• 대한소아치과학회지
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• 제48권4호
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• pp.425-436
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• 2021

이 연구는 서울대학교치과병원에서 시행된 소아 청소년 환자의 구강 병소 생검 결과를 후향적으로 분석하여, 소아 청소년의 구강 질환에 관한 병리학적 자료를 제시하고자 하였다. 2000년 1월부터 2020년 4월까지 서울대학교치과병원 구강병리과에서 만 16세 이하를 대상으로 시행된 구강 조직 생검 결과에 대한 의무기록을 열람하였다. 환자는 0 - 5세, 6 - 11세, 12 - 16세의 세 집단으로 나누었으며 병소는 염증성 및 반응성 병소, 종양 및 종양성 병소, 낭성 병소의 세 범주로 분류하였다. 총 2928개의 생검 조직 중 종양 및 종양성 병소(35.66%)가 가장 많았으며, 염증성 및 반응성 병소(34.29%), 낭성 병소(30.05%) 순이었다. 카테고리와 상관없이 가장 많은 수를 차지한 병소는 치아종이었으며, 점액종, 함치성낭이 그 뒤를 이었다. 이 연구는 대한민국에서 시행된 소아 구강 병리에 대한 최초의 후향적 연구로, 임상에서 이러한 병변을 마주칠 수 있는 소아치과 의사에게 유익한 식견을 제공할 수 있을 것으로 기대된다.

• Journal of Periodontal and Implant Science
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• 제48권4호
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• pp.213-223
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• 2018

Purpose: Oral lichen planus (OLP) is a chronic oral mucosal disease that has been recognized as an immune condition. The purpose of this study was to evaluate factors affecting the clinical outcomes of topical corticosteroid application on OLP lesions using dexamethasone gargle and ointment. Methods: The charts of patients who were clinically diagnosed with OLP and treated with dexamethasone from July 2003 to August 2017 at the Section of Dentistry of Seoul National University Bundang Hospital were thoroughly evaluated to identify subjects who were suitable for this retrospective study. For each patient, age at the index date, gender, medical history, and dental records related to OLP lesions and dexamethasone treatment were reviewed. Results: In total, 113 of the 225 patients were included in the present study. Among them, 79 patients were female (69.9%) and 34 were male (30.1%), with a mean age of 57.6 years. The average duration of dexamethasone treatment was 4.7 months and the mean follow-up period was 2.24 years. Improvements were observed within 1 year after dexamethasone treatment in most cases, and 17.7% of patients had a new OLP lesion after treatment. New OLP lesions were more frequently gingival than mucosal, although mucosal OLP lesions were more common than gingival OLP lesions in all age groups. In age- and gender-adjusted multivariate logistic regression, a history of malignant disease was found to be a significant factor affecting the formation of new lesions. Gingival OLP lesions and intermittent use of dexamethasone showed near-significant associations. In Kaplan-Meier failure analysis, history of malignancy, menopausal status, age, and the site of the OLP lesion were significant factors affecting clinical outcomes. Conclusions: The treatment outcomes of OLP were significantly influenced by age, history of malignancy, menopausal status, and the site of the OLP lesion, but not by factors related to dexamethasone treatment.

• Journal of International Society for Simulation Surgery
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• 제3권2호
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• pp.84-86
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• 2016

Heterotopic ossification (HO) is the formation of mature bone in soft tissue where bone normally does not exist. Although HO is among the most common complications after orthopedic surgery, it is not familiar to oral and maxillofacial surgeons. Here we report rare cases of HO. When a patient presents atypical osseous lesions, HO as well as similar lesions such as osteoma, osteochondroma should be considered in the provisional diagnosis. Three-dimensional reconstruction of preoperative computerized tomography imaging improves surgical success.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.22.1-22.6
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• 2016

Background: The aim of this study is to quantitatively evaluate the effect of rhBMP-2 for repair of bone defects after cyst enucleation using the osteogenesis index (OI). Methods: Under general anesthesia, 10 patients (12 lesions) underwent oral or maxillofacial surgery for cyst enucleation. Postoperatively, 12 lesions were divided into two groups: group A (six lesions) was treated with absorbable collagen sponge (ACS) in combination with rhBMP-2, and group B (six lesions) was treated with ACS alone. After 3 months, cone-beam computed tomographic scans were obtained to measure changes in the volume of the lesions. We then calculated the OI of each group at two different Hounsfield units to determine any statistically significant difference between these two groups (Mann-Whitney U test). Results: As tested at the level of new bone, the mean OI was 72.37 % in group A and 55.08 % in group B -a statistically significant difference (p = 0.041). As tested at the level of mature bone, the mean OI was 27.47 % in group A and 18.88 % in group B, but the difference was not statistically significant (p = 0.394). Conclusions: The application of rhBMP-2 after maxillofacial cyst enucleation accelerated new bone formation in the bone defects. Thus, the use of rhBMP-2 in combination with ACS may be considered an alternative to conventional bone grafting in some patients with postoperative bone defects.

• Journal of Oral Medicine and Pain
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• 제36권4호
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• pp.207-213
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• 2011

구강 점막에 발생하는 동통성 궤양은 다양한 질환에 의해 발생할 수 있다. 구강내 병소가 발생한 후 피부병소가 발생하는 질환 또는 구강과 피부 동시에 병소가 발생하는 질환의 경우, 구강내만 국한하여 검사를 시행하고 피부 병소를 간과할 때는 진단이 어려울 수 있다. 본 증례에서는 구강 및 전신에 발생한 통증성, 미란성 병소가 나타나는 다형홍반 및 Stevens-Johnson syndrome(SJS) 환자를 경험하여 이를 보고하고 피부병소가 동반되는 구강점막 질환에 대해 고찰해 보고자 한다.

