• Journal of Digital Convergence
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• v.12 no.8
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• pp.361-368
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• 2014

In order to investigate the effect of CGT on atopic dermatitis, various anti-inflammatory factors were studied. In-vitro, inflammatory mediators, such as MTT and nitric oxide and ROS were detected after the addition of LPS with or without CGT in RAW 264.7 cells. In-vivo, in order to verify the effectiveness of CGT in atopic dermatitis animal model, its role in inflammation factors and histological changes were observed in NC/Nga mice. CGT showed cell viability of 100% or higher in all concentration in RAW 264.7 cells. CGT inhibited LPS-induced productions of inflammatory mediators nitric oxide and antioxidant activity reactive oxygen species production in RAW 264.7 cells. CGT treated group showed significant decrease in serum of the expression of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ by 53%, 43% and 57% respectively. And CGT treated group showed decrease in serum of the expression of IgE by 56% respectively. Also, infiltration of adipocytes into skin was suppressed and the thickness of epidermis and dermis were relatively decreased in the CGT treated group. As a result, CGT has an anti-inflammatory effects in NC/Nga mouse. Thus, these results suggested a beneficial effect of CGT in treatment with Atopic dermatitis and inflammatory.

• The Journal of Korean Medicine
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• v.37 no.3
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• pp.112-122
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• 2016

Objectives: This study aimed to assess the validity of 'Korean Diagnosis Related Groups-Korean Medicine (KDRG-KM)' which was developed by Health Insurance Review & Assessment Service (HIRA) in 2013 Methods: Among inpatient EDI claim data issued by hospitals and clinics in 2012, the data which included Korean medicine procedures were selected and analyzed. We selected control targets in the Korean medicine hospitals which had longer Episodes-Costliness index (ECI) and Lengthiness index (LI) than average of total Korean medicine hospitals, and compared the results of selection between the major diagnosis-based patient classification system and the KDRG-KM system. Finally, the explanation power (R2) and coefficient of variation (CV) of the KDRG-KM system using practice expenses were calculated. Results: The numbers of control target in Korean medicine hospitals changed from 36 to 32 when patient grouping adjustment method was changed from major diagnosis to KDRG-KM. For expenses of all outpatient claim data on Korean medicine, explanation power of KDRG-KM system was 66.48% after excluding outliers. CVs of expenses of patient groups in Korean medicine hospitals were gathered from under 70% to under 90%, and those in long-term care hospitals mostly belonged under 70%. Conclusions: The validity of KDRG-KM system was assured in terms of explanation power. By adapting KDRG-KM system, fairness of control targets selection for costliness management in Korean medicine hospitals can be enhanced.

• The Korea Journal of Herbology
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• v.31 no.1
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• pp.69-75
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• 2016

Objectives : The aim of this study is to investigate the various effects of individual or combined extract of GamiSaengmaeksan (GSS) on cell viability, anti-inflammatory and antioxidant activityMethods : In order to evaluate cytotoxicity, MTT assay was performed. We investigated the levels of proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 and interleukin (IL)-1β, and nitric oxide(NO) in LPS-induced RAW 264.7 cells to check the effects on anti-inflammatory activity. The level of NO production in RAW 264.7 cells was measured by using Griess reagent. The levels of cytokines and ROS were measured by Luminex and Flow cytometry, respectively.Results : At concentration of 200 ㎍/㎖ GSS, cytotoxicity was observed in RAW 264.7 cells. However, at concentration less than 100 ㎍/㎖ of both combine and individual GSS, cytotoxicity was not observed in Raw 264.7 cells. However, the level of ROS in RAW 264.7 cells were decreased at both extract of 100 ㎍/㎖ GSS. Also, the level of NO in RAW 264.7 cells were decreased from extraction of concentration of 100 ug/ml in GSS and individual-extraction of Liriopis Tuber, White Ginseng and Glycyrrhizae Radix. In addition, productions of pro-inflammatory cytokines (TNF-α) in LPS-induced RAW 264.7 cells were decreased from extraction of concentration of 10 and 100 (㎍/㎖) in GSS and individual-extraction of Liriopis Tuber.Conclusions : It is concluded that combined extract of GSS appears to be more effective in anti-oxidation and anti-inflammatory effect than those in individual-extraction of GSS. These results may be developed as a raw material for new therapeutics to ease the symptoms related with inflammatory and oxidative stress.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1172-1177
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• 2009

This study is to determine the effects of BUDDEUMI(moxibustion and cupping a boli) therapy on the relief of shoulder pain among middle aged women. methods : A total of 39 middle aged women with shoulder pain are selected : 20 in the experimental group and 19 in the control group. The data was collected by using questionnaires. The BUDDEUMI(moxibustion and cupping a boli) therapy on the should and back was administered to the experimental group, and no treatment was given to the control group. All of the subjects were examined on a subjective symptom scale and on the grade of discomfort and pain in everyday life as developed by Japan's Industrial Fatigue Research Committee of the Industrial Hygienics Society(1988), Sohn, Mong Ho(1999), Visual Analogue Scale as developed by Cline (1992). SPSS/win 12.0 was used for Date analysis, General features demonstrated by frequency number and percentage. The effects of the BUDDEUMI(moxibustion and cupping a boli) therapy was analyzed by a t-test. The homogeneity testing revealed that all study variables are equally distributed between experimental and control groups. The hypothesis, 'the experimental group who received BUDDEUMI(moxibustion and cupping a boli) therapy will decrease in the grade of discomfort of shoulder', is supported. The hypothesis, 'the experimental group who received BUDDEUMI(moxibustion and cupping a boli) therapy will decrease in the Visual Analogue Scale is supported. Conclusion : As a result of this study, BUDDEUMI(moxibustion and cupping a boli) therapy will be able to be used as the self care therapy to improve the symptoms of middle aged women who has the shoulder pain.

