• The Journal of the Acoustical Society of Korea
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• v.38 no.5
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• pp.485-493
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• 2019

The parametric array phenomenon refers to the generation of a high directivity low frequency wave from a small size radiation plate using the nonlinearity of the medium. In order to improve the usability of parametric array, the beam steering method of low frequency wave is researched, and the beam steering phenomenon is predicted easily using the PD (product directivity) model. However, the PD model can only be applied to Gaussian sources under quasi-linear conditions. Also, the prediction accuracy of low frequency wave beam width is poor. In this paper, a method for predicting the beam steering characteristics of a parametric array that can overcome the limitation of the PD model is investigated. For this purpose, the numerical analysis algorithm of the KZK (Khokhlov-Zabolotskaya-Kuzentsov) equation widely used for parametric array phenomenon prediction is improved. Thus, the beam steering characteristics are calculated by applying the electrical beam steering condition and comparing experimental results. As a result, the numerical analysis using the modified KZK equation algorithm in this study confirms that the beam steering phenomenon can be predicted even in a parametric array source that does not correspond to the quasi-linear condition.

• Molecules and Cells
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• v.44 no.9
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• pp.658-669
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• 2021

Enhancers have been conventionally perceived as cis-acting elements that provide binding sites for trans-acting factors. However, recent studies have shown that enhancers are transcribed and that these transcripts, called enhancer RNAs (eRNAs), have a regulatory function. Here, we identified putative eRNAs by profiling and determining the overlap between noncoding RNA expression loci and eRNA-associated histone marks such as H3K27ac and H3K4me1 in hepatocellular carcinoma (HCC) cell lines. Of the 132 HCC-derived noncoding RNAs, 74 overlapped with the eRNA loci defined by the FANTOM consortium, and 65 were located in the proximal regions of genes differentially expressed between normal and tumor tissues in TCGA dataset. Interestingly, knockdown of two selected putative eRNAs, THUMPD3-AS1 and LINC01572, led to downregulation of their target mRNAs and to a reduction in the proliferation and migration of HCC cells. Additionally, the expression of these two noncoding RNAs and target mRNAs was elevated in tumor samples in the TCGA dataset, and high expression was associated with poor survival of patients. Collectively, our study suggests that noncoding RNAs such as THUMPD3-AS1 and LINC01572 (i.e., putative eRNAs) can promote the transcription of genes involved in cell proliferation and differentiation and that the dysregulation of these noncoding RNAs can cause cancers such as HCC.

• Journal of Applied Biological Chemistry
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• v.62 no.1
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• pp.7-10
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• 2019

The whole plants of Loranthus tanakae were repeatedly extracted with 80% aqueous MeOH and the concentrate was partitioned into ethyl acetate (EtOAc), n-butyl alcohol (n-BuOH) and $H_2O$ fractions. The repeated silica gel ($SiO_2$), octadecyl $SiO_2$ (ODS), and Sephadex LH-20 column chromatographies for the n-BuOH fraction led to isolation of a cyclofarnesane sesquiterpene glucoside. The chemical structure including stereo structure was determined to be a (1'R,3'S,5'R,8'S,2E,4E)-dihydrophaseic acid $3^{\prime}-O-{\beta}-{\text\tiny{D}}$-glucopyranoside on the basis of spectroscopic analyses. This compound was isolated for the first time from L. tanakae in this study. Compound 1 showed a moderate dose-dependent cytotoxicity against human Caucasian gastric adenocarcinoma cells and human hepatocyte cari-noma cells cell lines at higher than $50{\mu}g/mL$.

