• Journal of Photoscience
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• v.9 no.2
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• pp.521-523
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• 2002

5-aminolevulinic acid (ALA) has been used to stimulate endogenous protoporphyrin IX (PpIX) in tumor and then initiate PDT. Recently, ALA-Hexyl ester (He-ALA) was found much effective than ALA on producing PpIX in cancer cells. To clarify the transportation mechanism of ALA and He-ALA, the detection of them is the important step. ALA and its derivatives all don't emit fluorescence, so the Raman spectroscopy was used here for the direct detection of ALA and He-ALA. The results showed that ALA and He-ALA have the common strong Raman peaks at 2930, 2950 CM$\^$-1/, due to the CH$_2$ vibration. The peak 3050 CM$\^$-1/ appeared in ALA spectrum can be attributed to OH vibration, while the peaks of 2860, 2900 CM$\^$-1/ in He-ALA spectrum were assigned as the modes of CH$_3$. This Raman spectral characteristic is consistence with the structure difference of He-ALA and ALA. Thus, Raman spectroscopy provides a new way to detect and distinguish ALA and He-ALA, and could be explored further in biology system.

• Biomedical Science Letters
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• v.14 no.4
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• pp.269-274
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• 2008

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common nosocomial pathogens. It is associated with hospitals is now being isolated in the community. The aim of this study was to evaluate the antibacterial effect of photodynamic therapy using Photogem and 630 nm LED on MRSA and methicillin-sensitive Staphylococcus aureus (MSSA). The broth cultured MRSA and MSSA incubated with various concentrations of Photogem (500,50,5 and $0.5{\mu}g/mL$) for 4 h. Then 630 nm LED was given at $9\;J/cm^2$, $20{\mu}l$ of the exposed bacteria solution was inoculated onto agar plate. Plates were incubated for 24 hand colonies were counted. The PDT group was effective in killing MRSA and MSSA at the Photogem dose of $50{\mu}g/mL$. But MSSA is more sensitive than MRSA in photodynamic effect. Other groups (light only, sensitizer only, or no treatment) observed no bacterial cell killing. These results raise the possibility of using PDT with or without antimicrobial drugs to eradicate MRSA and MSSA. In order to confirm this result, we need to further study bacterial death mechanism and in vivo study.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04c
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• pp.229-231
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• 2003

일반적으로 음성은 시간함수로 표현되며 음성인식에서 표준모델을 모델링하는 것은 매우 중요한 문제이다. 음절 단어, 연속음성을 발성할 때 자음과 모음에 따라 발성시간에 차이가 있으며 이를 잘 모델링하는 것 또한 음성인식에서는 중요한 문제라고 할 수 있다. 따라서 본 연구에서는 강건한 음향모델을 학습하기 위해 시간의 변화와 상태분할과정에서의 모델의 변화를 고려하여 다양한 구조의 초기모델을 작성하였다. 각 초기모델에 의한 HM-Net 문맥의존 음향모델은 음소결정트리 기반 SSS 알고리즘(PDT-SSS)을 이용하였다. PDT-SSS 알고리즘은 미지의 문맥정보를 해결하기 위해 문맥방향과 시간방향으로 목표 상태수에 도달할 때까지 상태분할을 수행하여 모델을 작성하는 방법이다. 음성의 시간변이를 고려한 강건한 문맥의존 음향모델을 작성하기 위해 설정한 각 모델의 구조에 대한 유효성을 확인하기 위해 국어공학센터의 452 단어를 대상으로 음소와 단어인식 실험을 수행한 결과. 음소인식의 경우 상태수 2000개에서 2상태 구조의 모델에 비해 4상태 구조가 약 11.4% 향상된 인식성능과 39.2초의 인식시간을 단축할 수 있었다. 또한 단어인식의 경우 상태수 2000개에서 1상태 구조의 모델에 비해 4상태 구조가 약 5% 향상된 인식성능과 4상태 구조에서 한 단어를 인식하는데 평균 0.8초가 소요되었다. 따라서 강건한 문맥의존 음향모델을 작성하기 위해 수행한 초기모델의 구조에 관한 연구가 향후 음성인식 시스템을 구축하는데 유효함을 확인할 수 있었다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.6 no.2
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• pp.129-133
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• 2005

It is very important to use the charge coupled devices (CCDs) in spectrometry because we can study the molecular energy level, molecular structure, absorption or emission, intermolecular reaction, weakly bound molecular energy, photochemistry, fluorescence and photodynamic therapy (PDT). CCD is very essential to study the molecular structure and medical engineering combining laser spectroscopy in the modem physicsal and chemistry. Therefore, this study has designed and manufactured the electromagnetic spectrometry with CCD and then analyzed the printed electronic circuit. In the yesterday, CCD was thought to be used in only broadcasting system. But nowadays, it is used by industrial demand in observations, instrumentations and robotics as the industry develop.

