• Journal of Life Science
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• v.20 no.5
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• pp.723-728
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• 2010

The effect of abdominal respiration on electrocardiogram readings was examined using a 12-lead ECG in healthy young adults. Ten males and ten females without any cardiac and/or pulmonary problems participated in this study. ECG readings during periods of abdominal respiration and thoracic respiration were compared using a paired t-test. Results showed that the PR interval was longer in males compared to females during the period of abdominal respiration (p<0.05). There were no differences in amplitudes of the P, R, T waves, QTc, and degree of P axis between abdominal respiration and thoracic respiration in both male and female subjects. However, degrees of QRS axis in male subjects (p<0.05) and T axis (p<0.05) in female subjects were increased during the abdominal respiration. Therefore, abdominal respiration may cause positive electrical axis changes in the depolarization and relaxing re-polarization of the ventricles.

• Journal of the Korean Geotechnical Society
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• v.39 no.3
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• pp.5-16
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• 2023

The effect of raft flexibility on piled raft foundations in sandy soil was investigated using a numerical analysis and an analytical study. The investigation's emphasis was the load sharing between piles and raft following the raft rigidity (K_R), end-bearing conditions. The case of individual piles and subsequently the response of groups of piles was analyzed using a 3D FEM. This study shows that the α_pr, load-sharing ratio of piled raft foundations, decreases as the vertical loading increases and as the K_R decreases. This tendency is more obvious when using friction piles compared to using end-bearing piles. The effect of raft rigidity is found to be more significant for the axial force distribution - each pile within the foundations has almost similar axial forces of the pile head with a flexible raft; however, each pile has different values with rigid rafts, especially with the end-bearing piles. The axial force of the pile base with floating piles shows similar point-bearing resistance for all the piles; however, it shows different values with end-bearing piles. The differential settlement ratio of rafts showed a larger value with lower K_R.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.272-281
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• 2023

It has been known that Paeoniae Radix (PR) contains monoterpene glycosides showing a variety of biological activities such as anti-spasmodic, anti-inflammatory, anti-viral, neuroprotective, and sedative effects. This study aimed to find the cytotoxic compounds isolated from the dichloromethane (CH₂Cl₂)- and ethyl acetate-soluble fractions of PR. As results, thirteen compounds (1-13) were isolated and the chemical structures were identified. In addition, the human alveolar adenocarcinoma cell line (A549) was treated with isolated compounds to determine the cytotoxic effect via evaluation of cell viability. The reduction of A549 cell viability was shown as following order; gallic acid (8) > (2S)-naringenin (9) > methyl gallate (10)>6'-O-benzoylpaeoniflorin (7) > palmitic acid (3). Especially, 7 did not show the cytotoxicity in the human lung fibroblast cell line (MRC-5). The effect of 7 on the cell viabilities in A549 and MRC-5 is firstly reported in this study. Further study is required to find out the cytotoxic mechanism and the selectivity for the cancer cells of 7 in detail.

• Development and Reproduction
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• v.10 no.2
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• pp.147-154
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• 2006

Phthalates such as di(2-ethyl hexyl)phthalate(DEHP) are industrial chemicals with wide-ranging human exposures because of their use in plastics and other common consumer products. Consequently, their adverse effects as endocrine disruptor in the reproductive physiology of both laboratory rodents and human have been studied extensively. The present study was undertaken to examine whether prepubertal exposure to DEHP affects on the onset of puberty and the associated reproductive parameters such as hormone receptor expressions in female rats. DEHP(100mg/kg/day) was administered daily from postnatal day 25(PND 25) through the day when the first vaginal opening(VO) was observed, and the animals were sacrificed on the next day. Gross anatomy and weight of reproductive tissues were compared to test the DEHP's effects on the cell proliferation. Furthermore, histological studies were performed to assess the structural alterations in the tissues. Specific radioimmunoassay was carried out to measure serum LH levels. To determine the transcriptional changes in progesterone receptor(PR), total RNAs were extracted and applied to the semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). As a result, delayed VO was shown in the DEHP group(PND $37.3{\pm}0.7$) compared to the control group(PND $35.3{\pm}0.7$; p<0.05). DEHP treatment significantly decreased the wet weight of ovaries and uteri compared to the control group(p<0.05). Interestingly, elevation of serum LH levels was shown in the DEHP group(p<0.05). Graafian follicles and corpora lutea were observed only in the ovaries from the control animals. Numerous primary, secondary follicles and small atretic follicles were observed in the ovaries from DEHP-treated animals. Similarly, hypotrophy of luminal and glandular uterine epithelium was found in the DEHP-treated group. These effects were probably due to the inhibitory effects of DEHP on the synthesis and secretion of estrogen from granulosa cells. In the semiquantitative RT-PCR studies, the transcriptional activities of PR in both ovary(p<0.05) and uterus(p<0.01) from DEHP-treated animals were significantly lower than those from the control animals. The present studies demonstrated that the acute exposure to DEHP during the critical period of prepubertal stage could inactivate the reproductive system resulting delayed puberty in female rats.

