• Genomics & Informatics
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• v.6 no.3
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• pp.117-125
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• 2008

Recently, obesity has become a worldwide public health concern and the use of anorectic drugs has drastically increased. In this study, sibutramine and phendimetrazine, representative marketed anorectics, were repeatedly administered per os on a daily basis into C57BL/6 mice and the effects of these drugs on food intakes, body weight changes and gene expression profiles were monitored for up to following 7 days. Methamphetamine, which has a potent anorectic effect, was used as a positive control. Anorectic effects were sustained only for two days by phendimetrazine or methamphetamine, but for six days by sibutramine. The modulations of gene expressions in the hypothalamus and the striatum were investigated using microarrays on day 2 and day 7 post-administration, which corresponded to the anorectic period and a return of appetite respectively, for all three drugs tested. Differences in overall gene expression profiles in the stratum on day 2 for sibutramine and phendimetrazine seems to reflect difference between the two in terms of the onsets of drug tolerance. According to microarray findings, the Ankrd26 gene appears to have an important anorectic role, whereas the up-regulation of the olfaction system appeared to be involved in the drug tolerance of anorectics. The microarray data presented in this study demonstrates the usefulness of gene expression analysis for gathering information on the efficacy and safety of anorectic drugs.

• Genomics & Informatics
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• v.6 no.3
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• pp.153-156
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• 2008

Complex diseases such as stroke and cancer have two or more genetic loci and are affected by environmental factors that contribute to the diseases. Due to the complex characteristics of these diseases, identifying candidate genes requires a system-level analysis of the following: gene ontology, pathway, and interactions. A database and user interface, termed StrokeBase, was developed; StrokeBase provides queries that search for pathways, candidate genes, candidate SNPs, and gene networks. The database was developed by using in silico data mining of HGNC, ENSEMBL, STRING, RefSeq, UCSC, GO, HPRD, KEGG, GAD, and OMIM. Forty candidate genes that are associated with cerebrovascular disease were selected by human experts and public databases. The networked cerebrovascular disease gene maps also were developed; these maps describe genegene interactions and biological pathways. We identified 1127 genes, related indirectly to cerebrovascular disease but directly to the etiology of cerebrovascular disease. We found that a protein-protein interaction (PPI) network that was associated with cerebrovascular disease follows the power-law degree distribution that is evident in other biological networks. Not only was in silico data mining utilized, but also 250K Affymetrix SNP chips were utilized in the 320 control/disease association study to generate associated markers that were pertinent to the cerebrovascular disease as a genome-wide search. The associated genes and the genes that were retrieved from the in silico data mining system were compared and analyzed. We developed a well-curated cerebrovascular disease-associated gene network and provided bioinformatic resources to cerebrovascular disease researchers. This cerebrovascular disease network can be used as a frame of systematic genomic research, applicable to other complex diseases. Therefore, the ongoing database efficiently supports medical and genetic research in order to overcome cerebrovascular disease.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.191-199
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• 2014

This study was analyzed to relate between business performance and leadership types for global corporations practically. Also, in this study for research, Have developed a research model to analyze comprehensively using the business performance and leadership theory. One of the important things are leader's characteristics or contingency factors at global corporations, but leadership is being re-evaluated through how it enable to perceive and to evaluate at the organization. Therefore, this study had been analyzed to relationship with the type of global readers between the employee's perception and business performance focusing on research model The research results had shown that job satisfaction, performance variables like sales amount, and productivity to be impact on the leadership type of global enterprises. Therefore, this study concluded that the efficiency and performance of the Company may increase when assigned a leadership professional to be able to consider the nature of the global enterprise. Results of the study, will be expected to be a useful guide for control of business performance at global corporation in the future.