• Phonetics and Speech Sciences
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• v.1 no.3
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• pp.163-168
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• 2009

This study investigated the determination of speech rates, words per minute (WPM) and syllables per minute (SPM), of $5{\sim}7$ year-old normal children to understand if there are any differences in the rates according to the children's age and sex. All participants were required to conduct story retelling tasks (SRT) and picture description tasks (PDT). In SRT, there was a significant difference between the groups of 5 year-old and 7 year-old children on WPM. However, there was no significant difference between the groups of ages regarding SPM. In addition, there was no significant difference between the groups according to sex on WPM and SPM. In PDT, there was no significant difference between the groups according to their ages and sex on WPM and SPM. The current research found that the speech rates of the preschool children might be somewhat different in their utterance abilities according to their age, but there was no obvious difference according to their sex. The findings can advance development of a clinical tool to screen children with fluency disorders and to determine the steps in establishing speech rates of children in the language development period.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.93-96
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• 2008

This paper deals with the shaking table test(STT), the Quasi-Static Test(QST), and the Pseudo-Dynamic Test(PDT) to evaluate the seismic performance of RC bridge piers under near fault ground motion. Five scaled specimens were constructed the weight of the superstructure was applied through the prestressing strand at the centroid of the column section during the QST and PDT. However, the STT was simulated. The lateral inertia force of the superstructure by the mass frame which was linked with the pier because of the limited payload of shaking table. Particularly for the STT, friction underneath the mass frame was minimized by special details and it was verified by a series of pre-load test. Scale factor of the RC piers was 4.25.

• Journal of Veterinary Clinics
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• v.40 no.5
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• pp.323-329
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• 2023

Peripheral blood-derived mesenchymal stem cells (PB-MSCs) have shown promise in cell-based therapy, as they can be harvested with ease through minimally invasive procedures. This study aimed to isolate PB-MSCs from foals and mares and to compare the proliferation and cellular characteristics of the PB-MSCs between the two groups. Six pairs of mares and their foals were used in this study. MSCs were isolated from PB by direct plating in a tissue culture medium, and cell proliferation (population doubling time [PDT], and colony-forming unit-fibroblast assay [CFU-F]), and characterization (morphology, plastic adhesiveness, colony formation, trilineage differentiation) were examined. There was no significant difference in the PB-MSC yield, CFU-F, and PDT between the mares and foals. PB-MSCs from both mares and foals showed typical MSC characteristics in terms of spindle-shaped morphology, plastic adhesive properties, formation of colonies, trilineage differentiation. These results suggest that PB-MSCs isolated from horses, both adult horses, and foals, can be used for equine cell-based therapy.

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.4
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• pp.9-15
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• 2001

In this paper we investigate context dependent acoustic models to improve the performance of the Korean speech recognition . The algorithm are using the Korean phonological rules and decision tree, By Successive State Splitting(SSS) algorithm the Hidden Merkov Netwwork(HM-Net) which is an efficient representation of phoneme-context-dependent HMMs, can be generated automatically SSS is powerful technique to design topologies of tied-state HMMs but it doesn't treat unknown contexts in the training phoneme contexts environment adequately In addition it has some problem in the procedure of the contextual domain. In this paper we adopt a new state-clustering algorithm of SSS, called Phonetic Decision Tree-based SSS (PDT-SSS) which includes contexts splits based on the Korean phonological rules. This method combines advantages of both the decision tree clustering and SSS, and can generated highly accurate HM-Net that can express any contexts To verify the effectiveness of the adopted methods. the experiments are carried out using KLE 452 word database and YNU 200 sentence database. Through the Korean phoneme word and sentence recognition experiments. we proved that the new state-clustering algorithm produce better phoneme, word and continuous speech recognition accuracy than the conventional HMMs.

• Tuberculosis and Respiratory Diseases
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• v.62 no.3
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• pp.175-183
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• 2007

• Proceedings of the Korea Society of Design Studies Conference
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• 1999.05a
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• pp.76-77
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• 1999

대중적 건설중장비로서의 유압굴삭기는 1990년대 이후로 탈산업화(post-industrialization)의 영향을 받아, 형태나 색채에 있어서 변화를 시작한다. 이는 일반 소비재 분야에 비하여 다소 늦은 편이라 할 수 있다. 그 이유는 건설중장비 특성상 제한된 사용 충과 사용환경으로 인한 제품개발기간(PDT)과 제품수명주기(PLC)가 길고, 제품개발 비용이 상대적으로 거대하기 때문이다.(중략)