• Biomolecules & Therapeutics
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• v.15 no.1
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• pp.1-6
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• 2007

The application of the knowledge from the Human Genome Project to clinical medicine will be through both industrial drug development and the application of pharmacogenomics (PG) to patient care. The slow uptake of clinical innovations into clinical practice can be frustrating, but understanding the history of acceptance and sustaining medical innovation is critically important to position PG to succeed. This primarily means that PG tests must have legitimacy; they must be thoroughly validated, must be cost-effective, must be widely accepted by medical practitioners, must be supported by public policy, and must have a way of being easily incorporated into current medical practice. They must also lead to actionalble decisions by health care providers for their patients. Innovative PG assays should be tested in the best US laboratories, and reimbursement for testing must be accepted at the federal and state level. The companies providing these PG tests should be capable of sup-porting the interpretation and use of the test throughout medical practice. Advances such as the addition of PG information to drug labeling and the routine use of validated biomarkers to determine choice of cancer chemotherapy have been made. The PG research community must pay attention to the principles that have been previously described for acceptance and sustaining medical innovations in order for PG to be widely accepted in clinical medical practice.

• Journal of the Korean GEO-environmental Society
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• v.13 no.2
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• pp.67-73
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• 2012

Asphalt pavement waste can be recycled by crushing and heating methods with additional virgin materials and additives. In this study, a new additive using Sasol wax and Polyolefin elastomer was used for improving the quality of the Superior recycled asphalt pavement(SRP). Additive was added into the recycled mixture by 1.5% and 3% of binder content in order to have PG 70-22 and PG 76-22. Both mixtures were tested by Marshall apparatus, indirect strength testing methods, toughness testing methods, moisture susceptibility testing methods and wheel tracking testing methods. Test results met the standards of KS F 2349 and GR F 4005. Through research, it was found that these special recycled mixtures could be applied for the surface and base course of heavy traffic roads or equivalents. About 13,000 tons of the recycled mixture has been applied on Seoul Olympic road to provide new road to Hangang park for Seoul citizens.

• International Journal of Highway Engineering
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• v.14 no.5
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• pp.47-55
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• 2012

PURPOSES: SUPERPAVE binder grade tests including Multiple Stress Creep and Recovery(MSCR) test are applied to evaluate rheological properties of four polymer modified binders. METHODS: To evaluate grade of four modified binders, PG testing protocols, such as DSR, BBR and MSCR are employed. RESULTS: It is observed that MSCR test shows different performance grades especially on modified binders. Both DMP and EG binder show similar high temperature performance to SBS 5% modified binder. CONCLUSIONS: Binder Grading system in Korea need to be reviewed to properly reflect the performnace of modified binders. The binders modified with DMP and EG can be possible alternatives SBS 5% modified binder considering its performance and cost.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.23-39
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• 2006

The application of the knowledge from the Human Genome Project to clinical medicine will be through both industrial drug development and the application of pharmacogenomics (PG) to patient care. The slow uptake of clinical innovations into clinical practice can be frustrating, but understanding the history of acceptance and sustaining medical innovation is critically important to position PG to succeed. This primarily means that PG tests must have legitimacy; they must be thoroughly validated, must be cost-effective, must be widely accepted by medical practitioners, must be supported by public policy, and must have a way of being easily incorporated into current medical practice. They must also lead to actionalble decisions by health care providers for their patients. Innovative PG assays should be tested in the best US laboratories, and reimbursement for testing must be accepted at the federal and state level. The companies providing these PG tests should be capable of supporting the interpretation and use of the test throughout medical practice. Advances such as the addition of PG information to drug labeling and the routine use of validated biomarkers to determine choice of cancer chemotherapy have been made. The PG research community must pay attention to the principles that have been previously described for acceptance and sustaining medical innovations in order for PG to be widely accepted in clinical medical practice.

• 한국약용작물학회:학술대회논문집
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• 2006.11a
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• pp.23-39
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• 2006

The application of the knowledge from the Human Genome Project to clinical medicine will be through both industrial drug development and the application of pharmacogenomics (PG) to patient care. The slow uptake of clinical innovations into clinical practice can be frustrating, but understanding the history of acceptance and sustaining medical innovation is critically important to position PG to succeed. This primarily means that PG tests must have legitimacy; they must be thoroughly validated, must be cost-effective, must be widely accepted by medical practitioners, must be supported by public policy, and must have a way of being easily incorporated into current medical practice. They must also lead to actionalble decisions by health care providers for their patients. Innovative PG assays should be tested in the best US laboratories, and reimbursement for testing must be accepted at the federal and state level. The companies providing these PG tests should be capable of supporting the interpretation and use of the test throughout medical practice. Advances such as the addition of PG information to drug labeling and the routine use of validated biomarkers to determine choice of cancer chemotherapy have been made. The PG research community must pay attention to the principles that have been previously described for acceptance and sustaining medical innovations in order for PG to be widely accepted in clinical medical practice.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2003.11a
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• pp.108-108
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• 2003

The current study was performed to observe the effects of Panax ginseng (PG) and P. quinquefolia (PQ) on hemodynamics such as blood flow rate (BF), blood flow velocity (BV), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP, and body temperature (BT) in healthy young men. After testing equality of variance, Student's t-test using PROC TTEST was examined to. prove statistical differences between control and ginseng conditions at each time point. It was found that the BF data were fluctuated by personal deviation. In order to minimize the deviation, the results obtained for 6 hrs were reconstituted after dividing them into two periods of the first half from 1 to 3 hrs and of the latter half from 3.5 to 6 hrs. And then the reconstitution data and dose-response curves were obtained. Blood flow such as BF and BV shows significant increases both two periods in the dose of PG 2.25 and PG 9.0, whereas significant decrease in the dose of PG 4.5. However, in the PQ groups, the middle dose PQ 4.5 shows the highest significant increase among the three doses. Except for PG 2.25 in HR, other doses show significant decreases both in the first half and latter half. SBP of PQ 9.0 shows only a significant decrease in the first half; on the other hand, in the latter half, PG 4.5, PG 9.0 and PQ 9.0 significantly increase SBP. In addition, DBP of PG 2.25 and PG 4.5 show significant increase in the both periods. In the BT, PQ groups show gradual decrease from PQ 2.25 to PQ 9.0; however, PG groups show differently. PG 4.5 shows significant decrease, but PG 9.0 shows a increase without statistical meanings. In summary, PG is more effective in respect to keeping homeostasis of hemodynamics.

