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Evaluation of Hemodynamic Failure with Acetazolamide Challenged $^{123}I-IMP$ Brain SEPCT and PET (PET과 Acetazolamide 부하 $^{123}I-IMP$ 뇌혈류 SPECT를 이용한 혈역학적 부전의 평가)

  • Chun, Kyung-Ah;Cho, In-Ho;Won, Kyu-Jang;Lee, Hyung-Woo;Hayashida, Kohei
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.2
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    • pp.94-102
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    • 2003
  • Purpose : Cerebral blood flow (CBF) reactivity to acetazolamide (ACZ) is useful to select patients with hemodynamic failure. However, it is still a matter of speculation that varying degrees of regional CBF increases after ACZ administration represent the severity or stage of regional hemodynamic failure as assessed by positron emission tomography (PET). We studied to elucidate whether ACZ challenge $^{123}I-IMP$ brain single photon emission tomography (SPECT) can accurately grade the seventy of regional hemodynamic failure. Materials and Methods: Eighteen patients (M: 16, F: 2, average age: 61 years) with unilateral occlusive disease of the internal carotid artery or the trunk of the middle cerebral artery (MCA). Patients undewent $^{123}I-IMP$ brain SPECT study with acetazolamide challenge and PET study was carried out within 2 weeks before and after SPECT study. Five healthy volunteers with a mean age of 48 years (range: 28-73 yr, M: 3, F: 2) underwent PET studies to determine normal values. In SPECT study, an asymmetry index (Al)-the percentage of radioactivity of region of interest (ROI) in the occlusive cerebrovascular lesion to the contralateral homologous ROI-was used for numerical evaluation of relative $^{123}I-IMP$ distribution. In PET study, regional CBF, oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen ($CMRO_2$) and cerebral blood volume (CBV) values were measured with $^{15}O-labeled$ gas inhalation method and the values were used for comparison with Al (Al during acetazolamide challenge-Al of basal study) on the SPECT study. ROls were classified by severity into three groups (normal, stage I and stage II). Results: Mean values of Al in areas with normal, stage I and stage II hemodynamic failure were $6.25{\pm}7.77%\;(n=107),\;-10.38{\pm}10.41%\:(n=117)\;and\;13.30{\pm}10.51%\;(n=140)$, respectively. Al significantly differed with each groups (p<0.05). Correlation between Al and CBF, OEF and CBV/CBF in hemisphere with occlusive cerebrovascular lesion was 0.20 (p<0.01), -0.28 (p<0.01) and -0.28 (p<0.01), respectively. Conclusion: We concluded that $^{123}I-IMP$ brain SPECT with acetazolamide challenge could determine the severity ad stage of regional hemodynamic failure as assessed by PET.

The efficacy of ketogenic diet in childhood intractable epilepsy with malformation of cortical development (대뇌 피질 발달 기형을 동반한 난치성 소아 간질에서 케톤생성 식이요법의 효과)

  • Lee, Young-Mock;Kang, Du Cheol;Chung, Da Eun;Kang, Hoon Chul;Kim, Heung Dong
    • Clinical and Experimental Pediatrics
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    • v.49 no.2
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    • pp.187-191
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    • 2006
  • Purpose : Malformation of cortical development(MCD) constitutes an important etiology of intractable epilepsy and is considered an indication for surgical treatments, though their efficacy is limited and variable depending on MCD's location or distribution. Ketogenic diets are widely known to be effective, but as little study has been made concerning their efficacy on epilepsy with MCD, we evaluated the efficacy of ketogenic diets on MCD patients compared with that of epileptic surgery, which is more invasive. Methods : We performed retrospective studies and analyse on 30 patients with MCD diagnosed by brain MRI and treated with ketogenic diets for intractable epilepsy since 1998, checking decreases in their seizure episodes after starting the diets. Results : Cortical dysplasia was observed in 24(80.0 percent) patients as the most common type of MCD. Also, MCD was observed in unilateral hemisphere most commonly, in 23(76.7 percent) patients; it was observed in both hemispheres in 7(23.3 percent) patients. Nine(30.0 percent) out of 30 patients became seizure-free after starting ketogenic diets, and 14(46.7 percent) patients experienced 50 percent seizure reductions as well. Age of starting the diet or the duration of epilepsy period before starting showed no statistical relationship with the efficacy of the diet. Though the younger the patient and the longer the treatment the more effective the diet seemed to be, there was no statistical correlation between them. The location of MCD showed no significance neither. Conclusion : Considering various limits and invasiveness of surgical treatment, a ketogenic diet could be a good tool in treating children with intractable epilepsy with MCD.

