• 대한본초학회지
• /
• 제30권6호
• /
• pp.55-61
• /
• 2015

Objectives : Yongdamgosam-hwan(YGH) has been used as a traditional medicine from old times for antiinflammatory effects. Streptococcus mutans(S. mutans) is known as a prime bacteria responsible for causing caries by forming a biofilm referred to as dental plaque on the tooth surface. But antimicrobial activity of YGH with dental disease is not sufficiently understood. This study was designed to investigate the effects of YGH ethanol extract on antimicrobial effect against Streptococcus mutans.Methods : The antimicrobial effect of YGH ethanol extract was assessed by the paper disk diffusion method and optical density method to determine minimum inhibition concentration(MIC), also observed by fractional inhibitory concentration index(FICI) and time-kill assay to figure out the synergic effect on the combination of YGH ethanol extract with antibiotics.Results : The YGH ethanol extract 500 μg was 7.5-8.5 mm diameter of clear zone of inhibition against Streptococcus mutans in a concentration-dependent manner and MIC was 250 μg/mL. The administration of the ethanol extract in combination with gentamicin and streptomycin induced a reduction of ≥4-8-fold in all tested bacteria. Furthermore, time-kill study was found that a combination of YGH ethanol extract with oxacillin and streptomycin produced a more rapid decrease in the concentration of bacteria CFU/mL than the YGH ethanol extract or antibiotics alone.Conclusions : As a result, the YGH ethanol extract has good antimicrobial effects. And the results suggest that YGH could be employed as a natural antibacterial agent in dental care products.

• 한방비만학회지
• /
• 제7권2호
• /
• pp.27-37
• /
• 2007

Background Clinical practice guidelines (CPG) are systematically developed statements to assist practitioners and patients on healthcare decisions. They provide recommendations for the average patient, which should take into account individual clinical judgment and the patient's values and expectations. Ephedra has sympathomimetic effect and has been used for weight loss worldwide. However, its safety is controversial especially in autonomic and cardiovascular systems. Therefore, the need of appropriate CPG for ephedra prescription in obesity was advocated in Korean Traditional Medicine. Methods The committee comprised of specialists of obesity, oriental herbology, oriental cardiology, constitutional medicine. The committee collected all relevant references about adverse effect and safety of ephedra in the forms of meta-analysis, systematic review, randomized controlled trial, case-control study and observational study from international and domestic databases and paper journals. 11 English- and 5 Korean-language references were gathered and categorized by PICO (Patient, Intervention, Comparison, Outcome) method. We could not complete strength of recommendation which should be clarified according to the evidence grade estimation. Result The first version of CPG for ephedra prescription in obesity was issued by Korean Oriental Association for Study of Obesity. It includes topics of introduction, pharmacokinetics, side effects and adverse events, constitutional aspect and recommendations for dose, indication and contraindication. Conclusion There should be periodic upgrade of this CPG from now on. Although there are some drawbacks in this version of CPG, it has significance as the first CPG in Korean Traditional Medicine.

• Journal of Plant Biotechnology
• /
• 제48권2호
• /
• pp.115-122
• /
• 2021

Aspilia africana (Pers) C.D.Adams, a plant used for centuries in many African countries to treat diseases such as osteoporosis, malaria, tuberculosis, and diabetes, is of great pharmaceutical interest, yet there is limited scientific literature on its germination and growth. This research paper describes the effects of different commercial soils on the germination, growth, and chlorophyll content of A. africana. The germination parameters assessed included final germination percentage (FGP), mean germination time (MGT), and germination index (GI). Shoot length, leaf number, and fresh and dry weights were some of the parameters used to assess A. africana growth. The FGP was low and did not vary significantly; the MGT was 7 ~ 10 days; and the GI was significantly higher in PPS soil at 4.61 ± 0.332 days. Aspilia africana plants in HS:PPS soil showed the best overall growth, producing the highest mean leaf number (18.00 ± 1.129), longest mean shoot length (202.43 ± 13.451 mm), and highest mean fresh and dry weights (7.08 ± 1.061 g and 0.629 ± 0.112 g, respectively). The highest chlorophyll content in leaves of A. africana under HS:PPS conditions suggested a higher photosynthetic potential of plants in this soil. The best growth performance of A. africana in the HS:PPS soil could be attributed to a higher amount of certain mineral nutrients such as nitrogen, potassium, and phosphorus in the HS:PPS soil compared to the other soil categories. It is unclear why the FGP of A. africana was low and we recommend an exclusive study to investigate this further.

• 한국의사학회지
• /
• 제18권1호
• /
• pp.127-141
• /
• 2005

As we enter the 21st century, the Information Era, we are making a national effort to digitalize the information resources of Korean Studies, based on our leading digital technology. However, there is much difficulty of computerizing Chinese characters used in Korea, China, and Japan, with the of technologies developed by the West. This paper gives an example of how to register and process the Newly found ideographs(新出漢字) put forth by Digitalization of Knowledge information resource on Korean oriental medicine.