• The Journal of Fisheries Business Administration
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• v.41 no.3
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• pp.103-127
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• 2010

The FAO reports that IUU fishing activities have widespread economic, social, and management consequences, including depriving legitimate fishers of harvest opportunities. It affects all fisheries from small scale to industrial. It also affects the ability of governments to support sustainable livelihoods for fishers and, more broadly, to achieve food security. The complexity of IUU requires various measures to combat IUU fishing such as adoption of IUU vessel lists; stronger port State controls; improved monitoring, control and surveillance (MCS); implementation of market-related measures to help ensure compliance; and capacity-building assistance. Trade and market measures reduce opportunities for IUU fishing activities by precluding or impeding access to markets for IUU product in a manner consistent with international law. ICCAT, CCAMLR, and IATTC, have put in place trade tracking programs or catch documentation schemes, and WCPFC is considering such a program. Vessel lists assist enforcement authorities in determining which vessels are or are not authorized to be fishing or conducting fishing support activities in specified areas. A number of RFMOs maintain records of IUU vessels: CCAMLR, IATTC, ICCAT, NAFO, NASCO, NPAFC, WCPFC. Section 608 of the US MSRA calling on the Secretary of Commerce, in consultation with the Secretary of State, and in cooperation with relevant regional fishery management councils and any relevant advisory committees, to take actions to improve the effectiveness of international fishery management organizations in conserving and managing stocks under their jurisdiction. EU IUU Regulation entered into force on 1 January 2010, was intended to regulate the highly complex multi-channel fisheries supply system of the European Community (EC) in an effort to improve global fisheries sustainability.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.4
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• pp.418-424
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• 2015

Marine Environment Protection Committee of the International Maritime Organization has decided to reinforce the NOx emission standards for ships passing an ECA(Emission Control Area) with Tier III standards from January 1, 2016. In this study, real-time measurements of the exhaust gas, cylinder pressure and fuel consumption were conducted at each load of a T/S Hanbada main engine of Korea Maritime and Ocean University, which is controlled by single injection and double post injection for reducing NOx emissions. The results showed that the quantity of CO2 and NOx increased in proportion to the engine load, whereas the CO concentration was inversely proportional to the engine load. In addition, double post injection decreased 10 % of P-max and reduced 25~30 % of the NOx emissions compared to single injection, whereas there was a trade-off relation, such as increase 3~5 % of SFOC (Specific Fuel Oil Consumption).

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.6
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• pp.843-851
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• 2009

Much work has already been done to control and regulate the worldwide problems caused by climate change, particularly the issues on greenhouse gas (GHG) emissions. Carbon dioxide ($CO_2$), having the highest form of concentration among GHGs composed around 1.0 billion tons of emission, and comprises about 98% of the total emissions from the shipping industry. Korean trade mainly rely on the sea transportation. Korean ship tonnages that was brought about by shipbuilders all over the country, continues to grow annually due to the prevailing demands on goods or material supplies and depicting only a small part of the global maritime activity. Nowadays, new build ships coming from the Korean Shipbuilders are being optimized by hull, structure and appendages design, The operational capability of the propulsion and auxiliary machineries in its maximum capacity to achieve the highest possible efficiencies for energy and onboard power use to mitigate $CO_2$ emissions are continually being done through the help of research and development. In this paper, the energy efficiency design index and anboard power capacity of Korean new build ships have been analyzed with response to data collected by ship types, and its respective fuel consumption in relation to $CO_2$ emission results. In response to climate change convention outcome proposals, the best way for the new build ships to become energy efficient is by lowering its operational speed thru adopting the state of the art diesel propulsion engines, patronizing the best sailing practice to lower the transportation cost on the different sea trade routes also helps in $CO_2$ mitigation.

