• Journal of fish pathology
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• v.17 no.2
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• pp.131-137
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• 2004

In the present study, phosphatidylcholine (PC) hydrolyzing enzyme had been isolated from membrane of flounder liver. PC hydrolyzing enzyme solubilized in 1% Triton X -100 from membrane was partially purified by sequential chromatography on Heparin Sepharose CL-6B and Heparin-5PW columns. The products by membrane-bound hydrolyzing enzyme were identified as phosphatidic acid and choline, but in the presence of primary alcohol, phosphatidylethanol was produced at the expense of phosphatidic acid. These data suggest that membrane-bound enzyme may be a PC-phosphoipase D (PLD) type. The enzyme had pH optimum at below 6.0 and temperature optimum at $37^\circ{C}$. The activity of PC-PLD was dose-dependently increased by $Ca^{2+}$ but not $Mg^{2+}$. The activity of PC-PLD was stimulate by PC, PIP2 and PE.

• Korean Journal of Acupuncture
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• v.26 no.2
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• pp.15-25
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• 2009

Objective: This paper aimed to understand influences on EEG conducting acupuncture stimulation, by comparing the changes in the acupoints on the body before and after normal people are treated with acupuncture at PC9 and TE3, which are referred to as Wood points(木穴), and PC5 and TE1, which are referred to as the Metal points(金穴) among the five shu points of Yin pericardium Meridian and Yang Triple Energizer Meridian. Methods: The study was performed on 30 healthy female volunteers in their 20's. EEG was measured for 5 minutes before acupuncture stimulation was conducted on PC9, TE3, PC5 and TE1. During 20 minutes of acupuncture treatment, the same items were continuously measured to find out whether there were any changes in them, and they were measured for 5 minutes after removing the acupuncture needles in order to implement a comparative analysis. Results: Comparision of EEG data before and after the treatment at PC9 shows no significant differences in all wave. Compared with the pre-acupuncture period at TE3, $\delta-\theta$ wave decreased significantly (P<0.05) during the acupuncture stimulation periods. Compared with the pre-acupuncture period at PC5, $\delta-\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Mid $\beta$ wave and high $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods and the post acupuncture periods. Compared with the Pre-acupuncture period at TE1, $\delta-\theta$ wave, $\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Low $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods. Conclusion: When acupuncture stimulation was performed on PC9 and TE3, referred to as the "Wood points", brain waves were stabled, while when acupuncture was performed on PC5 and TE1, called the "Metal points", a brain was waked. From the findings of this study, we hypothesize that the wood properties, from which growing starts in all things, are related with fast waves of EEG, and the metal properties, which stabilize and converge in all things, are related with slow waves of EEG.

• Journal of Veterinary Clinics
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• v.25 no.5
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• pp.359-362
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• 2008

This study examined the efficacy of needle-acupuncture (AP) at Nei Guan (PC06) and Xin Shu (BL15) on canine tachycardia. A total of 18 beagle dogs were divided into three groups: a control (6 heads), PC06 (6 heads) and PC06 (6 heads) group. Tachycardia was induced by an intramuscular injection of glycopyrrolate. No treatment was given to the control group. Needle-AP at PC06 and BL15 were applied simultaneously at the same time as the glycopyrrolate injection for 20 minutes in PC06 and BL15 groups, respectively. The changes in R-R intervals and respiration rates were determined. The changes in the R-R intervals in the PC06 and BL15 groups were significantly higher than the control group. The R-R intervals of the BL15 group were significantly higher than in the PC06 group. The changes in the respiration rates in the PC06 group were similar to those of the control group. However, the respiration rates in the BL15 group were significantly lower than the control and PC06 groups. In conclusion, needle-AP at PC06 and BL15 is effective in assisting in the recovery from induced canine tachycardia. However, needle-AP at BL15 is more effective than that at PC06.

