• Journal of Korean Society of Water and Wastewater
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• 제27권4호
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• pp.429-438
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• 2013

This study was to develop effective water quality management measures using LDC (Load Duration Curve) curves for TMDL (Total Maximum Daily Loads) unit watershed. Using LDC curves, major factors for BOD and T-P concentration loads generation (i.e. point source or non-point source) in the case study area (Geumho river basin) were found for different hydrologic conditions. Different measures to deal with the pollutant loads were suggested to establish BMPs (Best Management Practices). It was found that the target area has urgent T-P management methods especially at moist and midrange hydrologic conditions because of point source pollutants occurred in developed areas. One example measure for this could be establishment of advanced treatment facility. This study proved that the use of LDC was a useful way to achieve TWQ (Target Water Quality) on the target watershed considered. It was also expected that the methodology applied in this study could have a wider application on the establishment of watershed water management measures.

• Journal of the Korean Wood Science and Technology
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• 제45권6호
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• pp.689-702
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• 2017

In this study, with the view to using effectively small and medium diameter Korean domestic woods as structural materials, cross-laminated woods were manufactured by using six species of Korean domestic softwoods and hardwoods, and bending creep properties were investigated for each species. The creep curves showed the shape of the exponential function plot, and the creep curves after 1 hour were able to estimate by fitting it to the power law. The initial and creep compliances of cross-laminated woods showed the higher values in wood species with a low density than in that with a high density. And by cross-laminating, the initial and creep compliances perpendicular to the grain considerably decreased, the extent of the decrease was found to be greater in creep deformation than in initial deformation. The creep anisotropies of cross-laminated woods were considerably decreased by cross-laminating. The relative creep of $C_{\bot}$ type composed of perpendicular-direction lamina in the faces decreased 0.59 - 0.64 times compared to that of $P_{\bot}$ type composed of perpendicular-direction laminae in all layers, and that for $C_{\parallel}$ type composed of parallel-direction laminae in the faces increased 1.5 - 1.6 times compared to that of $P_{\parallel}$ type composed of parallel-direction laminae in all layers.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4719-4722
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• 2015

Background: This study aimed to determine the utility and a cut-off level of serum squamous cell carcinoma antigen (SCC-Ag) to predict lymph node metastasis in locally advanced cervical cancer cases. We also investigated the correlation between SCC-Ag level and lymph node status. Materials and Methods: From June 2009 to June 2014, 232 patients with cervical cancer stage IB2-IVA, who were treated at Ramathibodi Hospital, were recruited. Receiver operating characteristic (ROC) curves were used to identify the best cut-off point of SCC-Ag level to predict lymph node metastasis. Quantile regression was performed to evaluate the correlation between SCC-Ag levels and pelvic lymph node metastasis, paraaortic lymph node metastasis, and parametrial involvement as well as tumor size. Results: Pelvic lymph node metastasis and paraaortic lymph node metastasis were diagnosed in 46.6% and 20.1% of the patients, respectively. The median SCC-Ag level was 6 ng/mL (range, 0.5 to 464.6 ng/mL). The areas under ROC curves between SCC-Ag level and pelvic lymph node metastasis, paraaotic lymph node metastasis, parametrial involvements were low. SCC-Ag level was significantly correlated with paraaortic lymph node status (p=0.045) but not with pelvic lymph node status and parametrial involvement. SCC-Ag level was also related to the tumor diameter (p<0.05). Conclusions: SCC-Ag level is not a good predictor for pelvic and paraaortic lymph node metastasis. However, it is still beneficial to assess the tumor burden of squamous cell carcinoma of the cervix.

• Journal of Pharmaceutical Investigation
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• 제24권2호
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• pp.85-94
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• 1994

