• 대한교통학회지
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• 제16권1호
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• pp.59-78
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• 1998

'90년대에 들어서면서 급속한 경제성장과 함께 자동차수가 급증하여 '97년에는 1.000만대를 돌파 하였다. 자동차수의 증가와 함께 교통사고도 나날이 늘어 '96년에는 사망자가 12,600여명에 이르렀다. 교 통사고는 막대한 인명피해와 함께 사회적으로 많은 비용을 소모한다. 교통사고로 인한 사회적 비용의 추정은 교통안전사업의 효과분석 및 기타 교통관련사업에서 꼭 필요한 자료이다. 이제까지 국내에서 수 행된 교통사고비용은 1년간의 전체 사고비용만을 추정하고 사고등급별 사고건당 사고비용은 도출하지 못하였다. 이에 본연구는 교통관련사업에서 꼭필요한 자료이다. 이제까지 국내에서 수행된 교통사고 비 용은 1년간의 전체 사고비용만을 추정하고 사고등급별 사고건당 사고비용은 도출하지 못하였다. 이에 본 연구는 교통관련사업에 필수적인 사고심각도에 따른 교통사고비용을 도출하려한다. 교통사고비용을 산출하는 대표적인 방법에는 총생산손실법과 개인선호성법이 있으나 본연구에서는 총생산손실법을 이용 하였다. 교통사고비용 항목은 사고로 인한 생산손실비용, 의료비용, 차량수리비용, 행정비용 및 PGS(Pain, Grief & Suffering) 비용으로 구분된다. 이중에서 PGS비용은 국내에서는 처음으로 고려된 항 목으로 교통사고 피해자 및 가족의 물질적·정신적 피해비용을 의미한다. 본연구에서는 각 항목의 비용 추계를 가능한 한 종합적이고 체계적이며 구체적으로 산출하였으며 그결과 사고등급별 건당 교통사고비 용을 도출하였다. PGS를 고려하지 않은 경우 사망사고 1건당 2억4천만원이고 중상사고 1건당 2천3백만 원 경상사고 1건당 7백 9십만원으로 추정되었다. 또한 사망자와 부상자 1인당 평균사고비용은 각각 2억 1천만원과 1천1백만원으로 나타났다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1399-1400
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• 2008

본 논문에서는 TSMC 0.18um 공정을 이용하여 2.45GHz 대역에서 동작하는 RFID 리더에 적용 할 수 있는 전압제어 발진기를 설계하였다. 위상 잡음 특성 향상을 위해 PMOS, NMOS 소자를 대칭으로 구성한 complementary cross-coupled LC 발진기 구조로 설계 하였고 MOS 배렉터를 이용하여 주파수를 가변 하였다. 또한 공정에서 사용되는 인덕터에 차폐 도체면(PGS:Patterned Ground Shield) 구조를 삽입했을 때 인덕터의 품질계수가 약 5.82% 향상되었고. 이에 따른 위상 잡음은 1MHz offset 주파수에서 PGS를 삽입하지 않는 구조에서는 -102.666dBc/Hz 이며, PGS 구조를 삽입한 구조는 -104.328dBc/Hz로 약1.662dBc 정도의 성능이 향상 되었다. 전압제어 발진기 Core 사이즈는 900um ${\times}$ 590um이고 주파수 가변 범위는 배렉터 전압 1.2${\sim}$2.1V에서 249MHz로 11.4% 특성을 보였다. 1.8V공급전압에서 5.76mW의 전력소모를 보였다.

• IMMUNE NETWORK
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• 제13권2호
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• pp.75-79
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• 2013

Evidence for immunoregulatory roles of prostaglandins (PGs) is accumulating. Since our observation of PG production by human follicular dendritic cells (FDCs), we investigated the regulatory mechanism of PG production in FDC and attempted to understand the functions of released PGs in the responses of adjacent lymphocytes. Here, using FDC-like cells, HK cells, we analyzed protein expression alterations in cyclooxygenase-2 (COX-2) in the presence of IL-4 or histone deacetylase (HDAC) inhibitors. Both IL-4 and HDAC inhibitors suppressed COX-2 expression in dose-dependent manners. Their effect was specific to COX-2 and did not reach to COX-1 expression. Interestingly, HDAC inhibitors gave rise to an opposing effect on COX-2 expression in peripheral blood monocytes. Our results suggest that IL-4 may regulate COX-2 expression in FDCs by affecting chromatin remodeling and provide insight into the role of cellular interactions between T cells and FDC during the GC reaction. Given the growing interests in wide-spectrum HDAC inhibitors, the differential results on COX-2 expression in HK cells and monocytes raise cautions on their clinical use.

