• Analytical Science and Technology
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• v.13 no.3
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• pp.323-331
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• 2000

Two chelating resins, XAD-16-TAC and XAD-16-TAO were synthesized by Amberlite XAD-16 macroreticular resin with 2-(2-thiazolylazo)-p-cresol (TAC) and 4-(2-thiazolylazo)-orcinol (TAO) as functional groups. The sorption behaviour of Zr(IV), Th(IV) and U(VI) with two chelating resins were examined with respect to the effect of pH and masking agent by batch methods. It was obtained that the optimum pH was in the range of 5-6, and two chelating resins showed good separation efficiency of Zr(IV) or Th(IV) by using $NH_4F$ as a masking agent. Characteristics of desorption were investigated with 0.1-2 M $HNO_3$ as desorption agent. It was found that 2 M $HNO_3$ showed high desorption efficiency to most of metal ions except Zr(IV). XAD-16-TAC resin is applied to separation and preconcentration of trace Zr(IV) from mixed metal ions. Also, Th(IV) ion can be successfully separated from U(VI) and Zr(IV) ion by using XAD-16- TAO resin.

• Archives of Pharmacal Research
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• v.6 no.2
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• pp.115-121
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• 1983

Cholesteryl p-[3-(2-chloroethyl_-3-nitrosoureido] phenylthioaccetate (2) was synthesized : an intermediate, p-[3(2-chloroethyl_-3-nitrosoureido] phenylthioacetic acid (1) is a congener of an antitumor chlorambucil which both the -CH$_{2}$CH$_{2}$-linkage and -N(CH$_{2}$CH$_{2}$Cl)$_{2}$ group of chlorambucil molecule is doubly modified into the respective -S-linkage and -NH-CO-NNO-CH$_{2}$CH$_{2}$CL group. The attackment of cholesterol moiety as a carrier group to p-[3-(2-chloroethyl-3nitrosoureido] phenylthioacetic acid was accomplished through the esterification of cholesterol with p-[3-(2-chloroethyl-3-nitrosoureido] phenylthioacetyl chloride which was obtained from the treatment of p-[3-(2-chloroethyl)-3-nitrosourei-do] phenylthioaceticacid with SOCL$_{2}$, p-[3-(2-chloroethyl)ureido]]-phenythioacetic acid was nitrosated with NaNO$_{2}$ IN 98-100% HCOOH to give exclusively p-[3-(2-chloroethyl_-3-nitrosoureido] phenylthioacetic acid. Antitumor evaluation of compounds, 1 and 2 on L 1210 leukemia did show significant activity (ED$_{40}$ : 1.14.mu./ml and 8.4.mu.g/ml, repectively). Further studies were subjected..

• Macromolecular Research
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• v.17 no.9
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• pp.709-713
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• 2009

The aim of this study was to develop novel intestinal specific drug delivery systems with pH sensitive swelling and drug release properties. The carboxyl group of ibuprofen was converted to a vinyl ester group by reacting ibuprofen and vinyl acetate as an acylating agent in the presence of catalyst. The glucose-6-acrylate-1, 2, 3, 4-tetraacetate (GATA) monomer was prepared under mild conditions. Cubane-1, 4-dicarboxylic acid (CDA) linked to two 2-hydroxyethyl methacrylate (HEMA) group was used as the crosslinking agent (CA). Methacrylic-type polymeric prodrugs were synthesized by the free radical copolymerization of methacrylic acid, vinyl ester derivative of ibuprofen (VIP) and GATA in the presence of cubane cross linking agent. The structure of VIP was characterized and confirmed by FTIR, $^1H$ NMR and $^{13}C$ NMR spectroscopy. The composition of the cross-linked three-dimensional polymers was determined by FTIR spectroscopy. The hydrolysis of drug polymer conjugates was carried out in cel-lophane membrane dialysis bags, and the in vitro release profiles were established separately in enzyme-free simulated gastric and intestinal fluids (SGF, pH 1 and SIF, pH 7.4). The detection of a hydrolysis solution by UV spectroscopy at selected intervals showed that the drug can be released by hydrolysis of the ester bond between the drug and polymer backbone at a low rate. Drug release studies showed that increasing the MAA content in the copolymer enhances the rate of hydrolysis in SIP. These results suggest that these polymeric prodrugs can be useful for the release of ibuprofen in controlled release systems.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.431-437
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• 2015