Plant Community Structure of Abies holophylla Community from Sinseongam to Jungdaesa in Odaesan National Park (오대산국립공원 신성암~중대사 전나무림 식물군집구조 특성)

  • Kim, Dong-Wook;Han, Bong-Ho;Kim, Jong-Yup;Yeum, Jung-Hun
    • Korean Journal of Environment and Ecology
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    • v.29 no.6
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    • pp.895-906
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    • 2015
  • This study was carried out to the structure of plant community from Sinseongam to Jungdaesa in Odaesan National Park, furthermore, it seeks to curate the basic data for planning of the Abies holophylla's forest management in Odaesan National Park. In order to identify the current ecological environment, this study explored the actual vegetation as primary research and set to twenty plots(i.e. $400m^2$) for analysing detailed structure of plant communities. The research methodology was qualitative analysis, therefore it used TWINSPAN and DCA analysis tools. Especially, TWINSPAN performed well in several comparisons of classification techniques, DCA is one of the ordination technique showed that the plant communities. The plant community was analysed classification and ordination by TWINSPAN and DCA, moreover it was analysed the structure of plant community such as importance percentage of woody species, DBH class distribution, the index of diversity and rate of sample tree growth. The main vegetation was A. holophylla-Quercus mongolica forest and Deciduous broad-leaved forest in the communities where located in low altitude and valley, whereas main vegetation where located in high altitude and slope was Q. mongolica forest. The research site's plant communities were classified four groups. In all of communities, A. holophylla was dominant species in main canopy layer, furthermore, the three communities (community I, II, III) are growing up next generation of A. holophylla excluding community IV. The communities (community I, II, III) can be sustained current status which dominates the A. holophylla communities, simultaneously, there might be expanded the Deciduous broad-leaved communities by Carpinus cordata, Betula schmidtii and so on. While, it showed that the community IV tended to be weaken the forces of A. holophylla, therefore the community IV can be transferred to C. cordata-Deciduous broad-leaved communities in the future. The age of sample trees was 79~128(i.e. A. holophylla), 75~87(i.e. Pinus koraiensis) and 190 years(i.e. Ulmus davidiana var. japonica). The index of Shannon's Species diversity (H') were ranged from 0.3889 to 1.3332 in the communities.

Interpretation of Soil Catena for Agricultural Soils derived from Sedimentary Rocks (퇴적암 유래 농경지 토양에 대한 카테나 해석)

