• Journal of Oriental Neuropsychiatry
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• v.20 no.4
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• pp.197-209
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• 2009

Objectives : Attention Deficit Hyperactivity Disorder(ADHD) is a psychiatric disorder, characterized by the primary symptoms of inattention and/or impulsivity and hyperactivity. the aim of this study is to investigate the clinical efficiency of Various Oriental Medical Therapy combinated with Learning therapy in the treatment of ADHD. Methods : This study is a clinical report of 1 ADHD child treated with Various Oriental Medical Therapy(Herb-med, acupunture, etc.) in Combination with Learning therapy. CAR(Conner's abbreviated Rating Scale), K-CBCL, ADS(ADHD Diagnostic System) were compared between before and after treatment. Results : The results show the Various Oriental Medical Therapy in Combination with Learning therapy is efficient in the treatment of ADHD. Conclusions : Various Oriental Medical therapy including herb-med, pharmacopuncture, electroacupuncture is efficient in improvement of ADHD child. also In case of combination with Learning therapy, it is more effective in child's school life and school work. therefore, it is practical useful in the treatment of ADHD.

• The Journal of Pediatrics of Korean Medicine
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• v.12 no.1
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• pp.145-162
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• 1998

The purpose of this study was to determine the effects of oriental medical care on growth deficiency children. These cases were collected to investigate the effects of oriental medical care on growth deficiency children. So the cases were divided into 5 groups. The growth velocity was compared to a normal growth curve, and the results are as follows: 1. Oriental medical care was efficient when the epiphysial plates were not closed. 2. In female middle school beyond 1st grade students and in male middle school 3rd grade students who had almost closed epiphysial plates, the oriental medical care was not efficient and did not promote growth velocity. endothelium were used for the experiment using organ bath. 3. In the cases where the parent were very short, the effects of the oriental medical care to promote growth velocity was not efficient. 4. when we treated children of normal height, their growth velocity was over the normal growth curve. 5. In preschool aged children, oriental medical care was very efficient to promote children's growth. 6. The principle oriental medical care was to make balanced their body and digestive organs by using herb medicines that have the capability to promote the growth of the bones, and build strong muscles.

• Animal cells and systems
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• v.5 no.2
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• pp.157-161
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• 2001

Mice homozygous for the lethal autosomal recessive anorexia mutation (anx) present with premature death around postnatal day 22. The anorexia mutant mice also present phenotypes such as reduced body weight, decreased food intake, and abnormal behavior characteristics such as body tremors, hyperactivity, uncoordinated gait, and head weaving. In order to investigate the expression of c-Fos in the hippocampus of anorexia mutant mice, the immunohistochemistry was performed in this study. The anorexia mutant mice exhibited lower expression of c-Fos in the hippocampus regions thBn the control group. In the CA3 and dentate gyrus, the number of c-Fos-positive cells in anorexia mutant mice was noticeably lower than that in control mice. However, no significant difference was found in the number of c-Fos-positive cells in CA1 of the two groups. The result suggests that the phenotypic characteristics of anorexia mutant mice may be associated with the hippocampal deficits of c-Fos expression.

• Journal of Society of Preventive Korean Medicine
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• v.9 no.1
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• pp.91-103
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• 2005

The purpose of this study was to find out the various opinions of Oriental Medical Doctors to give the recommendations for making the proper policy of the supply and demand of Oriental Medical specialist. This study was desinged of 480 doctors who answered about questions that is composed of 105 Oriental medical specialist, 227 Apprentice doctor and 148 Oriental Medical doctors. On the assumption that there are many different situations and visions about the Oriental medical specialty system, we wanted to know about the each situations and visions about oriental specialty system. Generally, as one grows older, they adapted high proportion about the propriate number of specialist. About this difference from each generations, we can explain that young doctors more worry about the supply of specialist. As well each achievement, the more higher achievement, the more higher proportions of specialist is adapted. Answers about the number of present specialist, the more aging the more negative response about the number of present, number of specialist, this is because of the proprotions who wanted to be a specialist in open doctors. About the property of the number of specialist, there are many different views in each other groups. Anyway it is important that hearing the opinion of each Oriental Medical Doctors for the better Oriental Medical System.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.3
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• pp.1-11
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• 2011

Objectives : This study was performed to evaluate the effects of root of Scutellariae Radix(SR) water extract against inflammatory response in the spinal cord injury(SCI). Methods : SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rat. SR was orally given once a day for 7days after SCI. Myeloperoxidase(MPO) positive neutrophils infiltration was examined. Inducible nitric oxide synthase(iNOS) and tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) expressions were observed with immunohistochemistry. Glial fibrillary acidic protein(GFAP) positive astrocytes were examined using immuno-fluorescence. Results : 1. SR reduced MPO-positive neutrophils infiltration in peri-damage regions of the contusive SCI-induced rats. 2. SR reduced iNOS positive cells in the white matter of the contusive SCI-induced rats. 3. SR reduced TNF-${\alpha}$ positive cells in the gray and white matter of the contusive SCI-induced rats. 4. SR reduced cell number and size of astrocytes in peri-damage regions of the contusive SCI-induced rats. Conclusions : These results suggest that SR plays an inhibitory role against inflammatory response in the SCI.

• Journal of Korean Medical classics
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• v.23 no.2
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• pp.141-155
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• 2010

Simpo(心包. Pericardium) was described early in "Hwangjenaegyeong(黃帝內經)". But there has been a lot of criticisms about this organ. Jinsatak(陳士鐸) is one of famous doctors in Cheong(淸) dynasty. He suggested a creative Oriental medical theory and he did a profound research on Simpo(心包). "Oegyeongmieon(外經微言)" is one of his books recording his oriental medical theory in detail so it is the good documentary record for observing his theory of the Simpo(心包). So we looked into his theory of Simpo(心包) in "Oegyeongmieon(外經微言)" and also referred to his other books. You might be able to get a viewpoint of utilizing Simpo(心包) in several ways through reading this paper.

