• 한국수산과학회지
• /
• 제51권2호
• /
• pp.148-156
• /
• 2018

This study was conducted to evaluate dietary hydrolyzed pig bristle meal (PBM) for juvenile olive flounder Paralichthys olivaceus. In Experiment 1 (EXP-1), six experimental diets were prepared to contain 0, 3, 6, 9, 12 and 15% PBM (designated Con, PBM3, PBM6, PBM9, PBM12 and PBM15, respectively). Triplicate groups of olive flounder (initial body weight, 8.69 g) were fed the diets to apparent satiation for 8 weeks during the optimal water temperature season ($20.5{\pm}2.12^{\circ}C$). All PBM supplemented groups except for PBM3 showed significantly lower growth performance and feed utilization compared to the control group. The protein digestibility of PBM3, PBM6, and PBM9 diets did not significantly differ from that of the control diet. In Experiment 2, 1% mono-calcium phosphate was added into the experimental diets used in Exp-1. Triplicate groups of olive flounder (10.6 g) were fed the diets to apparent satiation for 8 weeks during the low water temperature season ($12.5{\pm}1.12^{\circ}C$). The growth performances and feed utilization of fish fed all diets except for PBM15 diet did not significantly differ from those of the control diet. This study indicates that hydrolyzed PBM can replace fish meal by up to 12% with limiting amino acids and mono-calcium phosphate in diets for juvenile olive flounder.

• 한국광학회지
• /
• 제34권2호
• /
• pp.45-52
• /
• 2023

본 연구에서는 다양한 파장의 저출력 light-emitting diode (LED)를 이용한 photobiomodulation (PBM)이 각막 상처 치유에 미치는 영향을 분석하였다. 각막상피세포에 623 nm에서 940 nm 범위의 파장의 LED를 조사한 결과, 유의미한 세포독성 영향을 미치지 않는 것을 확인하였다. PBM의 세포이동 촉진 효과를 세포 이동능 평가 시험을 통해 분석한 결과 623 nm 파장의 광조사에 의한 PBM이 세포이동을 크게 증가시키고 상처 치유를 촉진하는 것으로 나타났다. 또한, 세포이동 및 상처 치유와 관련된 유전자의 발현을 분석한 결과, 623 nm 파장의 광조사에 의한 PBM이 세포 증식과 세포 외 기질 분해를 촉진하는 것으로 알려진 FGF-1과 MMP2 유전자의 발현을 상향 조절한다는 사실을 발견했다. 이러한 연구 결과는 특정 파장, 특히 623 nm 파장의 저출력 빛을 이용한 PBM이 각막 손상 치료에 활용될 수 있는 가능성을 시사한다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제16권9호
• /
• pp.1355-1359
• /
• 2003

This study examined the replacement of the fish meal (FM) with commercial poultry by-product meal (PBM) in practical diets for rainbow trout (Onchorynchus mykiss, Walbaum). Five isocaloric and isonitrogenous diets containing levels 0 (control), 10, 20, 30 and 40% of PBM as a replacement for FM were fed to three replicate groups of rainbow trout with a initial weight $34.50{\pm}0.43g$ (mean${\pm}$SE). Protein efficiency ratio (PER) of diets containing PBM up to 20% were similar to the control while significantly lower values were obtained from the groups receiving higher levels of PBM (p<0.05). Apparent protein digestibility coefficients (ADCs) were significantly lower than that of the control group when PBM was included at level of 20% or more. Similarly, significantly lower values were observed with diets containing 30 and 40% PBM in terms of dry matter, organic matter, ether extract, ash and energy digestibility (p<0.05). Dietary treatments did not significantly affect the body composition of the fish in terms of dry matter, crude protein, ether extract and ash. In conclusion, PBM in a proportion of 20% may replace about 40 % of FM in rainbow trout diet without significant impairment grow.

• 한국광학회지
• /
• 제32권5호
• /
• pp.235-243
• /
• 2021

Photobiomodulation (PBM) 치료법은 특정 파장대역의 광원이 미토콘드리아에서 ATP 생성을 촉진하는 현상을 이용하는 치료법으로서 상처 치유, 염증 감소, 통증 완화 효과가 있는 것으로 알려져 생물 및 의학 분야에서 많은 관심을 받고 있다. PBM 치료법에 대한 연구는 주로 레이저, 발광다이오드(LED)를 광원으로 사용하였고, 유기발광다이오드(OLED)가 가지는 장점에도 불구하고 PBM 치료법에 사용된 사례는 제한적이다. 본 연구에서는 적색(λ = 620 nm), 녹색(λ = 525 nm), 청색(λ = 455 nm) OLED 조명모듈을 사용하여 PBM에 의한 피부관리 효과를 분석하고 LED에 의한 PBM 효과와 비교하였다. OLED 조명모듈의 PBM에 의한 피부미용효과는 적색 OLED 조명모듈에 의한 collagen type 1 합성량 증가, 녹색 OLED 조명모듈에 의한 melanin 합성 억제, 청색 OLED 조명모듈에 의한 nitric oxide 생성 억제를 각각 측정하여 입증되었다.

• Medical Lasers
• /
• 제9권2호
• /
• pp.89-94
• /
• 2020

Photobiomodulation (PBM) therapy has been investigated to enhance and accelerate the recovery of injured peripheral nerves. Based on the wide range of benefits of PBM therapy and its clinical relevance, this study reviewed the efficacy of PBM in injured facial nerves. The search was performed in the PubMed database to find relevant articles published over the last 10 years. Four animal studies, two randomized controlled studies, one case series, and five case reports were reviewed. Despite the various parameters, functional analysis showed that PBM therapy using near-infrared irradiation has beneficial effects on the recovery of the acute phase of the damaged facial nerve, especially when related to faster functional improvement. There were no reported adverse effects of PBM therapy.

