• Current Optics and Photonics
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• 제2권1호
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• pp.1-6
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• 2018

Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.

• 대한한방소아과학회지
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• 제35권1호
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• pp.139-147
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• 2021

Objectives The purpose of this study is to investigate differences in brain activities when Neurodevelopmental treatment (NDT) is used alone compare to NDT is combined with intradermal acupuncture (IDA) treatment, using functional infrared spectroscopy (fNIRS) Methods Three children less than 7 year-old with cerebral palsy were participated. On their first visit, only NDT was used. After a week, they were treated with both NDT and IDA. During the treatment, fNIRS was used to measure any changes in their brain activities. Results In first patient with NDT, oxyhemoglobin level was increased during Standing exercise and Gait training compared to resting state. When the patient was treated with NDT and IDA, oxyhemoglobin level was decreased during Standing exercise and Gait training compared to resting state, and the result was significant (p<0.05). In second patient, oxyhemoglobin level was decreased in Gait training compared to resting state when NDT was used, but the level was increased when NDT and IDA were used in Gait training compared to resting state (p<0.05). In third patient, the difference in oxyhemoglobin levels between Gait training and resting state was significant (p<0.05). Conclusions Treatment involving both NDT and IDA has more potential to improve brain activities compared to that of NDT alone, and no adverse effect was reported. In order to confirm the finding, larger scale randomized controlled trials are needed.

• Physical Therapy Rehabilitation Science
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• 제11권4호
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• pp.571-578
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• 2022

Objective: Cognitive-motor trainings had a positive impact on cognitive function and dual-task trainings led to improvements of global cognitive function. The brain activity of the prefrontal cortex (PFC) is another indicator that can infer cognitive function. This study aims to confirm the usability of the interactive system cognitive-motor training program and the changes in the prefrontal cortex through training. Design: Cross-sectional study Methods: In this study, two cognitive tasks were randomly applied to 20 adults as cognitive-motor training using an interactive system, and the same task was performed using the original method. During all tasks, the brain activity of the prefrontal cortex was measured by the change in oxyhemoglobin (HbO) in real-time using Functional Near-Infrastructure. After performing the tasks, the usability of the developed interactive system was evaluated by a usability questionnaire which consists of five items, and each item consists of a 7-point Likert scale that responds from 1 point to 7 points. Results: The HbO levels were increased during cognitive task performance than at the resting phase. And evaluating the usefulness of the interactive system, a questionnaire result showed that it would be useful for cognitive-motor programs. Conclusions: The cognitive-motor training using the interactive system increased the activity of the prefrontal cortex, and the developed wearable sensor-based interactive system confirmed its usefulness.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2011년도 춘계학술대회
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• pp.91-92
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• 2011

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제11권2호
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• pp.59-66
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• 2007

The oxygen distribution at steady state is analyzed mathematically in a hexagonal cylinder. The domain is penetrated by parallel cylindrical capillaries of different oxygen squirt. Asymptotic solution is used to determine the effect of axial diffusion. Oxygen concentration profiles are displayed at some positions of capillary-beds. At the venous end some tissue areas suffer from a shortage of oxygen.

• Journal of Yeungnam Medical Science
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• 제11권1호
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• pp.49-54
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• 1994

숭모판 치환술이 예정된 10명의 환자를 대상으로 심폐우회술 동안 발생할 수 있는 뇌산소 요구량과 소모량 사이의 불균형을 조사하기 위해 내경정맥 내의 산소포화도를 체외순환 5분전과 시작후 1분 이내, 저체온 상태가 안정되었을 때와 재가온하여 체온이 $34^{\circ}C$가 되었을 때, 그리고 체외순환 종료 후 15분 이내 등 5단계로 나누어 혈액을 채취하여 평균 동맥압, 체온, 동맥내 이산화탄소 분압, 혈색 소치, PH 등을 비교 분석하여 다음과 같은 결과를 얻었다. 1. 심폐우회술 중 이산화탄소 분압과 혈색소치 및 PH의 특이한 변화는 없었다. 2. 체외순환 직후 체온 및 평균 동맥압과 혈색 소치의 급격한 변화가 있었으나 임상적인 의미는 없었으며, $SjO_2$의 변화도 없었다. 3. 저체온 상태가 안정되었을때 $SjO_2$ 평균치가 72.4%이었으나 체온을 $34^{\circ}C$로 재가온하였을 때 56.1%로 감소하였다. 4. 재가온 시기에 $SjO_2$감소를 예방하기 위해 재가온 속도를 천천히 하고 이산화탄소를 증가시킴으로써 뇌혈류를 증가시키고 마취약제 등을 이용하여 산소에 대한 뇌대사율을 관류지수를 증가시켜야 하겠다.