• Restorative Dentistry and Endodontics
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• 제25권2호
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• pp.193-201
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• 2000

Prostaglandins (PGs) and Leukotrienes (LTs) have been implicated in the genesis of pulpal and periapical inflammation. In this study, the relationships among $PGE_2$, 6-keto-PG $F_1{\alpha}$ (a stable metabolite of $PGI_2$) and $LTB_4$ concentrations in inflamed pulp and periapical lesions were discussed. Pulp tissue were obtained in routine endodontic treatment and periapical lesions in periapical surgery after clinical diagnoses were made. These specimens were divided into four groups as normal pulp group (Control group), acute pulpitis group, chronic pulpitis group, and periapical lesion group. Pulp tissue and periapical lesions were stored in liquid nitrogen. The concentration of $PGE_2$, $PGI_2$ and $LTB_4$ were measured with ELISA. The data were analyzed by one-way ANOVA. Significantly higher levels of $PGE_2$, 6-keto-PG $F_1{\alpha}$ a and $LTB_4$ were found in acute pulpitis group than chronic pulpitis group and periapical lesion group(p<0.05). Periapical lesion group showed significantly higher mean concentrations of $PGE_2$ and $LTB_4$ than chronic pulpitis group. In control and chronic pulpitis group, significant higher levels of $PGI_2$ than $PGE_2$ and $LTB_4$ were found. These results suggested that the high levels of $PGE_2$ and $LTB_4$ in periapical lesions may be due to rich endothelium., fibroblast and lymphocyte known as the main producers of $PGE_2$ and $LTB_4$. $PGI_2$ may be thought to one of the most abundant PGs in normal pulp tissue.

• 대한약리학회지
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• 제19권2호
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• pp.1-8
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• 1983

Prostaglandin(PG) is ubiquitously distributed in most mammalian tissue and their actions are complicated. Especially in autonomic nervous system, there are evidences indicating that PGs act as neuromodulators i.e., PGs, which are released in the vicinity of autonomic neuroeffector junctions, influence the release and the response of the neurotransmitter. Present study was undertaken to elucidate the interrelationship between $PGF_{2\alpha}$ and adrenergic ${\alpha}_2-receptor$ function in electrical field stimulation induced contractile response of vas deferens in rat. Male rat, weighing 150{\sim}200\;g, was sacrificed and vas deferens was obtained. The isolated vas deferens strip was placed between two platinum electrodes in temperature controlled $(37^{\circ}C)$ muscle chamber containing Tyrode's solution and the electrical field stimulation(EFS) induced contraction was recorded with Grass Polygraph(Model 7) via force displacement transducer (FT .03, Grass). The results are summarized as follows: 1) Electrical field stimulation for 1sec( 1 msec, 40 cps) induced contraction of vas deferens was completely blocked by tetrodotoxin. 2) Bretylium caused marked inhibition of the EFS-induced contraction, hut tyramine and cocaine augmented the contraction. 3) EFS-induced contraction was inhibited or little affected in distal portion of vas deferens by norepinephrine or methoxamine, but the contraction was rather augmented by the ${\alpha}-agonists$ in proximal portion. 4) Clonidine inhibited the EFS-induced contraction proportionally to the concentration in distal portion, which was blocked by yohimbine pretreatment, but in the presence of $PGF_{2\alpha}$ the blockade by yohimbine was reversed. 5) Indomethacin pretreatment reduced the effect of clonidine, but addition of $PGF_{2\alpha}$ after washing-out the indomethacin caused the contraction to the control level. From these results it is suggested that PG synthesis is a necessary step and the PG itself has a permissive role in ${\alpha}_2-adrenoceptor$ action in rat vas deferens.

• 한방안이비인후피부과학회지
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• 제30권3호
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• pp.201-210
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• 2017

만성 비소 중독으로 의심되는 피부염 환자를 양방 치료 없이 평혈음을 기본으로 한 한약과 침 치료 등 한방 단독 치료를 통하여 제반 증상을 호전시켰음을 관찰하여 보고한다.

