• Title/Summary/Keyword: Organic Compound

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Synthesis of Certain 6-(Arylthio)uracils and Related Derivatives as Potential Antiviral Agents

  • El-Emam, Ali A.;Massoud, Mohamed A.M.;El-Bendary, Eman R.;El-Sayed, Magda A.
    • Bulletin of the Korean Chemical Society
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    • v.25 no.7
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    • pp.991-996
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    • 2004
  • New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.

Development and Application of Pervaporation Membranes (투과증발막의 발전과 응용)

  • 유제강;임지원;이영무;남상용
    • Membrane Journal
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    • v.12 no.4
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    • pp.193-206
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    • 2002
  • Pervaporation separation is one of promising membrane technology for the energy saving processes and it has been developed to separate complex mixture systems including azeotropic mixture, close-boiling mixture, aqueous organic mixtures etc. Many researchers focused on dehydration pervaporation separation and they commercialized ethanol dehydration and isopropanol recycling processes. Nowadays, petroleum separation and volatile organic compound removal using pervaporation membranes is one of the emerging application of pervaporation separation. We reviewed the development and application of pervaporation membranes.

Studies on Light-Induced Mitochondrial ATPase in Pleurotus ostreatus -Effects of Organic Compounds- (느타리버섯 중의 Light-Induced Mitochondrial ATPase에 관한 연구 -유기물 효과-)

  • Lee, Ho-Yeon;Min, Tai-Jin
    • The Korean Journal of Mycology
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    • v.20 no.1
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    • pp.51-57
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    • 1992
  • Mitochondria in Pleurotus ostreatus were isolated and purified by stepped sucrose density gradient centrifugation, to compare the effects of organic compound on the activities of mitochondrial ATPase in Basidiomycotina with those in mammalian cell. The effects of N, N'-dicycio-hexylcarbodiimide (DCCD), carbonyl cyanide m-chlorophenylhydrazone (CCCP), sodium azide and aurovertin known as compounds to be related to electron transfer system in mitochondria were studied. A activity of mitochondrial ATPase was inhibited by 64%, 57% and 53% in the presence of 0.25 mM DCCD, 0.02 mM sodium azide and 1.5 $({\mu}g/mg\;of\;protein)$ aurovertin B, respectively. It was stimulated by 22% in the presence of 0.15 ${\mu}M$ CCCP.

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2-amino-3-[(E)-4-(diethylamino)-2-alkoxy-benzylideneamino]- fumaronitrile 유도체 ICT 화합물의 결정 구조

  • Kim, Byung-Soon;Matsumoto, Shinya;Son, Young-A
    • Proceedings of the Korean Society of Dyers and Finishers Conference
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    • 2011.03a
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    • pp.62-62
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    • 2011
  • Intramolecular charge transfer (ICT) system has received great attentions due to their promising optoelectronic properties For the efficient ICT of the chromophore, their organic compound mainly consists of strong electron donors (e.g. $NR_2$ or OR groups) and acceptors (e.g. CN or $NO_2$ groups). According to the molecular design and synthesis, the ICT compounds can be extended in many application fields. In this study, we have synthesized ICT compounds having a strong electron acceptor and donor. These novel ICT compounds were easily synthesized by a previously described method with some modifications. Their single crystals were grown and their structures were solved and described in this presentation.

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The Analysis of Volatile Organic Compounds in Water by Using the Purge-and-Trap and the Gas Chromatography/Mass Selective Detector with Modified Indirect Coupling (퍼지-트랩장치와 변형된 간접 결합기를 부착한 기체크로마토그래피/질량 선택성 검출기를 이용한 물중의 휘발성 유기화합물의 분석)

  • 정영자
    • The Korean Journal of Food And Nutrition
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    • v.12 no.2
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    • pp.191-191
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    • 1999
  • A Purge & Trap Concentrator was used to analyze various volatile organic compounds(VOCs) in wat-er. The object of this study was to observe the purge efficiency of 40 VOCs in water according to the change of parameters (purge time drypurge time sample temperature) and to determine the optimum condition for VOCs using the purge & Trap concentrator interfaced with a narrow capillary connected to a gas chromatography/mass spectrometry. The optimum condition of purge and trap is as follows: purge time at 11min drypurge time at 5min sample temperature at 6$0^{\circ}C$ at constant purge flow (40mol/min) constant desorption flow(20ml/min) desorption temperature(2$25^{\circ}C$) and desorption time (1min) At this analytical condition the detection limits of VOCs was in the range of 0.1~0.5$\mu$g/ml and the purge efficiency of each compound was over 70%.