• Journal of Nutrition and Health
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• 제7권4호
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• pp.30-32
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• 1974

Hemoglobinemia is found in hemolytic anemia, paroxysmal nocturnal hemolobinuria and paroxysmal hemoglobinuria. Recently increasing use of extracorporeal circulation in cardiac surgery has stimulated the development of more precise methods for rapidly evaluating the formation and clearance of extracoporeal hemoglobin. A spectrophotometric method of analysis seemed to offer the best solution to the requirements. The method presented is on the basis of hemoglobin derivatives converted to cyanmethemoglobin, and the absorbance is measured in a spectrophotometer at 540 and 680 nm. The blank value ismeasured at 680 nm while the absorbance at 540 nm measures the hemoglobin derivatives. This method estimates all the hemoglobin derivatives such as oxyhemoglobin, carboxyhemoglobin, methemoglobin, sulfhemoglobin and hemialbumin. The method was tested in recovery experiments, which is given table 1. A good degree of correlation was obtained in a comparision with the method described by Crosby and Furth for non-hemolyzed serum. The spectrophotometric technique described offers many advantages in speed and simplicity over the chemical procedure.

• 한국환경보건학회지
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• 제2권1호
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• pp.49-51
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• 1975

The accidents, homicides and suicides of carbon monoxide poisoning to increase in number every year are required precize, accurate, and rapid method for the determination of carbon monoxide in the blood samples. Here is the basis of this method for the determination of percentage saturation of hemoglobin by carbon monoxide which have found out to be suitable in laboratory as follows: A 0.1ml of blood is mixed with 20ml of 0.1% ammonium hydroxide, and 20mg sodium hydrosulfite is added to convert oxyhemoglobin to reduction hemoglobin. The absorbance is measured at 538nm and 578nm, the measurement was carried out within ten minutes of addition of sodium hydrosulfate.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 춘계학술대회
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• pp.116-119
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• 1993

In this paper, we implemented a pulse wave type oximeter system that continuously measure the of oxyhemoglobin saturation of the arterial blood(SaO2) and pulse rate with non-invasively. We use the transmission type and reflection type transducer for comparison the percentage of hemoglobin oxgen saturation. The light Iron the two kind of LEDs is transmitted through the tissue, then received by a single photodiode with alternatively. By the phase sensitive detection circuit, the output of the photodiode is separated in to red and near infrared signal. We calculated a ratio of light transmittance between two kind of LEDs, and then, it is applied to the oxgen saturation coefficent calculation formular.

• Journal of Dental Anesthesia and Pain Medicine
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• 제21권5호
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• pp.471-474
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• 2021

Methemoglobinemia is rare. It is classified into two types: congenital methemoglobinemia and acquired methemoglobinemia. Methemoglobin is incapable of binding oxygen, leading to complications such as cyanosis, dyspnea, headache, and heart failure. In the present case, a 35-year-old man with congenital methemoglobinemia underwent general anesthesia for thyroidectomy. The patient was diagnosed with hemoglobin M at 7 years of age. Ventilation was performed with FiO₂ 1.0. Arterial blood gas analysis showed that the pH was 7.4, PaO₂ 439 mmHg, PaCO₂ 40.5 mmHg, oxyhemoglobin level of 83.2%, and methemoglobin level of 15.5%. The patient had a stable course, although cyanosis was observed during surgery.