• Biomolecules & Therapeutics
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• 제31권4호
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• pp.417-424
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• 2023

Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced by Proteus mirabilis (P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-α, and intestinal α-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neuroinflammation and α-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis.

• 대한치과교정학회지
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• 제47권4호
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• pp.256-267
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• 2017

Objective: To evaluate transverse skeletal and dental changes, including those in the buccolingual dental axis, between patients with skeletal Class III malocclusion and facial asymmetry after bilateral intraoral vertical ramus osteotomy with and without presurgical orthodontic treatment. Methods: This retrospective study included 29 patients with skeletal Class III malocclusion and facial asymmetry including menton deviation > 4 mm from the midsagittal plane. To evaluate changes in transverse skeletal and dental variables (i.e., buccolingual inclination of the upper and lower canines and first molars), the data for 16 patients who underwent conventional orthognathic surgery (CS) were compared with those for 13 patients who underwent preorthodontic orthognathic surgery (POGS), using three-dimensional computed tomography at initial examination, 1 month before surgery, and at 7 days and 1 year after surgery. Results: The 1-year postsurgical examination revealed no significant changes in the postoperative transverse dental axis in the CS group. In the POGS group, the upper first molar inclined lingually on both sides (deviated side, $-1.8^{\circ}{\pm}2.8^{\circ}$, p = 0.044; nondeviated side, $-3.7^{\circ}{\pm}3.3^{\circ}$, p = 0.001) and the lower canine inclined lingually on the nondeviated side ($4.0^{\circ}{\pm}5.4^{\circ}$, p = 0.022) during postsurgical orthodontic treatment. There were no significant differences in the skeletal and dental variables between the two groups at 1 year after surgery. Conclusions: POGS may be a clinically acceptable alternative to CS as a treatment to achieve stable transverse axes of the dentition in both arches in patients with skeletal Class III malocclusion and facial asymmetry.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.611-614
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• 2006

ITU-R 결의 122는 47/48GHz 대역에서 위성 우주국 수신기와의 주파수 공유를 위해 HAPS 지상국에 대한 전력 제한에 대한 연구를 요구하고 있으며, ITU-R 권고 SF.1481-1에서는 FSS 시스템과의 주파수 공유를 위해 HAPS 지상국의 안테나 방사 패턴의 사이드 로브 특성을 개선하도록 권고하고 있다. 이에 본 논문에서는 HAPS 및 GSO FSS 서비스 커버리지간 비현실적인 이격거리를 줄이면서 결의 122에서 요구하고 있는 HAPS 지상국에 대한 전력 제한 및 권고 SF.1481-1의 지상국 안테나 사이드 로브 개선 등을 고려한 지상국의 최대 허용 off-axis e.i.r.p. 레벨을 제안함으로서 HAPS 지상국과 FSS 위성 수신기간의 주파수 공유의 가능성을 보인다.

• 한국안광학회지
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• 제15권2호
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• pp.195-199
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• 2010

목적: 알코올 섭취 후 발생하는 일시적인 눈의 근시성 굴절변화와 동반되어 나타나는 해부학적 변화가 갖는 상호 관련성을 알아보고자 하였다. 방법: 평균 $24.5{\pm}1.5$세의 남자 8명(16 안)을 대상으로 0.42 g/kg의 알코올을 30분간에 걸쳐 섭취토록 한 다음, 알코올 섭취 1시간, 4시간, 24시간 후의 교정굴절력, 각막곡률반경과 두께, 동공직경, 안압, 그리고 안구축의 길이 변화를 측정하여 알코올 섭취 전과 비교하였다. 결과: 알코올 섭취 1시간 후에 알코올 섭취전과 비교하여 호흡 중 알코올 농도가 가장 높았고(p<0.001), 교정굴절력의 구면 (-)굴절력 증가(p<0.05), 동공 크기의 감소(p<0.05), 안압의 하강(p<0.001), 그리고 안구축의 길이 증가가 나타났다. 알코올 섭취 4시간 후에도 모든 측정값들이 섭취 1시간 후와 동일한 경향이었다. 그러나 알코올 섭취 24시간 후에는 알코올 섭취 전과 비교하여 의의 있는 변화를 보이지 않았다. 결론: 알코올 섭취로 인한 일시적인 근시성 굴절변화는 안압하강과 안구축의 길이 변화와 관련성이 있을 것으로 판단된다.

• 한국잠사곤충학회지
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• 제39권2호
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• pp.169-173
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• 1997

The behavior of tyrosine(Tyr.) residue of Bombyx mori silk fiber from yellow fluorescent cocoon has been examined for the dependence of pH in aqueous silk solution under the presence of orange II salt. Through the peak separation of angular dependence of spectral pattern of 15N-Tyr. and [1-13C]-Tyr. between the fiber axis and the molecular bond direction, N-H bond in fiber as well as the orientation distribution around the fiber axis were analyzed. Also, and sericin component was obtained from these angular dependence of oriented spectral pattern. The pH dependence of the 13C NMR chemical shift of B. mori silk fibroin was examined in aqueous solution in the presince of orange II are broad at pH$\geq$7.0. However, these become sharper at pH$\geq$8.0 and remain sharp at higher pH. In these higher pH range, a chemical shift change occurs due to the deprotonation of the Tyr. side group of fibroin. At higher pH. such a hydrophobic cluster is destroyed because of the electrostatic interaction according to the deprotonation of the Tyr-OH group.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.998-1004
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• 2005

