• Proceedings of the IEEK Conference
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• 2003.07e
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• pp.2443-2446
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• 2003

본 논문에서는 한국전자통신연구원에서 제공된 대어휘 음성DB를 이용하여 HM-Net(Hidden Markov Network) 음성인식 시스템의 성능평가를 수행하였다. 음향모델 작성은 음성인식에서 널리 사용되고 있는 통계적인 모델링 방법인 HMM(Hidden Markov Model)을 개량한 HM-Net을 도입하였다 HM-Net은 PDT-SSS 알고리즘에 의해 문맥방향과 시간방향의 상태분할을 수행하여 생성되는데, 특히 문맥방향 상태분할의 경우 학습 음성데이터에 출현하지 않는 문맥정보를 효과적으로 표현하기 위해 음소결정트리를 채용하고 있으며, 시간방향 상태분할의 경우 학습 음성데이터에서 각 음소별 지속시간 정보를 효과적으로 표현하기 위한 상태분할을 수행한다. 이러한 상태분할을 수행하여 파라미터를 공유하게 되며 최적인 모델 네트워크를 작성하게 된다. 대어휘 음성데이터를 이용하여 음향모델을 작성하고 인식실험을 수행한 결과, 100명의 100단어와 60문장에 대해 평균 97.5％, 96.7％의 인식률을 보였다.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.912-921
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• 2009

Pulse-discharge technology (PDT) is an innovative technology which uses enormous energy developed by electric discharge for a very instant moment of time. Lately, it has been applied to make expanded sections at the ends of piles and anchors. The expanded section is formed by the deformation of bore-hole induced by shockwave energy developed in filling material by the pulse discharge. In this study, considering the phenomenon of pulse-discharge as an underwater explosion, finite element analyses were carried out to model the shockwave development by pulse discharge. The simulation technique was verified by comparing results with underwater discharge test results.

• Bulletin of the Korean Chemical Society
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• v.28 no.1
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• pp.129-132
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• 2007

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.1
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• pp.1-13
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• 2015

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04a
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• pp.767-769
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• 2003

컴퓨터와 무선 통신 기술의 발달로 인하여 LBS(Location based Service)와 같은 새로운 이동체 관련 서비스가 생겨나고 있다. 이와 같은 서비스들은 이동체들이 일정 주기를 가지고 자신의 정보를 서버로 전송하는데 이는 많은 디스크 입출력을 요구하게 된다. 그러므로 이동체 데이터에 대하여 다중 디스크를 이용한 병렬 입출력이 요구되고 있다. 그러나 기존의 디클러스터링 방법은 시간 도메인을 고려하지 않거나 공간 관련성만을 고려하여 디클러스터링을 하므로, 하나의 디스크에 특정 이동체의 궤적이 집중 되는 문제점이 있다. 이 문제점은 디스크의 병목현상으로 인한 느린 응답시간과 낮은 처리율의 결과를 발생시킨다. 그러므로 이동 객체의 빠른 질의 처리를 위한 새로운 디클러스터링 기법이 필요하다. 이 논문에서는 다중 디스크 기반의 시스템에서 이동 객체에 대한 영역질의시 빠른 응답시간과 높은 처리율물 얻기 위하여 새로운 디클러스터링 기법을 제시한다. 이동체 데이터의 궤적 MBB중 공간 좌표로부터 Predefined Disk를 생성하고 PDT-Proximity를 이용하여 시간 도메인을 고려하는 방법이다. 위와 같이 이동 객체의 특성을 고려한 새로운 디클러스터링 방법으로 시스템의 성능을 향상시킬 수 있다.

• Proceedings of the KSRS Conference
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• 2002.10a
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• pp.854-859
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• 2002

Location Based Services, or LBS refers to value-added service by processing information utilizing mobile user location. With the rapidly increasing wireless internet subscribers and world LBS market, the various location based applications are introduced such as buddy finder, proximity and security services. As the killer application of the wireless internet, the LBS has preconsidered technology about location determination technology, LBS middleware server for various application, and diverse contents processing technology. This paper describes the open architecture for LBS platform ensuring interoperability among the wireless networks and various location-based application services and the functional requirements for the LBS platform. The LBS platform in a narrow sense provides a standard interfaces for location management and network management for location services as follows, positioning (location acquisition through network or/and handset), location managing, location based functions, profile management, authentication and security, location based billing, information roaming between carriers and the system monitoring independent to specific network or ISP/CPs(Content Providers).