• Journal of Popular Narrative
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• v.25 no.3
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• pp.103-141
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• 2019

The purpose of this paper is to examine the logic of choice, transformation, and exclusion in The Song of sword, comparing it with the historical records. This paper explains how a novel is 'produced'. Through this, it searches for the aspects in which The Song of sword changed into 'a narrative revealing the disillusionment of the novel's subject with the world'. In the logic of choice, it explores which time and space were chosen in the novel, and which character was chosen to prepare the content and formal framework of the novel. In the logic of transformation, it is confirmed that the meaning of 'individual' is highlighted in the novel, unlike the historical records, by transforming both the character of the enemy and the meaning of war. In the logic of exclusion, it studies the characteristics of the modern (novel's) subject in the novel by excluding the characteristics of the historical subject that existed in a particular time and space. This paper differs from previous studies in that it examines the way in which a novel is produced by comparing and analyzing The Song of sword based on the historical records. Through these analyses, we can see the unity of various heterogeneous elements, such as the historical reality, the writer's ideology and imagination, and the desire of the contemporary in the form of a novel. Also, by examining the elements of text that can not be sutured into a complete form, we can see the meaning of the novel's text as an unstable system.

• Analytical Science and Technology
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• v.20 no.1
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• pp.25-32
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• 2007

The measurement methods for total nitrogen in wastewater containing a high concentration of nitrogen were evaluated. (1) The UV spectrophotometry, (2) reduction-distillation Kjeldahl, (3) total Kjeldahl nitrogen, and (4) ion chromatography methods were applied. The experimental procedure of the UV spectrophotometric method was simple, but it produced large errors deriving from the dilution of samples and calibration standards. While, the reduction-distillation Kjeldahl method didn't need dilution, but the amount of Devarda's alloy and NaOH lead to large errors up to 50 mg/L. The levels of total nitrogen measured by each method were as follows: reduction-distillation Kjeldahl ($568.6{\pm}38.7mg/L$) > UV spectrophotometry ($527.3{\pm}9.6mg/L$) > total Kjeldahl nitrogen method ($494.7{\pm}21.4mg/L$) > ion chromatography method ($417.9{\pm}7.3mg/L$). Therefore, the reduction-distillation Kjeldahl method is preferred for wastewater with the high concentration of nitrogen. Optimal conditions for each experimental procedure, however, are needed to be confirmed, and the Standard Operation Procedure (SOP) for total nitrogen is required for reliable measurements.

• Korean Journal of Culture and Social Issue
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• v.23 no.2
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• pp.271-293
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• 2017

Despite the benefits of social activity on happiness, humans still spend over one third of their time by themselves-sleeping. The effect of sleep quality on happiness as well as its underlying mechanism are examined in this study. Based on previous findings on the role of sleep in consolidation of memories, it was hypothesized that a good sleep would promote happiness by increasing the likelihood of recalling everyday episodes in a positively biased manner. In Study 1, regardless of one's demographic variables, social variables, and economic status, sleep quality was positively related to life satisfaction. To examine the causal direction of this effect, participants were asked to complete a survey twice with different time intervals. Controlling for baseline variables, sleep quality during previous two weeks (Study 2) or previous day (Study 3) significantly predicted the participants' life satisfaction. Moreover, this relationship was partially mediated by a positive memory bias (Study 3). This study opens interesting questions on a relatively unexamined nonsocial predictor of happiness, sleep quality.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.12 no.1
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• pp.24-31
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• 2007

Global fates of polychlorinated biphenyl(PCB) were investigated with a fugacity based multimedia transport and fate model, Globe-POP(persistent organic pollutant). The accumulation of PCB was directly affected by the emission patterns of PCB into the atmosphere and surface areas of environmental compartments. Partition coefficients and reaction rates also influenced on the accumulation patterns of PCB. The emission patterns of PCB in 10 climate zones were consistent for the past 70 years, while the contribution of PCB in high-latitude zones to the globe has increased by cold condensation. Considering the amounts of emission and accumulation of PCB, the North temperature zone is regarded as an important source and sink of PCB. Meanwhile, in spite of no significant sources, POPs accumulate in Antarctic environments mainly due to extremely low temperature. Finally we suggested that a global water balance accounting for snow/ice should be incorporated into multimedia environmental models for high-latitude zones and polar regions with the seasonal snow pack and/or permanent ice caps. The modified model will be useful to evaluate the influence of climate change on the fate of POPs.