This convergence study analyzed the effectiveness of contrast agent reduction by normal saline solution dilution in the computed tomography of arteries of lower limb. 48 patients of 125 cc contrast agent and 30 patients of the same amount divided at a ratio of 7:3 for the contrast agent and normal saline solution were studied. The average attenuation coefficient(HU) and signal to noise ratio(SNR) of abdominal aorta, femoral artery, popliteal artery and posterior tibial artery at each image were evaluated quantitatively and the four criteria in the five point scale was conducted qualitatively by two radiologists and four radiological technologists. In the quantitative evaluation, both HU and SNR had high average score before dilation but there were no statistical significance by independent t-test(p>0.05). In the qualitative evaluation, there were a little differences in the average scores between 4.86~4.77 of original contrast agent and 4.83~4.67 of dilated contrast agent but there were no statistical significance(p>0.05). In the computed tomography of arteries of lower limb, the dilated contrast agent doesn't influence image quality and reduces overall contrast agent and lowers iodine content per unit of molecular therefore will contribute to decrease side effect of contrast agent.

• Journal of Dental Rehabilitation and Applied Science
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• v.32 no.4
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• pp.293-300
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• 2016

Purpose: The purpose of this study is finding proper bonding agents to be used when adding bis-acryl composite provisional materials. Materials and Methods: Three bonding agents with different chemical compositions were included in this study. Forty disk shaped specimens of bis-acryl composite provisional material were prepared and divided into 4 groups according to the bonding agents. Control group didn't have bonding agent. Through the Teflon mould with 4.0 mm diameter hole with 4.0 mm thickness the same bis-acryl composite provisional material was added on the disks after the surface of each specimen was treated with designated bonding agent according to the manufacturer's instructions. Shear bond test was performed and the fractured surfaces were inspected with a microscope. One-way analysis of variance was conducted and the result was further analysed with Turkey post hoc test at the significance level of 0.05. Results: The highest strength was acquired from the specimens bonded with chemical cure system and it was statistically significant (P < 0.05). This group showed 100% cohesive failures. The lowest bonding strength was recorded from the specimens used conventional light cure bonding agent, and this group's result was similar with the control group. The group used a light cure bonding agent claiming improved compatibility revealed significantly higher bond strength to the traditional light cure bonding agent group in a statistically significant way (P = 0.043). Conclusion: According to the bonding agent used the shear bond strength was significantly affected. Therefore the choice of proper bonding agent is important when hiring a bonding agent to add bis-acryl composite provisional materials.

• Journal of the korean academy of Pediatric Dentistry
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• v.34 no.2
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• pp.204-214
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• 2007

The aim of this study was to investigate whether differences in surface treatment prior to repair influenced the seal of a resin fissure sealant placed on the occlusal surfaces of permanent molar teeth. One hundred and twenty extracted human molars were selected and a light curing sealant was placed on their occlusal surface following cleaning by prophylaxis and acid etching. The teeth were deliberately damaged, and then stored in artificial saliva for four weeks. Sixty teeth with the desired morphology of sealant failure were randomly divided into four groups where one group was treated with only etching agent, another by only air-abrasion, another by applying an etching agent followed by a bonding agent, and the last by air-abrasion followed by a bonding agent each. After sealant application, the samples were thermocycled and the degree of microleakage was determined. The results were as follows : 1. In the sealant/sealant interface group 2(0.22), 4(0.23) using air-abrasion showed a significantly lower microleakage score than group 1(0.38), 3(0.35) using an etching agent(p<0.05). There were no statistically significant differences(p>0.05) between groups 1, 2 and groups 3, 4. 2. In the sealant/tooth interface, group 3(0.20), 4(0.20) which used a bonding agent showed a significantly lower microleakage score than group 1(0.35), 2(0.40) (p<0.05). There were no statistically significant differences(p>0.05) between groups 1, 3 and groups 2, 4. 3. In SEM examination, while sealant surfaces treated with etching did not result in highly rough surfaces, those treated with air-abrasion did show rough surfaces.

