• Journal of Korean society of Dental Hygiene
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• 제4권2호
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• pp.209-223
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• 2004

The purpose of this study is to help dental hygienist's efficient work and 10 use this data as basic material for quality improvement of medical treatment by identify and analyze dental hygienist's job-stress and self-conception. This data was surveyed by 197 dental hygienists who working at Dental Clinic, Dentist's office, and Dental Dept on the General hospital in Daegu area. The result as follow. 1. General characters of dental hygienist who participated this survey was mostly less than 25years old and works in the Dentist's office. 2. The dental hygienist's job stress average 259, self-conception was average 3.06. 3. A stress degree by the primary factors appeared that the stress related to Role-conflict was the hygienist. On the other hand, stress related to employees was the lowest. 4. Concerning the stress of respondent's expert knowledge or technique, there exist statistically significant relations in age(p=0.000). Total period of work(p=0.000)), marriage(yes or no)(p=0.012), number of job movement(p=0.024). 5. Concerning the mutual analyze between stress by the primary factors and self-conception, there exist statistically significant relations in stress from expert knowledge or technique(p<0.05, r=0.l53), conflict with patient(p<0.001, r=0.347), conflict between dentist and patient(p<0.05, r=0.159), relationship with employee(p<0.05, r=0.l83). In conclusion, there were significant relations between job-stress and conception. The study of program development for the self-conceit, positive attitude and self-conception are highly required to help dental hygienist's efficient work.

• Clinical and Experimental Vaccine Research
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• 제13권2호
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• pp.155-165
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• 2024

Purpose: Pertussis bacteria have many pathogenic and virulent antigens and severe adverse reactions have occurred when using inactivated whole-cell pertussis vaccines. Therefore, inactivated acellular pertussis (aP) vaccines and genetically detoxified recombinant pertussis (rP) vaccines are being developed. The aim of this study was to assess the safety profile of a novel rP vaccine under development in comparison to commercial diphtheria-tetanus-acellular pertussis (DTaP) vaccines. Materials and Methods: The two positive control DTaP vaccines (two- and tri-components aP vaccines) and two experimental recombinant DTaP (rDTaP) vaccine (two- and tri-components aP vaccines adsorbed to either aluminum hydroxide or purified oat beta-glucan) were used. Temperature histamine sensitization test (HIST), indirect Chinese hamster ovary (CHO) cell cluster assay, mouse-weight-gain (MWG) test, leukocytosis promoting (LP) test, and intramuscular inflammatory cytokine assay of the injection site performed for safety assessments. Results: HIST results showed absence of residual pertussis toxin (PTx) in both control and experimental DTaP vaccine groups, whereas in groups immunized with tri-components vaccines, the experimental tri-components rDTaP absorbed to alum showed an ultra-small amount of 0.0066 IU/mL. CHO cell clustering was observed from 4 IU/mL in all groups. LP tests showed that neutrophils and lymphocytes were in the normal range in all groups immunized with the two components vaccine. However, in the tri-components control DTaP vaccine group, as well as two- and tri-components rDTaP with beta-glucan group, a higher monocyte count was observed 3 days after vaccination, although less than 2 times the normal range. In the MWG test, both groups showed changes less than 20% in body temperature and body weight before the after the final immunizations. Inflammatory cytokines within the muscle at the injection site on day 3 after intramuscular injection revealed no significant response in all groups. Conclusion: There were no findings associated with residual PTx, and no significant differences in both local and systemic adverse reactions in the novel rDTaP vaccine compared to existing available DTaP vaccines. The results suggest that the novel rDTaP vaccine is safe.

• Clinical and Experimental Pediatrics
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• 제52권4호
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• pp.435-440
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• 2009

