• 생약학회지
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• 제45권4호
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• pp.346-353
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• 2014

This study was performed to investigate the effects of cell-wall broken spores of Ganoderma lucidum on the lipid accumulation and body weight reduction in C57BL/6J mice. Six-week-old C57BL/6J mice were randomly divided into 5 groups and assigned to one of these groups; normal chew diet(Nor) group, high-fat diet(HFD) group, HFD plus spores of Ganoderma lucidum 800 mg/kg/day (HFD + GS/B) group, HFD plus cell-wall broken spores of Ganoderma lucidum 400 mg/kg/day (HFD + BGS/A) group and finally HFD plus cell-wall broken spores of Ganoderma lucidum 800mg/kg/day (HFD + BGS/B). The experimental groups which were treated oral co-administration with cell-wall broken(or original) spores of Ganoderma lucidum and HFD significantly attenuated accumulative body weight gain, compared with HFD group. Administration of these experimental materials also resulted in significant reduction not only the serum levels of total cholesterol, homocysteine but also the lipid accumulation in liver tissue. But in the almost of results the cell-wall broken spores of Ganoderma lucidum were evaluated superior than the original one. These results indicate that cell-wall broken spores of Ganoderma lucidum may inhibit the lipid accumulation in blood as well as liver tissue. Therefore it may be a valuable candidate for the therapy preventing obese induced hyperlipidemic symptoms.

• 대한소아치과학회지
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• 제45권4호
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• pp.521-527
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• 2018

치아의 외상에서 파절편의 재부착은 본래 치아의 형태, 질감, 색, 방사선투과성을 재현하여 우수한 심미성을 제공한다. 9세의 남자 환자가 상악 우측 중절치의 복잡 치관-치근 파절로 내원하였다. 심한 치관 손상과 골 연하로 연장된 파절로 인해 예후가 불량했지만 환자의 나이를 고려하여 치아 파절편을 재부착하기로 결정하였다. Mineral trioxide aggregate(MTA)를 이용한 일회 내원 치근관형성술 후에 골절제술과 포스트 식립을 동반하여 치아 파절편을 재부착하였다. 정기적인 관찰결과 임상 및 방사선학적으로 양호한 결과를 나타냈기에 보고하고자 한다.

• 한방안이비인후피부과학회지
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• 제37권1호
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• pp.69-85
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• 2024

Objectives : By analyzing articles on xerostomia and burning mouth syndrome, two representative diseases that cause various symptoms in oral cavity. Methods : We analyzed articles by dividing them into review articles, original articles, case reports. The subjects were 11 articles on xerostomia and 13 articles on burning mouth syndrome published in Korean medical journals. Results : 1. The subjects were 11 articles on xerostomia and 13 articles on burning mouth syndrome published in Korean medical journals. 2. The first article was published in 2007 and the most published articles were three each in 2013, 2018 and 2022. 3. Classification by type of article was as follows: 2 review articles(8.3%), 16 original articles(66.7%) and 6 case reports(25.0%). 4. The journal with the most published articles was journal of internal Korean medicine and the topics were xerostomia(72.7%), burning mouth syndrome(76.9%). 5. For both diseases, the number of female patients was higher than that of male patients. 6. The main symptom of xerostomia is dryness in the mouth and the main symptom of burning mouth syndrome is pain in the oral cavity. 7. Questionnaires, diagnosis based on dialectics and diagnostic devices were used to diagnose xerostomia and burning mouth syndrome. Conclusion : Diagnosis of xerostomia and burning mouth syndrome require overall consideration the entire hum an body along with the oral cavity. Since there are many different diagnostic methods, appropriate methods must be carefully selected and used.

• The Plant Pathology Journal
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• 제17권6호
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• pp.315-324
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• 2001

Tobacco (Nicotiana tabacum cvs.Xanthi-nc and NC 82) plants infected with Tobacco mosaic virus (TMV) were examined ultrastructurally. Local lesions produced by TMV were sunken and withered. The plants were subjected to temperature shift (TS), a method to produce programmed cell death (PCD), by placing the infected plants initially at high temperature (35$^{\circ}C$) for 2 days and then shifting them to greenhouse temperature (22-27$^{\circ}C$). As a result, expanded lesions around the original necrotic lesions were produced. The expanded area initially had no symptoms, but it withered and became necrotic 15 h after TS. No ultrastructural changes related to PCD were noted at 0 h after TS in Xanthi-nc tobacco tissues as well as in healthy and susceptible tobacco tissues infected with TMV, At 6 h after TS, chloroplasts were convoluted and cytoplasm began to be depleted; however no necrotic cells were found. At 17 h after TS, ground cytoplasm of affected cells was completely depleted and chloroplasts were stacked together with bent cell wall or dispersed in the intracellular space. Necrotic cells were also observed, containing virus particles in the necrotic cytoplasm. There were initially two types of symptoms in the expanded lesions: chlorosis and non-chlorosis (green). Abundant TMV particles and X-bodies were only found in the chlorotic tissue areas. These results suggest that PCD by TMV infection may start with the wilting of cells and tissues before necrotic lesion formation.

