• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1169-1181
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• 2018

Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin's lymphoma (NHL) is limited. Methods: Consecutive patients with aggressive NHL treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab-CHOP who underwent chemomobilization using HDC or DHAP plus granulocyte-colony stimulating factor (G-CSF) for up-front ASCT were enrolled from three institutions between 2004 and 2014. Results: Ninety-six patients (57 men) were included. Sixty-five patients (67.7%) received HDC; and 31 (32.3%), DHAP. The total CD34+ cells mobilized were significantly higher in patients receiving DHAP (16.1 vs. $6.1{\times}10^6/kg$, p = 0.001). More patients achieved successful mobilization with DHAP (CD34+ cells ${\geq}5.0{\times}10^6/kg$) compared to HDC (87.1% vs. 61.5%, respectively; p = 0.011), particularly within the first two sessions of apheresis (64.5% vs. 32.3%, respectively; p = 0.003). Mobilization failure rate (CD34+ cells < $2.0{\times}10^6/kg$) was significantly higher in patients receiving HDC (20.0% vs. 3.2%, p = 0.032). On multivariate analysis, the DHAP regimen (odds ratio, 4.12; 95% confidence interval, 1.12 to 15.17) was an independent predictor of successful mobilization. During chemomobilization, patients receiving HDC experienced more episodes of febrile neutropenia compared to patients receiving DHAP (32.3% vs. 12.9%, p = 0.043). Conclusions: The DHAP regimen was associated with a significantly higher efficacy for stem cell mobilization and lower frequency of febrile neutropenia. Therefore, DHAP plus G-CSF is an effective for mobilization in patients with aggressive NHL who were candidates for up-front ASCT.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.16 no.2
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• pp.53-60
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• 2010

Purpose : Neck pain is commonly experienced by both adolescents and adults. The purpose of this study was to measure neck disability index(NDI) and the cervical range of motion(CROM) following spinal manipulation and mobilization techniques. Methods : Thirty participants(manipulation=15, mobilization=15) with mild neck disability volunteered for this study. It was used to measure NDI with NDI questionnaire and six motions(neck flexion and extension, left and right lateral flexion, left and right rotation) with the CROM instrument. Independent t-test and paired t-test were used to estimate NDI and CROM, and compared left with right motions. Results : A significant decrease in NDI were found after spinal manipulation and mobilization treatment(p<.05). A trend toward increase in all cervical motions(flexion, extension, left and right lateral flexion, left and right rotation), after interventions, were revealed(p<.05). The significant differences were not found on NDI and CROM between the group(p<.05). It was presented asymmetric motions in cervical lateral flexion(p<.05) before and after treatment. Conclusions : Our results suggest that manipulation and mobilization probably provide at least short-term benefits for patients with mild neck pain. It is needed to be studied the factors and preventive methods influencing the asymmetric cervical motion.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.15 no.2
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• pp.69-79
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• 2009

Purpose : to investigate the effectiveness of joint mobilization and myofascial release on the neck pain and to provide the effective treatment. Methods : Twenty-two subjects with neck pain participated in the experiment. All subjects were randomly assigned to a joint mobilization group(n=11) or a myofascial release group(n=11). Both groups received treatment for 15 minutes four times during 2 weeks. Cervical range of motion(CROM) instrument was used to measure range of neck motion, and Algometer was used to measure tenderness. All measurements of the subjects were measured at pre-treatment and post-treatment. Results : 1. The range of neck right side-bending motion of the myofascial release group was significantly increased(P<0.05), and the range of neck extension, right side-bending, left side-bending, right rotation motion of the joint mobilization group was significantly increased(P<0.05). 2. There was no significant improvement of tenderness in both groups(p>0.05). Conclusion : These data suggest that joint mobilization is more effective against increasing the range of motion than myofascial release, but myofascial release is more beneficial to tenderness than joint mobilization although it does not have a significant difference in the tenderness because there was a little improvement.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.25 no.2
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• pp.11-20
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• 2019

