• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.127-134
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• 2008

Peroral administration is the most convenient one for the administration of pharmaceutically active compounds. Most of poorly water-soluble drugs administered via the oral route, however, remain poorly available due to their precipitation in the gastrointestinal (GI) tract and low permeability through intestinal mucosa. In this study, one of drug delivery carriers, lipid nanoparticles (LNPs) were designed in order to reduce side effects and improve solubility and stability in GI tract of the poorly water soluble drugs. However, plain LNPs are generally unstable in the GI tract and susceptible to the action of acids, bile salts and enzymes. Accordingly, the surface of LNPs was modified with polyethylene glycol (PEG) for the purpose of improving solubility and GI stability of paclitaxel (PTX) in vitro. PEG-modified LNPs containing PTX was prepared by spontaneous emulsification and solvent evaporation (SESE) method and characterized for mean particle diameter, entrapping efficiency, zeta potential value and in vitro GI stability. Mean particle diameter and zeta potential value of PEG-modified LNP containing PTX showed approximately 86.9 nm and -22.9 mV, respectively. PTX entrapping efficiency was about 70.5% determined by UV/VIS spectrophotometer. Futhermore, change of particle diameter of PTX-loaded PEG-LNPs in simulated GI fluids and bile fluid was evaluated as a criteria of GI stability. Particle diameter of PTX-loaded PEG-LNPs were preserved under 200 nm for 6 hrs in simulated GI fluids and bile fluid at $37^{\circ}C$ when DSPE-mPEG2000 was added to formulation of LNPs above 4 mole ratio. As a result, PEG-modified LNPs improved stability of plain LNPs that would aggregate in simulated GI fluids and bile solution. These results indicate that LNPs modified with biocompatible and nontoxic polymer such as PEG might be useful for enhancement of GI stability of poorly water-soluble drugs and they might affect PTX absorption affirmatively in gastrointestinal mucosa.

• Journal of Conservation Science
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• v.7 no.2
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• pp.80-85
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• 1998

The structure, dimensions, condition and other characteristics of the Koryo Buddhist Canon (the Koreana Tripitaka) Printing Wood Blocks stored at the Haein-sa Monastery were surveyed to obtain basic data needed for the conservation of the Wood Blocks. The dimensions of the Wood Blocks Were measured and we could figured out the blueprint designed at the time of the carving the Wood Blocks. The dimensions of the wooden board were as follows: width, 8'chi'('cun' in Chinese, 24 cm);thickness, 1 'chi' (3 cm); length, 2'cha' ('chi' in Chinese) and 3 'chi' (68 cm) or 2 'cha' and 6 'chi' (78 cm). The dimensions of the end pieces were as follows: width, 1 'chi' and 5 'fun' (4.5 cm; thickness, 1 'chi' and 4 'fun' (4 cm); length, 8 'chi' and 2-4 'fun' (24.6-25.2 cm). There were 6 types of metal strips and the length of the nails employed was 1 'chl' (3 cm). Investigation on the differences in the length of the wood Blocks and the shapes of the metal strips will be of interest. Since we surveyed only small portion of the Wood Blocks. the result may be different if entire Wood Blocks were examined. The data acquisition of the entire Wood Blocks will be the basis to the conservation of the Wood Blocks.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.58 no.1
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• pp.8-14
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• 2013

The newly developed fertilizer is the slow-releasing fertilizer which can be used as a basal fertilizer without no additional fertilization at tillering stage. It has 30-4-6% of $N-P_2O_5-K_2O$ and was coated with mixture of LDPE (Low density polyethylene), EVA (Ethylene vinyl acetate), BDP (Bio degraded polymer), TALC and nonionic surfactant for the controlled release up to 50 days after application. Coating materials were designed to be decomposed naturally. This fertilizer can be applied directly to the seedling tray mechanically just before transplanting, resulting in significant labor saving effect. The developed slow-release fertilizer, which can replace both basal fertilization and top dressing at tillering stage by single application directly to seedling tray, showed the highest release at 14~21 days after transplanting. Considering the plant growth at different growth stages and yield, the optimal application rate of developed slow-release fertilizer was 300 g per rice nursery tray and the yield of rice at this application rate was 5.25 MT/ha. Rice quality in terms of head rice grain ratio, amylose content, whiteness, and taste value decreased as fertilization rate increased from 200 g to 500 g per nursery tray. Fertilization rate based on quantity of fertilizer ingredients (N, P, K) was reduced by 49.3% compared to the standard application rate and there was 49.2% reduction in labor input for fertilization.

