• Asian-Australasian Journal of Animal Sciences
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• 제30권11호
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• pp.1651-1659
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• 2017

Objective: Lao PDR's recent accession to the World Trade Organization necessitates a greater understanding of the patterns and risk of livestock production in order to better align national policy with the Agreement on the Application of Sanitary and Phytosanitary Measures. This eco-health study was conducted to improve understanding of the interrelations between market chains and zoonotic infection risks at two strategic cross border points between Lao PDR, Thailand and Viet Nam. Methods: Information gained from smallholder farmer/trader interviews was integrated with serological surveys for pig-associated zoonoses-including hepatitis E virus (HEV), Taenia solium (T. solium) and trichinella-to identify potential linkages between disease risk and pig production and slaughter in low input systems common across the country. Results: Trichinella and HEV exposure was high in both humans and pigs in both study areas, significantly associated with pig slaughter and the subsequent consumption and handling of raw pork products. T. solium demonstrated a strong geographical and ethnic association with the northern study area bordering Vietnam. With the right knowledge and accessible, affordable inputs, the majority of smallholder farmers indicated a willingness to invest more in pig production, which could simultaneously improve livelihoods and decrease exposure to HEV, Trichinella, and T. solium through increased access to formal markets and an improved slaughter processes. Conclusion: The linkages identified when assessing disease risk in the context of potential economic and cultural drivers of transmission highlight the importance of a systems-based approach for the detection and control of zoonotic disease, and contributes to an improved understanding of the Lao PDR livestock sector.

• 산학경영연구
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• 제3권
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• pp.23-46
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• 1990

I. Introduction: In management control, business analysis has to do with a performance evaluation and is accounted much of manager's decision making, Business indicator accounting is the vehicle of decision making and also feedback can be accomplished by it. This study is to build up a logic about what capacity for use the business indicator accounting has in making decision. Therefore it is significant to make clear the adjustment of decision and to study the function of business indicator. II. Adjustment of Decision and Accounting Work: Adjustment of decision is connected with accounting now that business indicator accounting has a function of decision making. And it should be tied up with specialization as a structure of system, organization, communication and stage system. III. Adjustment of Decision and Managerial Accounting: Managerial account makes a great contributin to the management in which each adjustment of decision should be accomplished. Let me make mention of how the adjustment of decision is accomplished concretely, and what contribution che managerial accounting makes. In an adjustment of decision, centralization and decentrialization of enterprise are very import and I think the three problems, such as the extent of sphere (procurement, production and maketing), the face of affairs (planning, implementing and controlling), the final surge (decision making and action) can be accomplished by the business indicator accounting. IV. Structure of System and Disciplinary Approach for Decision: Decision can be classified into syncronized decision and continuous decision, and is closely connected with centralization and decentralization. In the course of systematizing, the sort of decision is classified into a man in charge of decision, and object of decision, conditions of decision, and an adjusting of decision. For it's object, it has an analogical thinking and an analytic subdivision about the target area. And it is premised on getting a scientific understanding. I think a disciplinary approach remains in solving these intricate problems. V. Conclusion: In this study I dealt with a specialization as a structure in management system and a theory that adjustment is a necessary process in decision making. For an adjustment of decision, exchanging informations and communication are necessary, and accounting is in charge of the process. And then the centralization and decentralization of decision should be connected in the way of adjustment of decision. In case of decentralization, the adjustment of decision is accomplished by the exchanging informations through feedback, and in case of centralization, by the all-round planning. And also I found that syncronized decision and decentralized decision are linked together. It is natural that the function of business indicator accounting is called for to render more services for it. Therefore, according to the extent of centralization and decentralization accounting to adjust the decision, can be various. Consequently, in relation to the structure of system. I think it is necessary to make a theoretical and empirical study of the business indicator accounting.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2002년도 추계학술대회
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• pp.180-182
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• 2002

Substantial genomic diversity has been expected among clinical isolates of H. pylori. We have suggested that the two complete H. pylori genomes already sequenced may be insufficient for providing a discriminatory tool for typing clinical isolates as well as an insight into the genomic diversity, which enable to establish strategy for control of H. pylori infection. In this study, we determine the nucleotide sequence of the entire genome of Korean strain 51 and compare it with two reported genomic sequences to suggest validity for extensive genomic sequencing of H. pylori. The genome of H. pylori 51 consists of a circular chromosome with a size of 1,591,297 bp, which is corresponding to $95.4\%\;and\;96.8\%$ of the 26695 and J99 chromosome length, respectively. We predict that there are 1,454 open reading frames (ORFs) in 51, representing $91.4\%\;and\;97.2\%$ of the reported numbers of ORF of 26695 and J99, respectively. In contrast to 26695 and J99 that have 123 and 65 strain-specific genes, respectively, of the 1,454 genes, only 39 genes are unique to 51. Differences in genomic organization between 51 and each foreign strain were greater than between 2 foreign strains in pair wise entire sequence alignments by BLASTN. Particularly, the extent of genomic rearrangement observed between 51 and 26695 is higher than between 51 and J99. Multiple sequence alignment of orthologous genes among 3 strains showed that 51 is genetically closer to 26695 rather than J99. Phylogenetic analysis of nonsynonymous and synonymous mutation indicated J99 has the longest branch length in the unrooted phylogenetic tree, suggesting that J99 has higher mutation rate than the other 2 strains.

