• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.369-378
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• 2010

In this study, a computer program to predict the behavior of laterally loaded single pile and pile groups was developed by using a beam-column analysis in which the soils are modeled as nonlinear springs by a family of p-y curves for subgrade modulus. The special attention was given to the lateral displacement of a single pile and pile groups due to the soil condition and the cap rigidity. The analysis considering group effect was carried out for $2{\times}2$ and $3{\times}3$ pile groups with the pile spacing 3.0B, 4.0B and 5.0B. Based on the results obtained, it is found that the overall distributions of deflection, slope, moment, and shear force in a single pile give a reasonable results irrespective of cap connectivity conditions. It is also found that even though there are some deviations in deflection prediction compared with the observed ones, the prediction by present analysis simulates much better the general trend observed by the centrifuge tests than the numerical solution predicted by PIGLET.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.831-837
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• 2005

In this study, a computer program to predict the behavior of laterally loaded single pile and pile groups was developed by using a beam-column analysis in which the soils are modeled as nonlinear springs by a family of p-y curves for subgrade modulus. The special attention was given to the lateral displacement of a single pile and pile groups due to the soil condition and the cap rigidity. The analysis considering group effect was carried out for $2\;{\times}\;2\;and\;3\;{\times}\;3$ pile groups with the pile spacing 3.0B, 4.0B and 5.0B. Based on the results obtained, it is found that the overall distributions of deflection, slope, moment, and shear force in a single pile give a reasonable results irrespective of cap connectivity conditions. It is also found that even though there are some deviations in deflection prediction compared with the observed ones, the prediction by present analysis simulates much better the general trend observed by the centrifuge tests than the numerical solution predicted by PIGLET.

• Earthquakes and Structures
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• v.11 no.1
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• pp.141-163
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• 2016

Fiber models have been developed and applied to various structural elements such as shear walls, beams and columns. Only scarcely have fiber models been applied to circular foundation systems such as cast in drilled holes shafts (CIDH). In pile foundations with constraint head boundary conditions, shear deformations can easily contribute to the lateral pile response. However, soil structure interaction formulations such as the p-y method, commonly used for lateral pile design, do not include structural shear deformations in its traditional derivation method. A fiber model that couples shear and axial-bending behavior, originally developed for wall elements was modified and validated on circular cross sections (columns) before being applied to a 0.61 m diameter reinforced concrete (RC) pile with fixed head boundary conditions. The analytical response was compared to measured test results of a fixed head test pile to investigate the possible impact of pile shear deformations on the displacement, shear, and moment profiles of the pile. Results showed that shear displacements and forces are not negligible and suggest that nonlinear shear deformations for RC piles should be considered for fixed-head or similar conditions. Appropriate sensor layout is recommended to capture shear deformation when deriving p-y curves from field measurements.

• Journal of the Korean Chemical Society
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• v.30 no.5
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• pp.456-464
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• 1986

The complex formation of branched poly(ethylene imine) (BPEI) with bivalent transition metal ions, such as Fe(II), Co(II), Ni(II) and Cu(II), have been investigated in terms of visible absorption and pH titration methods in an aqueous solution in 0.1M KCl at 30${\circ}$. The stability constants for M(II)-BPEI complexes was calculated with the modified Bjerrum method. The formation curves of M(II)-BPEI complexes showed that Fe(II), Co(II), Ni(II) and Cu(II) ions formed coordination compounds with four, two, two, and two ethylene imine group, respectively. In the case of Cu(II)-BPEI complex at pH 3.4 ∼ 3.8, ${\lambda}_{max}$ was shifted to the red region with a decrease in the acidity. The overall stability constants (log $K_2$) increased as the following order, Co(II) < Cu(II) < Ni(II) < Fe(II).

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.4079-4083
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• 2014

Background: Previous studies have showed that argonaute 2 is a potential factor related to genesis of several cancers, however, there have been no reports concerning gliomas. Methods: Paraffin specimens of 129 brain glioma cases were collected from a hospital affiliated to Binzhou Medical University from January 2008 to July 2013. We examined both argonaute 2 mRNA and protein expression by real-time quantitative PCR (qRT-PCR), Western blot analysis, and immunohistochemistry (IHC). The survival curves of the patients were determined using the Kaplan-Meier method and Cox regression, and the log-rank test was used for statistical evaluations. Results: Both argonaute 2 mRNA and protein were upregulated in high-grade when compared to low-grade tumor tissues. Multivariate analysis revealed that argonaute 2 protein expression was independently associated with the overall survival (HR=4.587, 95% CI: 3.001-6.993; P=0.002), and that argonaute 2 protein expression and WHO grading were independent prognostic factors for progression-free survival (HR=4.792, 95% CI: 3.993-5.672; P<0.001, and HR=2.109, 95% CI: 1.278-8.229; P=0.039, respectively). Kaplan-Meier analysis with the log-rank test indicated that high argonaute 2 protein expression had a significant impact on overall survival (P=0.0169) and progression-free survival (P=0.0324). Conclusions: The present study showed that argonaute 2 expression is up-regulated in gliomas. Argonaute 2 might also serve as a novel prognostic marker.

• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.10
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• pp.1093-1100
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• 2015

Since the security of RSA cryptosystem depends on the difficulty of factoring integers, it is the most important problem to factor large integers in RSA cryptosystem. The Lenstra elliptic curve factorization method(ECM) is considered a special purpose factoring algorithm as it is still the best algorithm for divisors not greatly exceeding 20 to 25 digits(64 to 83 bits or so). ECM, however, wastes most time to calculate $M{\cdot}P$ mod N and so Montgomery and Koyama both give fast methods for implementing $M{\cdot}P$ mod N. We, in this paper, further analyze Montgomery and Koyama's methods and propose an efficient algorithm which choose the optimal parameters and reduces the number of multiplications of Montgomery and Koyama's methods. Consequently, the run time of our algorithm is reduced by 20% or so than that of Montgomery and Koyama's methods.

