• Title/Summary/Keyword: P2X7r

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The Relation between Obesity among Middle School Students and Total Cholesterol, Blood Glucose and Blood Pressure (일 중소도시 중학생의 비만과 총콜레스테롤, 혈당, 혈압간의 관계)

  • Kim Eun Young
    • Journal of Korean Public Health Nursing
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    • v.19 no.1
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    • pp.5-17
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    • 2005
  • This research was conducted to determine the actual condition of obesity and obese students' total cholesterol. blood glucose and blood pressure, and to analyze the relationship between the obesity rate and total cholesterol. blood glucose and blood pressure among the students at 7 middle schools in A city in Kyoung ki-do. The results were as follows: 1. Among 12,148 student participants in this investigation. students of normal weight range were $91.5\%$ and obese students were $8.5\%$, breaking down to mildly obese of $4.3\%$ $(boys,\;5.4\%;\;girls,\;3.0\%)$. moderately obese of $3.4\% (boys,\;4.6\%;\;girls,\;2.1\%)$ and severely obese of $0.7\%(boys,\;0.9\%;\;girls,\;0.5\%)$, The gender difference was statistically significant $(x^2=111.5830. p=.0001). 2. To analyze the 1.027 obese students. the average of total cholesterol was 166.9mg/dl, 171.0mg/dl and 182.1mg/dl in the mild, moderate and severe obesity groups, respectively. The results became more significant with increasing obesity rate (F=10.06, p=.0001). The average of systolic blood pressure (SBP) was 121.9mmHg, 123.2mm, and 127.5mm, respectively. The results became more significant with increasing obesity rate (F=6.29, p=.0019). The average of diastolic blood pressure (DBP) was 74.4mmHg. 76.0mmHg. and 78.4mmHg, respectively. The results became more significant with increasing obesity rate (F=8.15. p=.0003). The average of blood glucose was 83.3mg/dl, 84.5mg/dl, and 82.3mg/dl, respectively. There was no significant difference with obesity rate. 3. There were significant correlations between obesity rate and cholesterol(r=.11288, p=.0003), between obesity rate and DBP(r=.14209, p=.000l). and between obesity rate and SBP(r=.14081. p=.0001). However, there was no significant correlation between obesity rate and blood glucose (r=.00655, p=.8339).

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Prediction of Water Activity for Gelatinized Model Foods (모형식품의 수분활성도 예측)

  • Jung, Seung-Hyeon;Chang, Kyu-Seob;Park, Young-Deok
    • Korean Journal of Food Science and Technology
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    • v.25 no.2
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    • pp.94-97
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    • 1993
  • This study was to predict water activity of gelatinized model foods containing moisture, protein and starch with different concentration of humectants such as sodium chlorife and sucrose. The water activity of each samples were determinded by electrical hygrometry. The degree of lowering water activity in model foods with humectant solutions was following order as NaCl>sucrose. Model food $P_2S_1$ was predominant in depression of water activity by humectants than other model foods. The multiple regression equations between water activity and different humectants concentration, compositions and solution ratio of model foods were obtained and $R^2$ values were higher than 0.91.

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Synthesis and Structure of Tetrahomodioxa p-phenylcalix(4)arene dihexylether (Tetrahomodioxa p-phenylcalix(4) arene dihexylether의 합성 및 구조에 관한 연구)

  • 노광현;박영자
    • Korean Journal of Crystallography
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    • v.13 no.3_4
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    • pp.158-164
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    • 2002
  • Tetrahomodioxa p-phenylcalix(4)arene dihexylether(C/sub66/H/sub68/O/sub6/) has been synthesized and structurally characterized by X-ray diffraction. Reaction of tetrahomodioxa p-phenylcalix(4)arene with hexyl halide and NaH in DMF leads to the dihexyl derivatives, 7,13,21,27-tetraphenyl-29,31-dihexyloxy- 2,3,16,17-tetrahomo-3,17-dioxacalit(4)arenes. The crystal is orthorhombic, P2₁2₁2₁, a= 9.764(2), b=16.167(2), c=32.994(3) Å, V=5208(1) Å, Z= 4, Dc = 1.221 gcm/sup -3/. The structure was solved by direct methods and refined by full-matrix least squares. Refinement converged at R = 0.070 for 2009 observed reflections. This molecule has a C-1,2-alternate conformation with pseudo-centrosymmetry and has two pairs of opposite phenyl rings, which are approximately parallel to each other. The benzene rings A and B are up, and the rings C and D rings are down with respect to the plane of the macrocyclic ring.