• The Journal of the Acoustical Society of Korea
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• v.43 no.1
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• pp.39-48
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• 2024

A car horn serves a crucial safety role as a means of communication between drivers and a part that alerts pedestrians in advance. While previous studies have utilized finite element method and electric circuit model to simulate and analyze characteristics of the car horns, there remains a lack of research on design methods of a trumpet horn. This paper presents a design approach that predicts the operating frequency based on the acoustic reactance at the throat of the horn, once the vibrating part is determined. We deal with a horn combining both an exponential horn and a waveguide in the acoustic section, and confirm that the acoustic reactance at the horn throat measured by impedance tube experiment agrees well compared with the numerical result obtained using the finite element method. The resonance frequency of the car horn is predicted using the COMSOL Multiphysics finite element numerical analysis model, and the proposed design method is validated by measuring the operating frequency of the designed horn in a sound pressure experiment. As a result, the resonance measured in a semi-anechoic chamber environment by applying a DC voltage of 12 [V] excluding the holder occurs accurately within a few [Hz] of the design operating frequency. This paper discuss the design method of a trumpet horn from the perspective of the horn's acoustic reactance, and is expected to be useful for designing horn systems.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.1
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• pp.101-108
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• 2005

Because the stone cultural properties located outdoors, they have been altered and deteriorated in external appearance due to environmental factors such as acid rain, extreme change in temperature, and salts. Damage to stone cultural properties is accelerated particularly due to recent industrial development and environmental pollution. An experimental study was conducted to evaluate the effect of environmental contaminants on the weathering of granite. And as part of the developing of conservation method, $TiO_2$ catalyst was prepared and tested. When fresh granite was dipped into the salt and acid solutions, dissolution rate of eight minerals (Si, Mg, Ca, Na, K, Fe, Mn, Al) are abruptly increased at initial stage of reaction and then increased steadily until 100 cycles. After salt and acid solution experiments, the mineral compositions of the granite surface were lower then that of the fresh granite and density of the weathered granite was steadily decreased from $2.60\;g/cm^3$ to $2.56\;g/cm^3$, but Poissions ratio and absorption ratio were slightly increased. It was expected at stone cultural assets could be weathered by salts and acid rain. In the case of $TiO_2$ was coated to the granite, the dissolution rate of minerals and absorption ratio of $TiO_2$ coated granite were decreased. Therefore, the $TiO_2$ coating method tested in this study considered to be a viable method to assist in the conservation of stone cultural properties from environmental contaminants.

• The Korean Journal of Blood Transfusion
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• v.23 no.2
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• pp.107-114
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• 2012

Background: Leukocyte reduction filters are widely used to prevent transfusion reactions caused by leukocytes in blood components. Commercial filters are not sufficient for removal of leukocytes for prevention of transfusion associated graft-versus-host disease; therefore, irradiation of blood components was performed using expensive equipment. Techniques using an aptamer substituted for antibody have been developed and are available in clinical areas. The purpose of this study is to develop the aptamer filter system and to evaluate its efficiency and the possibility of its clinical application. Methods: Aptamers targeted to CD45 were selected by the Postech Aptamer Initiative. The aptamer filter in which aptamers attached to beads were bound to leukocytes and removed by magnetic field was developed. Filtration of 14 units of leukoreduction-red blood provided by Korean Red Cross Blood Services was performed using aptamer filters. Leukocyte removal rate and red cell recovery rate were evaluated and bacterial culture was performed. Results: After filtration using the aptamer filters, 45.6% of leukocytes were additionally removed and the red cell recovery rate was 92.8%. No growth in the bacterial culture was observed. Conclusion: In order to apply the cell depletion technique utilizing an aptamer to blood filter system, we developed and evaluated the aptamer filter system. Through improvement of the binding efficiency of the aptamer and the filtering process, and application of the various aptamers for other different cells, we suggest that this technique can be applied in the clinical area, such as a substitution for the irradiation process for TAGVHD prevention.