• 환경영향평가
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• 제13권3호
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• pp.125-135
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• 2004

Environmental Impact Assessment(EIA) in Korea has been used to improve environmental conservation and decision-making. Since environmental impact statement(EIS) was introduced in 1981 with the promulgation of the Environmental Preservation Act in 1977, which replaced the Pollution Control Act legislated in 1963. With a rapid growth of environmental perception as well as the diversification of development activities, however, it has recently bring about a strong demand for a new assessment process related to the strategic level of policies, plan, programs. Method of this study includes analyses of the situation of local EIA and its problematic issues through survey and analysis of information and data, analysis of the level of environmental awareness of professionals and case studies including analysis of foreign strategic environmental assessment. Accordingly, I have elicited a concept of SEA. In addition, I have studied on costs of environmental assessment, and efficiency of internalization of HIA. The survey was carried between September and November 2003, and 177 professionals were asks to complete a questionnaire. As a result of questionnaire survey of environmental pundits, it revealed that 83.8% of participants were in favor of introduction of strategic assessment. This result demonstrated more or less higher approval rate than those of awareness survey done by the Ministry of Environment, i.e. 86.0% ayes, and 14.0% nays. 22.8% of participants agreed to the opinion; "For introduction of this system, earlier is better," 50% reported having an opinion such as, "Will introduce this system in an earliest possible time after correcting problems," 26.3% reported having an opinion such as, "Let's decide the time for introduction of this system after correcting problems first,' and 0.9% reported having an opinion, "it's too early to introduce this system." Specifically, the ratio of ayes on introduction of the system marked 72.8%, and it revealed that a majority of respondents have an opinion such as, "Will introduce this system in an earliest possible time after correcting problems." As means of solutions for the problem regarding the limits of applications that existed in SEA System, factors, such as collecting a wide variety of opinions, securing experts, and faithful implementation, etc. were reported important, and in addition to these factors, respondents revealed having opinions such as, consistent research and development, reflection of public interest, establishment of professional organization, enforcement of after-management service, expanding investments in large, systemizing reference materials, and encouraging public participation, etc. To improve problems involving with present EIA system, it has been identified through this study that SEA is efficient and useful. In order to have SEA introduced successfully, it has been cleared that internalization of effectiveness of environmental cost together with HIA must be accomplished.

• Archives of Plastic Surgery
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• 제38권2호
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• pp.131-134
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• 2011

Purpose: Stem cells continue to receive research attention in the clinical fields, and adipose-derived stem cells (ADSCs) have been shown to be a good source raw material. Many plastic surgeons are researching the ADSC adipogenesis with a view of conducting clinical trials, and many attempts have been made to identify the factors that promote the adipogenesis of ADSCs, but comparatively few correlation studies have been undertaken to explore the relation between reactive oxygen species (ROS) and the ADSC adipogenesis. We undertook this study is to investigate the effects of ROS on ADSC adipogenesis. Methods: ADSCs were isolated and cultured from abdominal adipose tissue, and cultured in different media; 1) DMEM(control), 2) adipogenesis induction culture medium, 3) adipogenesis induction culture medium with ROS ($20{\mu}M/50{\mu}M\;H_2O_2$), 4) adipogenesis induction culture medium containing ROS ($20{\mu}M/50{\mu}M\;H_2O_2$) and antioxidant ($10{\mu}M/20{\mu}M$ Deferoxamine). We compared adipogenesis in these different media by taking absorbance measurements after Oil-Red O staining every 5 days. Results: After culturing for 20 days, significant differences were observed between these various culture groups. Absorbance results showed significantly more adipogenesis had occurred in media containing adipogenesis induction culture medium and $H_2O_2$ (in a $H_2O_2$ dose-dependently manner) than in media containing adipogenesis induction culture medium and no $H_2O_2$ (p<0.001). Furthermore, in media containing adipogenesis induction culture medium, $H_2O_2$, and antioxidant, absorbance results were significantly lower than in adipogenesis induction culture medium and $H_2O_2$ (p<0.001). Conclusion: These findings suggest that ROS promote the adipogenesis of ADSCs. We suggests that ROS could be used in the adipose tissue engineering to improve fat cell differentiation and implantable fat tissue organization.