Inclusion complexes of ketoconazole (KT) with ${\alpha}-$, ${\beta}-cyclodextrin$ (CD) and dimethyl-${\beta}-cyclodextrin$ $(DM{\beta}CD)$ in a molar ratio of 1:2 were prepared by freeze-drying and solvent evaporation methods. The interactions of KT with ${\alpha}-CD$, ${\beta}-CD$ and $DM{\beta}CD$ in aqueous solution and in solid state were investigated by solubility study, infrared (lR) spectroscopy and differential scanning calorimetry (DSC). The stability constant of $KT-DM{\beta}CD$ inclusion complex (lC) was found to be the largest among three inclusion complexes. Clear differences in IR spectra and DSC curves were observed between inclusion complexes and physical mixtures (PM) of KT-CDs. It was also shown by IR spectra and DSC curves that solvent evaporation method might be. superior to the freeze-drying method in preparing the inclusion complexes of KT-CDs. The dissolution rate of KT was markedly increased by inclusion complex formation with CDs in the buffer solution at pH 4.0 and pH 6.8. The mean dissolution time (MDT,min), which represents the rapidity of dissolution, was in the order of $KT-DM{\beta}CD$ IC (3.20) < $KT-{\beta}-CD$ IC (4.36) < $KT-{\alpha}-CD$ IC (6.99) < $KT-{\alpha}-CD$ PM (17.46)< $KT-{\beta}-CD$ PM (19.36) < $KT-{\beta}-CD$ PM (28.53). The dissolution rates of KT-CD ICsprepared by solvent evaporation method were faster than those of KT-CD ICs prepared by freeze-drying method.

• Applied Biological Chemistry
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• 제35권2호
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• pp.132-138
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• 1992

For effective determination of methylthiohydantoin amino acids(MTHs) by gas liquid chromatography in the protein sequencing, derivatization with N-methyl-N-(tert.-butyl-dimethylsilyl)trifluoroacetamide(MTBSTFA), a new silylating reagents, was attempted instead of trimethylsilyl(TMSi) derivatives by N,O-bis(trimethylsilyl)trifluoroacetamide(BSTFA) used up to the present and N(O)-butyldimethylsilyl MTHs derivatized by MTBSTFA were analysed on HP-1 capillary column. Twenty one protein amino acids except cystine were indentified. Especially arginine that did not detected with TMSi derivative on packed column until now was resolved by derivatization with MTBSTFA. N(O)-butyldimethylsilyl MTHs showed multiple peaks by MTBSTFA were proline, isoleucine, glycine and tyrosine and hydroxyproline especially showed several extraneous peaks more than two. Calibration curves of N(O)-butyldimethysilyl MTHs of amino acids in the range of $2.5\;nmol{\sim}7.5\;nmole$ showed good linearity. however, those of lysine, histidine and arginine showed linearity in the range of $5.0\;nmole{\sim}15.0\;nmole$. Correlation coefficients and regression coefficients of all calibration curves were highly significant(p<0.001).

• Computers and Concrete
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• 제1권4호
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• pp.371-388
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• 2004

Our objective is to model static multi-cracking processes in concrete. The explicit dynamic relaxation (DR) method, which gives the solutions of non-linear static problems on the basis of the steady-state conditions of a critically damped explicit transient solution, is chosen to deal with the high geometric and material non-linearities stemming from such a complex fracture problem. One of the common difficulties of the DR method is its slow convergence rate when non-monotonic spectral response is involved. A modified concept that is distinct from the standard DR method is introduced to tackle this problem. The methodology is validated against the stable three point bending test on notched concrete beams of different sizes. The simulations accurately predict the experimental load-displacement curves. The size effect is caught naturally as a result of the calculation. Micro-cracking and non-uniform crack propagation across the fracture surface also come out directly from the 3D simulations.

• Journal of the Korean Geotechnical Society
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• 제19권6호
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• pp.127-149
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• 2003

The bridge tested was 3 spans 90m-long PSC beam concrete bridge with a stub-type abutment which had a skew of 60$^{\circ}$ about the axis of bridge. A cement concrete was placed at the superstructural slab of the bridge. Inclinometers and straingauges were installed at piles as well. During 7 days-curing of superstructural slab, the pile behavior in response to hydration heat and drying shrinkage of the slab was monitored. Then monitored values were compared with the horizontal movement obtained from the HACOM program and the calculated lateral behavior obtained from the nonlinear p-y curves of pile. As a result, lateral behavior of H-piles by the field measurement occurred due to the influence of hydration heat and drying shrinkage obtained during curing of superstructural concrete. The lateral displacements by hydration heat and drying shrinkage were 2.2mmand 1.4mm respectively. It was observed as well that the inflection point of lateral displacement of pile was shown at 1.3m down from footing base. It means that the horizontal movement of stub abutment did not behave as the fixed head condition of a pile but behave as a similar condition. The measured bending stress did not show the same behavior as the fixed head condition of pile but showed a similar condition. The increment of maximum bending stress obtained from the nonlinear p-y curves of pile was about 300(kgf/$\textrm{km}^2$) and was 2 times larger than measured values regardless of installation places of straingauges. Meanwhile, lateral load, maximum lateral displacement, maximum bending stress and maximum bending moment of pile showed a linear behavior as curing of superstructural concrete slab.

