• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.541-549
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• 2015

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with higher metastatic rate and both local and systemic recurrence compared to non-TNBC. The generation of reactive oxygen species (ROS) secondary to oxidative stress is associated with DNA damage, chromosomal degradation and alterations of both hypermethylation and hypomethylation of DNA. This study concerns differential methylation of promoter regions in specific groups of genes in TNBC and non-TNBC Saudi females in an effort to understand whether epigenetic events might be involved in breast carcinogenesis, and whether they might be used as markers for Saudi BCs. Methylation of glutathione S-transferase P1 (GSTP1), T-cadherin (CDH13), Paired box protein 5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-${\beta}$ ($RAR{\beta}1$) genes was analyzed by methylation specific polymerase chain reaction (MSP) in 200 archival formalin-fixed paraffin embedded BC tissues divided into 3 groups; benign breast tissues (20), TNBC (80) and non-TNBC (100). The relationships between methylation status, and clinical and pathological characteristics of patients and tumors were assessed. Higher frequencies of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 hypermethylation were found in TNBC than in non-TNBC. Hypermethylation of GSTP1, CDH13, ID4, DAPK, HIN-1 and PAX5 increased with tumor grade increasing. Other statistically significant correlations were identified with studied genes. Data from this study suggest that increased hypermethylation of GSTP1, ID4, TWIST, DAPK, PAX5 and HIN-1 genes in TNBC than in non-TNBC can act as useful biomarker for BCs in the Saudi population. The higher frequency of specific hypermethylated genes paralleling tumor grade, size and lymph node involvement suggests contributions to breast cancer initiation and progression.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.730-733
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• 2008

원자력 발전소 정보 관리 시스템인 GPM 시스템에서 원자력 발전소 유지보수 프로세스에서 발생하는 도면, 문서 등 데이터와 비즈니스 프로세스를 모델링한 데이터 모델을 범용 제품 모델 (GPM, Generic Product Model) 클래스 라이브러리에 통합하였다. 이를 통해 제시하는 표준 데이터 모델은 지능적 P&ID 시스템의 기본 데이터 모델로 사용될 수 있으며, 이를 기반으로 향후에는 지식화된 정보 서비스 제공이 가능하게 된다.

• Journal of KIISE:Information Networking
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• v.34 no.2
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• pp.88-99
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• 2007

P2P systems are distributed data sharing systems, and each node in them plays the role of client as well as server. There are several studies using Distributed Hash Table, such as Chord, CAN, Tapestry, Pastry, but these systems don't consider the physical latency, therefore they have a weakness of difficulty to guarantee stable performance. To improve this problem, we present the TP2P system. This system is a self-organizing hierarchical overlay system and it uses Chord routing mechanism for lookup data. This system is organized by several subnets, each subnet is organized by physically close nodes, and global network organized by all nodes. In each subnet, one node finds a data, it saves in a node in the subnet, therefore it has higher probability to reduce physical lookup latency than Chord system. And each node has global information of some nodes in its subnet, and it is used to lookup data, therefore the number of hops decrease about 25% as well as the physical lookup latecy are reduced.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.130.1-130.1
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• 2010