• 기술혁신연구
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• 제26권1호
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• pp.1-30
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• 2018

본 연구는 과학기술행정체제와 혁신 거버넌스 연구의 큰 변화 흐름을 살펴보고, 성찰적 자리매김을 통해 향후 나아가야 할 방향을 제시하였다. 분석 대상은 "한국행정학회보", "한국정책학회보" 등의 행정학 조직학 분야와 "과학기술학연구", "기술혁신연구", "기술혁신학회지" 등의 과학기술혁신 분야에 실린 과학기술행정체제 및 혁신 거버넌스 관련 논문을 중심으로 살펴보았다. 이와 함께 각 학회 학술대회 발표 논문과 주요 저서, 그리고 과학기술정책연구원 한국행정연구원 등 국책 연구기관에서 발표된 정책보고서와 정부 문건자료도 분석에 포함하였다. 분석 결과, 연구 자체가 정부조직개편의 일부에서 독자 영역으로 진화하고 그 주제도 세분화되었으며, 역사적 규범적 비교분석 제도론적 접근방법이 주를 이루었다. 또한 과학기술정책의 조정 통합 문제가 연구에서 중요한 과제로 다루어졌으며, 혁신체제론(NIS) 및 거버넌스 관점이 연구에 반영되기 시작했다. 그러나 작은 정부론과 큰 정부론, 거버넌스론과 컨트롤 타워론 등 몇 가지 차원에서 여전히 쟁점을 드러내고 있으며, 귀인 오류, 합리적 모형의 지배, 처방위주의 연구와 연구의 쏠림, 거대 및 세부 담론의 부재 등에서 한계를 러내고 있다. 향후 과제로 합리성 효율성 종합성 설계의 관점에서 벗어나 진화적 합리성 강조, 다차원적 연구 방법론 활용, 한국적 이론 개발과 보편성 확보, 거버넌스 관점의 주류화, 조직문화 등 소프프웨어 측면에 관한 연구 촉진 등을 제시하였다.

• 의료법학
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• 제12권1호
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• pp.133-173
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• 2011

Since mid-1960s the reports from the Surgeon General, the World Health Organization, and other health experts state that there is no risk-free level exposure to smoking and secondhand smoke. Tobacco smoke is made up of more than 7,000 chemicals. Hundreds are toxic, and at least 70 are carcinogens. The chemicals in tobacco smoke reach smoker's lungs quickly every time smoker inhale causing damages immediately. Inhaling even the smallest amount of tobacco smoke can also damage smoker's DNA, which can lead to cancers. Smoking is responsible for more than 87% of lung cancers, but there are a host of other chronic diseases directly related to exposure to tobacco smoke. It's also a major cause of heart disease, stroke, aortic aneurysm, peripheral arterial disease and most of the other diseases. In the United States, each year with more than from 440,000 to 520,000 deaths caused by smoking and exposure to involuntary smoke. They conclude that smoking is the single most important source of preventable morbidity and mortality. The United States of America have about 60-year history of tobacco litigation. Tobacco litigation has been an important tool in tobacco control strategies aimed at limiting the activities of tobacco companies and providing redress to people who have become ill as a result of their use of tobacco products. Tobacco litigation is a kind of tort litigation. Quite often, as in the asbestos and other mass tort litigation episodes, tobacco litigation can play an educational role, warning the public about the magnitude of health risks that might otherwise be less clearly perceived. Tobacco litigation allows smokers, their families or other victims of smoking to sue tobacco companies in order to be compensated for the harm they have suffered. Potential benefits of tobacco litigation include compensation for smoking-related damages, strengthening regulatory activity, publicity, documents disclosure and changing tobacco industry behavior. And also tobacco litigation can limit the political activities of tobacco industry, protect human rights of smokers and non-smokers, increase burden to tobacco price-up and enhance the effects of law and politics in public health.

• 인터넷정보학회논문지
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• 제9권2호
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• pp.107-118
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• 2008

