• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.3
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• pp.160-164
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• 2015

Hunter syndrome(Mucopolysaccharidosis type II, MPS type II) is an X-linked disorder of glycosaminoglycans (GAGs) metabolism caused by an iduronate-2-sulfatase (IDS2) deficiency. A 24-month-old boy visited the department of pediatrics with the chief compliant of chronic purulent rhinorrhea beginning at age one. He had a history of repeated acute otitis media and chronic rhinitis. On physical examination he had a coarse face, enlarged tongue, distended abdomen, joint stiffness, and Mongolian spots at his first visit. The urine GAGs level was elevated at 66.10 mg/mmolCr (reference range, <11.1) and iduronate-2-sulfatase activity in leukocyte was decreased at 0.21 nmol/mg protein/hr (reference range, 18.7-57). Finally with an IDS gene mutational analysis, recombinant known mutation between intron 7 and distal of exon 3 in IDS2 was detected. Recombinant iduronate-2-sulfatase therapy was started without any infusion related reactions. The author highlights the importance of suspecting Hunter syndrome when pediatric patients visit with chronic purulent rhinorrhea which is a common cause of hospital visits for infants and children.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.622-624
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• 2009

Psoroptic mites can cause severe pruritic otitis externa with crusts in rabbits. In this case report, three rabbits with a psoroptic mite infestation were treated with a formulation containing 10% imidacloprid and 50% permethrin at a dose of 0.4 ml regardless of body weight. One week after treatment, the rabbits showed mild pruritus with no crusts, mites or eggs. Four weeks after treatment, there were no clinical signs, mites or eggs observed in the rabbits. The rabbits were treated successfully with this combination without adverse reactions for 8 weeks after treatment. This case report suggests that a single topical application of a combination of imidacloprid and permethrin may be an effective and practical treatment for psoroptic mite infestations in pet rabbits.

• Korean Journal of Veterinary Research
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• v.58 no.1
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• pp.61-64
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• 2018

Eight rabbits exhibited head tilt and subsequently died. At necropsy, three rabbits had crusty deposits in ears and four had reddish lungs. The main histopathological features were severe diffuse suppurative meningoencephalitis (75.0% of rabbits), fibrinopurulent pneumonia (37.5%), and otitis externa (37.5%). Pasteurella multocida (P. multocida) was isolated from brains, ears, and lungs. The capsular serogroups of the isolates were untypable. Based on histopathological features and bacterial analysis results, the rabbits were diagnosed as P. multocida infection. P. multocida infections might result in considerable economic loss in commercial rabbit production facilities in Korea.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1987.05a
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• pp.11.3-12
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• 1987

삼출성 중이염은 소아연령군의 이비인후과질환중 유병율이 가장 높은 질환의 하나로 1867년 Politzer가 최초로 기술하고 치료법을 소개한 이후 그 병인 및 치료법이 다양하게 연구 개발되어 왔으며 1950년대 및 1960년대 electroacoustic impedance unit의 발전에 따라 진단법에 많은 변혁이 이루어졌다. 연자들은 1981년 1월1일 부터 1986년 12월31일까지 삼출성 중이염으로 중이내 통기관유치술 및 고막천자를 시행한 15세 이하의 290명의 환자를 대상으로 tympanogram의 양상 및 술전 기골도차를 조사하여 중이내 삼출액의 유무 및 점성도의 예측도에 대하여 살펴 보았다. Tympanometric peak pressure (T. P. P.) 가 -50mm$H_2$O 미만이며 compliance가 0.4 c.c.미만인 영역을 B영역으로. T.P.P.가 -50mm$H_2$O 미만이며 compliance가 0.4 c.c. 이상인 영역을 C영역으로 정하였을 때 중이내 삼출액 유무의 예측도는 B영역이 87.5%. C영역은 81.48%였으며 삼출액이 장액성일 경우의 예측도는 B영역이 24.51%, C영역이 22.72%이었고, 삼출액이 점액성일 경우의 예측도는 B영역이 70.39%, C영역이 54.54%이었다. 연령을 15세 - 7세군과 6세이하의 군으로 세분하였을 경우에도 비슷한 결과를 얻었다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.3
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• pp.88-94
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• 2004

Hemifacial spasm is painless uncommon disorder characterized by involuntary paroxysmal movement of one side face. In the treatment of hemifacial spasm, the Western operation or non-operation therapy has many side effect such as hearing loss, exudative otitis media, facial paralysis etc. So we studied mainly the effect of cause, treatment frequency, diseased part of 29 cases with hemifacial spasm for effective clicical application of oriental medicine. The results of study are as follow; 1. It shows more female patients than male patients, and mostly patients in their forties. 2. The diseased part is shown more on left side than right side, and the left side hemifacial spasm is cured more effective. 3. The causes of hemifacial spasm are mainly stress, ignorance, overwork, and the stress, a cold are more effective causes than ignorance in. 4. The disease period is mainly within six months, and that period is the most effective time. 5. The palpebral site is the most frequent site, ineffective site. 6. The effect go with the treatment frequency is not available. 7. There is a 55 percent improvement of 29 cases.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.7 no.2
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• pp.119-122
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• 2011