  • SONN, Yeon-Kyu;LEE, Dong-Sung;KIM, Keun-Tae;HYUN, Byung-Keun;JUN, Hye-Weon;JEON, Sang-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.20 no.4
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    • pp.1-14
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    • 2017
  • In Korea, the soil series derived from sedimentary rocks are classified into seven soil series of coarse loamy soil such as Dain, Danbug, Dongam, Imdong, Jeomgog, Maryeong, and Yonggog; seventeen soil series of fine loamy soil such as Angye, Anmi, Banho, Bigog, Deoggog, Dogye, Dojeon, Gamgog, Gugog, Jincheon, Maji, Mungyeong, Oggye, Samam, Yanggog, Yeongwol, and Yulgog; six soil series of fine silty soil such as Goryeong, Bonggog, Juggog, Gyeongsan, Yuga, and Yugog; and four soil series of clayey soil such as Mitan, Pyeongan, Pyeongjeon, and Uji. All thirty-four soil series have different drainage rates and topography. However, the soil texture depends on the parent rock. The buffer functions in GIS (Geographic Information System) techniques were used to calculate adjacent soil series from a soil series. The length of the adjacent soil series was adjusted because a side of the buffer area was one meter long. The cluster analysis was conducted using the CCC (Cubic Clustering Criterion) method, in which the number of clusters is calculated based on the individual soil series ratio. Soil survey has been carried out since 1964 as "The reconnaissance soil survey", and 1:5,000 detailed soil survey was completed in 1999 with a five-years plan in Korea. Today, all the soil survey information has been computerized. GIS techniques were used to establish a digital soil map; however, there have not been any studies to interpret pedogenesis using the GIS technique. In this study, the area of the adjacent soil series were obtained using the GIS technique. The area of the adjacent soil series can be calculated based on the information area. The similarities of soil originated from sedimentary rocks were estimated using the length. As a result, the distribution of grain size was different based on the types of sedimentary rocks and the location. The clusters were distinguished into limestone, sandstone, and shale. In addition, the soil derived from shale was divided into red shale and gray shale. This means that quantitative interpretation of the catena and this established method can be used to interpret the relationship between soil series.

A Clinical Therapeutic Results on Small Cell Lung Cancer (소세포 폐암의 치료성적에 대한 고찰)

  • Kim, Eun-Hwa;Lee, Soon-Hyoung;Huh, Won-Young;Kim, Han-Sik;Jo, Jin-Ung;Kim, Mee-Ae;Kim, Sang-Kyun;Kim, Kwi-Wan;Chung, Weon-Kuu;Kim, Soo-Kon
    • Tuberculosis and Respiratory Diseases
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    • v.41 no.3
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    • pp.262-269
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    • 1994
  • Background : A clinical study was carried out on 153 new cases with small cell lung cancer registered at Presbyterian Medical Center, Chonju during the 7 years from 1986 to 1992. They were analyzed by sex and age distribution, symptoms and signs, classification of stage and site and its treatments. Especially, an effort was made to compare the overall survival time between limited stage and extensive stage. Methods : Among 806 lung cancer patients diagnosed by biopsy or cytologic evaluation for the 7 years, 153 patients was shown small cell lung cancer. These 153 cases was analyzed retrospectivery through patient's records, letters or telephones. Results : The results of evaluation of small cell lung cancer are as follows. Over 85 percent of the small cell lung cancer patients were over 50 years of age and prominent clinical features were cough(86.3%), sputum(75.8%) and dyspnea(54.9%). One hundred and five patients(68.7%) was staged to have limited stage. Mean survival time of the chemotherapy and chemoradiotherapy in limited stage has significant difference and its survivals are 5.3 months and 15.0 months. Patients whose disease was staged as limited, regardless of whether or not chemotherapy was administered, had a median survival time of 10.9 months, compared with 4.8 months for those with extensive stage. Conclusion : Lung cancer is one of the malignant diseases tend to increase gradually in Korea and proven to be the most common cancer next to the gastric cancer among various cancers in males found at the Presbyterian Medical Center in the past seven years. This report is a retrospective view of the clinical therapeutic results of the small cell lung cancer patients. Especially at the limited stage, the combined therapy revealed higher survival rate than the chemotherapy alone. For a more accurate evaluation. a prospective view, without any bias, of patients selected at random is needed.

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Biomass Expansion Factors for Pinus densiflora in Relation to Ecotype and Stand Age (소나무의 생태형과 임령에 따른 물질 현존량 확장계수)