• 대한한의진단학회지
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• 제9권1호
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• pp.23-46
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• 2005

Background and purpose: Maek Kyoung(脈經) is a book written, compiled, and edited by Wang Hui circa 3 A.D. This book is the first technical book devoted to the diagnostics. These are very important data but never make a special study and translate. so I hope this treatise can be great help to understand diagnosis study. Methods: Maek Kyoung(脈經) consists of ten volumes, and the third volume consists of the five chapters, including inter-generation and inter-restriction of the five viscera and the six entrails and prognosis of diseases. This treatise is made up of principal, notes, study and conclusion, we tried to make a translation faithful to the original. Results and Conclusion: Chapter 3 refers to five things. The first is relation between spleen and stomach, the second is how to diagnose diseases by using intergneration and inter-restriction of five elements, the third is roles of spleen that has an influence on four viscera through four seasons, the forth is the fact that quantity of gastroqi decides prognosis of diseases, and the fifth is that climate change has influence on the seriousness of diseases. Chapter 4 refers to four things. The first is relation between lung and large intestines, the second is ordinary and extraordinary pulse condition of lung, the third is that pulse condition including its speed, and the forth is how to diagnose diseases by using intergneration and inter-restriction of five elements and climate change.

• 식물병연구
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• 제22권1호
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• pp.44-49
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• 2016

2015년 6월에 경북 문경시에서 재배하는 오미자에서 줄기마름증상이 발생하였다. 발병 초기에는 잎의 선단 부위부터 위축되면서 고사현상이 발생하였고, 병이 진행됨에 따라 줄기를 거쳐 식물체 전체가 고사하였으며 주변으로 전염되었다. 감염된 줄기에서 병원균을 분리배양하여 배양적, 형태적 특징을 관찰한 결과 해당 병원균은 Botryosphaeria속에 속하는 것으로 나타났으며, 인공접종에 의한 병원성 검정에서도 동일한 병징을 나타내었다. 병원균의 정확한 동정을 위해 ITS 영역과 ${\beta}$-tubulin, EF1-${\alpha}$ 유전자의 염기서열을 복합적으로 사용한 염기서열 분석을 수행하였으며, 분석 결과 오미자의 줄기마름 증상을 일으키는 원인균은 B. dothidea로 동정되었다. 지금까지 국내에서 B. dothidea에 의한 오미자의 병이 보고되지 않았기에 본 연구를 통해 국내 처음으로 B. dothidea에 의한 오미자 줄기마름병을 보고한다.

• Korean Journal of Acupuncture
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• 제21권1호
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• pp.149-173
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• 2004

Objective & Methods : In the point of several medical books included 'Internal Classic' and Hyungsang medicine, the writer studied about meridian theory and it's disorders, after adapting to acupuncture and herb medicine. Results : 1. Dr. Jisan explained concretely physiological and pathological meridian appearances with using metaphor about phenomenons of nature and human living. 2. Shapes corresponding to meridian are considered as Yukkyunghyung formed by more or less of vigor and blood, and by tendency of up and down in eyes and nose, and also contained diseases of viscera and characters. 3. The colors connected with meridian are changed according to conditions, and meridian is seen through colors. And then colors is the properties of vital energy and symbol of spirit, that is expressed as aspect of essence, vigor, spirit and blood, as the original color of five viscera, as the colors of four seasons and as the colors of diseases. So the changes of feelings are appeared to meridian flow. 4. The method of examining pulse for meridian disorders is applied to Jisan diagram. Jisan diagram is devised from mutual communication of viscera and connection with inside and outside. It is conjugated widely in clinical examination to be distinguished into Dam-Bangkwang, into diseased part of viscera and into meridian. Also it is conjugated recuperation of diseases. 5. The meridian diseases are appeared all the distributed parts of meridian, especially skin, hair, eyebrow, and the ends of the extremities which are sensitive to stimulus. The causes are the disharmony between vital energy and blood and the discordance of six atmospheric variation. The symptoms are skinny aches, itching and eruption, etc. Conclusions : The acupuncture of Hyungsang medicine which utilizes classification of shapes, examining pulse according to Jisan diagram and demonstration of symptoms, is very effective and required systematical study from now on.