• Journal of the Korean Society of Industry Convergence
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• v.23 no.4_2
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• pp.611-616
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• 2020

Polycarbonate (PC) materials having electrical insulation properties, are thermoplastic material and are easily processed, have excellent strength and heat resistance characteristics, and also have transparent and hard characteristics. In this study, we tried to derive the ε-N curve of strain-life, which shows the relationship between the strain characteristics and the life of the material when repeated impact loads are applied to the PC plastic material. As the impact load increased to 3.0kg, 4.0kg, 5.0kg, and 6.0kg, the strain also increased linearly to 0.033, 0.041, 0.046, and 0.055. At 3.0kg of mass impact, the test piece broke with 12000 impact cycles, 8400 times at 3.5kg, 7400 times at 4.0kg, 6600 times at 4.5kg, 4700 times at 5.0kg, 3000 times at 5.5kg, and 1000 times at 6.0kg. The number of fractures exponentially decreased as the load gradually increased. Using these results, an ε-N curve for PC plastic was derived.

• Proceedings of the Korean Environmental Health Society Conference
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• 2002.04a
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• pp.6-8
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• 2002

Many adolescents stay long time in the PC game room and are exposed to much of tobacco smoke. To evaluate the effect of passive smoking in the PC game room, airborne nicotine concentrations and urinary cotinine concentrations were measured for 20 adolescents at 2 PC game rooms in Sung-nam city. And the subjects were interviewed for duration and time in PC game room and smoking pattern. Subjects are composed of each of 10 smokers(5 males and 5 females) and 10 non-smokers(5 males and 5 females). They stayed for three hours in the PC game room without smoking. Concentrations of nicotine in smokers and non-smokers were 129.72 $\mu\textrm{g}$/㎥ and 99.99 $\mu\textrm{g}$/㎥, respectively. Urinary cotinine concentrations were increased as time goes on after exposure to nicotine and showed maximum value at 9.45 hours after nicotine exposure and were 32.21 and 110.66 $\mu\textrm{g}$/L for non-smoker and smokers. Urinary cotinine has a tendency to be increased by passive smoking. Therefore, it is recommended that the effective control for indoor air quality and extensive research be needed to reduce nicotine concentration by passive smoking in the PC game room.

• Korean Journal of Veterinary Research
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• v.27 no.1
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• pp.53-60
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• 1987

This experiment was performed on mice to investigate the effects of an immunopotentiator, picibanil(PC), on the immune responses such as phagocytic activity of reticuloen-dothelial(RE) system, E rosette formation rate of splenic lmphocytes and morphological changes of lymph node tissue. Groups of mice were treated with a single(1KE/kg BW) or sequential(0.1, 0.25 and 0.5KE/kg BW for successive 3 days) intravenous injections of PC. PC treated and untreated control mice were sensitized with 50% sheep erythrocyte suspension(0.2ml/mouse) at 1, 3, 5, 7 and 10 days after PC treatment. Functional and morphological examinations were carried out 5 days after sensitization. The following results were obtained: The phagocytic activity of RE system and the weight of liver and spleen were increased significantly at 3rd, 5th and 7th day. The peripheral polymorphonuclear leukocyte and percent of lymphocyte and monocyte were slightly increased. The rates of E rosette formation of splenic lymphotytes, sequential PC treated groups were more increased at 3rd and 5th day in sequential PC treated groups than in single treated groups. Thereafter it returned gradually to the control level by the time of 10th day. Microscopically primary lymph follicles with indistinct germinal center (GC) were partially disrupted and the parafollicular areas were consisted of the pyroninophilic cells in control group. In PC treated group, the parafollicular areas were markedly proliferated and developments of secondary lymph follicles with enlarged and prominent GC were more pronounced in the sequential injected groups compared to single injected groups. These results indicate that PC affected not only parafollicular area of the T-cell area, but also GC of the B-cell area. It suggests that PC may potentiate both cell mediated immunity and humoral immunity.