Background: The purpose of this study was to investigate the immediate effect of thoracic self mobilization on balance and gait of acute stroke patients. Methods: Patients (n=10) with acute stroke applied to thoracic self mobilization. There are two thoracic self mobilization of both extension and rotation. Each thoracic self mobilization was performed ten times per direction in a total of three sets and the total time required for two thoracic self mobilization was twenty minutes. The break time between sets was one minute. Balance ability was measured using the timed up and go test and the five times sit to stand test for patients. The 10 meter walk test and the functional gait assessment were used for measurement of gait ability for patients. Results: Significant improvements were observed on balance ability (p<.05) and gait ability (p<.05). Conclusion: These results show that thoracic self mobilization is immediate effective on balance and gait ability. Thus, thoracic self mobilization will help recovery of balance and gait ability in acute stroke patients.

• Journal of Korea Entertainment Industry Association
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• v.14 no.3
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• pp.383-392
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• 2020

This study was to compare the effects of joint mobilization, treadmill with insole, and joint mobilization and treadmill with insole on pain, pelvic angle, and foot pressure in patients with sacroiliac joint pain. 24 patients randomly assigned to joint mobilization group(n=8), treadmill with insole group(n=8), or joint mobilization and treadmill with insole group(n=8). Each groups were conducted 30 minutes a day, two days a week for four weeks. Pain was evaluated using visual analogue scale and pelvic angle was measured using palpation meter and foot pressure(fore/rear ratio) was measured using Gateview AFA-50 before intervention and after 4 weeks. All groups were significant differences pain in intragroup(p<.01). In pelvic angle, the joint mobilization group was statistically significant in the anterior tilt only, the joint mobilization and treadmill with insole group showed statistically significant improvement in both anterior and posterior tilt(p<.01), and the treadmill with insole group did not show any statistically significant change(p>.05). Also the joint mobilization and treadmill with insole group were significant differences in foot pressure(p<.01). All the interventions reduce sacroiliac joint pain and joint mobilization and treadmill with insole training are most effective changes in pelvic angle and foot pressure. This study can be used as a basic data for prevention of injury, posture correction and gait training in patients with sacroiliac joint pain, as well as chronic low back pain and plantar pressure problem.

• Journal of Industrial Convergence
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• v.18 no.2
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• pp.27-35
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• 2020

The purpose of this study was to investigate the effect of cervical and thoracic joint mobilization on cervical pain, cervical range of motion(ROM) and balance in adults with forward neck posture. A total 26 subjects were divided into a cervical joint mobilization group(CMG, n=13) and a thoracic joint mobilization group(TMG, n=13). performed joint mobilization three times per week for four weeks. As for changes in pain and ROM, statistically significant decrease were founded within group comparison(p<.05). In changes of static balance within group comparison, the CMG showed statically significant improvement in right foot on eyes closed(p<.05), while there were no significant changes in the TMG(p<.05). There were no significant differences were observed between group comparison(p<.05). In changes of dynamic balance within group comparison, the CMG and TMG were showed statistically significant improvement(p<.05). In conclusion, the joint mobilization on cervical and thoracic were effective on improving cervical pain, cervical range of motion and balance in adults with forward neck posture.

• Physical Therapy Rehabilitation Science
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• v.12 no.3
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• pp.240-250
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• 2023

Objective: The purpose of this study was to characterize the movement of adjacent segments that occurred when posteroanterior joint mobilization was applied to the 3rd lumbar and thereby to provide basic clinical data. Design: Randomized controlled trial design. Methods: While the subjects were receiving posteroanterior joint mobilization of the 3rd lumbar vertebra, LD (lumbar displacement), LID (lumbar intervertebral distance), LIA (lumbar intervertebral angle), and LLA (lumbar lordosis angle) were measured using X-ray, and the data were then analyzed. Changes before and after posteroanterior joint mobilization were analyzed using a paired-sample t-test, and a one-way ANOVA of variance was performed to determine the difference between segmental movements. In addition, Pearson's correlation analysis was performed to determine the correlation between segmental movements. Results: The results revealed that there was a significant change in LD before and after the application of joint mobilization of the 3rd lumbar in all lumbar vertebrae (p<0.000), among which the 2nd lumbar vertebra, an adjacent segment, showed the most significant change. A significant change in LIA angle was observed in all segments (p<0.000), with the most significant change observed between the 2nd and 3rd lumbar vertebrae. There was a significant change in LLA before and after the application of posteroanterior joint mobilization (p<0.000). The correlation analysis showed a high correlation between displacement of the 3rd lumbar vertebra and displacement of all the other lumbar vertebrae. Conclusions: The presence of kinematic movements of the lumbar vertebrae when segmental movements were generated through the application of posteroanterior joint mobilization of the 3rd lumbar vertebra.

