• Journal of Acupuncture Research
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• 제22권5호
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• pp.49-55
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• 2005

Objectives : In order to ensure safe Herbal Acupuncture treatment, the quality of needle tip is much important. Therefore we investigated micromorphological characteristics of Herbal Acupuncture needle tip according to the number of injection. Methods : We have selected the 26 Gage syringes & 29 Gage syringes that using currently in Herbal Acupuncture treatment. And we evaluated the change of shape of Herbal Acupuncture needle tip after several times of injection by Inverted System Microscope(x 200). Results & Conclusion : We found at Herbal Acupuncture needle tips had several defects such as hooked, scuffed, lump and irregular, stubbed or malformed shape in spite of new syringes. And we found at Herbal Acupuncture needle tips had several defects that is harmful to body such as mild pain, possibility of damage of tissue after several times of injection. Therefore it is necessary to pay attention to use Herbal Acupuncture needle tips.

• 대한한방소아과학회지
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• 제20권2호
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• pp.35-44
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• 2006

Objective : As today obese children have increased rapidly in Korea, the interest has been much increased. And parents concern about the effect of Herbal Medication(HM) on gaining weight. Therefore we had a retrospective study HM and obesity for children. Method : We examined medical record of 38 patients who visited to Department of Pediatrics in 00 medical center from 2002 to 2006 and took HM. Their Hight, Weight, Obesity Index(OI) were estimated at two points: before and after HM treatment. And they were divided into two groups according to the HM type and analyzed for differences of OI. Result : There were no significant changes in 38 patients's OI before and after treatment. But only one case gained over weight(OI: 21.31). OI increased slightly after treatment but there were not statistically significance. OI according to the HM type had slightly difference but there were not statistically significance. There were no connections between HM type, the number of days taking HM and changes of OI. Conclusion : On the basis of this study, we thought there were no connections between HM and obesity for children. But this study's cases are small in number so more study is need.

• 대한수의학회지
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• 제51권2호
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• pp.83-91
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• 2011

In this study, immunohistochemistry was used to examine the changes in the density of colonic endocrine cells - argyrophil and argentaffin cells, chromogranin A (CGA), serotonin, somatostatin and glucagon-containing cells in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis. Ulcerative colitis was induced by the instillation of 10 mg of TNBS into the colonic lumen through the anus. To confirm the inducement of ulcerative colitis, the macroscopic and microscopic scores as well as the colonic myeloperoxidase (MPO) activities were monitored for 8 days after TNBS instillation in the colonic lumens. In addition, the number of argyrophil and argentaffin cells, CGA, serotonin, somatostatin and glucagon-immunoreactive cells were counted in the colonic mucosa, respectively. After TNBS instillation into the lumen of the colon from the anus in rats, increases in macroscopic and microscopic scores in the colon tissues were observed along with increases in the colonic MPO activities. Therefore, ulcerative colitis was relatively well induced by the TNBS instillations. Marked decreases in the number of colonic endocrine cells were detected in the TNBS-treated animal compared to the sham control. These results suggest that colonic endocrine cells were also disrupted by TNBS-induced ulcerative colitis.

• 대한한방소아과학회지
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• 제24권1호
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• pp.9-35
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• 2010

Objectives The purpose of this study is to investigate the effect of SPDJTK(SoPungDoJeokTangKami) and concurrent administration of AJ(Atopy cream, Jawoongo)+SPDJTK on atopic dermatitis-like skin lesions by using in NC/Nga atopic dermatitis mouse induced by BMAC-induced mice. Methods Clinical skin score, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mice were evaluated. Moreover, the cytokine level, total cell number, Immunohistochemical staining and Histological features of axillary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue were used in NC/Nga mice. Results Orally administrated SPDJTK with concurrent administration of SPDJTK and AJ decreased the clinical skin score, total cell number of WBC, eosinophils in blood, serum total IgE & IgG1, IL-5, IL-13, IFN-$\gamma$. Also, total cell number of ALN and dorsal skin tissue, absolute cell number of CD4+, CD8+, CD3+CD69+, CD3+CCR3+, CCR3+, CD4+CXCR5+ in ALN, absolute cell number of CD3+CCR3+, CCR3+ in DLN, granulocytes in PBMCs, activation cell number of CD3+CD69+, CCR3+, total cell number of CD3+ T cell in dorsal skin tissue were significantly decreased. Furthermore, thickness of epidermis, infiltrated inflammatory immune cell and mast cell in dermis, amount of Eotaxin2 mRNA, CCR3 mRNA in dorsal skin tissue, gene expression of IL-5, IL-13 mRNA in ALN, CD4+ Th cell in dorsal skin tissue and CCR3+ eosinophils in ALN were all significantly decreased. However, total number of DLN, absolute number of CD3e+ T cell and CD19+ B cell, absolute number of CD4+, number of Th cell in DLN and gene expression of foxp3 mRNA were significantly increased significantly. Conclusions Concurrent administration of SPDJTK and AJ on atopic dermatitis in NC/Nga atopic dermatitis mouse was very effective treatment for atopic dermatitis.