• Advances in Traditional Medicine
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• v.7 no.4
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• pp.395-408
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• 2007

This study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, ${\beta}$-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

• Journal of Haehwa Medicine
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• v.22 no.2
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• pp.67-79
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• 2014

In order to investigate the efficacy of BJBB on atopic dermatitis, various immune related factors were studied. The results and conclusions are as follows. Atopic dermatitis symptoms were improved in BJBB treated group and significant decrease in dermatitis index were observed in 13 weeks. ALT, AST and BUN, Cr levels were all with in the normal ranges in BJBB treated group, indicating no induced toxicity. BJBB treated group showed significant decrease in CD4+, CD11b+/Gr-1+ immune cell ratio in dorsal skin by 33% and 62% respectively. BJBB treated group showed significant decrease in the expression of IL-4, IL-5, IL-13 and histamine by 83%, 62%, 53% and 61% respectively. Also the group showed decrease in the transcription of IL-4, IL-5 and IL-13 mRNA in spleen by 41%, 52% and 50% respectively. BJBB treated group showed decrease in the expression of IgE by 57% respectively. The results above indicated that treatment of BJBB improved atopic dermatitis symptoms by immune modulation activity a clinical evidence. thus, BJBB has a potential use as a composition of medicinal plants for treatment against inflammation related disease.

• The KIPS Transactions:PartB
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• v.14B no.2
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• pp.71-80
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• 2007

In this paper, We propose face type classification, tongue region extraction and tongue color analysis method for Oriental medicine diagnosis system to supply web based medical treatment information. This presents to construct system that takes super aging society and uses ocular inspection and longue diagnosis in web-based to embody this by an IT Technology as generalization and popularization of medical benefit are social requirement and supplies medical treatment information. Place that reflect living body signal of human body ordinarily and appear becomes iris or tongue, five sensory organs etc. This paper proposes classification of face type, extraction of five sensory organs for observing a person's shape and color among diseases diagnosis based on home health care that propose to develop and region extraction and color analysis etc, of tongue which intensively represents the bio-signals of human-beings. Finally, the effectiveness of this paper is verified by several experiments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.7C
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• pp.610-618
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• 2012

In this paper, using a image processing techniques to develop an color analysis program to apply the influence analysis by smoking were analyzed. So, this study was conducted to analyze is based on oriental medicine diagnosis theory, especially ocular inspection, of the right cheek area of the lung and lung function and weakness associated with it closer to white by applying IT image processing techniques based on smoking to compare the change in color according to the face. From this, 15 patients with 20 male subjects before and after smoking extract the color of the area on the right cheek, a values and b values in Lab digital color system were analyzed by smoking how to analyze what is changing. Also, health care system based on this variation reflects the individual, personalized will be constructed. Experimental results on the right cheek area approach to the color white according to the amounts of smoking, this is by smoking adversely affects lungs function that can be analyzed.

• Journal of Digital Convergence
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• v.14 no.6
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• pp.317-323
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• 2016

The aim of the convergence study is to evaluate anti-asthma effects of white ginseng complex extract(WGCE) on OVA-induced allergic asthma in mice. WGCE was administered at 100 mg/kg and 300 mg/kg to mice, where asthma was induced by OVA. Th2 cytokine including IL-4, IL-5 and IL-13 were measured by Luminex. Also, OVA-IgE and eosinophil were measured by haemocytometer and BALF total cells were measured microscope. Production of IL-4, IL-5, IL-13 and OVA-IgE in serum was decreased, respectively, in comparison with control. The eosinophil in whole blood decreased significantly. In addition, WGCE groups showed a decrease in the BALF total cells. These results demonstrated that WGCE decreases the Th2 cytokine and asthma factors. Therefore, we strongly suggest that WGCE could be effectively used as a therapeutic drug based on its anti asthma factors.

• Journal of Digital Convergence
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• v.12 no.11
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• pp.617-623
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• 2014

This study aims to organize the pharmacological component of native chicken(NC) by analyzing the bill presented in traditional medicine NC relevant literature. And the analyze the heterogeneity and the common prescription of chicken that a variety of traditional technologies to existing treatment books private data to organize information about the scientific verification. After the analysis by building a DB and want a prescription to traditional book, herbal medicine usability throughout the assessment of the special treatment provided the basis for further product and a variety of functional food development. In addition, the continued expansion of the country and future growth engine industry related businesses through added value of cultural knowledge resources. NC of the relevant search and information system for prescription knowledge. so standardized, conceptualization, formalization is to build a knowledge of traditional medicine NC recipe DB assess the usefulness of medical literature through interdisciplinary research systems to suggest practical ways of alternative medicine and functional food development.