• The Journal of Information Systems
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• v.8 no.1
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• pp.149-176
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• 1999

Regional information infrastructure(RII) plays an increasingly important role in determining the competitiveness of companies operating within the region. The purposes of this research are (1) to identify the types of RII demanded by the companies operating within Pusan and KyungNam areas in Republic of Korea, (2) to explain the levels of RII demand using variables including organizational environment, organizational strategy, and the importance of information systems for the organization, and (3) to examine whether the types of RII demand are different depending on the competition strategies that companies are pursuing. The most important type of RII that region companies demand is information systems personnel having knowledge in systems control, systems planning, communication network, database administration, and system construction. In addition, demanded are TSDN, satellite communication network, and shareable software and hardware. The levels of RII demand are different depending on the importance of information systems(IS) roles for the businesses. The more important IS role is for a company, the more sharable computing equipments and facilities are demanded. The importance of IS role is affected by the organizational environment and organizational strategy. The levels of RII demand are different also depending on the competitive advantages that companies are pursuing. Companies focusing on achieving short-term and direct benefits using information technology tend to have higher demands on sharable computing equipments and facilities as well as on information communication services. This research is explorative in nature One major limitation of this research, therefore, is that the plausibility of the postulated hypotheses was not examined simultaneously. This research is meaningful in that it first attempted to measure the demands of regional companies for RII.

• The Journal of Information Systems
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• v.19 no.2
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• pp.23-36
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• 2010

The focus of this study is to analyze between South Korea and China in terms of diversity in Management Information Systems research. As a result, there is herding phenomenon regarding researches in both of the countries compared to other previous studies. There also seemed to be lack of in-depth study of basic theories and connection to related field of study considering the broad topics of management information, unlike other international journals that pursue diversity in control referencing various methodologies, analysis units and many citations. Therefore, both South Korea and China should stabilize theoretical base of MIS through securing independent field of MIS along with founding the fundamentals by searching in diversified fields, methodologies and analysis units with focused topics. The upshot here is that with respect to diversity in MIS from both countries, to alleviate herding phenomenon, enforcing accuracy of data collection and reducing convenience pursuit should be implemented. Also as criteria to select a topic, different kinds of consulting concepts and taking social issues into consideration that helps tool development and analysis power should be done. Through varied methodologies, tool development and analysis power should be assisted and analysis unit should be shifted to organization unit for Korea and team or individual for China only to augment the accessibility. As a limitation for the paper is that the data used in this analysis is secondary data. In addition, although time period used in both countries were the same, object of analysis had homogeneity in Korean case while Chinese one having heterogeneity from 19 different journals. For the future studies, multicultural comparison or time series analysis and their comparison in deeper approach with regard to object of analysis and methodologies can contribute to further MIS diversity.

• Journal of Digital Convergence
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• v.8 no.4
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• pp.1-17
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• 2010

Many organizations have had deep interests in studies concerning leadership and also in academic area, not only management but also psychology. Until now, the leadership has been accentuated to managers or team leaders especially. Recently, however, the concept of self-leadership that lead one's own activities toward right direction through self-control or self-management is being focused on practices and academia. This study is to investigate the influence between self-leadership strategies and learning performance at IT classes mediated by attitude of attendance focused on the social science students in an university. Research results can give us right direction of task-taking attitudes in firms or learning attitudes in teaching organization and implications to human resource manager who are in charge of improving learning performance or productivity.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.11 no.2
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• pp.58-61
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• 2015

The people with disabilities living in residential facilities have more difficulty in caring oral hygiene than those living at home. The purpose of this study is to evaluate the recent 2014 dental treatment records of free mobile dental clinic service for disabled people in Korea. 203 disabled living in residential facilities participated in mobile dental clinic. Patients classified according to types of disability. Mental retardation were 75.3%, mental disorder were 6.0%, crippled disorder were 7.4%, brain disorder were 6.5%, visual disorder were1.4%, auditory and speech disorder were 2.3% and autism disorder were 0.9%. Performed treatments were 99 scaling and curettage, 88 fluoride varnish and TBI, 4 extraction, 1 endodontic treatment, 16 caries control (resin filling, GI filling), 1 denture repair and 8 refuse the treatment. Free mobile dental clinic can not provide complex dental treatment. So, the organization should systemize advanced dental treatment and regular preventive programs. Furthermore, we need to have a more concerns about the people with disabilities living in residential facilities and constantly participate on a dental voluntary work.