Regulation Problem and Technical Improvement for Livestock Manure Utilization (가축분뇨의 배출규제문제와 처리개선방안)

  • 유덕기
    • Korean Journal of Organic Agriculture
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    • v.11 no.1
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    • pp.1-19
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    • 2003
  • Nowadays liquid manure can no longer be regarded as a waste product, but as a compound fertilizer, which should be used as efficiently as possible, especially on the farm. Additionally, there is the intensified public discussion about environmental issues. With respect to the ecological effects of the proper application of liquid manure, administrative regulations in the form of guidelines, decrees and ordinances have been established in region. It is questionable though, if such quantifying restrictions bring a reduction of ground water pollution, or if not through these measures new problems will be created, i. e. be temporarily postponed. Moreover, in this Study, possible Operation and technical Improvement are presented.

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Electrochemical Studies on Heptamethine Cyanine Dyes

  • Kim, Young-Sung;Shin, Jong-Il;Park, Soo-Youl;Jun, Kun;Son, Young-A
    • Textile Coloration and Finishing
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    • v.21 no.5
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    • pp.35-40
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    • 2009
  • Computational calculations of molecular orbital and electrochemical redox/oxidation potentials are of very importance to determine the compound properties. The energy levels of molecular orbital were calculated by the density function theory (DFT) with exchange correction functional of local density approximation (LSA) based on the Perdew-Wang (PWC) setting and cyclic voltammetry.

Synthesis of Long Chain Alkyl Urocanate and Solubilization in Organic Solvent (긴사슬 알킬 우로칸에스테르의 합성 및 유기물질에서의 가용성)

  • Ro, Y.C.;Jeong, H.K.;Nam, K.D.;Lee, J.H.
    • Journal of the Korean Applied Science and Technology
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    • v.10 no.1
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    • pp.83-91
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    • 1993
  • The syntheses of urocanic acid esters was optimized, starting from p-toluenesulfonic acid salt of this acid and long chain fatty alcohols in the organic solvent and extracting water from it by means of azeotropic Compound. The salts of these urocanic acid esters showed amphoteric properties, but their micellization enhances their rate of hydrolysis leading to the free amine. Nevertheless the long chain gives to the esters themselves an amphoteric character allowing their solubilization in micellar media and in microemulsions the result, yield could enhanced.

Crystal Structure Analysis of 3-(4-ethylphenyl)-3H-chromeno[4,3-c]isoxazole-3a(4H)-carbonitrile

  • Malathy, P.;Ganapathy, Jagadeesan;Srinivasan, J.;Manickam, Bakthadoss
    • Journal of Integrative Natural Science
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    • v.8 no.4
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    • pp.250-257
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    • 2015
  • The crystal structure of the potential active 3-(4-ethylphenyl)-3H-chromeno[4,3-c]isoxazole-3a(4H)-carbonitrile ($C_{19}H_{16}N_2O_2$) has been determined from single crystal X-ray diffraction data. In the title compound crystallizes in the monoclinic space group $P2_1/c$ with unit cell dimension a=6.6869 (8) ${\AA}$, b=15.8326 (19) ${\AA}$ and c= 15.237 (2) ${\AA}$ [${\alpha}=90^{\circ}$, ${\beta}=100.663^{\circ}$ and ${\gamma}=90^{\circ}$]. In the structure chromene, isoxazole and carboxylate are almost coplanar each other. All geometrical parameters revelled that chromene ring of pyran ring adopt sofa conformation. The crystal packing is stabilized by intermolecular C-H...N and C-H...O hydrogen bond interaction.

Crystal Structure Analysis of Methyl-3-phenyl-3H-chromeno[4,3-c]isoxazole-3a(4H)-carboxylate

  • Ganapathy, Jagadeesan;Srinivasan, J.;Manickam, Bakthadoss
    • Journal of Integrative Natural Science
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    • v.8 no.3
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    • pp.184-191
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    • 2015
  • The crystal structure of the potential active methyl-3-phenyl-3H-chromeno[4,3-c]isoxazole-3a(4H)-carboxylate ($C_{18}H_{15}NO_4$) has been determined from single crystal X-ray diffraction data. In the title compound crystallizes in the orthorombic space group $P2_12_12_1$ with unit cell dimension $a=9.8320(17){\AA}$, $b=9.9890(18){\AA}$ and $c=15.588(3){\AA}$ [${\alpha}=90^{\circ}$, ${\beta}=90^{\circ}$ and ${\gamma}=90^{\circ}$]. In the structure chromene, isoxazole and carboxylate are almost coplanar each other. All geometrical parameters revelled that chromene ring of pyran ring adopt sofa conformation. The crystal packing is stabilized by intermolecular C-H...O and C-H...N hydrogen bond interaction.