미국과 유럽에서는 이미 10여 년 전부터 250MW급 이상의 대용량 석탄IGCC 플랜트를 상업운전 하고 있으며, 일본과 중국을 비롯한 아시아에서도 대용량 플랜트를 시운전하고 있거나 건설 중에 있다. 한국에서는 제4차 전력수급계획에 의거 태안화력 부지 내에 300MW급 IGCC 플랜트 건설을 추진 중이며, 두산중공업은 '10년 상반기에 IGCC 가스화 플랜트에 대한 FEED 설계 (Front-Eng Engineering Design)를 완료하였다. 그 과정 중 설계조건에 의한 기본 엔지니어링 사항과 석탄 가스화 플랜트에 대한 성능예측 결과를 본 연구에서 소개한다. 가스화 플랜트의 엔지니어링은 가스화 블록과 가스정제 블록으로 구분하여 수행하였다. Process Data를 이용하여 PFD Development, P&ID Generation, Equipment Specification 개발, HAZOP 수행, Architecture Engineering 등의 순으로 FEED 설계를 진행하였다. BOD (Basis of Design)를 기준으로 운전조건별 Heat & Mass Balance와 Process Flow를 재검토하고 각 기기별 운전개념을 반영하여 P&ID를 개발하였다. 그리고 배관, 전기 및 제어에 대한 각종 Diagram 개발과 HSE (Health, Safety and Environment) 관련 설계를 수행하였다. IGCC 1호기의 엔지니어링 수행과 함께 Next 호기 자체설계 역량 확보를 위해 두산중공업은 'DIGITs'로 명명된 개념기본설계 Tool을 개발하고 있다. DIGITs는 공정모델링, 단위기기 개념설계, 공정구성 (Process Configuration) 및 종합 Database Package 형태로 구성된다. DIGITs에 의한 계산 결과 공정사 Process Data 기준시 가스화 블록 출구에서 Syngas HHV와 Syngas 현열은 각각 약 $636MW_{th}$와 약 $18MW_{th}$로, Plant 설계조건 $630MW_{th}$를 만족하는 것으로 예측되었다. 향후 DIGITs는 가스정제 블록 및 주변 BOP 설비 등과 연계한 종합 개념기본설계 Tool로써 개발 진행 중이다.

• Journal of Ocean Engineering and Technology
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• v.11 no.3
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• pp.200-211
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• 1997

Most recently, offshore Engineering & Construction field is concerned about integration management technology such as CIM(Computer Integrated Manufacturing), PDM(Product Data Management) and Enterprise Information Engineering in order to cope with the rapid change of engineering and manufacturer specification as per owner's requirement during construction stage of the project. System integration and integrated data modeling with relational database in integration management technology improve the quality of product and reduce the period of the construction project by reason of owing design information jointly. This paper represents the design methodology of system integration using Business Process Reengineering by the case study. The case study is about the offshore plant material information process from front end engineering design to detail engineering for the construction and the basis of monitoring system by integrating and sharing the design information between the 2D intelligent P&ID and 3D plant modeling using relational database. As a result of the integrated data modeling and system integration, it is possible to maintain the consistency of design process in point of view of the material balancing and reduce the design assumption/duration. Near future, this system will be expanded and connected with the MRP(Material Requirement Planing) and the POR (Purchase Order Requisition) system.

• Journal of the Korean Home Economics Association
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• v.36 no.11
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• pp.119-128
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• 1998

This study was designed to find tendencies of housing value orientation of the model steel house visitors. Questionnaires were collected in June, 1997, 1,550 in total, 508 cases from Seoul, 456 cases from Pohang, and 486 cases from Kwangyang. Data were analyzed in terms of housing value orientation, using statistical methods including frequencies, mean, percentages, chi-square test and multiple regression. The major findings are as follows; 1. The subjects were highly educated(64% of them were college graduates) with the monthly income over 2,000,000won(approximately $1,540). The average monthy income of the subjects in Seoul, about 4,000,000won($3,070), was much higher than that of other areas. Most of the subjects were condominium owners(72%), who preferred single detatched houses or town houses located in suburban areas. 2. Differences in general tendencies among the three regional groups were statistically significant. Most significantly, subjects living in Pohang regarded the reputation of the building construction company most importnat. Subjects of all three regional areas, especially in Pohang, emphasized investment value. The price of the steel house was regarded as very important by all the groups tested. The housing value orientation was analyzed in 3 aspects; (1) Facility.Plumbing.Structure(FPS), (2) Interior space formation.Design(ID) and (3) Developmental complex.Near Environment(DN). Interior environment level, stability of house structure, and finighing state of interiors were identified as the important factors in the area of FPS(p<.05). The Interior plan organization was the most important factor among ID. As for DN, rated importantly were educational facilities, green areas, convenience of commercial facilities within the developmental complex were rated importantly.