• Medical Lasers
• /
• 제9권2호
• /
• pp.134-141
• /
• 2020

The use of stem cell therapy to treat various diseases has become a promising approach. The ability of stem cells to self-renew and differentiate can contribute significantly to the success of regenerative medical treatments. In line with these expectations, there is a great need for an efficient research methodology to differentiate stem cells into their specific targets. Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), is a relatively non-invasive technique that has a therapeutic effect on damaged tissue or cells. Recent advances in adapting PBM to stem cell therapy showed that stem cells and progenitor cells respond favorably to light. PBM stimulates different types of stem cells to enhance their migration, proliferation, and differentiation in vitro and in vivo. This review summarizes the effects of PBM on targeted differentiation across multiple stem cell lineages. The analytical expertise gained can help better understand the current state and the latest findings in PBM and stem cell therapy.

• 한국식품과학회지
• /
• 제50권4호
• /
• pp.430-436
• /
• 2018

본 연구에서는 여주의 산화방지 활성과 알파글루코시데이스 저해 활성을 측정하고 총폴리페놀, $\text\tiny{L}$-아스코브산, 카란틴, 루테인 등 유효성분의 함량을 분석하였으며 초절임조건에서 카란틴과 루테인의 함량 변화를 비교하였다. 본 실험에 사용된 여주는 카란틴 $777.92{\pm}27.59mg/100g$, 루테인 $16.87{\pm}2.07mg/100g$, $\text\tiny{L}$-아스코브산 $94.78{\pm}0.61mg/100g$, 총폴리페놀 $22.07{\pm}0.74mg\;CE/g$으로 나타났다. 여주추출물의 알파글루코시데이스 저해 활성은 추출물의 농도에 따라 0.5 mg/mL에서 $55.60{\pm}1.34%$, 1 mg/mL에서 $80.40{\pm}0.87%$로 측정되었다. ABTS 라디칼 제거 활성은 여주추출물 5 mg/mL에서 $31.76{\pm}0.42%$, 10 mg/mL $61.98{\pm}0.27%$였고, DPPH 라디칼 제거 활성은 여주추출물 5 mg/mL에서 $56.19{\pm}2.39%$, 10 mg/mL에서 $89.51{\pm}0.25%$로 측정되었다. 여주초절임의 전처리조건별 카란틴과 루테인의 함량을 비교한 결과, 여주초절임의 카란틴 함량은 PBM11 $205.47{\pm}29.91mg/100g$, PBM13 $281.66{\pm}4.45mg/100g$, PBM51 $292.01{\pm}18.20mg/100g$, PBM53 $375.63{\pm}9.03mg/100g$로 대조군 $74.32{\pm}9.57mg/100g$과 비교하여 모두 높게 나타났고. 여주초절임의 루테인 함량은 PBM11 $1.57{\pm}0.13mg/100g$, PBM13 $1.99{\pm}0.28mg/100g$, PBM51 $3.18{\pm}0.52mg/100g$, PBM53 $4.07{\pm}0.40mg/100g$이며 대조군은 $0.70{\pm}0.07mg/100g$보다 모두 높았다. 이는 여주초절임을 제조할 때 소금물침지와 데치기 단계가 여주에 함유된 카란틴과 루테인과 같은 유용성분의 손실이나 파괴를 방지하는 효과가 있는 것으로 판단된다. 특히, 5%소금물 침지와 3분 데치기를 한 PBM53군이 여주초절임의 루테인과 카란틴을 보존하는데 가장 효과적인 것으로 나타났다.

• Medical Lasers
• /
• 제10권4호
• /
• pp.195-200
• /
• 2021

Evidence shows that nerve injury triggers mitochondrial dysfunction during axonal degeneration. Mitochondria play a pivotal role in axonal regeneration. Therefore, normalizing mitochondrial energy metabolism may represent an elective therapeutic strategy contributing to nerve recovery after damage. Photobiomodulation (PBM) induces a photobiological effect by stimulating mitochondrial activity. An increasing body of evidence demonstrates that PBM improves ATP generation and modulates many of the secondary mediators [reactive oxygen species (ROS), nitric oxide (NO), cyclic adenosine monophosphate (cAMP), and calcium ions (Ca²⁺)], which in turn activate multiple pathways involved in axonal regeneration.

• Journal of Electrical Engineering and information Science
• /
• 제2권5호
• /
• pp.100-107
• /
• 1997

W have developed the simplified formalism of PSBM in order to save calculation time and to increase the accuracy. Using this new formalism of PBM, we have evaluated the loss of the three kinds of waveguide; bent, Y-branch, and cascaded Y-branches. It takes nearly half of the conventional PBM calculation time, even in spite of increasing of he calculation accuracy. This simplified formalism of PBM would be used efficiently in analysis of complicated three dimensional dielectric optical waveguide.

• Medical Lasers
• /
• 제10권4호
• /
• pp.189-194
• /
• 2021

Breast cancer-related lymphedema (BCRL) is characterized by the persistent accumulation of interstitial fluid in the peripheral tissues after treatment for breast cancer. Photobiomodulation (PBM) therapy is widely used as supportive care for patients with BCRL. A search was performed in the PubMed database to find relevant articles published over the last 20 years. Randomized controlled trials that evaluated the efficacy of PBM therapy on BCRL were included. A total of 24 studies were identified through the PubMed database. Seven studies were used for the final analysis, after excluding items that did not meet the duplication and inclusion criteria. Although PBM showed some improvement in reducing arm circumference and the symptoms related to BCRL, the results of the meta-analysis did not show any significant benefit in alleviating lymphedema. Further studies are needed with the recruitment of more participants to evaluate the long-term efficacy and safety of PBM in the management of BCRL.