• Journal of the Korea Organic Resources Recycling Association
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• v.7 no.1
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• pp.43-52
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• 1999

This study was carried out to investigate how much coal fly ash could be substituted for sawdust as a bulking agent for livestock waste composting. The mixtures of coal fly ash and sawdust in the weight ratio of 8 to 2, 7 to 3, 6 to 4, 5 to 5, 4 to 6, 3 to 7 and 2 to 8 were added to livestock waste as the bulking agent. The same amount of the bulking agents and livestock waste was mixed and composted during 21 days. Following effects were analyzed during composting experiment : the variation of temperature, pH and various compound contents. The results were summarized as follows: The more the sawdust was added, the higher the maximum temperature in slurry type livestock farm but faster it reached in scrapper type. Water content was maintained under good condition by adding the bulking agent mixed of the same amount of coal fly ash and sawdust. pH was in the range of 7~10 by adding the bulking agent mixed of the same amount of coal fly ash and sawdust. The more the sawdust was added, the higher organic matter content was measured. Nitrogen content with increasing the amount of sawdust added but it was higher did not showed any tendency Organic matter/Nitrogen ratio reduced during the composting period in scrapper type but it showed contrary tendency in slurry type with that of scrapper type.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.7
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• pp.2708-2712
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• 2010

Amines, ammonia or 3-methoxypropylamine (MPA), are used to maintain the optimized pH for the prevention of corrosion in the secondary side of Pressurized Water Reactors (PWRs). They are differently dissociated as a function of temperature which is not same in each location of the water-steam cycle. pH at the operation temperature depends on temperature of fluid and equilibrium constants of water and amines. Thus, every amine provides the different pH in the entire secondary side so that pH is not only the sufficient parameter in corrosion control. The secondary parameter, i.e., buffer intensity, is the ability to maintain a stable pH when $H^+$ are added or removed due to the ingress of impurities or the reaction of corrosion. The buffer intensity is necessary to provide the selection criteria for the best pH control agent for secondary side and the basic understanding of the reason why the flow-accelerated corrosion(FAC) rate may demonstrate the bell-shape curve over temperature. The buffer intensities of ammonia and MPA were reviewed over the entire operation temperature of PWRs. The sufficient buffer intensity is provided for the inhibition of corrosion by ammonia in low temperature $(25{\sim}100^{\circ}C)$ and by DMA in high temperature $(150{\sim}250^{\circ}C)$. In terms of buffer intensity, i) the best pH control agent is an amine with $pK_a(T)$ range of pH(T)- $1{\leq}pK_a(T){\leq}pH(T)$ + 0.5 and ii) the amine solution should have sufficient buffer intensity, ${\beta}$ to inhibit corrosion, and iii) FAC rate may be maximum at the temperature, where ${\beta}_B/{\beta}$ ratio is lowest.

• Transactions on Electrical and Electronic Materials
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• v.6 no.1
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• pp.29-32
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• 2005

Chemical mechanical polishing is an essential process in the production of copper-based chips. On this work, the stability of hydrogen peroxide ($H_{2}O_{2}$) as an oxidizer of copper CMP slurry has been investigated. $H_{2}O_{2}$ is known as the most common oxidizer in copper CMP slurry. But $H_{2}O_{2}$ is so unstable that its stabilization is needed using as an oxidizer. As adding KOH as a pH buffering agent, stability of $H_{2}O_{2}$ decreased. However, $H_{2}O_{2}$ stability in slurry went up with putting in small amount of BTA as a film forming agent. There was no difference of $H_{2}O_{2}$ stability between pH buffering agents KOH and TMAH at similar pH value. Addition of $H_{2}O_{2}$ in slurry in advance of bead milling led to better stability than adding after bead milling. Adding phosphoric acid resulted in the higher stability. Using alumina C as an abrasive was good at stabilizing for $H_{2}O_{2}$.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2005.11a
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• pp.399-402
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• 2005

기존의 사용자 성향 분석 방법은 사용자의 정보를 일정 수준 이상 축적하고, 이를 분석하여 필요한 서비스를 지원해 준다. 하지만 유비쿼터스 컴퓨팅 환경에서는 사용자의 정보가 전혀 축적되지 않아도 사용자의 현재 상황에 적합한 서비스가 제공되어야 한다. 본 논문에서는 지능형 P2P 모바일 에이전트를 이용하여 사용자의 컨텍스트 정보를 공유하고 유사한 사용자들을 그룹화시킴으로써, 사용자의 성향을 분석하는 시간과 비용을 최소화할 수 있는 사용자 성향 분석 시스템을 제안한다.