• The Journal of the Korea Contents Association
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• v.11 no.7
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• pp.219-224
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• 2011

To improve medical service and customers' satisfaction by reducing actual waiting time for medical inspection by personalized examination guidance contents (PEGC) linked with medical information system (MIS). The suggested PEGC was completed with preparing transmission for data and PEGC by using transmission control protocol internet protocol (TCP/IP) which can be built up creditable data transmission service. When patient signal event appeared in MIS while the communication was in standby, the ID and data of the customer were shown as text and image on monitors in waiting room. Guiding inspections, steps of examination, and undressing information extracted from the PEGC was also shown to the appropriate patient. After installation of the suggested PEGC, we rechecked satisfaction rates of 60 customers who visited the hospital with a same method as initial survey. The results of this study suggest that 3.6 point of waiting time satisfaction index were improved, after installation of the suggested PEGC, as 4.6 point.

• The Korean Journal of Nuclear Medicine
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• v.32 no.1
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• pp.50-60
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• 1998

I-123 labelled fatty acids are suitable for investigation of regional myocardial metabolism, so they are on the clinical trial. However, the precise properties of these materials are not characterized yet. We have synthesized phenylpentadecanoic acid and labeled this compound with I-123. The purpose of this study was to examine the stability, biodistribution, metabolism and SPECT imaging of [I-123]15-(p-iodophenyl)pentadecanoic acid(I-123-IPPA) that we made. The stability test of I-123-IPPA in serum of rat, mouse and human showed no free I-123 after 1 hour. In biodistribution study in mice for various time intervals after injection(5, 10, 15, 30, 60 minutes), uptake in myocardium was 14.5%ID/g(5 min), and 1.9%ID/heart(5 min), while uptake in muscles was 2.6%ID/g(5 min). Myocardium to blood ratio and myocardium to lung ratio increased for 5 min after injection and then decreased rapidly. Chromatographic data of rat blood and urine showed that little PPA was found in blood and urine at 15-20 min after injection. The myocardial I-123-IPPA SPECT images of a dog with myocardial infarction showed defects similar to those of Tc-99m-MIBI and F-18-FDG. These data suggest that I-123-IPPA is quite stable in vitro and shows favorable biodistribution in mice. SPECT imaging with I-123-IPPA demonstrated infarct zone as photon defect in dog model of myocardial infarction. I-123-IPPA may be used for the evaluation of fatty acid metabolism in clinical trials in Korea.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.2059-2063
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• 2004

Most power plants have operated many independent computerize systems for maintenance. Independence of systems have caused complexity of business process and inconvenience of computer system management. Because the equipment and material master data is not standardize and structurize, it is difficult to manage equipment maintenance history and material delivery. Especially equipment classification criterion is important for standardization of every maintenance information. It is necessary to integrate function of independent systems for business process simplification and rapid work flow. this paper provides equipment classification criterion design and system integration method with the case of live system development.

• The Korean Journal of Emergency Medical Services
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• v.24 no.2
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• pp.123-131
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• 2020

Purpose: This study aimed to find out the effectiveness of gum elastic bougies for intubation in comparison to stylet according to airway type using a manikin. Methods: The study subjects were 52 paramedic students who intubated using a Macintosh laryngoscope and compared stylet and gum elastic bougie use in a 7.5 mmID endotracheal tube, on a manikin with either normal or difficult airway. Difficult airway was made Philadelphia neck collar. Collected data included intubation time, accuracy and ease of intubation, later analyzed by frequency analysis, descriptive analysis, independent t-test, chi square test, paired t-test, and McNemar test using SPSS Statistics 18.0. Results: There was a significant difference in intubation time according to intubation device and airway type (p=.000). There was no significant difference in accuracy of intubation according to intubation device or airway type (normal airway p=1.000, difficult airway p=.052). There was a significant difference in ease of intubation scale according to intubation device and airway type (p=.000, p=.000). Conclusion: Based on the speed and ease of intubation, gum elastic bougie is recommended for intubation in patients with difficult airways such as those with cervical injury.