• Journal of Microbiology and Biotechnology
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• v.27 no.9
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• pp.1566-1575
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• 2017

MicroRNAs (miRNAs) are abundant in bovine milk and milk derived from other livestock, and they have functional roles in infants and in the secretion process of mammary glands. However, few studies have evaluated miRNAs in dairy processes, such as during cheese making and ripening. Thus, we investigated the characteristics of milk-derived miRNAs during the manufacturing and ripening of Camembert cheese as well as the microbiota present using the quantitative reverse transcription polymer chain reaction (RT-qPCR) and 16S rRNA pyrosequencing, respectively. Pyrosequencing showed that the cheese microbiota changed dramatically during cheese processing, including during the pasteurization, starter culture, and ripening stages. Our results indicated that the RNA contents per $200mg/200{\mu}l$ of the sample increased significantly during cheese-making and ripening. The inner cheese fractions had higher RNA contents than the surfaces after 12 and 22 days of ripening in a time-dependent manner (21.9 and 13.2 times higher in the inner and surface fractions than raw milk, respectively). We performed a comparative analysis of the miRNAs in each fraction by RT-qPCR. Large amounts of miRNAs (miR-93, miR-106a, miR-130, miR-155, miR-181a, and miR-223) correlated with immune responses and mammary glands were present in aged cheese, with the exception of miR-223, which was not present on the surface. Considerable amounts of miRNAs were also detected in whey, which is usually disposed of during the cheese-making process. Unexpectedly, there were no significant correlations between immune-related miRNAs and the microbial populations during cheese processing. Taken together, these results show that various functional miRNAs are present in cheese during its manufacture and that they are dramatically increased in amount in ripened Camembert cheese, with differences according to depth.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.1
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• pp.1-7
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• 2008

When historical or cultural buildings need to be repaired or reinforced, the changes of original features should be minimized, and the strengths of structures should be improved. Among the existing methods to reinforce historical wood structures, the carbon fiber reinforcement polymer (CFRP) installation method is one of the best ones to achieve the afore-mentioned requirements. Therefore, this study aims at investigating the reinforcing effects and failure modes of timber beams reinforced with the inserted CFRP, a part of roof trusses in modern wood structures, and at providing the fundamental test data to estimate the CFRP rein-forced timber beam in the application of this reinforcing method. The primary parameters in this study were the layout and amount of CFRP. It was observed that, when $0.3{\sim}0.7%$ of CFRP were installed, the strengths of reinforced timber beams increased up to 173% compared to its original strength, but their strengthening effects were heavily influenced by the characteristics of timber such as burls. In order to improve the applicability of this strengthening method, fundamental understandings on the characteristics of wood would be necessary, and there would be in need of researches on the non-destructive test for wood structures as well.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.84-87
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• 1996

We have been developed electrohydraulic left ventricular assist device and done various in vivo evaluation on the device. Through the in vivo experiment conducted from Jan. 23, 1996 to Feb. 8, we could have experience of long-term evaluation fur the first time. The sheep used in this experiment had survived for 16 days. We used new actuator with reduced size and linear motion guide replacing oil box and ball bearings. Also, we used improved blood chamber with reduced size, reduced weight facilitating fixing the chamber to animal's body, and polymer sac having improved folding pattern. Against suction problem, we used absolute pressure limiter only. Motor current for driving this new actuator was not much higher than older one. Effective stroke volume was about 48 cc. Thrombosis was found around top area and peripheral boundary of the sac and valves. There was no sign of damage from suction problem in the atrium observed at autopsy. Main cause of death was presumed to be progressive formation of thrombosis in the cannulae. In this paper, the results of this experiment are documented.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.6
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• pp.4245-4252
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• 2015

In this study, an experiment which utilized glass fiber reinforced polymer(GFRP) plank as the permanent formwork of cast-in-place high strength concrete structures was performed. The GFRP plank currently being produced has smooth surface so that it causes problems in behavior with concrete. Therefore, this research analyzed the flexure/shear failure behavior of composite beams, which used GFRP plank as its permanent formwork and has short shear span ratio, by setting the sand coated at GFRP bottom surface, the perforation and interval of the GFRP plank web, and the width of the top flange as the experimental variables. As a result of the experiments for effectiveness of sand attachment in case of not perforated web, approximately 47% higher ultimate load value was obtained when the sand was coated than not coated case and bending/shear failure mode was observed. For effectiveness of perforation and interval of gap, approximately 24% higher maximum load value was seen when interval of the perforation gap was short and the fine aggregate was not coated, and approximately 25% lower value was observed when the perforation gap was not dense on the coated specimen. For effectiveness of top flange breadth, the ultimate load value was approximately 17% higher in case of 40mm than 20mm width.

