• 대한본초학회지
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• 제25권3호
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• pp.35-41
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• 2010

Objectives : Allergy is an immune dysfunction caused by degranulation from mast cells in the early phase of allergic disease including allergic rhinitis (AR). The purpose of this study was to investigate the effects of Osterici Radix, roots of Ostericum koreanum Maximowicz in human mast cells and experimental allergic animal models. Methods : The anti-allergic effect of Osterici Radix water extract (NK-W) was investigated in human mast cell line, HMC-1 cells, and compound 48/80-induced systemic anaphylactic response in rats and ovalbumin (OVA)-induced AR in mice. Animals were orally administrated with NK-W (10 and 50 mg/kg) or anti-histamine drug, dosodium cromoglycate (50 mg/kg), and then intraperitoneally injected with compound 48/80 (8 mg/kg) or sensitized with 0.1% OVA into nasal. Animals were observed plasma histamine and histological changes of nasal mucosa. Also, mast cell degranulation and histamine production were determined in compound 48/80-stimulated HMC-1 cells. Results : NK-W inhibited compound 48/80-induced degranulation of mast cells and histamine releasing in HMC-1 cells. NK-W decreased mortality and serum histamine releasing in compound 48/80-induced anaphylatic rats in a dose-dependently manner. NK-W also inhibited serum histamine levels in OVA-induced AR mice and improved abnormal histological changes such as expansion of grandular cells and hypertrophy of epithelium in the nasal mucosa. These results indicate that Osterici Radix water extract suppress allergic response through downregulation of mast cell activation. Conclusions : This study suggests that a therapeutic potential of Osterici Radix as a source of anti-allergic agents for use in a number of allergic diseases.

• 혜화의학회지
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• 제14권1호
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• pp.15-22
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• 2005

Source : sources used by Qianghuo is Ostericum koreanum Maximowicz, Notopterygium incisum Ting and Notopterygium forbesii Boissier etc. in Korea and China. And we cirulate a Qianghuo dividing Nanqianghuo and Beiqianghuo. Thought source of Korea Qianghuo is different from china's we use a same name. And source of Beiqianghuo has not made clear yet. According to research accomplished 2002, we have to use Nanqianghuo producted at Jinbu in aspect of aspect. but, Beiqianghuo the outside form of Beiqianghuo similar to china so we think that we have to more make clear source of domestic Qianghuo, verify a source Beiqianghuo and re-establish about effects and functions of domestic Qianghuos. Culture : A term of culture is an nearly one year. so to product Qianghuo of good quality, we must plant directly in autumn or raise seedlings and transplant in spring. Processing : To protect turning to brown, Qianghuo are cirulate mostly as the original form without washing in water, To proteet crushing of Qianghuo when we cut off, Qianghuo were cut off after being soaked in water or steamed by heat. So when we wash and cut off, it has to be made processes which have no decreases of medical effects and be suggested a proper index which verify a medical effects. In summury, after harvesting Qianghuo the first washing $\rightarrow$ the first dry $\rightarrow$ selection $\rightarrow$ the second washing $\rightarrow$ the second dry $\rightarrow$ selection $\rightarrow$ cutting off $\rightarrow$ the third dry.