  • Park, In Hyeop;Park, Min Su;Lee, Kyeong Hak;Son, Yeong Mo;Seo, Jeong Ho;Son, Yowhan;Lee, Young Jin
    • Journal of Korean Society of Forest Science
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    • v.94 no.6
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    • pp.441-445
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    • 2005
  • Researches on estimating national-scaled forest biomass are being carried out to quantify the carbon stock of forests with the Kyoto Protocol. In general, estimates of national-scaled forest biomass are based on forest inventory data which provides estimates of forest area, stem volume, and growth of stem by age classes. Estimates of forest biomass are, however, obtained by converting stem volumes to dry weight with stem density and thereafter to whole tree biomass with biomass expansion factors (ratios of whole tree dry weight to stem dry weight). Pinus densiflora is widely distributed and one of the most economically important timber species in Korea. The species are largely grouped into two ecotypes of Geumgang and Jungbu. Stems of Geumgang type trees are straight and high compared to those of Jungbu type trees. The objective of this study was to determine and compare stem density and biomass expansion factors fore two ecotypes of Pinus densiflora according to stand age. Stem density of both ecotypes of Pinus densora increased and biomass expansion factors of them decreased with increasing tree age. In he same age class, stem density and biomass expansion factor of Geungang type Pinus densiflora were lower than those of Jungbu type Pinus densiflora. There were statistically significant differences in stem density and biomass expansion factors between Geumgang type and Jungbu type Pinus densiflora in 0-20-year-old stands and 40-60-year-old stands. Our results suggested that the reliability of the national forest biomass inventory could be improved by applying the ecotype- and age-dependent stem density and biomass expansion factors.

A Flora of Vascular Plants in Boraebong (보래봉 일대의 관속식물상)

  • Ji Eun Kim;Young-Soo Kim;Jung Sim Lee;Ju Eun Jang;Hyeon Jin Jeong;Aleksey L. Kim;Sang-Kuk Han;Hee-Young Gil
    • Korean Journal of Plant Resources
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    • v.37 no.1
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    • pp.35-61
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    • 2024
  • Floristic study can help to understand the current status of species diversity, evaluate and predict distribution changes of plants based on the specimens, and record the climate environment and biodiversity of the Korean Peninsula. Boraebong is an area that has plant resources of conservation value, but there is concern about artificial interference through trail and forest road. Therefore, this study aims to report the vascular plants of Boraebong based on voucher specimens and photos and to use them as baseline data to conserve biodiversity of Boraebong. Also, it will be useful to prevent additional influx of invasive species through comparison with previous studies. The investigation was carried out 11 times from April to September in 2022 and confirmed a total of 455 taxa including 87 families, 269 genera, 401 species, 13 subspecies, 35 varieties, 6 forms. In addition, we confirmed the 4 taxa of red list plants (EN 2 taxa, NT 2 taxa), 18 taxa of Korean endemic plants, and 102 taxa of floristic target species (V degree 1 taxon, IV degree 16 taxa, III degree 31 taxa, II degree 31 taxa, I degree 23 taxa). Furthermore, alien plants 17 taxa, invasive species 2 taxa, useful plants 439 taxa were confirmed in Boraebong. As the results of comparison with previous studies, 98 total taxa including 38 families, 76 genera, 86 species, 1 subspecies, 8 varieties, 3 forms were newly identified in this study.

Taxonomical Classification and Genesis of Yongheung Series in Jeju Island (제주도 토양인 용흥통의 분류 및 생성)

  • Song, Kwan-Cheol;Hyun, Byung-Geun;Moon, Kyung-Hwan;Jeon, Seung-Jong;Lim, Han-Cheol
    • Korean Journal of Soil Science and Fertilizer
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    • v.42 no.6
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    • pp.478-485
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    • 2009
  • This study was conducted to reclassify Yongheung series based on the second edition of Soil Taxonomy and to discuss the formation of Yongheung series in Jeju Island. Morphological properties of typifying pedon of Yongheung series were investigated and physico-chemical properties were analyzed according to Soil Survey Laboratory Methods Manual. The typifying pedon contains 3.2~3.4% oxalate extractable (Al + 1/2 Fe), less than 85% phosphate retention, and higher bulk density than $0.90Mg\;m^{-3}$. That can not be classified as Andisol. But it has an argillic horizon from a depth of 15 to 150 cm and a base saturation (sum of cations) of less than 35% at 125 cm below the upper boundary of the argillic horizon. That can be classified as Ultisol, not as Andisol or Alfisol. The typifying pedon has 0.9 % or more organic carbon in the upper 15 cm of the argillic horizon and accordingly, can be classified as Humult. It has a clay distribution in which the percentage of clay does not decrese from its maximum amount by 20% or more within a depth of 150 cm from the mineral soil surface, and keys out as Palehumult. Also that meets the requirements of Typic Palehumult. That has 35 % or more clay at the particle-size control section and has mesic soil temperature regime. Yongheung series can be classified as fine, mixed, thermic family of Typic Palehumults, not as fine, mixed, thermic family of Typic Hapludalfs. Most soils distributed in the southern coastal areas in Jeju island which have a humid climate are developed as Andisols. But Yongheung series distributed in this areas and derived from mainly trachyte, trachytic andesite, and volcanic ash are developed as Ultisols.

