• Title/Summary/Keyword: PIDD

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PIDD mediates and stabilizes the interaction between RAIDD and Caspase-2 for the PIDDosome assembly

  • Jang, Tae-Ho;Park, Hyun Ho
    • BMB Reports
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    • v.46 no.9
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    • pp.471-476
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    • 2013
  • The PIDDosome, which is an oligomeric signaling complex composed of PIDD, RAIDD and caspase-2, can induce proximity-based dimerization and activation of caspase-2. In the PIDDosome assembly, the adaptor protein RAIDD interacts with PIDD and caspase-2 via CARD:CARD and DD:DD, respectively. To analyze the PIDDosome assembly, we purified all of the DD superfamily members and performed biochemical analyses. The results revealed that caspase-2 CARD is an insoluble protein that can be solubilized by its binding partner, RAIDD CARD, but not by full-length RAIDD; this indicates that full-length RAIDD in closed states cannot interact with caspase-2 CARD. Moreover, we found that caspase-2 CARD can be solubilized and interact with full-length RAIDD in the presence of PIDD DD, indicating that PIDD DD initially binds to RAIDD, after which caspase-2 can be recruited to RAIDD via a CARD:CARD interaction. Our study will be useful in determining the order of assembly of the PIDDosome.

A Study on the Magnetically Suspended Spindle with 16-pole Radial Magnets (16 극의 반경방향 전자석을 갖는 자기부상 주축계 연구)

  • Park, Jong-Kweon;Ro, Seung-Kook;Kyung, Jin-Ho
    • Journal of the Korean Society for Precision Engineering
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    • v.19 no.2
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    • pp.203-212
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    • 2002
  • Active magnetic hearings allow much high surface speed than conventional ball bearings and therefore greatly suitable for high speed cutting. This paper describes a design and test of an active magnetic bearing system with 16-pole radial magnets. The spindle is originally designed for a CNC lathe and driven by outer motor with 5.5 kW power and maximum speed 10,000 rpm. Considering static load condition and geometric restrictions, radial magnet is designed 16-pole type for smaller outer diameter of the spindle system. Dynamic system characteristics such as natural frequency, critical speed, stiffness, damping and system stabilities are simulated with a rigid rotor model including direct feedback controller. The designed spindle system is realized with digital PIDD controller to compensate phase lag of PWM amplifier and magnet coils. With levitation and step response experiment the control system characteristics are tested, and the spindle is rotated up to 10,000 rpm stab1y.

Digital control of active magnetic bearing using digital signal processor

  • Shimomachi, T.;Ishimatsu, T.;Taguchi, N.;Fukata, S.
    • 제어로봇시스템학회:학술대회논문집
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    • 1989.10a
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    • pp.760-765
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    • 1989
  • Digital control laws are implemented on an active magnetic bearing system with DSP. The results of tests using a experimental apparatus are (1) in a case that conventional PID, PIDD2 controls are employed, implemention of digital control law has similar characteristics to that of analogue control law. (2)The experiments reveal the results that the dynamic compensation based on the observer may be better than that of the other conventional controllers.

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Design and Performance Analysis of PID type Controllers for Automatic Voltage Regulator(AVR) System Based on i-PID, GPI and OCD Methods (AVR(Automatic Voltage Regulator)시스템을 위한 PID형 제어기의 설계 -i-PID, GPI 및 OCD 알고리즘을 중심으로 -)

  • Choe, Yeon-Wook
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.65 no.8
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    • pp.1383-1391
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    • 2016
  • This paper is concerned with applicability of a new type of controllers, called i-PID and GPI in which unknown parts of the plant are taken into account without any modeling procedure, to automatic voltage regulator (AVR) system. First, the procedure for applying i-PID and GPI algorithms to AVR system is proposed, which uses model reduction technique based on the given information of AVR. Second, simulations are given to verify their effectiveness comparing to various PID algorithms including PIDD2 which is four-term controller, that is, consisting of PID and second order derivative terms. Superior response performances of i-PID and GPI in comparison to conventional PID controllers are shown. Moreover, i-PID can highly improve the system robustness with respect to model uncertainties, especially to load variations.

Men, Work, and Mental Health: A Systematic Review of Depression in Male-dominated Industries and Occupations

  • Roche, Ann M.;Pidd, Ken;Fischer, Jane A.;Lee, Nicole;Scarfe, Anje;Kostadinov, Victoria
    • Safety and Health at Work
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    • v.7 no.4
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    • pp.268-283
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    • 2016
  • Among men, depression is often unrecognised and untreated. Men employed in male-dominated industries and occupations may be particularly vulnerable. However, efforts to develop tailored workplace interventions are hampered by lack of prevalence data. A systematic review of studies reporting prevalence rates for depression in male dominated workforce groups was undertaken. Studies were included if they were published between 1990 - June 2012 in English, examined adult workers in male-dominated industries or occupations (> 70% male workforce), and used clinically relevant indicators of depression. Twenty studies met these criteria. Prevalence of depression ranged from 0.0% to 28.0%. Five studies reported significantly lower prevalence rates for mental disorders among male-dominated workforce groups than comparison populations, while six reported significantly higher rates. Eight studies additionally found significantly higher levels of depression in male-dominated groups than comparable national data. Overall, the majority of studies found higher levels of depression among workers in male-dominated workforce groups. There is a need to address the mental health of workers in male-dominated groups. The workplace provides an important but often overlooked setting to develop tailored strategies for vulnerable groups.