게 된다. 비행소프트웨어 모드에서는 듀얼 NVMEM중 선택된 NVMEM에 대한 CRC를 체크하여 정상적일 경우 NVMEM에 저장되어 있는 탑재소프트웨어를 코드가 수행 될 RAM으로 적재 한 후 VxWorks RTO5를 구동하여 테스크를 생성하여 탑재소프트를 수행하게 된다. 모니터 모드에서는 지상에서 NVMEM reprogramming을 가장 메인으로 수행하며 기본적인 보드 레벨 테스트를 수행할 수 있다. 본 논문에서는 차세대 저궤도 위성의 부트 롬 소프트웨어 설계 및 시뮬레이터 기반의 검증 방법에 대하여 기술한다.

• 아시안잔디학회지
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• 제1권1호
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• pp.56-68
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• 1987

During the regrowth the process after mowing, NRA in the leaf was the highest activity from the 5th day to the 7th day. Before mowing, the NRA in the root was not almost detected. But, the NRA in root appeared a rapid increasing activity from the 3rd day to the 4th day after mowing ( Figs.27 ~ 32). During the regrowth process after mowing, a general tendency of AA in the aboveground parts appeared an increasing tendency from the 1st day to the 4th day, a rapid increasing tendency from the 7th day to the 8th day reaching its peak, and a decreasing rate on the 8th and 9th day reaching its peak, and a decreasing rate on the 8th and 9th day. But the AA in the root appeared rapid increasing rate from the 2nd day to the 7th day, the heginning of reagrowth, this tendency showed a similar figure in the case of Total Soluble Carbohydrate ( TSC) in the internode. Both AA and NRA were appeared recovery stage frorn the 8th day after mowing(Figs.15~20). During the regrowth process after mowing, changes of the maximum plant lengths were 18.27cm in the 6cm mowing plot on the 24th day after mowing, 18.83cm in the 3cm mowing plot on the 18th day after mowing, and 18.16cm in the 6cm mowing plot on the 14th day after mowing ( Fig.2). During the regrowth process after mowing. changes in Dry Matter (DM) contents in leaf and stem were a slow decreasing tendency from the 1st day to the 4th day. From the 5th day to the 8th day it appeared a rapid increasing tendency. And afterward until the 15th day. All treatments were reached at a steady state ( Figs.3 ~ 8). During the regrowth process after mowing, changes in the TSC contents of stem and crown were a slow decreasing tendency from the 1st day to the 5-6th day. Prom the 7th to the 8th day three was a rapid increasing tendency. And afterward until the 15th day there was a decreasing rate at a steadyv state. In root there was a similar tendency to that of leaf and stem organs. A general tendency in internode, the TSC content appeared a similar figure to increment of AA (Figs. 9 - 14). During the regrowth process after mowing, changes in te Crude Proem (CP) content of ahoveground parts appeared a slow increasing tendency from the 1st day to the 5-6th day, where it is peak. And afterward to the 15th day there was a decreasing rate at a steady state. But, in toot there were a contrary tendency to that of aboveground