• 대한산업공학회지
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• 제28권3호
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• pp.240-246
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• 2002

In this paper, economic screening procedures with dichotomous performance variable T and continuous screening variable X are considered when the rejected items are reprocessed. Two models are considered; normal and logistic models. It is assumed that X given T is normally distributed in the normal model, and P(T=1|X=x) is given by a logistic function in the logistic model. Profit models are constructed which involve four price/cost components; selling price, cost from an accepted nonconforming item, and reprocessing and inspection costs. Methods of finding the optimal screening procedures are presented and numerical examples are given.

• KIEE International Transactions on Electrophysics and Applications
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• 제3C권1호
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• pp.1-4
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• 2003

This paper presents an attempt to develop probabilistic multistress life models to evaluate the lifetime characteristics of epoxy-encapsulated magnet wire with heavy build polyurethane enamel. A set of accelerated life tests were conducted over a wide range of pulsating voltages, temperatures, and frequencies. Samples of fine gauge twisted pairs of the encapsulated magnet wire were tested us-ing a pulse endurance dielectric test system. An electrical-thermal lifetime function was combined with the Weibull distribution of lifetimes. The parameters of the combined Weibull-electrical-thermal model were estimated using maximum likelihood estimation. Likewise, a generalized electrical-thermal-frequency life model was also developed. The parameters of this new model were estimated using multiple linear regression technique. It was found in this paper that lifetime estimates of the two proposed probabilistic multistress life models are good enough. This suggests the suitability of using the general electrical-thermal-frequency model to estimate the lifetime of the encapsulated magnet wire over a wide range of voltages, temperatures and pulsating frequencies.

• Steel and Composite Structures
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• 제7권5호
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• pp.405-419
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• 2007

This paper presents the development of some numerical models based on the results of laboratory tests performed on axially loaded RC columns strengthened with steel angles and strips. These numerical models consider the nonlinearity of the building materials and the effects of the contact interfaces between different materials. The results of the finite element models accurately describe the general behaviour of the strengthened columns. This study allows engineers to assess the relative importance of the mechanisms acting on the strengthened RC columns. Constructive recommendations are also provided in this paper.

• Water Engineering Research
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• 제3권2호
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• pp.143-153
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• 2002

As the natural flows in rivers dramatically decrease during drought season in Korea, a deterioration of river water quality is accelerated. Thus, consideration of downstream water quality responding to changes in reservoir release is essential for an integrated watershed management with regards to water quantity and quality. In this study, water quality models based on artificial neural networks (ANNs) method were developed using historical downstream water quality (rm $\NH_3$-N) data obtained from a water treatment plant in Geum river and reservoir release data from Daechung dam. A nonlinear multiple regression model was developed and compared with the ANN models. In the models, the rm NH$_3$-N concentration for next time step is dependent on dam outflow, river water quality data such as pH, alkalinity, temperature, and rm $\NH_3$-N of previous time step. The model parameters were estimated using monthly data from Jan. 1993 to Dec. 1998, then another set of monthly data between Jan. 1999 and Dec. 2000 were used for verification. The predictive performance of the models was evaluated by comparing the statistical characteristics of predicted data with those of observed data. According to the results, the ANN models showed a better performance than the regression model in the applied cases.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.1047-1055
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• 2014