The Soil Factors Affecting the Growth of Populus alba X glandulosa (Populus alba X glandulosa의 생장과 토양인자화의 관계)

  • Son Doo-sik;Kim Kyu-hyun;Lee Weon-Yeol
    • Journal of Korea Foresty Energy
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    • v.1 no.2
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    • pp.20-27
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    • 1981
  • Populus alba x glandulosa shows greater growth performance in the lower part of the hill than in the upper part. In order to study this reason, correlation between the soil factors and the growth was examined. The results were as follows. 1. Annual mean height growth was 1.29m in foot hill but 0.7m in upper part, showing 184$\%$ better growth in the foot hill than in the upper part and the similar situation was shown in the diameter growth. The longer slope distance, the better growth: generally the good growth shows in the first harf of the distance. 2. High positive correlation shows between the growth performance and soil moisture: r=0.76 in the hight and r=0.71 in the diameter, and also positive correlation between soil depth and the growth performance. r=0.65 in the height and r=0.79 in the diameter. On the other hand, negative correlation between the slope and soil depth are considered as limiting factors to the growth. 3. A significant correlation appeared between growth performance and organic matter and between the growth performance and total nitrogen as well. This shows that the nutrient elements were contained much in the foot hill. 4. The correlation between the height growth and potassium, and between the growth and calcium and pH were shown . 5. However, no correlation was shown between the growth and available phosphate, magnesium and available managanese .

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Identification of novel mutations of the ATP7A gene and prenatal diagnosis of Menkes disease by mutation analysis (DNA 분석을 이용한 ATP7A 유전자의 새로운 돌연변이 발견과 멘케스병의 산전 진단)

  • Choi, Jin-Ho;Kim, Gu-Hwan;Yoo, Han-Wook
    • Journal of Genetic Medicine
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    • v.4 no.1
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    • pp.38-44
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    • 2007
  • Purpose : Menkes disease is an X-linked recessively inherited disorder caused by the mutation of the ATP7A gene encoding copper-transporting P-type AT Pase. The phenotypic features are progressive neurological degeneration, mental retardation, loose skin, and vascular complications. Early diagnosis and treatment are very important for the prognosis of Menkes disease. Here, we describe nov el mutations of the ATP7A gene and prenatal diagnosis by mutation analysis. Methods : Five unrelated Korean Menkes patients were included in this study. They presented with depigmented wool-like hair, progressive neurologic deterioration, and hypotonia in infancy. Serum copper and ceruloplasmin levels w ere decreased. Brain magnetic resonance imaging revealed tortuous intracranial vessels. Mutation analysis has been carried out using cDNA from cultured skin fibroblasts or genomic DNA from peripheral leukocytes. Prenatal diagnosis was performed in two cases using chorionic villi samples or amniocytes. Results : Four novel mutations have been identified from four different families; c.3511+1G>A (p.E1099_N1171delinsMfsX 18), c.4005+5 G>A (p.V1268_R1335del), c.1870_2172del (p.S624_Q724del), and c.3352 G>A (p.G1118S). T he remaining one was previously reported (c.1933 C>T (p.V 1268_R1335del)). On prenatal DNA analysis, one w as diagnosed as normal, while the other turned out to be a female heterozygote with p.S624_Q724del mutation of the ATP7A gene. Conclusion : We identified 4 novel mutations of the ATP7A gene. Prenatal diagnosis in families at risk is critical in order to choose preventiv e options including an early treatment with copper-histidine therapy or therapeutic termination. Most mutations of the ATP7A gene were frame-shift mutations and prenatal diagnosis has been successfully carried out.