• Korean Journal of Weed Science
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• v.3 no.2
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• pp.208-222
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• 1983

To control ideally the weeds in orchards and systematize the utility of herbicides, the mixing effect of oxyfluorfen and paraquat was evaluated. Combinations of oxyfluorfen with paraquat were increased the control efficacies at any treatment without giving damage to fruit trees and appeared a synergism. The control effects were reduced from 80-90% to 40-60% as the time advanced. However, the relative synergistic index was higher at 60 days after treatment in preemergence treatment and at 90 days after treatment in early and late postemergence treatment, respectively. Also the index was relatively higher at lower dosage of both herbicides.

• Development and Reproduction
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• v.11 no.3
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• pp.245-251
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• 2007

Vinclozolin(VCZ), a systemic dicarboximide fungicide, has been used in the control of diseases caused by microorganism of some species in fruits, vegatables and ornamental plants. Although VCZ itself is a very weak antagonist for androgen receptor binding, both melabolites M1 and M2 are effective antagonists. The present study was undertaken to examine whether prepubertal exposure to VCZ affects on the onset of puberty and the associated reproductive parameters such as hormone receptor expressions in female rats. VCZ(10 mg/kg/day) was administered daily from postnatal day 21(PND 21) through the day when the first vaginal opening(V.O.) was observed. Gross anatomy and weight of reproductive tissues were compared to test the VCZ's effects on the cell proliferation. Furthermore, histological studies were performed to assess the structural alterations in the tissues. To determine the transcriptional changes in progesterone receptor(PR), total RNAs were extracted and applied to the semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). As a result, delayed V.O. was shown in the VCZ group(PND $34.00{\pm}1.22$) compared to the control group(PND $38.20{\pm}1.92$; p<0.01). VCZ treatment significantly decreased the wet weight of ovaries and uteri compared to the control group(p<0.01). Graafian follicles and corpora lutea were observed only in the ovaries from the control animals, while numerous primary, secondary follicles and small atretic follicles were observed in the ovaries from VCZ group. Similarly, hypotrophy of luminal and glandular uterine epithelium was found in the VCZ group. In the semi-quantitative RT-PCR studies, the transcriptional activity of PR in ovary(p<0.01) from VCZ group were significantly lower than those from the control group while in uterus were similar compared with the control group. The present studies demonstrated that the acute exposure to VCZ during the critical period of prepubertal stage could inactivate the reproductive system resulting delayed puberty in female rats.

• Journal of Veterinary Clinics
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• v.20 no.1
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• pp.1-6
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• 2003

Immunoenhancing effects of conjugated linoleic acid (CLA) isomers (l0t-l2c CLA, 9c-11t CLA, CLA mixture, 9c-11c CLA and 9t-11t CLA) on chemotactic activity of porcine peripheral blood polymorphonuclear cells (PMN) were examined. The chemotactic activity of PMN was evaluated by a modified Boyden chamber assay. CLA isomers at higher concentration of 50 to 200$\mu$M exhibited a low viability of cells by trypan blue exclusion. CLA isomers were used at concentration of 20uM showing no cytotoxic effect and high cell viability. CLA isomers themselves were not active or slight chemotactic for PMN. But culture supernatant from mononuclear cells (MNC) treated with 10t-12c CLA, 9c-11t CLA and CLA mixture except for 9c-11c. CLA and 9t-11t CLA enhanced remarkably chemotactic activity or porcine PMN PMN migration by culture supernatant from MNC treated with CLA mixture was found to be true chemotaxis by checkboard assay. This migration was also induced by porcine recombinant interleukin (rIL)-8. PMN chemotaxis caused both culture supernatant from MNC treated with CLA mixture and porcine rIL-8 was inhibited in a dose-dependent manner by addition of anti-porcine IL-8 polyclonal antibody. Therefore, these results strongly suggested that CLA (10t-12c CLA, 9c-11t CLA and CLA mixture) could stimulate porcine MNC to release and IL-8 like chemotactic activity.