• 동의생리병리학회지
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• 제17권5호
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• pp.1141-1146
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• 2003

In order to investigate different and original theories on pathology of eyes from the past main etiology of fire and heat, two texts of Si-sheng-xin-yuan written by Huang Yuan Yu and Eui-gam-jung-ma written by Lee Gyu Jun are selected and analysed in terms of pathology and prescription. Huang explained that diseases of the eyes are usually born of functional disorders of spleen and stomach(脾胃升降失調) accompanied with turbidity change of energy and blood(氣血淸濁變化). In the meantime, Lee described that the diseases are made from disorders of activities of essence, spirit, energy and blood stored in 5 viscera. So following them, the main point of treatment for the diseases of eyes is to restore and clarify the stagnated gastrointestinal(GI) function, or to supply the clear essence and blood to eyes respectively. Also they have same opinions that the fire and heat are the secondary symptoms of the optical diseases. Therefore Huang focused on cleaning the phlegm and leaking the moisture of GI tract to treat those symptoms, and Lee emphasized on nourishing essential energy of kidney and liver on the other hand. Although they preferred to use radical therapy than symptomatic one. But it can be deduced that Huang's theory is more positive and direct therapy and Lee's one is more basic but indirect treatment.

• 대한한의학원전학회지
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• 제7권
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• pp.113-160
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• 1994

The Sa-Ahm monk, who was believed to have existed in the middle of Cho-Seon Dynasty in Korea, have created an original Sa-Ahm's acupuncture method and written down, "Book of Sa-Ahm's 5 Element Acupuncture Method" using not only laws of creation and suppression in 5 element theory but also its main and other connected meridians according to the daignosis of visceras and bowels. Also the written time and background of its theory have not been known, and after obtaining Ji-San's book on Sa-Ahm's acupuncture method, I studied on them. The results are as follows : 1) The treatment chapter of Book of Sa-Ahm's 5 Element Acupuncture Method was written down by Sa-Ahm himself, and the chapter for Medical Experience was found to be written down by Ji-San. 2) It seemed that Sa-Ahm adopted the main ideas of "Eui Hak Jeong Jon(醫學正傳)" for the section of physiology, pathology and classification of disease symptoms the contents of which covered 40 of 43 parts, and the ideas of "Dong Eui Bo Gam(東醫寶鑑)" for YunGi treatise(運氣篇), and SangHan part(傷寒門) in classification of diease symptoms was intensified by the ideas of "Eui Hak Ip Moon(醫學入門)", and the contents of apoplexy, diseases characterized by acute diarrhea and vomiting, beriberi, diseases of oral cavity were intensified by the ideas of "Chim Ku Kyeong Hearn Bang(鍼灸經驗方)". 3) The written date of the Book of Sa-Ahm's 5 Element Acupuncture Method has been established as 1644 AD(22nd year of In Jo king of Cho-Seon Dynasty) after studying preface, contents and acknowledgement of Heo Im's "Chim Ku Kyeong Hearn Bang(鍼灸經驗方)". 4) The philosophic background of "Sa-Am Acupuncture Method(舍巖鍼法)" seems to be derived from the theories of "I Ching(周易)" and Yin Yang 5 Element Theory(陰陽五行學說), and to be influenced by such medical scholars as Tan Ke(丹溪), Woo Bak(虞搏), and Heo Im(許任).

• 동의생리병리학회지
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• 제19권4호
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• pp.865-871
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• 2005

The Wenbing tiaobian(온병조변) is the first systematic disease monograph on warm factor disease(온병), written by Wu Jutong(오국통). It was most influenced by the Linzheng zhinan yian(임증지남의안), which was a book of gathering medical case records of Ye tianshi(엽천사). Therefore, there are plenty of quotations from this book in the Wenbing tiaobian. This study investigates the quotations from Linzheng zhinan yian, especially focusing on the way of transformation and correction of the original medical case records on the warm factor disease. The results are as follows: About 104 of 265 provisions in the Wenbing tiaobian were directly quoted from the Linzheng zhinan yian. The provisions quoted from Ye's case records were rearranged according to the categories of the triple burners pattern differentiation(삼초변증) and the causes of warm factor disease. And eve case record was transformed into more general descriptive form in order to put it into the book. For example, the specific figures, and some patients' peculiar symptoms, causes, sex and disease names were omitted. On the other hand, the tongue moss, pulse shape and some symptoms, which were necessary for differentiating patterns, were added. In the case of the formula, some formulas originated from Ye's case records were named newly. And the dose of each herb consisting a formula was determined, and therapeutic principle, taking method and detailed explanation was added to every formula.