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Biochemical Overripeness Characterization of Artificially Maturated Japanese Eel Anguilla japonica Egg (인위적으로 성숙시킨 뱀장어 Anguilla japonica 성숙란의 생화학적 과숙 특징)

  • Kwon, O-Nam;Adachi, Shinji
    • Journal of Aquaculture
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    • v.21 no.3
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    • pp.176-180
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    • 2008
  • This study clarified biochemical overripeness characterization of ovulated eggs of Anguilla japonica and suggested a method maintained overripeness after ovulation for high hatching rates. In maturated Japanese eel eggs, the relationships between fertilization rate and hatching rate, and fertilization and survival rates were measured. DNA contents showed the significantly low 0.653 pg/ug protein in 20% downward hatching rate trial with decrease of hatching rate(P<0.05), whereas RNA/DNA ratio showed the significantly high 1.058 in 20% downward hatching rate trial(P<0.05). And activities of total alkaline protease and ACPase according to the hatching rate groups did not show the significant difference(P>0.05). The protein contents were assayed the significantly high 186.16 ug/mg protein in 20% downward hatching rate trial(P<0.05). However, the overripened eggs had lowed hatching rate, because of stimulate the overripening of normal maturated eggs due to the continuous supplement of protein (vitellogenin). We suggested that need to reduce supplement speed or interception of vitellogenin produced in live for prevent overripeness of maturated eggs after ovulation

Pulmonary artery index as a predictor of early postoperative result and a critrion for rastelli operation of cyanotic congenital heart disease (폐동맥 면적지표가 청색증 심장 기형에 있어서 라스텔리씨 수술후 조기 예후 판정에 미치는 영향)

  • Kim, Jin-Guk;No, Jun-Ryang
    • Journal of Chest Surgery
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    • v.21 no.6
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    • pp.957-969
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    • 1988
  • There is tendency of increasing number and decreasing age of patients who are indicated for Rastelli operation for their cyanotic congenita heart disease. So there is the need to find the creiterion which saves the patients from early postoperative hemodynamic disturbances. We reviewed the 26 patients who had been performed Rastelli operation at Seoul national University hOipital from January 1981 to June 1988. mean age of the patients was 7.8 $\pm$ 3.4 years (range 2.5-1.5 years), mean body surface area(BSA) 0.79 $\pm$ 0.25 $m^{2}$(range 0.49-1.51 $m^{2}$) and mean hematocrit 57.95 $\pm$ 12%(range 48-80%). We diveded these patients into survived group and died group before postoperative 72 hours, and analysed preoperative arterial oxygen saturation($SaO_{2}$), the ratio of diameter of fight pulmonary artery to ascending aorta(RA:/AA), the ratio of both right and left pulmonary artery diameter to descending thoracic aorta(RPA+LPA/DTA), pulmonary artery index(PA index), cardiopulmonary bypass time, aorta cross-clamping time, postoperative perfusion state and total amount of dopamine infused postoperatively. The results showed that RPA+LPA/DTA and PA index were statistically significatn factors to influence early postoperative cardiac death rate (P<0.05). Especially there were good linear correlations between PA index(X) and perpheral perfusion index(Y)(Y = -1.15 + 0.02 X, r = 0.86, P<0.01) and between PA index(X) and total amount of dopamine infused before postoperative 72 hours(mg/kg, Y)(Y = 61.94 - 0.15 X, r = - 0.80, P<0.01). Also there were tendencies that the higher RPA + LPA/DTA(Y), the betterperipheral perfusion (X) and the lower need of dopamine(X), but no statistical significance. (Y = 0.78 + 1.60 X, r = 0.49, P>0.05) And the discrimant analysis showed that patients with PA index over 221 $mm^{2}$/BSA could undergo correction with 25 per cent of error rate. In conclusion, early postoperative hemodynamic states could be predicted by preoperatively measured PA index, and which can be used as a criterion for Rastelli operation performed on cyanotic congenital heart disease.

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Influence of changing combustor pressure and secondary fuel injection on flame stabilization and emission characteristic in swirl flame (연소실 압력변동과 2차 연료 분사가 스월 화염에서 화염안정화와 배출 특성에 미치는 영향)

  • Kim, Jong-Ryul;Choi, Gyung-Min;Kim, Duck-Jool
    • 한국연소학회:학술대회논문집
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    • 2007.05a
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    • pp.133-138
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    • 2007
  • Influence of changing combustor pressure on flame stabilization and emission index in the swirl-stabilized flame was investigated The combustor pressure was controlled by suction fan at combustor exit. Pressure index ($P^{\ast}=P_{abs}/P_{atm}$), where $P_{abs}$ and $P_{atm}$ indicated the absolute pressure and atmosphere pressure, respectively, was controlled in the range of $0.7{\sim}1.3$ for each equivalence ratio conditions. The flammable limits of swirl flames were largely influenced by changing combustor pressure and they showed similar tendency with laminar flames. $NO_x$ emission index decreased with decreasing pressure index for overall equivalence ratio conditions. R.m.s. of pressure fluctuations is increased with decreasing combustor pressure. This flame fluctuation caused incomplete combustion , hence CO emission index increased. These oscillating flames were measured by simultaneous $CH{\ast}$ chemiluminescence time-series visualization and pressure fluctuation measurement.