Achondroplasia is one of the most common types of dwarfism and is inherited as an autosomal dominant trait. Clinical features of achondroplasia include disproportionate short stature with normal trunk length, shortening of the extremities, bowing of the lower extremities, short stubby trident hands, spinal stenosis and lumbar lordosis. Characteristic craniofacial features include macrocephaly, prominent forehead, depressed nasal bridge, maxillary hypoplasia, otolaryngeal system dysfunction, and foramen magnum stenosis. These characteristics may lead to number of complications including hydrocephalus, apnea, upper-airway obstruction, otitis media, sinusitis and dental malocclusion. Apart from these features, the affected children have good general health and normal intelligence. Dentists should be aware of the clinical characteristics of achondroplasia and the complications that may arise as a result of this disorder. This case report is to present dental treatment of a patient with achondroplasia under general anesthesia and discuss special considerations.

• Journal of Korean Public Health Nursing
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• v.25 no.2
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• pp.197-208
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• 2011

Background: This study investigated the hearing status in Korean adults according to data from the Korea National Health and Nutrition Examination Survey 2009. Methods: The data of 3,479 adults(${\geq}20$ years, 1,492 men, 1,987 women) collected by the Korean Center for Disease Control was analyzed using ${\chi}^2$-test and logistic regression. Results: Differences in hearing loss according to individual factors were evident by follows gender, region, education status, economic status, current smoking and recognition of stress. Differences in - hearing loss according to ear related factors were evident subjective hearing status, experience of tinnitus, prevalence of chronic otitis media, and tympanomembrane abnormality. Conclusion: Hearing-related disorders can cause many social problems. This study investigated a representative cross-section of Koreans to determine the hearing status. The study was limited in that the risk factors of hearing loss were not identified. It is also recommended that a program be developed that can help control the variables identified in this study along with follow-up studies to verify the model.

• Annals of Clinical Neurophysiology
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• v.9 no.2
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• pp.81-84
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• 2007

Vernet's syndrome is a complex of multiple cranial nerve palsy including ninth, tenth, and eleventh cranial nerves which results from various lesions involving the jugular foramen. There are several kinds of lesions that can cause Vernet's syndrome. It includes congenital cholesteatoma, vascular lesions such as protruded jugular bulb, infections such as external otitis or abscess, and tumoral lesions such as schwannoma or paraganglioma. We present a rare case of Vernet's syndrome caused by non-specific inflammatory mass lesion in the neck area sparing jugular foramen.

• Journal of Veterinary Clinics
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• v.36 no.5
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• pp.266-270
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• 2019

A 13-year-old spayed female American cocker spaniel dog was submitted to an animal hospital with a mass from left ear canal and enlarged left parotid lymph node. Given one-year history of odorous exudates and chronic otitis externa, total ear canal ablation was performed. Grossly, because of the neoplastic mass in both inner and outside of annular cartilage in external ear, vertical ear canal was severely narrowed. Histologically, there were numerous proliferated glands in the ear canal mass. Many neoplastic glands contained secretory vesicles on the free margin and necrotic cellular debris. Severe multifocal necrosis and strong invasion were also observed throughout the mass. Massive metastatic foci of glandular structures originated from ceruminous gland were presented in the enlarged parotid lymph node. Neoplastic glandular epithelia contained PAS-positive diastase-resistant eosinophilic cytoplasmic granules. Immunohistochemically, the neoplastic cells showed positive reactions for cytokeratin (CK) 7 and negative for CK 5/6. Based on the clinical implication and gross findings, histopathology and immunohistochemistry, this case was diagnosed as metastatic ceruminous gland adenocarcinoma in the American cocker spaniel.

• Journal of the Optical Society of Korea
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• v.15 no.1
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• pp.74-77
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• 2011

We report a novel extension of 840 nm wavelength- based spectral domain optical tomography to in vivo/real-time human middle ear diagnosis. The system was designed to access the middle ear region with a specifically dedicated handheld probe. The real-time displaying feature was mandatory for in vivo imaging human subject with the handheld probe, and the system could provide about 20 frames per second for 2048 pixels by 1000 A-scans without using any graphics process units under the Labview platform. The inner ear structure of a healthy male volunteer was imaged with the developed system with the axial and lateral resolutions of $15\;{\mu}m$ and $30\;{\mu}m$, respectively. The application of the OCT technology to early diagnose otitis media(OM) is very promising and could be another extensive branch in the OCT field because it provides the depth resolved image including tympanic membrane (TM) and structures below TM whereas the conventional otoscope technique only gives asurface image of the TM.