• 대한한의학원전학회지
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• 제19권4호
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• pp.101-112
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• 2006

For the purpose of profound comprehension of the Current education of Oriental medical classics in Korea, I investigated the results of direct survey of the Current education of Oriental medical classics from each professor, and came to following conclusions. 1. The education of Oriental medical classics mainly lasts for 2 years. Students have average 6.59 hours of lecture every week. The rate of full service professor reaches 74.4%. But the department of Oriental medical classics in every college takes charge of many subjects which are related to Oriental medical classics, so the appointment of large number of full service professor is essential for the improvement of educational environment of Oriental medical classics. 2. After the publishing of the common textbook of Oriental medical classics, it gradually became the main textbook. But it is necessary that we should complement the textbook and it is also necessary that we should develop another textbook for Nangyeong(難經). 3. Most professors emphasize on the cultivation of the ability which enables Oriental medical thought through precise comprehension of original text. By the way, for the purpose of motivation of studying Oriental medical classics, it is necessary to develop a lecture which is related to clinical medicine. From the same context it is also necessary to read clinical original text such as Dongui-bogam(東醫寶鑑) and Uihakimmun(醫學入門) in class.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.127-133
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• 2007

Objectives : This study were aimed to estimate the needs for clinical research educational program development focused on oriental medicine. Methods : Department Medical Research of Korea Institute of Oriental Medicine surveyed 204 certified subjects in total by using web-based questionnaires through e-mail from Jan. 17th to Jan. 31th, 2007. Reply from 62 on-line correspondents were collected and statistically analyzed. Results : The number of clinical trial involving oriental medicine continues to increase. According to the survey, many Issues were raised as problems such as difficulty of recruitment, lack of fund and lack of stepped program. Emphasized issues were clinical research methodologies, development of protocols and case report form (CRF), and Regulations including Institutional Review Boards (IRBs) in these three consecutive education training program. Conclusion : The results of this study may contribute to the development of an educational program for oriental medicine, a program that should be taken into consideration for developing practical items, such as, problem-based learnings which reflects participants' actual needs in their works. Also this report be used for future strategy plans and execution of training program for oriental medical clinical trial.

• 동의생리병리학회지
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• 제16권1호
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• pp.117-123
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• 2002

To investigate the antiinflammatory and analgesic effects of Sophorae radix extracts administered to the arthritic rat model, immunohistochemical stains for CGRP in the L4, L5 and L6 spinal cord and ganglia were done, and paw swelling thickness were measured. Complete Freund,s Adjuvant(CFA) were injected to subcutaneous tissue of left foot paw of rats to induce arthritis. Sophorae radix extracts was administered immediately after CFA injection for 10 days. The spinal cord and ganglia were frozen sectioned(30㎛). These sections were stained by CGRP immunohistochemical staining method, and observed with light microscope. The results were as follows : 1. The change of paw swelling thickness of experimental group decreased from 4 day to 10day after CFA injection compared to control group. 2. The change of differential leukocytes counts of experimental group increased the ratio of lymphocytes. and decreased the ratio of neutrophils compared to control group. 3. The change of CGRP immunoreactive nerve fiber of dorsal horn of experimental group was dense stained compared to control group. 4. The number of CGRP immunoreactive neurons of L4 and L5 spinal cord of experimental group was less than in those control group. These results suggested that Sophorae radix extracts reduces the number of CGRP immunoreactive neurons and nerve fibers of spinal cord and ganglia, and decrease paw swelling thickness in arthritic rat model, which may be closely related to analgesic and antiinflammatory effects of Sophorae radix.