• 대한한방종양학회지
• /
• 제7권1호
• /
• pp.99-107
• /
• 2001

In the present studies, decursinol angelate, decursin isolated from Angelica gignatis radix and oil fraction of Cnidii rhizoma was analyzed by normal phase HPLC and GC/MS respectively. The standardized water extracts of Angelica gignatis radix, Cnidii rhizoma and its complex named Gung-gui-tang was tested the anti mutagenic effects by in vitro genotoxicity using Salmonella reversion assay (Ames test) and micronucleus test in chinese hamster ovary(CHO) cells. Angelica gignatis radix, Cnidii rhizoma and Gung-gui-tang was not exhibited the antimutagenic effects in the Salmonella reversion assays with or without metabolic activation. However, the micronucleus test assays, Angelica gignatis radix and Gung-gui-tang was showed the antimutagenic effects significantly. The maximum inhibition observed with Gung-gui-tang was reduced by 59% in the micronucleus test without metabolic activation. In this paper, results are presented on the availability of potential antimutagenic activity of the water extracts of Gung-gui-tang.

• 대한한의학원전학회지
• /
• 제24권4호
• /
• pp.23-32
• /
• 2011

The texts of "Hwangjenaegyeong(黃帝內經)" explains Hakjil(瘧疾) in detail, especially in the "Jahak(刺瘧)" chapter, where bloodletting treatment is applied in many cases. The following paper categorized and organized Hakjil(瘧疾) cases treated by bloodletting methods, then analyzed applicable subjects and appropriate time for the procedure based on the texts. Afterwards, the mechanism for the cessation of Hakjil(瘧疾) seizures was examined. The findings of this research are as follows. 1. In the contents of "Hwangjenaegyeong(黃帝內經)", the appropriate time for acupuncture and bloodletting procedure is when Hakjil(瘧疾) seizures start to present themselves. 2. When a seizure takes place as a symptom of the body getting rid of the Hak(瘧) pathogen, Yanggi(陽氣) rushes to the locus of the pathogen, causing congestion of Gi(氣) and Blood(血) resulting in static blood[瘀血]. Therefore, bloodletting at the time of seizure initiation helps the flow of Gi(氣) and Blood(血), preventing the rush of Yanggi(陽氣). This is a restoration of the balancing function of Eum(陰) and Yang(陽), which indicates that bloodletting not only promotes smooth flow of Gi(氣) and Blood(血), but extends its effects to mental functions that balances Eum(陰) and Yang(陽). 3. Although Hakjil(瘧疾) seizures are presented in terms of Gi(氣) and Blood(血) in symptoms such as chill and fever[寒熱], static blood[瘀血], pain, etc., a fundamental disturbance in mental functions that control cold and heat seems to be present.

• 동의생리병리학회지
• /
• 제16권2호
• /
• pp.209-214
• /
• 2002

At this paper, I classified ‘tetanus’ in 『DongEuiBoGam』 and studied the concept, causes, symptoms, pathological mechanisms of that disease and then I had a new understanding that concept of tetanus in 『DongEuiBoGam』 is different with concept of tetanus in Western Medicine. In the mean time, I investigated the classification in 「Classification of Korean Standard Cause of Death(Oriental Medicine)」 (1995, The Korean Economic Planning Board), and concluded the concept of tetanus in "DongEuiBoGam".

• 동의생리병리학회지
• /
• 제17권5호
• /
• pp.1151-1156
• /
• 2003

To obtain both of the fast and complete data entry and the acquisition of reusable data in a Computer-based Patient Record system (CPR), we are building the ontology that is used by the entry supporting agents. Our application domain is Traditional Chinese Medicine. As the tool for the implementation, we used protege 2000 which is ontology building tool and provides frame knowledge representation language. In this paper, the construction methodology of our ontology is reported.

• 동의생리병리학회지
• /
• 제24권1호
• /
• pp.26-34
• /
• 2010

"Yifangjijie" is a collection of prescription in Traditional Medicine, which was published in Qing dynasty. In this book, effectiveness of prescriptions 1s described by means of Meridians uniquely compared with any others. Therefore, I tried to pay attention to those explanations and arrange by Meridians and effectiveness of prescriptions. Classification by effectiveness of prescriptions has a few points of emphasis in Meridians and Classification of Meridians by effectiveness of prescriptions has intent in somehow. In this paper, authors will explain those classification.

• 동의생리병리학회지
• /
• 제25권2호
• /
• pp.334-338
• /
• 2011

Personality is an important factor in diagnosing Sasang constitutions, and has been studied by researchers with various statistical methods. Using these statistical methods, we obtain several clinical factors including significant p-value. In this paper, we applied a graph for analyzing personality questionnaires. The graph can well represent pairwise relations among items from the collected clinical information. In our analysis, we can find several meaningful personality patterns according to Sasang constitutions.