• Journal of the Korean Society for information Management
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• v.37 no.2
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• pp.47-69
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• 2020

This research provides a quantitative analysis on research articles published in PLoS ONE, a multidisciplinary open access journal, by authors affiliated with Korean institutions. Korean authors published more than 6,500 research ariticles in the mega journal between 2006 and 2019. Korea is ranked the top 11th place in terms of article publishing in the journal. Most articles by Korean authors are concentrated in the biomedical fields. In recent years, the overall production of PLoS ONE has decreased as authors migrated to competing mega journals such as Scientific Reports and BMJ Open. The change might have been affected in part by the delay in the review period and the dropping impact factor score. The open access share of the Korean PLoS ONE authors of more than 10 articles hovers around 30%. However, there is a significant variation among researchers reaching up to 50% discrepancies. Among altmetrics provided by PLoS ONE, the saves are highly correlated with the views and the citations. On the contrary, the shares show low correlation with other use metrics. A follow up, survey questionnarie based research involving researchers who have published in PLoS ONE is planned in order to investigate author motivation and experience in the review process.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.114-114
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• 2020

Water contamination in a water distribution network (WDN) is harmful since it directly induces the consumer's health problem and suspends water service in a wide area. Actions need to be taken rapidly to countermeasure a contamination event. A contaminant source ident ification (CSI) is an important initial step to mitigate the harmful event. Here, a CSI approach focused on determining the contaminant intrusion possible location and time (PLoT) is introduced. One of the methods to discover the PLoT is an inverse calculation to connect all the paths leading to the report specification of a sensor. A filtering procedure is then applied to narrow down the PLoT using the results from individual sensors. First, we spatially reduce the suspect intrusion points by locating the highly suspicious nodes that have similar intrusion time. Then, we narrow the possible intrusion time by matching the suspicious intrusion time to the reported information. Finally, a likelihood-score is estimated for each suspect. Another important aspect that needs to be considered in CSI is that there are inherent uncertainties, such as the variations in user demand and inaccuracy of sensor data. The uncertainties can lead to overlooking the real intrusion point and time. To reflect the uncertainties in the CSI process, the Monte-Carlo Simulation (MCS) is conducted to explore the ranges of PLoT. By analyzing all the accumulated scores through the random sets, a spread of contaminant intrusion PLoT can then be identified in the network.

• Journal of Information Management
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• v.34 no.2
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• pp.1-23
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• 2003

The serials pricing and licensing crises have caused the problem of limited access to scholarly information and the problem of its preservation. To cope with these crises, various types of scholarly communication models are under study now. Open Access is one of the possible solutions among these new trials. This study has investigated the history of Open Access, articulated the first considerations for the spread of Open Access, and proposed the role of librarians during the progress.

• Biomaterials and Biomechanics in Bioengineering
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• v.1 no.1
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• pp.27-39
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• 2014

We have previously described a new multilayer alginate microcapsule system, and the goals of the present study were to assess the in vitro function of islets encapsulated in its inner layer, and the angiogenic ability of FGF-1 delivered from the external layer in an omentum pouch. Following isolation and culture, islets were encapsulated in the inner core of microspheres ($500-600{\mu}m$ in diameter) with a semi-permeable poly-L-ornithine (PLO) membrane separating two alginate layers, and both unencapsulated and encapsulated islet function was assessed by a dynamic glucose perifusion. For angiogenesis experiments, one group of microcapsules without FGF-1 (control) and another (test) containing FGF-1 with heparin encapsulated in the external layer were made. One hundred microcapsules of each group were transplanted in Lewis rats (n = 5/group) and were retrieved after 14 days for assessment of angiogenesis. Glucose perifusion of unencapsulated and encapsulated islets resulted in similar stimulation indices. The release of FGF-1 resulted in increased vascular density compared to controls. In conclusion, islets encapsulated in the core of multilayer alginate microcapsules maintain functionality and the microcapsule's external layer is effective in delivery of FGF-1 to enhance graft neovascularization in a retrievable omentum pouch.

• Radiation Oncology Journal
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• v.15 no.3
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• pp.197-206
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• 1997

Purpose : Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid (PA) and choline. Recently, PLD has been drawing much attentions and considered to be associated with cancer Process since it is involved in cellular signal transduction. In this experiment, oleate-PLD activities were measured in various tissues of the living rats after whole body irradiation. Materials and Methods : The reaction mixture for the PLD assay contained $0.1\;\muCi\;1,2-di[1-^{14}C]palmitoyl$ phosphatidylcholine 0.5mM phosphatidylcholine, 5mM sodium oleate, $0.2\%$ taurodeoxycholate, 50mM HEPES buffer(pH 6.5), 10mM $CaCl_2$, and 25mM KF. phosphatidic acid, the reaction product, was separated by TLC and its radioactivity was measured with a scintillation counter. The whole body irradiation was given to the female Wistar rats via Cobalt 60 Teletherapy with field size of 10cmx loom and an exposure of 2.7Gy per minute to the total doses of 10Gy and 25Gy. Results : Among the tissues examined, PLD activity in lung was the highest one and was followed by kidney, skeletal muscle, brain, spleen, bone marrow, thymus, and liver. Upon irradiation, alteration of PLD activity was observed in thymus, spleen, lung, and bone marrow. Especially PLD activities of the spleen and thymus revealed the highest sensitivity toward $\gamma-rar$ with more than two times amplification in their activities In contrast, the PLD activity of bone marrow appears to be reduced to nearly $30\%$. Irradiation effect was hardly detected in liver which showed the lowest PLD activity. Conclusion : The PLD activities affected most sensitively by the whole-body irradiation seem to be associated with organs involved in immunity and hematopoiesis. This observation s1ron91y indicates that the PLD is closely related to the physiological function of these organs, Furthermore, radiation stress could offer an important means to explore the phenomena covering from cell Proliferation to cell death on these organs.