Agile 소프트웨어 개발의 대표적인 방법론인 XP(eXtreme Programming)에서는 현장에서 바로 활용할 수 있는 아주 기본적인 프로세스만을 정의하고, 개발 그 자체에 집중하여 효율성을 극대화한다. 그러나 XP의 실천사항들은 개발에 집중되어 있어 개발 산출물에 대한 관리는 간과되기 쉬우며, 또한 관리적인 부분에 대한 지침이나 연구는 그 중요성에 비하여 미흡한 실정이다. 개발 과정 중 합의된 산출물의 변경과정에 대한 절차나, 지속적인 통합과 리팩토링을 위한 적절한 절차도 정의되어 있지 않아 산출물의 무결성을 보장하기가 어렵다. 이러한 문제점을 극복하기 위해서는 주요 산출물들에 대한 형상관리가 요구된다. XP에 형상 관리를 적용하기 위해서는 CMMI의 형상 관리 프로세스 영역을 참조하는 것이 바람직하다. CMMI는 형상 관리의 요건을 정의하고, 그 구현은 환경에 맞게 조정하는 것을 권장하기 때문에, 각 개발방식의 특성에 맞추어 적용할 수 있다. XP 방법론을 채택한 조직들에게 XP의 특성을 살리면서 CMMI에 기반한 형상 관리를 수행할 수 있는 지침이 제공된다면, XP의 지속적인 통합과 리팩토링, 짧은 릴리즈 주기와 같은 기민함을 유지하면서 산출물들의 무결성도 보장 할 수 있을 것이다. 본 연구에서는 CMMI를 기반으로 XP에서 적용될 수 있는 형상 관리 프로세스 요소를 추출하고, 그 요소들을 기반으로 XP의 형상 관리 활동을 위한 적용 지침을 개발하였다.

• 생명과학회지
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• 제25권5호
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• pp.585-593
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• 2015

Stress fiber (SF) 변화는 세포외부의 결합인자와 세포 수용체와 결합후 리모델링을 위해 액틴골격에 신호를 전달하며 일어난다. 이 연관은 결합장소에서 기계적 활동과 신호전달활동을 조절하는 다양한 스케폴드들과 신호 전달자에 의해 매게된다. Heterotrimeric transmembrane lymphotoxin α1β2 (LTα1β2)는 용해성 homotrimeric LT α를 포함하는 tumor necrosis factor (TNF) 계로 림프조직을 구성하는데 중요한 역할을 한다. LTα1β2와 LTβR의 결합은 fibroblastic reticular cell (FRC)에서 신호전달을 촉발한다. Agonistic anti-LTβR antibody 단독 혹은 LTα 그리고 TNFα의 조합으로 LTβR 자극은 세포의 액틴과 형태적 변화를 보았다. Agonistic anti-LTβR antibody의 FRC에서 작용을 통한 세포골격 재배열이 myosin과의 관련성을 확인하기위해 myosin light chain kinase (MLCK)의 저해제인 ML-7과 myosin light chains (MLC)와 myosin phosphatase target subunit 1 (MYPT1)의 인산화에 대한 효과를 확인하였다. MLCK 저해는 액틴 세포골격 재배열과 세포형태 변화를 유도하였다. 또한, MLC와 MYPT1인산화가 LTβR 자극에 의해 줄어드는 것을 확인하였다. DNA chip 분석은 myosin and actin 구성선분이 전사체 수준에서도 줄어드는 것을 보였다. 결론적으로 LTβR 자극은 FRC에서 SF변화는 myosin과 관련되어 있다는 것을 제시한다.

• 치위생과학회지
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• 제17권6호
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• pp.472-480
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• 2017

치과의료기관 의료장비 표면 및 치과위생사 손의 S. epidermidis 오염도 조사를 위해 2017년 7월부터 8월까지 일부지역 20개 치과의원에서 치과위생사 20인의 손 오염, 치과별 7부위 표면 140부위의 S. epidermidis 오염도를 조사하였다. S. epidermidis 오염도는 핸드플레이트와 로닥플레이트를 사용하였으며, $35^{\circ}C$ 24시간 배양하였다. 손 오염도는 핸드플레이트 기준에 근거하여 저, 중, 고 그룹으로 분류한 후 그룹별 손 부위별 오염도를 ANOVA 분석하였다. 의료장비 표면 오염수준은 집락을 계수하여 기술통계 하였다. 치과위생사 55%는 중등도 이상의 손 오염이 있었고, 부위별로는 손바닥이 29.45 CFU로 가장 높게 나타났으며, 그 다음으로는 중지 7.8 CFU, 약지 6.4 CFU, 엄지 6 CFU 순서였다. 의료장비 표면 오염도 조사결과 3-way 손잡이 4.45 CFU, 컴퓨터 마우스 3.37 CFU, 거울 손잡이 1.60 CFU로 다른 영역보다 높게 조사되었다. 손 오염도가 높은 집단일수록 손의 S. epidermidis 오염도가 높은 양적 상관관계를 나타내었다. S. epidermidis 오염도는 의료장비 표면 오염보다 손에서 높게 나타났다. 그러므로 의료진들은 손 위생의 중요성을 인식하고 WHO에서 제시한 방법으로 손 위생을 실천하는 것이 요구되었다. 의료진들이 감염관리 업무수행에 책임감을 갖고 안전한 의료 환경을 조성할 수 있도록 감염관리 지침과 체계적인 감염관리 업무 수행에 관한 교육이 요구되었다.