• Journal of Acupuncture Research
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• 제15권2호
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• pp.17-28
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• 1998

The present study was designed to investigate the effect of different stimulation-duration of high frequency electroacupuncturet(EA) treatment on the neuronal activities in the spinal cord and brainstem using Fos immunohistochemical technique. Three different stimulus-duration was used in this experiment : 30minutes, 1 hour and 2 hours. The summerized results were summerized as follow : 1. The number of Fos expression was significantly increased in the spinal cord dorsal horn depending upon the increase of stimulus-duration (P<0.05). Otherwise, there was no significant difference between 30 minutes EA treated group and anesthetic control. 2. High frequency EA biphasic stimulation significantly enhanced the Fos expression in the DR, middle and rostral portion of PAG LD, and caudal PAG LV after 1 hour and 2 hours treatment. The number of Fos immunoreactive neuron in the brainstem was increased accorcting to the length of stimulus-duration. Those results indicate that at least 1 hour EA treatment was necessary to increase the neuronal activities in the spinal cord and brainstem. Those basic data from this study can be applied to establish the effective treatment of EA for pain control in the clinical field.

• 대한한의학방제학회지
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• 제14권2호
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• pp.1-8
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• 2006

ElM (Eighteen Incompatible Medicaments) is an important component in Oriental pharmacology and is directly related to clinical prescriptions. Medical practitioners argued that the definite cause and meaning of ElM was ambiguous and therefore debated the issue of clinical application of the ElM. This study conducted an in-depth literary research on the origin, meaning and contents of ElM with the purpose to contribute in its efforts to be used clinically. Even after thousands of years have past since establishment of Oriental medicine. ElM is still tabooed and was an obstacle that hindered ideologies. Modern herbal medicine texts claim that the use of ElM can reduce treatment effects and promote poisoning and side effects. However, since long ago, there has been medical practitioners who reject this as false. Recently, poisoning caused by ElM has been claimed to be from the toxicity of the drug itself, rather than the result of interaction between the drugs. and therefore they suggest that ElM is not a forbidden domain. In addition. ElM showed a difference in number depending on the era. However, this can be understood not as a definite number. but instead as a warning to be careful during combination of drugs for use as clinical medicine. Historically. there were very few cases in which ElM was used for clinical tests and thus, the clinical value is not yet clear. However. some medical practitioners clinically applied it and found clear results for it. while others applied ElM directly to their bodies. which showed signs for the usefulness and potential of ElM for us. A more concrete and in-depth study must be made on ELM.

• 대한한방내과학회지
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• 제40권6호
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• pp.1193-1201
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• 2019

Objectives: This study aimed to assess the clinical characteristics of patients who complained of heartburn and to report the effects of Sogunjung-tang granules on heartburn. Methods: Observation was carried out on 30 patients with heartburn who were treated in Dongshin University Oriental Medicine Hospital from 1 October 2018 to 3 July 2019. For relieving heartburn, an oriental medical therapy of Sogunjung-tang granules was administered. To evaluate the effect of treatment, the visual analog scale (VAS) was used. Results: Females predominated among the patients (86.7% of the total). The patients were mostly aged in their 50s and the average age was 56.8 years. In the medical histories of the patients, other diseases (neuropsychiatric disease, cardiovascular disease, cerebrovascular disease, urologic disease, uterine disease etc.) were the most common (34.7%) and gastrointestinal disease was the second most common (22.4%). The patients took Sosiho-tang granules plus Sogunjung-tang granules for a maximum of 282 days. The number of patients who took medication within 10 days of experiencing heartburn was the highest and the number of patients who took medication more than 30 days of experiencing heartburn was the lowest. The scores on the visual analog scale (VAS) were significantly improved after treatment, the average decreasing from 7.0 to 3.1. Before taking the granules, the average rate of improvement for patients who recorded less than VAS 6 was 80%. Six out of seven inpatients showed more than two VAS changes on 3.8 day of taking medicine, and 23 outpatients showed more than two VAS changes on the second visit. Conclusions: This study suggests that Sogunjung-tang granules is probably effective in the treatment of heartburn.