Background: MicroRNAs (miRNAs) are an abundant class of endogenous small non-coding RNAs of 20-25 nucleotides in length that function as negative gene regulators. MiRNAs play roles in most biological processes, as well as diverse human diseases including cancer. Recently, many studies investigated the association between SNPs in miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs229283, miR-499 rs3746444 and colorectal cancer (CRC), which results have been inconclusive. Methodology/Principal Findings: PubMed, EMBASE, CNKI databases were searched with the last search updated on November 5, 2013. For miR-196a2 rs11614913, a significantly decreased risk of CRC development was observed under three genetic models (dominant model: OR = 0.848, 95%CI: 0.735-0.979, P = 0.025; recessive model: OR = 0.838, 95%CI: 0.721-0.974, P = 0.021; homozygous model: OR = 0.754, 95%CI: 0.627-0.907, P = 0.003). In the subgroup analyses, miR-$196a2^*T$ variant was associated with a significantly decreased susceptibility of CRC (allele model: OR = 0.839, 95%CI: 0.749-0.940, P = 0.000; dominant model: OR = 0.770, 95%CI: 0.653-0.980, P = 0.002; recessive model: OR = 0.802, 95%CI: 0.685-0.939, P = 0.006; homozygous model: OR = 0.695, 95%CI: 0.570-0.847, P = 0.000). As for miR-149 rs2292832, the two genetic models (recessive model: OR = 1.199, 95% CI 1.028-1.398, P = 0.021; heterozygous model: OR = 1.226, 95% CI 1.039-1.447, P = 0.013) demonstrated increased susceptibility to CRC. On subgroup analysis, significantly increased susceptibility of CRC was found in the genetic models (recessive model: OR = 1.180, 95% CI 1.008-1.382, P = 0.040; heterozygous model: OR = 1.202, 95% CI 1.013-1.425, P = 0.013) in the Asian group. Conclusions: These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC.

• 구강회복응용과학지
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• 제30권3호
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• pp.223-230
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• 2014

목적: 하악 절치 발치 치료를 받은 환자들의 치료로 인한 향상과 유지기간 후의 안정성을 평가하는 것이다. 연구 재료 및 방법: 하악 절치를 발치한 환자 총 20명을 대상으로 치료 전, 치료 직후, 2년의 유지기간 후의 모형 및 파노라마 방사선 사진을 분석하였다. Irregularity index, overjet, overbite, 치아 크기와 악궁 길이의 차이, 견치간 폭경, 제1 대구치간 폭경 및 미국교정학회에서 제시한 방법(ABO-CRE)을 평가하였다. 통계분석은 Wilcoxon signed-rank test를 이용하였다. 결과: 치료 전후 irregularity index가 유의하게 감소되었고(P = 0.000), 치아 크기와 악궁 길이의 차이는 유의하게 증가 하였다(P = 0.028). 유지기간 동안에 irregularity index는 유의하게 악화 되었다(P = 0.001). ABO-CRE 전체값의 변화는 치료 전후에 유의한 감소를 보이고(P = 0.000), 유지 전후에는 유의한 차이를 보이지 않았다(P = 0.053). 결론: 모형과 파노라마 방사선 사진을 이용하여 치료의 안정성 평가 결과, 하악 절치 발치 치료는 2년간의 유지기간 동안 치료 결과가 안정적으로 유지되었다고 할 수 있다.

• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1123-1127
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• 2012

P-gp (P-glycoprotein) is a member of the ATP binding cassette (ABC) family of transporters. It transports many kinds of anticancer drugs out of the cell. It plays a major role as a cause of multidrug resistance (MDR). MDR function may be a cause of the failure of chemotherapy in cancer and influence pharmacokinetic properties of many drugs. Hence classification of candidate drugs as substrates or nonsubstrate of the P-gp is important in drug development. Therefore to identify whether a compound is a P-gp substrate or not, in silico method is promising. Recursive Partitioning (RP) method was explored for prediction of P-gp substrate. A set of 261 compounds, including 146 substrates and 115 nonsubstrates of P-gp, was used to training and validation. Using molecular descriptors that we can interpret their own meaning, we have established two models for prediction of P-gp substrates. In the first model, we chose only 6 descriptors which have simple physical meaning. In the training set, the overall predictability of our model is 78.95%. In case of test set, overall predictability is 69.23%. Second model with 2D and 3D descriptors shows a little better predictability (overall predictability of training set is 79.29%, test set is 79.37%), the second model with 2D and 3D descriptors shows better discriminating power than first model with only 2D descriptors. This approach will be used to reduce the number of compounds required to be run in the P-gp efflux assay.