• International Journal of Highway Engineering
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• v.14 no.5
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• pp.85-91
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• 2012

PURPOSES: In this study, various laboratory tests were performed to investigate the suitability of wasted vinyl as a modifier of asphalt binder. METHODS: Based on the ASTM specification, variations in material properties of asphalt binder such as penetration, flash point, softening point, ductility, penetration index (PI), and performance grade (PG) with vinyl content were tested and analyzed. RESULTS: Lavoratory tests revealed that penetration and ductility of the asphalt binder increased with the vinyl content. The flash point, softening point, and PI decreased, and PG changed from 64-22 to 70-22 with increase of the vinyl content. CONCLUSIONS: Wasted vinyl modified the material properties of the asphalt binder. However, the asphalt binder with vinyl content over 6.0% was unsuitable as a pavement material.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.5
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• pp.487-493
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• 2011

Alpha fetoprotein(AFP), which is serological marker for hepatocellular carcinoma, was quantitatively measured by its normal concentration, 10 ng/ml, with a label-free piezoelectric microcantilever mass sensor. The principle of detection is based on changes in the resonant frequency of the piezoelectric microcantilever before and after target molecules are attached to it, and its resonant frequency is measured electrically using a conductance spectrum. The resonant frequency of the developed sensor is approximately 1.34 MHz and the mass sensitivity is approximately 175 Hz/pg. The sensor has high reliability as mass sensor by reducing the effect of surface stress on resonant frequency due to attached proteins. 'Dip and dry' technique was used to react the sensor with reagents for immobilizing AFP antibody on the sensor and detecting AFP antigen. The measured mass of the detected AFP antigen was 6.02 pg at the concentration of 10 ng/ml, and 10.67 pg at 50 ng/ml when the immunoreaction time was 10 min.

• International Journal of Highway Engineering
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• v.9 no.2 s.32
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• pp.51-62
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• 2007

Recently, the pavement distresses in the bridge deck have seriously affected the durability of bridge deck and driver's safety. The existing asphalt materials have the limitations in reducing the pavement distresses of brides deck. To protect the bridge deck and withstand the high deflection, it is necessary to develop the asphalt materials with good fatigue resistance for bridge deck pavement. The asphalt binder combined with SBS and two other admixtures has been developed for improving the resistance to fatigue cracking, productivity, and workability for bridge deck pavement. Based on the various binder test results, the developed binder is found to be PG 70-34 indicating very higher resistance against fatigue cracking. Fatigue testing, wheel tracking testing, and moisture susceptibility testing have been conducted to evaluate the performance of asphalt mixtures developed in this study. Laboratory test results show that the developed asphalt material has three times higher fatigue lives than the typical modified asphalt mixture. Full scale accelerated testing was also performed on the typical asphalt mixture and newly developed asphalt mixture to evaluate the full scale performance of asphalt mixtures. Test results indicate that the length of cracking on the new materials is only 38% of the typical material at the 250,000 load repetitions.

• Korean Journal of Agricultural Science
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• v.12 no.2
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• pp.324-332
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• 1985

Aspergillus niger B-15 with strong Endo-polygalacturonase (Endo-PG) activities was selected out from a total of 1,573 fungal strains isolated from various testing materials. A mutant strain, U-46, was obtained from the Aspergillus niger B-15 by repeated irradition of ultra-violet light. The objectives of the study were to investigate the fungal properties of the parental and mutant strains obtained and to study the condition of enzyme production and reaction. The results obtained are summarized as follows: 1. The size of conidial head of the U-46 mutant was smaller than that of the parental strains, B-15 and the length of the conidiophore was also shorter than that of the parental strains. 2. The optimum conditions for the Endo-PG production of the parental B-15 strain in the wheat bran Koji were obtained when 40% of water was added to the wheat bran and the temperature was 30 to $35^{\circ}C$. However, the best condition for the mutant U-46 strain was attained when 60 to 70% of water was added and the temperature was $35^{\circ}C$. The optimum growing periods were two to three days for both parental and mutant strains. 3. Under the optimum producing conditions of each strains, the enzymatic activity of the mutant U-46 was 20 times higher than the Endo-PG of the parental strain, B-15. 4. When both strains were cultured in the wheat bran Koji containing 60% of water at $35^{\circ}C$ for three days, the mutant strain. U-46, was about 46 times higher in the Endo-PG activity and about 18 times greater in Exo-PG activity than the parental strain, B-15. The activities of cellulase, $\alpha$-amylase, and glucoamylase were also highly increased in the mutant strain. 5. The mutant strain, U-46, increased its Endo-PG activity up to 20% over that of ordinary case when 1.2 to 1.5% of ammonium sulphate was added to the wheat bran. 6. The optimum condition for Endo-PG activity of crude enzyme of the mutant strain, U-46, was attained when pH of reaction solution was 4.0 to 4.5 and the temperature was $50^{\circ}C$.