• Journal of Society of Preventive Korean Medicine
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• v.9 no.1
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• pp.1-16
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• 2005

This study was conducted to identify the needs of introducing new medical specialties in oriental medicine. Three stakeholders in introducing new oriental medical specialties are oriental medical doctors, policy makers and medical consumers. Of the three, this study intended to focus on opinions of oriental medical doctors. About 1,150 self-administered questionaries were sent to the potential respondents, 320 specialists, 250 interns & residents and 580 private oriental medicine practitioners, and 480 doctors responded. The study revealed that 62% of respondents showed negative attitudes towards the introduction of new oriental medicine specialties. The private oriental medical practitioners were more likely not in favor of adding new medical boardmanship. The reasons of objection were as follows : First, it is more important to enrich the existing oriental medical boardmanship (70%). Second, the newly established specialties are most likely to be weakened(15%). The study revealed that the first and most likely specialties to be introduced was Chuna(18%), subspecialization of oriental internal medicine (15.8%), the next oriental family medicine (15.1%) and so on. And the second specialties to be desired most by the respondents were (1) cooperative medicine between the westem and oriental medicine (28%), (2) oriental preventive medicine (17.4%) and (3) oriental family medicine (16.8%). Caution must be exercised in introducing new oriental medicine specialties. The failures of western medicine in the operation of its specialist production should carefully by examined here.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.799-806
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• 2011

This study was performed in order to evaluate the neuroprotective effect of Boyanghwano-tang (BYT) water extract on intracerebral hemorrhage (ICH). ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. BYT was orally given once a day for 3 days after ICH. Hematoma volume and percentage edema were examined. As imflammatory markers, myeloperoxidase (MPO)-positive neutrophils infiltration and iNOS expression in the peri-ICH regions were examined using immunohistochemistry. As cellular damage markers, c-Fos, Bax, and HSP72 positive cells in the peri-ICH regions were measured also. BYT significantly reduced the hematoma volume and percentage edema of the ICH-induced rat brain. In the peri-hematoma regions, BYT significantly reduced MPO-positive neutrophil infiltration and iNOS expression of the ICH-induced rat brain. Additionally, BYT significantly reduced c-Fos, Bax, and HSP72 positive cells in the peri-hematoma regions of the ICH-induced rat brain. These results suggest that BYT plays a neuroprotective role against ICH through suppression of inflammatory responses, apoptosis and cellular damage.

• The Korea Journal of Herbology
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• v.25 no.4
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• pp.85-93
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• 2010

Objectives : This study aimed at evaluation of the effects of Gastrodiae Rhizoma on brain edema and aquaporin water channel expressions in the brain. Methods : Brain edema following intracerebral hemorrhage (ICH) was induced by the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. Then ethanol extract of Gastrodiae rhizoma was treated once a day for 3 days. Brain edema % and water contents, and cell size of neurons in the cerebral cortex were examined. Immuno-histochemistry was processed for AQP4, AQP1, and AQP9 expressions in the brain sections and area % of immuno-labeling was analyzed with image analysis. Results : 1. Ethanol extract of Gastrodiae Rhizoma reduced brain edema of ICH induced rats significantly. 2. Ethanol extract of Gastrodiae Rhizoma reduced excessive brain tissue water contents of ICH induced rats significantly. 3. Ethanol extract of Gastrodiae Rhizoma reduced cellular edema of neurons in cerebral cortex of ICH induced rats significantly. 4. Ethanol extract of Gastrodiae Rhizoma reduced AQP4 immuno-positive area % in cerebral cortex and external capsule of ICH induced rat brain significantly. 5. Ethanol extract of Gastrodiae Rhizoma reduced AQP9 immuno-positive area % in glia limitans externa of ICH induced rat brain significantly. Conclusions : These results suggest that Gastrodiae Rhizoma reveals protective effects against brain edema and cytotoxic edema of neurons by means of down-regulation of AQP4 expression in the brain.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.1
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• pp.1-13
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• 2013

Objectives : The pathophysiology of acute spinal cord injury(SCI) may be divided into primary and secondary mechanisms of injury. The secondary mechanism involves free radical formation, excitotoxicity, inflammation and apoptotic cell death, and sets in minutes after injury and lasts for weeks or months. During this phase the spinal tissue damages are aggravated. Therefore, secondary mechanisms of injury serve as a target for the development of neuroprotective drug against SCI. The present study investigated the effect of tetramethylpyrazine(TMP), an active ingredient purified from the rhizome of Ligusticum wallichii(川芎, chuanxiong), on neuronal apoptosis in spinal cord compression injury in rats. Methods : SCI was subjected to rats by a static compression method(35 g weight, 5 mins) and TMP was treated 3 times(30 mg/kg, i.p.) during 48 hours after the SCI. Results : TMP ameliorated the tissue damage in peri-lesion of SCI and reduced TUNEL-labeled cells both in gray matter and in white matter significantly. TMP also attenuated Bax-expressed motor neurons in the ventral horn and preserved Bcl-2-expressed motor neurons. Conclusions : These results indicate that TMP plays a protective role in apoptotic cell death of neurons and oligodendrocytes in spinal cord injury. Moreover, it is suggested that TMP and TMP-containing chuanxiong may potentially delay or protect the secondary spinal injury.