• Journal of the Korean Geosynthetics Society
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• v.16 no.2
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• pp.121-129
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• 2017

There have been a number of water and sewer pipe breakdown reports followed by ground subsidence. Also, the excavating works for construction due to overcrowding of city have been common. Particularly, in urban areas ground becomes unstable because of the lowered lifeline sinkage followed excavation and backfilling. In order to solve the problem, some reinforcement works for ground by rod tamping or grouting have been applied. However, it is hard to predict when the buried utilities in underground will be damaged. Also, there is a limit for the underground exploration and investigation methods. Therefore, in this study, the estimated about the water soluble polymer pouch including poor mixed admixture which is designed to eliminate the dangerous factors. The reinforcement strength of this method was confirmed by verifying three points: meltiness in a certain period, water solubility in the ground water level, and characteristics of the pouch, which can be stored in daily conditions. It is also proved that this method allows to keep the ground from getting weakened in the installation of water and sewer pipe along with back filling materials.

• Macromolecular Research
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• v.17 no.8
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• pp.616-622
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• 2009

In-depth understanding of the influence of hot pressing and melt processing on the properties of thermoplastic polyurethane (TPU) is critical for effective mechanical recycling of TPU scraps. Therefore, this study focused on the effects of hot pressing and melt mixing on molecular weight (MW), polydispersity index (PDI), melt index (MI), characteristic IR peaks, hardness, thermal degradation and mechanical properties of TPU. The original TPU pellet (o-TPU) showed two broad peaks at lower and higher MW regions. However, four TPU film samples, TPU-0 prepared only by hot pressing of o-TPU pellet and TPU-1, TPU-2 and TPU-3 obtained by hot pressing of melt mixed TPUs (where the numbers indicate the run number of melt mixing), exhibited only a single peak at higher MW region. The TPU-0 film sample had the highest $M_n$ and the lowest PDI and hardness. The TPU-1 film sample had the highest $M_w$ and tensile modulus. As the run number of melt mixing increased, the peak-intensity of hydrogen bonded C=O stretching increased, however, the free C=O peak intensity, tensile strength/elongation at break and average MW decreased. All the samples showed two stage degradations. The degradation temperatures of TPU-0 sample (359 $^{\circ}C$ and 394 $^{\circ}C$)were higher than those of o-TPU (342 $^{\circ}C$ and 391 $^{\circ}C$). While all the melt mixed samples degraded at almost the same temperature (365 $^{\circ}C$ and 381 $^{\circ}C$). The first round of hot pressing and melt mixing was found to be the critical condition which led to the significant changes of $M_n$/$M_w$/PDI, MI, mechanical property and thermal degradation of TPU.

• The Journal of Engineering Research
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• v.1 no.1
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• pp.23-30
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• 1997

Energy transfer by free convection arises in many engineering applications, such as a hot steam radiator for heating a room, refrigeration coils, electric transformers, heating elements and electronic equipments. Generally unsteady natural convection flow in a horizontal channel with arbitrary wall temperatures and the mathematical and physical basis of convection transport has been considered in general. A physically meaningful exact solution of the problem has been obtained in a closed form by the application of the standard finite sine transform technique. Influences of the governing parameters, the Prandtl number and the Rayleigh number, to bring the flow and heat transfer to final steady states have been discussed separately. For constant values of the arbitray wall temperatures and of the function, determining the average axial velocity, the final steady state is approached in different times respectively for the cases when the Prandtl number Pr>1 and Pr<1. It is also seen that the function, representing the axial temperature gradient, is influenced by none of the governing parameters : but the steady state flow is influenced only by the Rayleigh number. There are, of course, many applications. Free convection strongly influences heat transfer from pipes and transmission lines, as well as from various electronic devices. It is also relevant to the environmental sciences, where it is responsible for oceanic and atmospheric motions, as well as related heat transfer processes.