• 공업화학
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• 제3권3호
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• pp.499-506
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• 1992

모노머의 반응성비가 각각 $r_1=0.53$, $r_2=0.44$반응인 styrene과 GMA(glycidyl methacrylate)를 일정 몰비로 반응시켜서 styrene과 GMA의 공중합체인 PGS를 합성한 후, 에틸렌 디아민을 반응시켜서 공중합체내에 아민기를 도입시켰다. 아민기가 도입된 중합체인 NPGS는 PGMA와 블렌드시에 DSC분석 결과, 단일 Tg를 나타내므로 두 폴리머는 상용 성이 있다는 것이 관찰되었다. 이 NPGS-PGMA의 블렌드를 PS-PGMA블렌드물에 일정무게비로 첨가하여서 이에 따른 상용성의 변화를 관찰하였다. 즉, 비상용성인 PS-PGMA블렌드에, 에폭시기와 아민기와의 화학적 반응에 의하여 상용성을 나타내는 NPGS-PGMA블렌드의 첨가에 따른 상용성의 향상을 DSC분석을 통한 Tg변화와 SEM (Scanning electron microscopy)측정에 의한 morphology변화를 통하여서 관찰하였다. 측정 결과, PS-PGMA 블렌드는 NPGS-PGMA 블렌드가 첨가됨에 따라 Tg변화를 나타내었고, PGMA의 PS내에서의 분산은 향상되었다. 따라서, NPGS-PGMA의 블렌드는 PS-PGMA블렌드의 상용성을 향상시키는 상용화제로서의 작용을 하였다.

• Journal of Microbiology and Biotechnology
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• 제30권4호
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• pp.515-525
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• 2020

Interferon (IFN)-λ plays an essential role in mucosal cells which exhibit strong antiviral activity. Lactobacillus plantarum (L. plantarum) has substantial application potential in the food and medical industries because of its probiotic properties. Alphacoronaviruses, especially porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV), cause high morbidity and mortality in piglets resulting in economic loss. Co-infection by these two viruses is becoming increasingly frequent. Therefore, it is particularly important to develop a new drug to prevent diarrhea infected with mixed viruses in piglets. In this study, we first constructed an anchored expression vector with CWA (C-terminal cell wall anchor) on L. plantarum. Second, we constructed two recombinant L. plantarum strains that anchored IFN-λ3 via pgsA (N-terminal transmembrane anchor) and CWA. Third, we demonstrated that both recombinant strains possess strong antiviral effects against coronavirus infection in the intestinal porcine epithelial cell line J2 (IPEC-J2). However, recombinant L. plantarum with the CWA anchor exhibited a more powerful antiviral effect than recombinant L. plantarum with pgsA. Consistent with this finding, Lb.plantarum-pSIP-409-IFN-λ3-CWA enhanced the expression levels of IFN-stimulated genes (ISGs) (ISG15, OASL, and Mx1) in IPEC-J2 cells more than did recombinant Lb.plantarum-pSIP-409-pgsA'-IFN-λ3. Our study verifies that recombinant L. plantarum inhibits PEDV and TGEV infection in IPEC-J2 cells, which may offer great potential for use as a novel oral antiviral agent in therapeutic applications for combating porcine epidemic diarrhea and transmissible gastroenteritis. This study is the first to show that recombinant L. plantarum suppresses PEDV and TGEV infection of IPEC-J2 cells.

• Asian-Australasian Journal of Animal Sciences
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• 제5권1호
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• pp.29-32
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• 1992

The effects of prostaglandins (PG) and indomethacin, a PG synthesis inhibitor, on ovulation in the perfused fowl ovary were studied. Laying hens were killed by cutting the jugular vein 18-19 h before expected ovulation of the second follicle of a clutch sequence. The cannulated ovary was dissected free and connected with a recycling perfusion apparatus. Agents to be studied for their effects on ovulation were added to the perfusion fluid. $PGF_{2{\alpha}}$ at 0.1 and 1 mg/l induced ovulation, with a success rate of 25% and 30%, respectively. The same doses of $PGE_2$ were effective at 60% and 63%, respectively. Indomethacin partially blocked gonadotrophin-induced ovulation. It is suggested that PGs may play a supportive role in the process of follicular rupture in the domestic fowl.

• 약학회지
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• 제43권1호
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• pp.117-123
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• 1999

Because of the potent effects of lipid mediators such as prostaglandins (PGs), leukotriens (LTs) and platelet activating factor (PAF) on a variety of cells and tissues, they are considered as major contributors to the process leading to inflammation and allergy. To pursue the mechanism of anti-inflammatory activity of Lonicera japonica, we tested inhibitory effects of 7 flavonoids from Lonicera japonica on arachidonic acid cascade related enzymes, such as inflammatory phospholipase $A_2$, cyclooxygenase-1 and 2, 5-lipoxygenase, in bone marrow derived mast cell (BMMC), and lyso PAF-acetyltransferase in rat spleen microsomes. Anti-inflammatory activities of lonicera japonica are thought to be attributed at least in part to the inhibition of arachidonic acid cascade releated enzymes by flavonoids such as apigenin, luteolin quercetin.