Purpose : The concentration of soluble transferrin receptor (sTfR) is estimated as an iron parameter to evaluate erythropoiesis and iron status. The aim of our study is to evaluate the correlation between sTfR concentration and inflammatory parameters and to distinguish iron deficiency anemia from anemia of inflammation. Methods : One hundred and forty-four infants younger than two years of age who visited Gyeongsang University Hospital for 7 years from 2000 to 2006 were enrolled. Patients who had hemoglobin (Hb) <11 g/dL and ferritin <12 mg/L were excluded. Routine hematologic lab, serum ferritin, sTfR, and inflammatory markers [C-reactive protein(CRP), interleukin-6(IL-6), and absolute neutrophil count (ANC)] were investigated. Results : In all patients, the sTfR concentration showed a correlation with Hb, ferritin, MCV, and ANC, but not with CRP and IL-6. In multiple regression models, positive correlations were found between sTfR concentration and IL-6 (r=0.078, P=0.043), and negative correlations were found between sTfR concentration and ANC (r=-0.117, P=0.033) and MCV (r=-0.027, P=0.009). Conclusion : sTfR concentration was influenced by inflammatory parameters. Therefore, sTfR does not appear to be a useful parameter for discriminating between iron deficiency anemia and anemia of inflammation in infants.

• Journal of the Korean Applied Science and Technology
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• 제38권3호
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• pp.813-823
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• 2021

This study was conducted to identify the factors affecting the compliance of standard precautions for nurses working in long term care hospitals. As a result of the analysis, 8.50 points in perception of the standard precautions, 3.76 points in health beliefs(subcategories- 4.03 points in perceived sensitivity, 4.04 points in perceived seriousness, 3.91 points in perceived benefits, 3.54 points in perceived barrier, 2.92 points in cues to action), 37.90 points in compliance status of the standard precautions. The performance of the standard precautions was positively correlated with perception of the standard precautions(r=0.419, p=.001) and health beliefs (r=0.443, p<.001), perceived sensitivity (r=0.169, p=.044), perceived barrier(r=0.486, p<.001), perceived benefits (r=0.207, p=.013), cues to action (r=0.204, p=.014). The compliance status of the standard precautions was influenced by the perceived barrier(β=0.373, p<.001), cues to action (β=0.271, p<.001), perception of the standard precautions(β=0.245, p=.004)explanatory power was 32.5%.

• The Journal of the Convergence on Culture Technology
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• 제10권2호
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• pp.159-166
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• 2024

The purpose of this study was investigate the effect of self-efficacy, self-directedness and self-leadership on reslience in nursing students and to provide the basic data of to enhance resilience. Data were collected from 199 nursing students in B city. Data analysis was analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression analysis using the SPSS 22.0 program. The degree of self-efficacy of the subjects was 3.63±0.52. Resilience of the subjects was positively correlated with self-efficacy (r=.677, p<.001), self-directedness (r=.573, p<.001), and self-leadership (r=.654, p<.001). Self-leadership of the subjects showed a positive correlation with self-efficacy (r=.517, p<.001), self-directedness (r=.665, p<.001). Self-directedness of the subjects showed a positive correlation with self-efficacy (r=.491, p<.001). The factors influencing the subject's resilience were identified as self-efficacy (β=.435, p<.001) and self-directedness (β=.133, p=.036), self-efficacy (β=.341, p<.001), and the explanatory power was 57.5%. Therefore, in order to improve nursing students' resilience, it is necessary to consider self-efficacy, self-directedness and self-leadership.

• Journal of the korean academy of Pediatric Dentistry
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• 제30권4호
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• pp.554-562
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• 2003

Xylitol has been used as sugar substitute to prevent dental caries. It is not fermented by most dental plaque bacteria and interferes with the growth of mutans streptococci. Therefore the production of acidic metabolites and the growth of mutans streptococci are inhibited. S. mutans strains which are inhibited to grow under the presence of xylitol are referred as xylitol-sensitive ($X^S$) strains. However, experimental and clinical studies have shown that there were mutated groups of S. mutans strains that are not affected by xylitol. They are referred as xylitol-resistant($X^R$) strains. The aim of the present study was to investigate that emergence of $X^R$ strain would effect on the anticariogenecity of xylitol by comparing the growth rate, the extracellular pH, hydroxyapatite adhesion and the agglutination of the $X^R/X^S$ strains. Overall we came out with following results : 1. No difference in the growth rate and the extracellular pH was found between the $X^S$ strain and the $X^R$ strain. 2. No difference in adhesion to hydroxyapatite surface was found between the $X^R$ strain and the $X^S$ strain (p>0.05) and adhesion of the $X^S$ strain was greater than that of $X^R$ strain in the sucrose-dependent adhesion to hydroxyapatite (p<0.05). 3. The $X^R$ strain was agglutinated in the lower concentration of saliva than that of $X^S$ strains.