• Development and Reproduction
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• v.17 no.3
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• pp.257-268
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• 2013

Morphometric changes in the Ussurian bullhead, Leiocassis ussuriensis, and the Korean bullhead, Pseudobagrus fulvidraco, were observed during the early period of growth. Yolk length, yolk height, and yolk volume in the two species decreased within 9 days post-hatching (DPH) (p<0.05). The body lengths and body heights of both species increased gradually to 150 and 130 DPH, respectively (p<0.05). The horizontal distance between the anteriormost extension of the head and the anterior insertion of the pectoral fin, the anteriormost extension of the head ${\times}$ the verticality position of the anterior insertion of the primary dorsal fin rays, and the anterior insertion of the primary dorsal fin ${\times}$ the anterior insertion of the pectoral fin were greater in the Korean bullhead than in the Ussurian bullhead (p<0.05). However, the relative sizes of the head region, pectoral fin, ventral fin, and anal fin were greater in the Ussurian bullhead than in the Korean bullhead (p<0.05), and relative body depth and the size of the outer-mandible barbel were greater in the Korean bullhead than in the Ussurian bullhead (p<0.05). The growth curves of the morphometric characteristics of both species were divided into three types.

• Corrosion Science and Technology
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• v.16 no.5
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• pp.257-264
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• 2017

Film of new Ti-15Zr-5Nb alloy formed during galvanic anodizing in orthophosphoric acid solution was characterized by optical microscope, scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), and Raman micro-spectroscopy. Its anticorrosive properties were determined by electrochemical techniques. The film had a layer with nanotube-like porosity with diameters in 500-1000 nm range. The nano layer contained significant amounts of P and O as well as alloying element. Additionally, Raman micro-spectroscopy identified oxygen as oxygen ion in $TiO_2$ anatase and phosphorous as $P_2O_7{^{4-}}$ ion in phosphotitanate compound. All potentiodynamic polarization curves in artificial Carter-Brugirard saliva with pH values (pH= 3.96, 7.84, and 9.11) depending on the addition of 0.05M NaF revealed nobler behavior of anodized alloy and higher polarization resistance indicating the film is thicker and more compact nanolayer. Lower corrosion rates of the anodized alloy reduced toxicity due to less released ions into saliva. Bigger curvature radii in Nyquist plot and higher phase angle in Bode plot for the anodized alloy ascertain a thicker, more protective, insulating nanolayer existing on the anodized alloy. Additionally, ESI results indicate anodized film consists of an inner, compact, barrier, layer and an outer, less protective, porous layer.

• Archives of Pharmacal Research
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• v.26 no.11
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• pp.979-983
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• 2003

The pharmacokinetic of tolbutamide was studied after the oral administration to normal rabbits or rabbits with mild to medium folate-induced renal failure. The plasma concentrations of tolbutamide were significantly elevated (p<0.05) during 9 to 24 h in rabbits with mild or medium folate-induced renal failure. Consequently, the area under the plasma concentration-time curves (AUC) was significantly higher in mild (p<0.05) and medium (p<0.01) folate-induced renal failure rabbits (i.e., 2906 $\mu$g/mL$.$h for mild renal failure and 4074 $\mu$g/mL$.$h for moderate renal failure) than that in normal rabbits (i.e., 2295 $\mu$g/mL$.$h). The cumulative urinary excretion of tolbutamide was significantly depressed (p<0.05) in medium folate-induced renal failure rabbits (i.e., 3.3 mg) compared with that in normal rabbits (i.e., 5.9 mg). The elimination rate constant (Kel) of tolbutamide was significantly decreased in medium renal failure rabbits (i.e., 0.027 $h^{-1}$) than that in normal rabbits (i.e., 0.044 $h^{-1}$ ); As a result, the terminal half-life of tolbutamide in medium folate-induced renal failure rabbits (i.e., 25.5 h) was significantly longer (p<0.01) than that in normal rabbits (i.e., 15.7 h). The change in pharmacokinetic parameters is consistent with the hypothesis that the alteration is mediated by the depressed metabolic elimination of the drug by the induction of renal failure. Therefore, these observations indicated that the dosage adjustment may be necessary for tolbutamide in patients with renal insufficiency.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4717-4721
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• 2013

Complete surgical resection of the primary tumour is a crucial predictive step for head and neck squamous cell carcinoma (HNSCC), because incomplete resection may lead to increase in the recurrence rate. Molecular cancer markers have been investigated as potential predictors of prognosis marker, to identify patients who are at high risk of local recurrence. This retrospective study aimed to determine the prognostic correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival. Forty eight HNSCC patients were selected between 2006 and 2009 diagnosed at the Royal Darwin Hospital, Darwin, Northern Territory, Australia. Out of 48, only those 24 with negative surgical margins with hematoxylin and eosin (HandE) were chosedn for further analysis. A total of 77 surgical margins were obtained and subsequently analysed by immunohistochemical (IHC) staining with monoclonal p53 and polyclonal eIF4E antibodies. Contingency table and ${\chi}^2$-test were used to investigate the correlation between p53 and eIF4E expression and clinical characteristics, recurrence and overall survival of the HNSCC patients. The follow up period was 74 months (range 1-74 months). The Kaplan-Meier method was used to generate recurrence and survival curves. This is a first retrospective study of Northern Territory patients, including Indigenous and non-Indigenous Australians. Molecular study of surgical margins could help to identify patients with and without clear margins after surgery and help in choice of the most appropriate adjuvant treatment for HNSCC patients.