• Journal of International Academy of Physical Therapy Research
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• v.9 no.4
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• pp.1614-1618
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• 2018

The purpose of this study was to evaluate the effect of joint mobilization and manual stretching exercises in patients with hallux valgus. Twenty-three participants were divided into two groups; joint mobilization (n=11) and manual stretching exercises (n=12). The subjects participated in the experiment for 15minutes, three times a week, four weeks. The joint mobilization (Grade III, Maitland) was performed to experimental group for a minute and then rested for 10 seconds for each set. The manual stretching was performed to control group with three exercise session (preparatory and finishing exercises, agonist contraction exercises, agonist contraction and hold-relax exercises). In the results of the study, intragroup comparison of the deformity angles (DA) was shown to decrease from $15.18^{\circ}$ to $13.09^{\circ}$ in the joint mobilization group (p<.05) and from $19.00^{\circ}$ to $16.83^{\circ}$ in the stretching exercises group (p<.05). However, left static foot pressure (LSFP), right static foot pressure (RSFP), left dynamic foot pressure (LDFP) and right dynamic foot pressure (RDFP) did not significantly increase or decrease after the experiment. Intergroup differences also were not statistically significant in all variables (p>.05). The current study suggests that JM and MSE are effective in decreasing the DA in patients with hallux valgus.

• Journal of the Korean Society of Physical Medicine
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• v.10 no.4
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• pp.69-80
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• 2015

PURPOSE: The purpose of the present study was to apply joint mobilization in a sitting position and in a prone position to patients with acute mechanical neck pain and compare the immediate treatment effects in these two positions. METHODS: After the baseline was assessed, 46 patients were randomly assigned to two groups: experimental group I ($n_1=23$) for joint mobilization in the sitting position and experimental group II ($n_2=23$) for joint mobilization in the prone position at the symptomatic cervical level. The patients in both groups received treatment by unilateral posterior-anterior gliding for 30 seconds per trial, 10 trials per session, for a total of 5 minutes, and two trials of 10 active extending motions with distraction per trial. RESULTS: In the Wilcoxon signed-rank test, all the pain and physical function variables were significantly improved after intervention in both groups (p<.05). In the Mann-Whitney U test, which compared the differences before and after the intervention between the two groups, experimental group I showed significant improvement over experimental group II in resting pain (p<.01), satisfaction with the treatment (p=.01), left rotation (p<.01) and CCFE (p<.01). In the analysis of covariance results, experimental group I showed significant improvement over experimental group II in the most painful motion pain (p<.01) and the most painful quadrant motion pain (p<.01). CONCLUSION: These outcomes suggest that joint mobilization should be applied in sitting positions for patients with acute mechanical neck pain that feel pain during sustained positions, extension or rotation.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.24 no.1
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• pp.23-29
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• 2018

Background: This study aimed to the effects of hip mobilization on pain, trunk flexibility, function for chronic low back pain patients. Methods: Patients were randomly assigned to control group (n=15) and experimental group (n=15). Both groups received conventional physical therapy, three times a week for four weeks. Experimental group was performed additional hip mobilization, three times a week for four weeks. All measurement of each subject were measured at pre-intervention and post-intervention (after 4 weeks). Results: Assessed items included the visual analog scale score (VAS), Korean version of the Oswestry disability Index (KODI) a significant reduction was observed post intervention compared to pre-intervention values in both group (p<.01). Trunk flexibility was significant increased post intervention compared to pre-intervention values in both group (p<.01). There were significant difference between two groups in VAS (p<.01), trunk flexibility (p<.05) and except KODI. Conclusions: Our results indicate that conventional physical therapy with the hip mobilization may be useful for improving chronic low back pain patient.