• Mycobiology
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• v.46 no.4
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• pp.448-451
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• 2018

Fungal perylenequinones have photodynamic activity and are promising photosensitizers for photodynamic therapy (PDT). Here, we investigated the bactericidal and antitumor activities of phleichrome from the fungal perylenequinone family in vitro. Photodynamic bactericidal activity of phleichrome was analyzed by agar-well diffusion method under dark and illuminated conditions. The photodynamic antitumor activity of phleichrome was analyzed in MCF-7, HeLa, SW480, and HepG2 human cancer cell lines using in vitro cytotoxicity assays. Photodynamic bactericidal activities against Gram-negative and Gram-positive bacteria were species-specific. Antitumor activity against all tumor cell lines increased under the illuminated condition. Depending on the results of the analyses, Phleichrome has potential for further drug development related to its antibacterial and antitumor activities.

• Journal of Dental Rehabilitation and Applied Science
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• v.35 no.3
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• pp.160-169
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• 2019

Purpose: The purpose of this study was to evaluate the antimicrobial effects of a toothbrush with light-emitting diodes (LEDs) on periodontitis-associated dental biofilm attached to a zirconia surface by static and dynamic methods. Materials and Methods: Zirconia disks (12 mm diameter, 2.5 mm thickness) were inserted into a 24-well plate (static method) or inside a Center for Disease Control and Prevention (CDC) biofilm reactor (dynamic method) to form dental biofilms using Streptococcus gordonii and Fusobacterium nucleatum. The disks with biofilm were subdivided into five treatment groups-control, commercial photodynamic therapy (PDT), toothbrush alone (B), brush with LED (BL), and brush with LED+erythrosine (BLE). After treatment, the disks were agitated to detach the bacteria, and the resulting solutions were spread directly on selective agar. The number of viable bacteria and percentage of bacterial reduction were determined from colony counts. Scanning electron microscopy (SEM) was performed to visualize alterations in bacterial morphology. Results: No significant difference in biofilm formation was observed between dynamic and static methods. A significant difference was observed in the number of viable bacteria between the control and all experimental groups (P < 0.05). The percentage of bacterial reduction in the BLE group was significantly higher than in the other treated groups (P < 0.05). SEM revealed damaged bacterial cell walls in the PDT, BL, and BLE groups, but intact cell walls in the control and B groups. Conclusion: The findings suggest that an LED toothbrush with erythrosine is more effective than other treatments in reducing the viability of periodontitis-associated bacteria attached to zirconia in vitro.

• Journal of the Institute of Convergence Signal Processing
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• v.4 no.4
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• pp.30-39
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• 2003

In this paper, we carried out the performance evaluation of HM-Net(Hidden Markov Network) speech recognition system for Korean speech databases. We adopted to construct acoustic models using the HM-Nets modified by HMMs(Hidden Markov Models), which are widely used as the statistical modeling methods. HM-Nets are carried out the state splitting for contextual and temporal domain by PDT-SSS(Phonetic Decision Tree-based Successive State Splitting) algorithm, which is modified the original SSS algorithm. Especially it adopted the phonetic decision tree to effectively express the context information not appear in training speech data on contextual domain state splitting. In case of temporal domain state splitting, to effectively represent information of each phoneme maintenance in the state splitting is carried out, and then the optimal model network of triphone types are constructed by in the parameter. Speech recognition was performed using the one-pass Viterbi beam search algorithm with phone-pair/word-pair grammar for phoneme/word recognition, respectively and using the multi-pass search algorithm with n-gram language models for sentence recognition. The tree-structured lexicon was used in order to decrease the number of nodes by sharing the same prefixes among words. In this paper, the performance evaluation of HM-Net speech recognition system is carried out for various recognition conditions. Through the experiments, we verified that it has very superior recognition performance compared with the previous introduced recognition system.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.273-278
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• 2015

The purpose of this study was to evaluate the in-vitro efficacy of PDT using red light emitting diode (LED) with Radachlorin for biofilm inhibition of clinical Candida albicans isolates. The suspensions containing C. albicans at $9{\times}10^8CFU/mL$ were prepared on yeast nitrogen base containing 5% glucose. The biofilm formation was grown for 3 h after seeding suspensions each 100 ul on a 96-well plate and then supernatant was discarded. Each well was treated with $0.39{\mu}g/mL$ from $50{\mu}g/mL$ concentrations of Radachlorin on adherent biofilm. After a 30-minute incubation, light was irradiated for 30, 60, or 90 minutes using the following light source of wavelength 630 nm LED, at energy densities of 14, 29, and $43J/cm^2$. Afterwards, all supernatant was removed and dried. Adherent cells were stained with safranin O and dried. The cell viability was measured using a microplate reader at 490 nm. Also, a fluorescent signal on C. albicans was observed by saturation of a photosensitizer. In conclusion, a significant inhibition of 72.5% was observed to C. albicans on biofilm at the Radachlorin dose of $50{\mu}g/mL$ with 630 nm LED. The Photosensitizer (Radachlorin) was adequate at 30 minuttes for C. albicans. Overall, the results showed that inhibition of biofilm formation was Radachlorine dose-dependent. The results suggest that PDT, using Radachlorin with 630 nm LED, is able to decrease biofilm formation of C. albicans.