• Biomolecules & Therapeutics
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• 제10권3호
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• pp.175-179
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• 2002

Human growth hormone (hGH) forms antibody by repeated administration. The present study investigated to confirm formation of antibody by repeated subcutaneous administration of hGH for two months in rats and dogs. In this result, hGH-injected sera were significantly higher than control sera by 1:1,000,000 of dilution factor. After antibody formed sera (anti-hGH sera) and control sera were added to 30 $\mu\textrm{g}$/ml hGR, the complex incubated for overnight at $30^{\circ}C$. Anti-hGH sera decreased hGH contents about 90% compared to control sera. Also, body weight gain conducted decreased about 67% compared to control sera in hypophysectomised rat. Inconclusion, repeated administration of hGH formed antibody because hGH was foreign protein to rats and dogs. And formed antibody of hGH was blocked and decreased many efficacy of hGH, the antibody was proved to be neutralizing antibody. Thus, because neutralizing antibodies were decreased pharmacological effects of hGH, administration more than two months were no significance.

• Clinical and Experimental Pediatrics
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• 제46권4호
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• pp.363-369
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• 2003

목 적 : 본 연구는 저신장 소아 중 성장호르몬 약물자극검사에서는 정상반응을 나타낸 특발성 저신장 소아들을 대상으로 야간의 수면 양상과 성장호르몬 분비가 정상 신장의 아동과 차이가 있는지 알아보고자 하였다. 방 법 : 성장호르몬 약물자극검사에서 정상반응을 보인 신장이 3 백분위수 이하인 특발성 저신장 아동 12명과 정상 신장 아동 9명을 대상으로 30분 간격으로 야간수면 동안의 자발적 성장호르몬 분비를 측정하고 동시에 polysomnography로 수면양상을 비교 분석하였다. 결 과 : 1) 야간 수면 중 분비된 성장호르몬의 평균농도는 저신장 아동군이 정상 아동군에 비해 유의하게 낮았으며($2.8{\pm}0.2 ng/mL$ vs $4.7{\pm}0.6 ng/mL$), 특히 수면개시 후 서파 수면과 동반되는 성장호르몬 최대 분비치가 저신장 아동군이 낮았다. 2) 수면 중 성장호르몬 농도가 5 ng/mL 이상인 성장호르몬 분비 최대치의 횟수는 각각 $4.1{\pm}0.5$회, $5.8{\pm}0.6$회로 저신장군이 유의하게 적었다. 3) 전체 수면 시간에 대한 서파 수면 시간의 백분율도 저신장 아동군이 정상 아동군에 비해 감소되어 있었다($16.4{\pm}1.3%$ vs $20.8{\pm}1.2%$). 결 론 : 야간 수면 동안의 자발적인 성장호르몬 분비 검사가 약물자극검사에서 정상반응을 보이는 특발성 저신장 아동의 추가적인 진단에 도움을 줄 수 있으며 이들 저신장 아동에서 보이는 야간 성장호르몬 분비 감소는 수면구조의 차이와 일부 관련이 있는 것으로 생각된다.

• The Korean Journal of Physiology
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• 제10권1호
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• pp.67-71
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• 1976

Effect of Electro Convulsion Therapy (ECT) on the Human Growth Hormone (HGH) response was observed in 32 cases of various mental illness. The patients were fasting overnight and ECT was induced in the morning by application of $90{\sim}120V$ for a period of $0.1{\sim}0.5\;sec$. In all patients, venous blood samples were taken prior to simultaneously with 1 and 4 hours after the ECT. Plasma was immediately seperated and stored in $-20^{\circ}C$ refrigerator. HGH concentrantion was determined by means of radioimmunoassay Results were as follows: 1. Application of electric current was not followed by a significant change in mean plasma HGH of 52 cases. 2 Increases of plasma HGH following ECT were observed in about half cases showing low initial level but in 20 other cases with high initial level of plasma HGH, reasonable decreases after therapy were not found. 3. Plasma concentration of HGH one hour after application of current were always higher than just after the current. 4. There were no differences between HGH responses to a 1st, 2nd or 5th ECT. 5. Discussions were made on the possible modification of HGH response following ECT by the autoregulatory control mechanism.

• Tuberculosis and Respiratory Diseases
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• 제42권4호
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• pp.610-617
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• 1995

저자들은 활동성 선단거대증과 이로 인하여 생긴 확장형 성근병증에 의한 울혈성 심부전과 중증의 심실성 부정맥이 있는 환자에 동반된 폐쇄성 수면 무호흡증후군을 치료하기 위하여 4개월간 지속적 영양공급치료를 시행한 예를 경험하였기에 문헌고찰과 함께 보고한다.