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Effect of Maternal Under-nutrition during Late Pregnancy on Lamb Birth Weight

  • Gao, F.;Hou, X.Z.;Liu, Y.C.;Wu, S.Q.;Ao, C.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.3
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    • pp.371-375
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    • 2008
  • This study investigated the effects of maternal undernutrition during late pregnancy on lamb birth weight. 45 Mongolian ewes, synchronized for oestrus and then mated, were divided into four groups and offered 0.86 MJME/kgw-0.75d-1 (control group; CG : ad libitum access to feed), $0.44MJME/kgw^{-0.75}d^{-1}$ (Restricted Group 3; R3), $0.33MJME/kgw^{-0.75}d^{-1}$ (Restricted Group 2; R2) and $0.20MJME/kgw^{-0.75}d^{-1}$ (Restricted Group 1; R1) respectively during late pregnancy (90-150 days). During restriction, maternal net body weight loss, insulin and NEFA concentrations and lamb birth weight were measured. The results indicated that loss of maternal body weight in R3, R2 and R1 was 4.42, 7.23, 11.13 kg respectively, which was significantly (p<0.01) higher than that in CG (0.93 kg). Insulin concentrations of the ewes in R1, R2 and R3 were lower and were significantly different (p<0.05) between restricted groups and CG at 124 d of pregnancy. NEFA concentrations in all groups tended to decrease from 90d of gestation to parturition and in R1 were significantly (p<0.05) lower than in CG at 124 d of gestation. Lamb birth weight in R1 was significantly lower than in R2, R3 and CG (p<0.05). In conclusion, with decreasing supply of maternal nutrition, the retardation of fetal growth became worse. When the plane of nutrition was below $0.33MJME/kgw^{-0.75}d^{-1}$, significant effects of maternal undernutrition on lamb birth weight were observed.

Efficacy of a Protective Grass Shield in Reduction of Radiation Exposure Dose During Interventional Radiology (방사선학적 중재적 시술시 납유리의 방사선 방어효과에 관한 연구)

  • Jang, Young-Ill;Song, Jong-Nam;Kim, Young-Jae
    • Journal of the Korean Society of Radiology
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    • v.5 no.5
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    • pp.303-308
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    • 2011
  • Background/Aims : The increasing use of diagnostic and therapeutic interventional radiology calls for greater consideration of radiation exposure risk to radiologist and radiological technician, and emphasizes the proper system of radiation protection. This study was designed to assess the effect of a protective grass shield. Methods : A protective grass was following data depth, 0.8 cm; width, 100 cm; length, 100 cm, lead equivalent, 1.6 mmPb. The protective shield was located between the patient and the radiologist. Thirty patients (13 male and 17 female) undergoing interventional radiology between September 2010 and December 2010 were selected for this study. The dose of radiation exposure was recorded with or without the protective grass shield at the level of the head, chest, and pelvis. The measurement was made at 50 cm and 150 cm from the radiation source. Results : The mean patient age was 69 years. The mean patient height and weight was $159.7{\pm}6.7$ cm and $60.3{\pm}5.9$ kg, respectively. The mean body mass index (BMI) was $20.5{\pm}3.0$ kg/m2. radiologists received $1530.2{\pm}550.0$ mR/hr without the protective lead shield. At the same distance, radiation exposure was significantly reduced to $50.3{\pm}85.2$ mR/hr with the protective lead shield (p-value<0.0001). The radiation exposure to radiologist and radiological technician was significantly reduced by the use of a protective lead shield (p value <0.0001). The amount of radiation exposure during interventional radiology was related to the patient' BMI (r=0.749, p=0.001). Conclusions : This protective shield grass is effective in protecting radiologist and radiological technician from radiation exposure.