• Biomolecules & Therapeutics
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• 제29권3호
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• pp.311-320
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• 2021

Accumulation of reactive oxygen species (ROS) is associated with the development of various diseases. However, the molecular mechanisms underlying oxidative stress that lead to such diseases like autosomal dominant polycystic kidney disease (ADPKD) remain unclear. Here, we observed that oxidative stress markers were increased in Pkd1f/f:HoxB7-Cre mice. Forkhead transcription factors of the O class (FOXOs) are known key regulators of the oxidative stress response, which have been observed with the expression of FoxO3a in an ADPKD mouse model in the present study. An integrated analysis of two datasets for differentially expressed miRNA, such as miRNA sequencing analysis of Pkd1 conditional knockout mice and microarray analysis of samples from ADPKD patients, showed that miR-132-3p was a key regulator of FOXO3a in ADPKD. miR-132-3p was significantly upregulated in ADPKD which directly targeted FOXO3 in both mouse and human cell lines. Interestingly, the mitochondrial gene Gatm was downregulated in ADPKD which led to a decreased inhibition of Foxo3. Overexpression of miR-132-3p coupled with knockdown of Foxo3 and Gatm increased ROS and accelerated cyst formation in 3D culture. This study reveals a novel mechanism involving miR-132-3p, Foxo3, and Gatm that is associated with the oxidative stress that occurs during cystogenesis in ADPKD.

• Journal of applied mathematics & informatics
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• 제40권1_2호
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• pp.283-288
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• 2022

In this paper we characterize the sets of summability factors (|C, 0|_k, |R, p_n|_s) and (|R, p_n|_k, |C, 0|_s), 1 < k ≤ s < ∞, which also extends some known results.

• Women's Health Nursing
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• 제13권4호
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• pp.290-298
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• 2007

Purpose: This study was to measure the quality of life(QOL) and to identify the related factors in gynecological cancer patients during chemotherapy. Method: The subjects of this study were the patients who had undergone a hysterectomy and were admitted for chemotherapy at S university hospital between November 2006 and April 2007. Data was collected from 106 gynecological cancer patients with the use of a structured questionnaire which measured the QOL(FACT-G), body image, the presence of anxiety & depression, uncertainty, and family support. The data was analyzed by the SPSS win 12.0 program. Results: The mean FACT-total score was 62.1$({\pm}16.7)$ (range; 26-107). Positive correlations were found between QOL and body image(r= .67, p= .00), and QOL and family support(r= .32, p= .00), whereas there were negative correlations between QOL and anxiety(r= -.54, p= .00), QOL and depression(r= -.70, p= .00), and QOL and uncertainty(r= -.59, p= .00). Fifty seven pre cent of the variance in subjective overall QOL can be explained by depression, body image, and uncertainty(Adj $R^2$= .57, F=47.00, p= .00). Conclusion: Our patients had a relatively low QOL score. Factors significantly affecting quality of life were depression, body image and uncertainty. Nursing interventions, therefore, should be focused on improving QOL in gynecological cancer patients during chemotherapy, particularly so in patients with depression, uncertainty or poor body image.

• Korean Parent-Child Health Journal
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• 제8권2호
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• pp.97-111
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• 2005

Purpose: The purpose of the study was to analyze the families values of the family with hospitalized children in order to offer descriptive data, which will facilitate family adjustment in those families. Method: It's intended in this study, as of descriptive approach, to verify the theoretical framework based on McCubbin's Resiliency Model and to examine the influence of family values on family adaptation. The survey was conducted from June 20, 2003 to November 30, 2003 and the analysis included 202 parents of the hospitalized children. The data analysis utilized SPSS 11.0 program. Result: The correlation coefficients among major variables showed that family stressor was positively related with family strains(r=.249, P<.01), and negatively related with family hardiness(r=-.183, P<.05). Family strains was negative related with general family value(r=-.243, p<.01), and family adaptation(r=-.505, P<.05). Correlations of general family value was positive with family hardness (r=.153, p<.05), and family adaptation (r=.200, p<.01). Conclusions: There was correlating relationship between family strains and family adaptation, and general family value showed correlation with family strains, family hardiness, and family adaptation. Theresfore the continuing future research on the relationship between family value and family adaption is necessary.