U.J.S.(Ultra Jetting System) is a new ground improvement method registered as a Utility Model No.0205798, which has fundamentally improved the existing jetting method of J.S.P.(Jumbo Special Pattern System). In this study, the uniaxial compressive strengths of improved soil-grout structures by U.J.S. and J.S.P. which have been conducted on the construction site are compared. Also, the differences between the U.J.S. and J.S.P. are analyzed by considering the role of the auger bit, the injection distance measured from the axis of boring tubes, and angle of injection measured from the horizontal. The specimens of soil-grout structures are taken from the improved soils by using the U.J.S. and J.S.P. The uniaxial tests for the samples are conducted after the curing period of 28 days. The uniaxial compressive strengths and the coefficients of elasticity of surface and distance from the axis of boring. This study shows that the mean strength of the improved structure by J.S.P. is 1.9 times greater than by J.S.P.

• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2553-2559
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• 2012

The adsorption properties of benzene, toluene, p-xylene in MCM-41 with heterogeneous and cylindrical pore were studied using grand canonical ensemble Monte Carlo simulation. The simulated isotherms were compared with experimental ones, and the different adsorption behaviors in MCM-41 with pore diameters of 2.2 and 3.2 nm were investigated. The simulated adsorption amounts above the capillary-condensation pressure agreed with the experimental ones. The simulation results showed that most molecular planes were nearly parallel to the pore axis. This orientation was not affected by the molecular position in the pore. The molecular planes were nearly parallel to the pore surface for the adsorbate molecules close to the pore wall, and the molecules in the MCM-41 with the pore diameter of 3.2 nm were ordered along the pore axis.

• 한국전기전자재료학회논문지
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• 제17권3호
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• pp.329-332
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• 2004

ZnO thin films were grown with different plume-substrate angles by pulsed laser deposition (PLD) to control the amount of ablated species arriving on a substrate per laser shot. The angles between plume propagation direction and substrate plane (P-S angle) were 0$^{\circ}$, 45$^{\circ}$ and 90$^{\circ}$. The growth time was changed in order to adjust film thickness. From the XRD pattern exhibiting a dominant (002) and a minor (101) XRD peak of ZnO, all films were found to be well oriented along c-axis. From the AFM image, it was found that the grain size of ZnO thin film was increased, as P-S angle decreased. UV intensity investigated by PL (Photoluminescence) increased as P-S angle decreased.

• 대한수학회보
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• 제58권1호
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• pp.21-30
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• 2021

In this paper, we prove some rigidity results about embedded minimal hypersurface M ⊂ ℝn+1 with compact ∂M that has one end which is regular at infinity. We first show that if M ⊂ ℝn+1 meets a hyperplane in a constant angle ≥ ��/2, then M is part of an n-dimensional catenoid. We show that if M meets a sphere in a constant angle and ∂M lies in a hemisphere determined by the hyperplane through the center of the sphere and perpendicular to the limit normal vector nM of the end, then M is part of either a hyperplane or an n-dimensional catenoid. We also show that if M is tangent to a C2 convex hypersurface S, which is symmetric about a hyperplane P and nM is parallel to P, then M is also symmetric about P. In special, if S is rotationally symmetric about the xn+1-axis and nM = en+1, then M is also rotationally symmetric about the xn+1-axis.

• 대한치과교정학회지
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• 제25권3호
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• pp.287-297
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• 1995

경북대학교 치과 대학에서 두개안면골 성장에 관한 누년적 연구의 일환으로 남자 25명, 여자 21명을 대상으로 평균 연령 8.5세에서 16.5세까지 격년 간격으로 촬영한 두부X선 규격사진을 이용하여 Ricketts분석법의 항목중 V.T.O.작성의 초기 단계인 치료전의 성장 예견시에 필요한 각도 및 거리 계측 항목을 선정 계측하여 다음과 같은 결론을 얻었다. 1. 계측항목중 연령에 따른 변화를 보이지 않는 항목은 성장 방향을 나타내는 facial axis angle, FH to palatal plane angle, BA-NA-A angle, lower facial height 및 lower incisor protrusion이었다. 2. 연령에 따라 지속적으로 증가하는 항목(anterior and posterior cranial base length, facial axis length, condyle axis length, corpus axis length)에서 연간 성장 변화량, 평균 연성장량 및 8년간 변화량을 구하였다. 3. 연령에 따라 지속적으로 증가하는 모든 계측 항목에서 12세 이후의 대부분의 연간 성장변화량, 평균 연성장량 및 8년간 변화량에서 남녀간 유의차를 나타내었다(P<0.05). 4. 남녀별로 각 연령에서 각 계측치의 평균치를 이용하여 visual norm을 작성하였다. 남자의 경우 각 기간동안 상당한 성장을 보였으며 특히 12-14세 기간에 가장 많은 성장을 나타내었고, 여자의 성장 변화에서는 10-12세 사이에서 가장 많은 성장을 나타내었으며 이후 점차 감소를 보였다.