• 한국환경과학회지
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• 제24권11호
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• pp.1393-1404
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• 2015

Ten empirical disinfection models for the plasma process were used to find an optimum model. The variation of model parameters in each model according to the operating conditions (first voltage, second voltage, air flow rate, pH, incubation water concentration) were investigated in order to explain the disinfection model. In this experiment, the DBD (dielectric barrier discharge) plasma reactor was used to inactivate Phytophthora capsici which cause wilt in tomato plantation. Optimum disinfection models were chosen among ten models by the application of statistical SSE (sum of squared error), RMSE (root mean sum of squared error), $r^2$ values on the experimental data using the GInaFiT software in Microsoft Excel. The optimum models were shown as Log-linear+Tail model, Double Weibull model and Biphasic model. Three models were applied to the experimental data according to the variation of the operating conditions. In Log-linear+Tail model, $Log_{10}(N_o)$, $Log_{10}(N_{res})$ and $k_{max}$ values were examined. In Double Weibull model, $Log_{10}(N_o)$, $Log_{10}(N_{res})$, ${\alpha}$, ${\delta}_1$, ${\delta}_2$, p values were calculated and examined. In Biphasic model, $Log_{10}(N_o)$, f, $k_{max1}$ and $k_{max2}$ values were used. The appropriate model parameters for the calculation of optimum operating conditions were $k_{max}$, ${\alpha}$, $k_{max1}$ at each model, respectively.

• Imaging Science in Dentistry
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• 제45권1호
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• pp.23-29
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• 2015

Purpose: This study aimed to assess the reliability of measurements performed on three-dimensional (3D) virtual models of maxillary defects obtained using cone-beam computed tomography (CBCT) and 3D optical scanning. Materials and Methods: Mechanical cavities simulating maxillary defects were prepared on the hard palate of nine cadavers. Images were obtained using a CBCT unit at three different fields-of-views (FOVs) and voxel sizes: 1) $60{\times}60mm$ FOV, $0.125mm^3$ ($FOV_{60}$); 2) $80{\times}80mm$ FOV, $0.160mm^3$ ($FOV_{80}$); and 3) $100{\times}100mm$ FOV, $0.250mm^3$ ($FOV_{100}$). Superimposition of the images was performed using software called VRMesh Design. Automated volume measurements were conducted, and differences between surfaces were demonstrated. Silicon impressions obtained from the defects were also scanned with a 3D optical scanner. Virtual models obtained using VRMesh Design were compared with impressions obtained by scanning silicon models. Gold standard volumes of the impression models were then compared with CBCT and 3D scanner measurements. Further, the general linear model was used, and the significance was set to p=0.05. Results: A comparison of the results obtained by the observers and methods revealed the p values to be smaller than 0.05, suggesting that the measurement variations were caused by both methods and observers along with the different cadaver specimens used. Further, the 3D scanner measurements were closer to the gold standard measurements when compared to the CBCT measurements. Conclusion: In the assessment of artificially created maxillary defects, the 3D scanner measurements were more accurate than the CBCT measurements.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.3007-3013
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• 2014

본 연구의 목적은 블루 LED 기반의 치과용 스캐너를 이용하여 제작된 3차원 디지털 모형의 정확도를 평가하는 것이다. 본 연구를 위하여 20개의 동일한 석고 모형 제작 후 블루 LED기반의 치과용 스캐너를 이용하여 석고 모형과 동일한 20개의 3차원 디지털 모형을 제작하였다. 정확도를 평가하기 위해 두 집단의 모형을 대상으로 6개의 계측 거리를 지정한 후 측정하였다. 통계분석은 비모수 검정법인 윌콕슨 순위 합 검정법을 이용하여 비교 분석하였다(제1종 오류수준=0.05). 비록 모든 부위에서 디지털 모형이 석고 모형보다 작은 것으로 분석되었으나(p<0.05), 임상적 허용 수치를 벗어나지 않았다.