• YAKHAK HOEJI
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• v.49 no.2
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• pp.156-161
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• 2005

Tetrahydropapaveroline (THP) at 5-15 ${\mu}$M has been found to induce L-DOPA-induced oxidative apoptosis in PC12 cells. In this study, the inhibitory effects of THP on dopamine bios ynthesis in PC12 cells and tyrosine hydroxylase (TH) activity in bovine adrenal were investigated. Treatment of PC12 cells with THP at 2.5-10 ${\mu}$M significantly decreased the intracellular dopamine content in a concentration-dependent manner (18.3% inhibition at 10 ${\mu}$M THP). In these conditions, TH activity was markedly inhibited by the treatment with THP at 2.5-10 ${\mu}$M in PC12 cells (23.4% inhibition at 10 $\mu$ M THP). In addition, THP had an inhibitory effect on bovine adrenal TH activity IC50 value, 153.9${\mu}$M). THP exhibited uncompetitive inhibition on bovine adrenal TH activity with a substrate L-tyrosine with the KI value of 0.30 mM. Treatment with L-DOPA at 20~50 ${\mu}$M increased the intracellular dopamine content in PC12 cells, and the increase in dopamine content by L-DOPA was inhibited in part when THP at non-cytotoxic (5-10 ${\mu}$M) or cytotoxic (15${\mu}$M) concentrations was associated with L-DOPA (20 and 50 ${\mu}$M) for 24 h incubation. These results suggest that THP at 5-10${\mu}$M decreases the basal dopamine content and reduces the increased dopamine content induced by L-DOPA in part by the inhibition of TH activity, and that THP at 15${\mu}$M also decreases dopamine content by oxidative stress in PC12 cells.

• The Optical Journal
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• v.13 no.1 s.71
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• pp.43-47
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• 2001

최근 열린 첨단 컴퓨터 장치의 경연장인 컴덱스(2000년 11월 라스베이거스)에서는 PC 자체보다 PC와 연결해 이용하는 주변 이용장치 분야가 각광 받았다. PC카메라를 포함한 PC 주변기기의 세계시장규모는 2003년 10억달러에 달할 것으로 보이며, 앞으로도 지속적인 성장을 보일 것으로 기대된다. 국내는 2000년에 적어도 전해보다 5배 이상 성장했을 것으로 추측된다.

• Journal of Digital Convergence
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• v.11 no.5
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• pp.285-290
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• 2013

In a MPC coding using excitation source of voiced and unvoiced, it would be a distortion of speech waveform. This is caused by normalization of synthesis speech waveform of voiced in the process of restoration the multi-pulses of representation section. To solve this problem, this paper present a method of position compensation(PC-MPC) in a multi-pulses each pitch interval in order to reduce distortion of speech waveform. I was confirmed that the method can be synthesized close to the original speech waveform. And I evaluate the MPC and PC-MPC using multi-pulses position compensation method. As a result, $SNR_{seg}$ of PC-MPC was improved 0.4dB for female voice and 0.5dB for male voice respectively. Compared to the MPC, $SNR_{seg}$ of PC-MPC has been improved that I was able to control the distortion of the speech waveform finally. And so, I expect to be able to this method for cellular phone and smart phone using excitation source of low bit rate.

• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2391-2399
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• 2014

Novel dual responsive pectin hydrogels composed from poly(acrylamidoglycolic acid-co-vinylcaprolactam)/Pectin (PAV-PC) and also PAV-PC hydrogels are used as templates for the production of silver nanoparticles. 5-Fluorouracil is an anticancer drug and has been loaded in situ into PAV-PC hydrogels. Structure and morphology characterization of PAV-PC hydrogels were investigated by fourier transform infrared spectroscopy, differential scanning calorimetry, thermo gravimetric analysis, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. The results revealed a molecular level dispersion of the drug in PAV-PC hydrogels. In vitro release of 5-fluorouracil from the PAV-PC hydrogels has been carried out in GIT fluids as well as in various temperatures. 5-Fluorouracil released from PAV-PC hydrogels was 50% at pH 1.2, and 85% at pH 7.4 within 24 h. The release profile was characterized with PAV-PC hydrogels and initial burst effect was significantly reduced in two buffer media (1.2 and 7.4), followed by a continuous and controlled release phase, the drug release mechanism from polymer was due to Fickian diffusion. In situ fabrication of silver nanoparticles inside the hydrogel network via the reduction of sodium borohydrate by PAV-PC chains led to hydrogel nanocomposites. The diameter of the nanocomposites was about 50-100 nm, suitable for uptake within the gastrointestinal tract due to their nanosize range and mucoadhesive properties. These nanocomposite PAV-PC hydrogels showed strong antimicrobial activity towards Bacillus subtilis (G+ve) and Escherichia coli (G-ve).