• Clinical Endoscopy
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• v.51 no.6
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.

• Korean Journal of Environment and Ecology
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• v.30 no.6
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• pp.1057-1066
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• 2016

This study examined how 'forest name' or 'information of forest healing effectiveness' influence their perceived environmental restorativeness (PER) and perceived healing effectiveness (PHE). Study area was the 'Forest Healing Road (FHR)' in Mudeungsan National Park. Data were collected from 247 visitors selected by convenient sampling method using questionnaire survey during May-June, 2015. Respondents who read interpretive signs (forest name and information on forest healing effectiveness of FHR were written) installed along the FHR were regarded as placebo group and respondents who didn't read them as control group. The results showed that there were no overall differences on PER and PHE between control and placebo groups. Placebo group, however, rated more positive on 'being away' factor of PER than control group. All four factors (i.e., being away, coherence, fascination, comparability) of PER statistically influenced PHE (p<0.001), and these factors explained 51.1% of PHE. The 'coherence' was the most influential to PHE, followed by 'being away', 'comparability', and 'fascination' in order. Placebo effects on PER were shown in male, in lower age group(age${\leq}54$), or respondents with lower visiting experience to FHR(${\leq}20$ times/year). Placebo effects on PHE were found in male, in small group (${\leq}2$ persons), in respondents who visited 'alone' or 'with relatives/family', or in respondents with lower visiting experience to FHR(${\leq}20$ times/year). Some research and managerial implications were suggested.

• Journal of Microbiology and Biotechnology
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• v.11 no.4
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• pp.649-655
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• 2001

The kinetics of the thermolysin-catalyzed synthesis of N-(benzyloxycarbonyl)-L-phenylalanyl-L-leucine ethyl ester (Z-Phe-LeuOEt) from N-(benzyloxycarbonyl)-L-phyenylalanine (Z-Phe) and L-leucine ethyl ester (LeuOEt) in an ethyl acetate saturated aqueous system in a batch operation were studied. The kinetics for the synthesis of Z-Phe-LeuOEt were expressed using a rate equation for the rapid equilibrium random bireactant mechanism. The four kinetic constants involved in the rate equation were determined numerically by the quasi-Newton method so as to fit the calculated results with the experimental data. Within the pH and temperature range examined, the $K_{cat}$ value for the synthesis of Z-Phe-LeuOEt reached a maximum at pH 7.0 and $45^{\circ}C$, whereas the affinity between Z-Phe and thermolysin reached a maximum at pH 6.0 adn $40^{\circ}C$. The inhibitory effect of Z-Phe on the condensation reaction decreased as the pH and temperature decreased. In contrast, they affinity between LeuOEt and thermolysin remained unchanged within the pH and temperature range examined. Therefore, it was concluded that the protonation state of the carboxyl groups. of Z-Phe was more imprtant than that of the amono groups of LeuOEt for the synthesis of Z-Phe-LeuOEt in the present solvent system. The equilibrium yield at pH 6.0 and $30^{\circ}C$ was 8% higher than that at pH 7.0 and $40^{\circ}C$, although the rate was much slower. This result suggested that the affinity between the enzyme and the substrate rather than the overall rate was a more important factor affecting the equilibrium yield, when the peptide synthesis was carried out in a product-precipitation system.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.3
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• pp.29-37
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• 2019

PURPOSE: Prone hip extension (PHE) has been used for assessment of lumbo-pelvic movement and strengthening exercise for weakness of the hip joint muscles in patients with chronic low back pain (CLBP). On the other hand, few studies have examined which are the best PHE exercises to activate the gluteus maximus (GM) selectively in physical therapy practice. To aim of this study compared the muscle activity of the GM, rectus femoris (RF), biceps femoris (BF), tibialis anterior (TA) during these four different prone hip extensions, PHE, PHE with quadriceps activation (PHEQA), PHE with ankle dorsiflexion (PHEAD), and PHE with ankle plantarflexion (PHEAP), in subjects with CLBP. METHODS: Nineteen subjects with low back pain participated in this study. Subject performed four PHE exercises and surface electromyography (EMG) was used to evaluate the muscle activity. Data were analyzed by one-way repeated-measures analysis of variance (${\alpha}=.05/3=.017$) and a Bonferroni adjustment was performed if a significant difference was found. RESULTS: The muscle activities recorded by EMG showed significant among the four exercises. The muscle activity of the GM increased significantly during PHEQA than during PHEAP (P=.012). CONCLUSION: PHEQA is the most effective exercise for eliciting greater GM muscle activation among the four PHE exercises in subjects with CLBP.

• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.347-354
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• 2009

Plate Heat Exchnager(PHE) has recently become widely adopted for cogeneration systems owing to its small installation space and high thermal efficiency. The gap between plates can be changed depending on its assemble type, i.e. gasket or blazing. The gap is known to affect thermal efficiency and working pressure drop in PHE with complicated geometrical features. Numerical simulation techniques have been developed to deal with PHE with complex configuration of chevron plates. The present study is aiming at identifying the gap effect on pressure drop and thermal efficiency of the PHE. The numerical simulation results show that the gap has relatively large effects on working pressure drop than thermal efficiency in performance of PHE.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.8 no.1
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• pp.1-7
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• 2012

A PHE (Process Heat Exchanger) is a key component required to transfer heat energy of $950^{\circ}C$ generated in a VHTR (Very High Temperature Reactor) to the chemical reaction that yields a large quantity of hydrogen. A small-scale PHE prototype made of Hastelloy-X is being tested in a small-scale gas loop at Korea Atomic Energy Research Institute. In order to properly evaluate the high-temperature structural integrity of the small-scale PHE prototype, it is very important to impose a proper constraint condition on its structural analysis model. For this effort, we tried to impose several constraint conditions on the structural analysis model and consequently fixed a proper and effective displacement constraints.

• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.1013-1016
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• 2002

Cyclo(L-prolyl-L-phenylalanyl) [cyclo(pro-phe)] was isolated from Streptomyces sp. AMLK-335 and found to inhibit DNA topoisomerase I activity. In a DNA relaxation assay using supercoiled pBR322 DNA, cyclo(pro-phe) inhibited the DNA topoisomerase activity more strongly than camptothecin, a known topoisomerase inhibitor. However, at a concentration of $10{\mu}M$, cyclo(pro-phe) produced a lower degree of DNA relaxation than camptothecin, therefore, the inhibition of topoisomerase I activity by cyclo(pro-phe) was also found to be dose dependent. Accordingly, the current results suggest that cyclo(pro-phe) may be a novel inhibitor of topoisomerase I.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.8 no.2
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• pp.1-6
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• 2012

A PHE (Process Heat Exchanger) in a nuclear hydrogen system is a key component required to transfer heat energy of $950^{\circ}C$ generated in a VHTR (Very High Temperature gas cooled Reactor) to the chemical reaction that yields a large quantity of hydrogen. A small-scale PHE prototype made of Hastelloy-X is being tested in a small-scale gas loop at Korea Atomic Energy Research Institute. Previous research on the high-temperature structural analysis of the small-scale PHE prototype had been performed only using parent material properties. In this study, high-temperature structural analysis using weld properties in weld zone was performed and the analysis results compared with the previous research.

• Textile Coloration and Finishing
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• v.9 no.2
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• pp.17-24
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• 1997

PET/PHE blends were prepared by the mixing of poly(ethylene terephthalate) and poly(hydroxyether of bisphenol A) at melt state above PET melting temperature and modified PET fibers having less than 5 wt% of PHE were also prepared by the melt spinning of the PET/PHE blends. The PET/PHE blends were able to prepare by means of physical mixing concept, except the chemical interaction between hydroxyl groups of PHE and ester groups of PET. It has been revealed that the modified PET fibers have some hydrophilic properties such as low contact angle and easy-dyeable characters.

• Journal of the Korean Chemical Society
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• v.55 no.6
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• pp.978-982
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• 2011

In order to enhance the target action of chitosan-based drug, this paper firstly prepared phenylalanyl-glycylchitosan (Phe-Gly-CS) by grafting the key intermediate, bromoacetyl-phenylalanine (BA-Phe) onto chitosan. Then the target sugar molecule, lactobionic acid (LA), was grafted to Phe-Gly-CS and the topic compound lactobionic acid grafted phenylalanyl-glycyl-chitosan (Phe-Gly-CS-LA) was finally obtained in a yield of 78.8%. The product were characterized by FTIR, MS and 1H NMR. The preparing condition of BA-Phe was optimized as follows: the best pH was 10-11, the optimum temperature was $-4^{\circ}C$, the reaction time was 1.5 h.