• Journal of Korean Society on Water Environment
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• 제18권4호
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• pp.401-409
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• 2002

In this study, to evaluate the applicability of ORP and pH as process control parameters for an intermittent aeration process, a 200L/d bench-scale plant was installed and operated for 90 days. It was fed with synthetic wastewater which contained $COD_{Cr}$ : 400mg/L, TN : 40mg/L and TP : 7mg/L. ORP & pH were measured on-line and compared with the variation of nutrient concentrations. As the results, both of the ORP and pH were able to monitor successfully nitrification and denitrification. Bending-points on the ORP curve and peak points on the pH curve corresponded to the termination of nitrification and denitrification. For P uptake and release, pH was the best indicator for performance evaluation. The aerobic pH apex was appeared when P uptake was accomplished and there was a relationship between the P release and pH variation. But the pH curve needed filtering because there were many noises on it. In this study, the shape of the ORP & pH curves were varied as the operating conditions such as aeration rates and organic loads were changed. It allowed the operating states of biological systems to be effectively evaluated. If it is properly managed to show the bending points and peak points clearly, the on-line monitoring of ORP & pH will be a reliable and effective technique for process control of intermittent aeration processes.

• Toxicological Research
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• 제12권2호
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• pp.155-161
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• 1996

The enzymatic properties for NADPH-P450 reductase domain of a fusion protein between human cytochrome P450 1A1 and rat NADPH-P450 reductase expressed in Escherichia coli were investigated. The fusion plasmid pCW/1A1OR-expressed E. coli membrane showed high NADPH-cytochrome c reductase activity ($830.1\pm 85.8 nmol\cdot min^{-1}\cdot mg protein^{-1}$), while pCW control vector and P 450 1A1 expression vector pCW/1A1 showed relatively quite low activity ($4.35\pm 0.49, 3.27\pm 0.50 nmol\cdot min^{-1}\cdot mg protein^{-1}$, respectively). The kinetic curves for NADPH-cytochrome c reductase followed typical Michaelis-Menten kinetics. The $K_{max}$ and $V_{max}$ for NADPH-dependent reductase activity were $8.24\pm 2.61\mu $and $817.9\pm 60.8 nmol\cdot min^{-1}\cdot mg protein^{-1}$, respectively, whereas those for cytochrome c-dependent reductase activity were $19.97\pm 2.86\mu M$ and $1303.5\pm 67.1 nmol\cdot min^{-1}\cdot mg protein^{-1}$. The reductase activities were also compared with those of rat, porcine and human liver microsomes. The activity of pCW/ 1A1OR-expressed E. coli membrane was 15.2-fold higher than that of rat liver microsome. Treatment with benzo(a)pyrene, 7-ethoxyresorufin and $\alpha$-naphthofiavone which are known as specific substrates or inhibitor for human P450 1A1 increased NADPH-cytochrome c reductase activity of fusion protein in E. coli membrane dose-dependently. These results demonstrate that the membrane topology of fused enzyme may be important for activity of its NADPH-P450 reductase domain.

• Journal of the Institute of Electronics and Information Engineers
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• 제53권2호
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• pp.117-122
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• 2016

Recently, the detection of pH with real-time and in vivo has been focal pointed in the environmental or medical fields. In this work, we developed the pH sensor using graphene sheet. Graphene has high biocompatibility. We fabricated flexible solution-gated field-effect transistors (SGFETs) on graphene sheet transferred on the polyethylene terephthalate (PET) substrate to detect pH in electrolyte solution. The gate length was $500{\mu}m$ and the gate width was 8 mm. We evaluated the current-voltage (I-V) transfer characteristics of graphene SGFETs in pH solution. The drain-source current ($I_{DS}$) and the gate-source voltage ($V_{GS}$) curves of graphene SGFETs were depended on pH value. The Dirac point of graphene SGFETs linearly shifted to the positive direction about 19.32 mV/pH depending on the pH value in electrolyte solution.