• Women's Health Nursing
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• v.9 no.3
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• pp.224-234
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• 2003

Purpose: This study was to test the effects of a full body massage on labor pain and delivery stress reaction for primipara during labor. Method: This study employed a quasi- experimental method(nonequivalent control group, pre-post test design). The subjects of this study were 57 primipara hospitalized at the U OB & GYN hospital in Inchon from November 1. 2001 to July 31, 2002. 28 women were assigned to the experimental group and 29 to the control group. The experimental group was given 20 minutes full body massage for each of three delivery phases. The control group was given conventional delivery care. The levels of labor pain were measured by the Visual Analogue Scale and the expression scores of the labor pain and the levels of delivery stress reaction were measured by pulse rate, respiration rate, and blood pressure, and State-Anxiety Scale. Data were analyzed using the repeated measures analysis of covariance(ANCOVA), t-test, $X^2$- test, simple ANCOVA with SPSS program. Result: There was no interaction effect between time and group(F=.370, p=.693), but significant time effects were found for subjective labor pain(F=3.840, p=.028). There was no interaction effect between time and group(F=.112, p=.894), but significant group effects were found for objective labor pain(F=12.299, p=.001). There was no interaction effect between time and group for PR(F=.172, p=.843), RR(F=.626, p=.539), SBP(F=.089, p=.915), DBP(F=.748, p=.479), but significant group effects were found for SBP(F=7.547, p=.008). The level of status anxiety of the experimental group was significantly lower than the control group(F=11.787, p=.001). Conclusion: This study showed that the full body massage has partially positive effect on labor pain and delivery stress reaction. Therefore this study suggested that the full body massage might be used clinically to help primipara during labor.

• Culinary science and hospitality research
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• v.22 no.4
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• pp.277-287
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• 2016

This research was conducted over four weeks from April 1, 2016 until April 30. Data collection was of responses from customers who a self-targeting customers who have visited more than 10 eating out establishments in downtown Seoul. First, a regression analysis was conducted to analyze the effect of activity of the food service industry marketing communications on customer satisfaction. First, advertising, B=0.107 (p<.001), convenient, B=0.093 (p<.05), social B=0.294 (p<.01), PR B=0.334 (p<.001), sales promotion B=0.542 (p<.001), personnel sales each had a significant positive influence (+) on customer satisfaction B=0.111 (p<.01). Secondly, menu selection catering property between marketing communications and customer satisfaction analysis of the impact of human Sales were significantly positive (+) Publicity Department had the effect of (-). In addition, advertising and sales promotion did not have any moderating effect.

• Electrical & Electronic Materials
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• v.10 no.5
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• pp.467-472
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• 1997

In this study, we investigated the thickness dependence of thermal bleaching(TB) effect as well as photo-induced scalar phenomena, such as photodrakening(PD) effect and photorefraction(PR) change, in chalcogenide A $s_{40}$ G $e_{10}$S $e_{15}$ $S_{35}$ thin films. We found that when these films were exposed for 15 minutes using blue-pass filtered Hg lamp(~4300$\AA$) after annealing for 30 minutes around the glass transition temperature Tg(20$0^{\circ}C$), the refractive index change ($\Delta$n) was varied up to 0.02~0.46 according to each thickness condition and the optical energy gap ($\Delta$ $E_{op}$ ) was shifted to a longer wavelength of approximately 0.67eV, especially for 1000$\AA$-thickness. Also, the TB PD effects have been understood by the results related to optical absorption characteristics. The TB effect could be estimated as increasing the stabilization of amorphous chalcogenide films since absorption slope of extended regions(U) was not changed by annealing. On the other hand, the PD effect could be understood as due to the enhancement of disorder since U and the slope of Urbachs tail(1/F) around an absorption edge were decreased by exposing.ing.n edge were decreased by exposing.