• Journal of Oral Medicine and Pain
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• 제38권1호
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• pp.1-5
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• 2013

다형 홍반은 피부 혹은 점막에 영향을 미치는 수포성, 궤양성의 염증성 질환이다. 이는 단순포진 바이러스와 같은 감염이나, 항생제나 진통제와 같은 약물에 의해 유발하는 것으로 알려져 있다. 증상으로는 피부에 과녁모양의 전형적인 병소가 나타나는 것으로 알려져 있으며, 구강 내에 증상이 발현 될 경우, 입술, 볼, 혀에 미란성의 병소가 발현되는 것으로 알려져 있고, 이는 다른 구강내 병소와의 감별을 필요로 한다. 본 증례에서 트리코모나스 감염 또는 메트로니다졸 투여로 인해 유발되었을 것으로 추정되는, 구강에 발생한 다형홍반의 사례를 소개하고, 다형홍반의 진단 및 치료에 대해서 고찰해 보고자 한다.

• 치과방사선
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• 제27권2호
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• pp.117-125
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• 1997

The purpose of this study was to evaluate the detectability of various radiographic techniques for mandibular condylar lesions. Erosive lesion, osteophyte and flattening were formed on the artificial mandibular condyle, and panoramic, transcranial, transorbital radiography, lateral and frontal tomography were taken. The results were as follows; 1. The detectability for erosive lesions was superior in the order of frontal tomography(96％), lateral tomography(78％), transorbital(59％), transcranial(16％) and panoramic(48％) radiography. 2. The location of erosive lesion that showed the highest detectability was the medial third in panoramic, the lateral third in transcranial, the central portion of anteroposterior direction in transorbital, the central portion of mediolateral direction and the posterior third in lateral tomography. Frontal tomography disclosed all erosive lesions except one anterolateral lesion. 3. The detectability of osteophyte was 100％ in lateral tomography, 78％ in transcranial and 56％ in panoramic radiography. 4. For flattening, lateral tomography showed the flattened condyle, but both panoramic and transcranial views showed only decreased bone density without the change of condylar shape.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1633-1637
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• 2012

Introduction: The incidence of oral premalignant and malignant lesions is on the rise due to an increased number of people taking in tobacco and alcohol related habits. Material and Methods: 1028 patients with tobacco, alcohol and areca nut habits attending our Department of Oral Medicine and Radiology formed the study sample. An interviewer based questionnaire was used to record the habit details. All the patients were then examined clinically for the presence of lesions. Chi square and Fisher exact tests were used to assess the statistical significance of the study parameters. Results: Males had a higher prevalence and comprised 87.9% of the sample. The commonest habit in this study sample was smoking (39.2%) followed by smokeless tobacco use (28.1%). Out of the 1028 patients with habits 40% had no clinically detectable changes in their mucosa. Of the mucosal changes leukoplakia (14%) was the commonest. Conclusions: This study provided information about the habit trends in the patients visiting this institution. The study may serve as a useful tool in educating the patients about the deleterious effects of oral tobacco, alcohol and betel exposure.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제45권6호
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• pp.316-323
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• 2019

Objectives: This study aimed to determine the prevalence of odontogenic cysts, tumors, and other lesions among reports in the archives of the Department of Oral and Maxillofacial Surgery at the Faculty of Dentistry affiliated with Kocaeli University collected over a four-year period. Materials and Methods: In this retrospective study, patient records from the archive of the Department of Oral and Maxillofacial Surgery from 2014 to 2018 were reviewed. Patient demographic information (age and sex) and lesion location were recorded and analyzed. Results: From a total of 475 files reviewed, odontogenic cyst was confirmed in 340 cases (71.6%), and odontogenic tumor was confirmed in 52 cases (10.9%). Regarding odontogenic cyst type, the most common was radicular cyst (216 cases), followed by dentigerous cyst (77 cases) and odontogenic keratocyst (23 cases). Among odontogenic tumors, the most frequent was odontoma (19 cases), followed by ossifying fibroma (18 cases) and ameloblastoma (9 cases). Giant cell granuloma was also reported in 35 cases. Conclusion: The distribution pattern of odontogenic cysts and tumors in our retrospective study is relatively similar to that reported in the literature. Complete clinical reports for final diagnosis of these lesions and routine follow-up examinations are very important for treatment.

• 대한치과의사협회지
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• 제50권12호
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• pp.727-731
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• 2012

An ulcer is defined as loss of epithelium. Although many oral ulcers have similar clinical appearances, their etiologies encompass many disorders, including trauma, infection, immunologic disease, and malignant oral cancer. Oral squamous cell carcinoma(SCC) occupying about 90% of oral cancer, usually manifests as unhealed ulcer over 2 weeks. Oral SCC can metastasize to the cervical neck lymph node, and therefore the surgical therapeutic modality for oral SCC could encompass the neck node dissection as well as wide excision for primary lesions, which should leave the post-operative complication of functional damage like dysphagia and facial deformity. Therefore, it is important to discriminate oral SCC from other ulcerative conditions to make a prompt management. The knowledge for the pathogenesis of the ulcerative lesions could help the clinicians to understand the differences of clinical features and to practice an appropriate therapeutics.