• Title/Summary/Keyword: Oxadiazoles

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Synthesis of Some 2-Amino-5-Substituted-1,3,4-Oxadiazoles Through the Electrooxidation of Semicarbazone (세미카바존의 전기적 산화에 의한 2-Amino-5-Substituted-1,3,4-Oxadiazoles 합성)

  • Kumar, Sanjeev
    • Journal of the Korean Chemical Society
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    • v.53 no.2
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    • pp.159-165
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    • 2009
  • The synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles 4 were carried out from the electrooxidation of semicarbazone 3 at the platinum electrode under controlled potential electrolysis in an undivided cell. This is an environmentally benign method in the field of synthetic organic chemistry. The non-aqueous solvents acetic acid and acetonitrile and a supporting electrolyte lithium perchlorate were used for the electrolysis in the electrooxidation. The products were structurally charecterised by IR, $^1H$-NMR, $^{13}C$-NMR and elemental analysis.

Ecofriendly Synthesis of Antifungal Azoles

  • Kidwai, M.;Mohan, R.
    • Journal of the Korean Chemical Society
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    • v.48 no.2
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    • pp.177-181
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    • 2004
  • 1,2,4-Triazoles, pyrazolones and 1,3,4-oxadiazoles have been synthesized from substituted hydrazide using various solid supports under microwave irradiation (MWI). The results obtained highlight the versatility of the solid supports. All synthesized compounds were screened for their antifungal activity against A. niger and A. flavus and were found to possess good activity.

Four-Component Preparation of Disubstituted 1,3,4-Oxadiazoles from (N-isocyanimino)triphenylphosphorane, Phenylacetylenecarboxylic Acid, Biacetyl and Primary Amines

  • Ramazani, Ali;Abdian, Behnaz;Nasrabadi, Fatemeh Zeinali;Shajari, Nahid;Ranjdoost, Zahra
    • Bulletin of the Korean Chemical Society
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    • v.33 no.11
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    • pp.3701-3705
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    • 2012
  • A simple method has been developed for four-component synthesis of disubstituted 1,3,4-oxadiazoles using (N-isocyanimino)triphenylphosphorane, a primary amine, a carboxylic acid and biacetyl in $CH_2Cl_2$ by the Ugi-4CR/aza-Wittig sequence at room temperature in excellent yields.

Synthesis and Characterization of 1-Benzofuran-2-yl thiadiazoles, Triazoles and Oxadiazoles by Conventional and Non-conventional Methods (반응방법에 따른 1-Benzofuran-2-yl thiadiazoles, Triazoles과 Oxadiazoles의 합성)

  • Shinde, Ananta D.;Kale, Bhima Y.;Shingate, Bapurao B.;Shingare, Murlidhar S.
    • Journal of the Korean Chemical Society
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    • v.54 no.5
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    • pp.582-588
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    • 2010
  • The synthesis of benzofuran based 1,3,4-thiadiazoles, 1,3,4-triazoles and 1,3,4-oxadiazole via cyclocondensation of thiosemicarbazides have been carried out by conventional and non-conventional methods in excellent yields of product.

Facile Synthesis and Biological Evaluation of Heterocyclic Compounds Containing Diazepam

  • Berghot, M.A.
    • Archives of Pharmacal Research
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    • v.24 no.4
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    • pp.263-269
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    • 2001
  • Diazepamoxadiazoles 4,5,6,12,14 and 22 were prepared with the binary form system. Diazepamthiadiazoles 15,20 and Diazepamtriazoles 7,8,9,17,18,19 and 21 were also shapely synthesized. Some of these compounds were screened to test their antibacterial activity against E. coli and B. subtilis compounds 15 and 20 show potent activity against these bacteria.

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Synthesis of New Xanthenone Derivatives of Expected Antibilharzial Activity

  • Omar, Mahmoud-T.
    • Archives of Pharmacal Research
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    • v.20 no.6
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    • pp.602-609
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    • 1997
  • A new series of 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles and 1, 2, 4-triazoles incorporated directly and/or indirectly into a xanthenone moiety at position-2-were synthesized. Some of the newly prepared compounds were biologically tested as schistosomicides in experimental animals.

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Synthesis and Antimicrobial Screening of Some Fluorinated Azoles Containing (2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl) Nucleus ((2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl)핵종을 가지고 있는 불소화된 아조화합물의 합성과 항균활성의 스크리닝)

  • Shelke, Sharad;Salunkhe, Nilesh;Sangale, Sandeep;Bhalerao, Swapnil;Naik, Nilesh;Mhaske, Ganesh;Jadhav, Ranjana;Karale, Bhausaheb
    • Journal of the Korean Chemical Society
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    • v.54 no.1
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    • pp.59-64
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    • 2010
  • The synthesis of a series of fluorinated thiadiazoles 3, triazoles 4 and oxadiazoles 5 are synthesized from thiosemicarbazides 2 containing (2-(6-methyl-2-p-tolyl-lH-imidazo[1,2-a]pyridin-3-yl nucleus. These reactions were carried out by conventional method as well as ultra sound irradiation method. All products have been characterized by IR, 1H NMR, MS study and screened for their antimicrobial activity.

Synthesis of Polyphenylene-1,2,4-Owadiazoles and Quinone Polymer by the Reactions of Tere- and Iso-Phthalohydroxamoyl Chlorides with Bisdipolarophiles

  • Suck-Ju Hong
    • Journal of the Korean Chemical Society
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    • v.15 no.3
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    • pp.121-125
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    • 1971
  • Tere-and Isophthalohydroxamoyl chlorides were condensed with 1, 4-benzoquinone to afford quinone type polymer with the oxidation of the ring structure. Similarly, tere-and isophthalohydroxamoyl chlorides were condensed with tere-and isophthaldioximes and terephthalonitrile to give crystalline polyphenylene-1,2,4-oxadiazoles, among which the reaction product of terephthalohydroxamoyl chloride with terephthalonitrile in xylene afforded the highest crystallinity.

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