Current Status and Challenge of Hospice.Palliative Care in Korea (한국 호스피스.완화의료 기관 현황 및 과제)

  • Lee, Kun-Sei;Joo, Ji-Soo;Kim, Jung-Hoe;Kim, Keon-Yeop
    • Journal of Hospice and Palliative Care
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    • v.11 no.4
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    • pp.196-205
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    • 2008
  • Purpose: The purpose of this study was to evaluate the current status of hospice palliative care facilities, and to identify problems and improve hospice palliative care in Korea. Methods: The questionnaire survey was implemented from October to December, 2007. It was consisted of general characteristics of organization, health manpower, facilities & equipments, service programs, and so on. Sixty two (79.5%) out of 78 hospice palliative care facilities returned the questionnaires. Results: They were 42 hospital-based hospice palliative care hospitals and 9 clinics, and most of them are located at central metropolitan areas (Seoul and Gyeonggi Province). more than 80% of hospitals met with the requirements (one doctor per 10 patients and one nurse per 1.5 patients), whereas 42.9% of clinics met the requirements. Approximately 22% of them met the requirement of sick room (4 patients for 1 room). Most of them provided various hospice palliative care programs. The proportion of giving regular education programs to hospice palliative care personnels were about half (41.9%). Thirty two (51.6%) facilities provided home visiting hospice palliative care service. Conclusion: There were lack of enough health manpower, rooms, and programmes and they varied among facilities. It is necessary to increase the number of hospice palliative care facilities with consideration of regional fair distribution and standardization of programmes.

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Comparison of Dose When Prescribed to Point A and Point H for Brachytherapy in Cervical Cancer (자궁경부암 근접치료에서 A점과 H점을 이용한 치료계획 시 선량 비교)

  • Gang, Ji-Hyeong;Gim, Il-Hwan;Hwang, Seon-Boong;Kim, Woong;Im, Hyeong-Seo;Gang, Jin-Mook;Gim, Gi-Hwan;Lee, Ah-Ram
    • The Journal of Korean Society for Radiation Therapy
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    • v.24 no.2
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    • pp.61-66
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    • 2012
  • Purpose: The purpose of this study is to compare plans prescribed to point A with these prescribed to point H recommended by ABS (American Brachytherapy Society) in high dose rate intracavitary brachytherapy for cervical carcinoma. Materials and Methods: This study selected 103 patients who received HDR (High Dose Rate) brachytherapy using tandem and ovoids from March 2010 to January 2012. Point A, bladder point, and rectal point conform with Manchester System. Point H conforms with ABS recommendation. Also Sigmoid colon point, and vagina point were established arbitrarily. We examined distance between point A and point H. The percent dose at point A was calculated when 100% dose was prescribed to point H. Additionally, the percent dose at each reference points when dose is prescribed to point H and point A were calculated. Results: The relative dose at point A was lower when point H was located inferior to point A. The relative doses at bladder, rectal, sigmoid colon, and vagina points were higher when point H was located superior to point A, and lower when point H was located inferior to point A. Conclusion: This study found out that as point H got located much superior to point A, the absorbed dose of surrounding normal organs became higher, and as point H got located much inferior to point A, the absorbed dose of surrounding normal organs became lower. This differences dose not seem to affect the treatment. However, we suggest this new point is worth being considered for the treatment of HDR if dose distribution and absorbed dose at normal organs have large differences between prescribed to point A and H.

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